483 research outputs found
Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after platinum-based chemotherapy
En este trabajo damos una demostración simple de la descomposición de ciertas representaciones polinomiales del grupo simétrico basadas en la parametrización de sus representaciones irreducibles desarrollada en (2)
A Study of the Scintillation Induced by Alpha Particles and Gamma Rays in Liquid Xenon in an Electric Field
Scintillation produced in liquid xenon by alpha particles and gamma rays has
been studied as a function of applied electric field. For back scattered gamma
rays with energy of about 200 keV, the number of scintillation photons was
found to decrease by 64+/-2% with increasing field strength. Consequently, the
pulse shape discrimination power between alpha particles and gamma rays is
found to reduce with increasing field, but remaining non-zero at higher fields.Comment: 15 pages, 12 figures, accepted by Nuclear Instruments and Methods in
Physics Research
Método de obtención de un biomaterial
La presente invención está dirigida a un método de
obtención de un biomaterial que comprende un
soporte de fibras de carbón activado y células de
linaje osteocondral, en el que células madre se ponen
en contacto con dicho soporte y se cultivan en
presencia de suero y ausencia de factores de
diferenciación osteogénica y/o condrogénica
adicionales. La invención se dirige asimismo al
biomaterial así obtenido y a las diferentes
aplicaciones médicas de dicho biomaterial.Peer reviewedUniversidad de Granada, Consejo Superior de Investigaciones CientíficasA1 Solicitud de patente con informe sobre el estado de la técnic
Analysis of the small-scale fleet’s coverage under two sampling strategies: from the DCR stock-based to the DCF concurrent sampling in the Northern Spanish coastal gillnets fleet
Working document presented at the WGCATCH 2015 meeting.The Northern Spanish coastal small scale fleet represents a major challenge for sampling due to the multi-species and multi-gear character and the complexity of the fleets’ dynamics. Particularly, the small-scale gillnets called “beta” (GNS_DEF_60-79_0_0) represents a complex Spanish métiers in terms of catches, effort, geographical distribution and the number of exploited species. Comparison of data obtained in 2008, under a stock-based approach, versus concurrent sampling realized in 2014 resulted in the increase of the information obtained and provided to ICES without detected failures in data quality. Concurrent sampling could represent a source of information for small-scale fisheries which often target a set of coastal species some of which are presently unassesed
Specific heat and magnetic measurements in Nd0.5Sr0.5MnO3, Nd0.5Ca0.5MnO3 and Ho0.5Ca0.5MnO3 samples
We studied the magnetization as a function of temperature and magnetic field
in the compounds Nd0.5Sr0.5MnO3, Nd0.5Ca0.5MnO3 and Ho0.5Ca0.5MnO3. It allowed
us to identify the ferromagnetic, antiferromagnetic and charge ordering phases
in each case. The intrinsic magnetic moments of Nd3+ and Ho3+ ions experienced
a short range order at low temperatures. We also did specific heat measurements
with applied magnetic fields between 0 and 9 T and temperatures between 2 and
300 K in all three samples. Close to the charge ordering and ferromagnetic
transition temperatures the specific heat curves showed peaks superposed to the
characteristic response of the lattice oscillations. Below 10 K the specific
heat measurements evidenced a Schottky-like anomaly for all samples. However,
we could not successfully fit the curves to either a two level nor a
distribution of two-level Schottky anomaly. Our results indicated that the peak
temperature of the Schottky anomaly was higher in the compounds with narrower
conduction band.Comment: submitted to PR
GEANT4 : a simulation toolkit
Abstract Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics. PACS: 07.05.Tp; 13; 2
Meloidogyne and Pratylenchus species in sugarcane fields in the state of Alagoas, Brazil
Spatial and temporal variation of fish assemblage associated with aquatic macrophyte patches in the littoral zone of the Ayapel Swamp Complex, Colombia
ABSTRACT: Aim: The purpose of the present study was to examine spatial and temporal variation in fish assemblage structure associated with aquatic macrophytes in the littoral zone of the ASC. Methods: Specimens were caught between January 2008 and February 2009, over four limnimetric moments, using both cast net and seine net. Data on the temperature, electrical conductivity, pH and dissolved oxygen was recorded for the characterization of the water mass in the sites. Results: A total of 34,151 specimens from 44 species were collected. The most abundant species were Eigenmannia virescens, Astyanax caucanus, Astyanax fasciatus, Roeboides dayi and Cyphocharax magdalenae, which together accounted for more than 75% of the sample. Temporal and spatial comparisons showed variation in the environmental conditions and highlighted the existence of heterogeneous abiotic conditions (p0.05) regarding the fish assemblage structure. The multivariate analysis showed no significant relationship between existing environmental conditions and the fish assemblage (p=0.04). The analysis also showed the absence of a relationship between the fish assemblage and environmental variables with respect to the flood pulse and sampling sites (p>0.05). Conclusion: The uniformity of the fish communities that inhabit aquatic macrophyte patches in the littoral region of the ASC may
be related to the availability of suitable habitat in structural terms, that probably supports a more abundant and varied wildlife
Machine Learning Framework to Identify Individuals at Risk of Rapid Progression of Coronary Atherosclerosis : From the PARADIGM Registry
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk of RPP at a single point in time. This study integrated coronary computed tomography angiography-determined qualitative and quantitative plaque features within a machine learning (ML) framework to determine its performance for predicting RPP. Methods and Results Qualitative and quantitative coronary computed tomography angiography plaque characterization was performed in 1083 patients who underwent serial coronary computed tomography angiography from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry. RPP was defined as an annual progression of percentage atheroma volume 651.0%. We employed the following ML models: model 1, clinical variables; model 2, model 1 plus qualitative plaque features; model 3, model 2 plus quantitative plaque features. ML models were compared with the atherosclerotic cardiovascular disease risk score, Duke coronary artery disease score, and a logistic regression statistical model. 224 patients (21%) were identified as RPP. Feature selection in ML identifies that quantitative computed tomography variables were higher-ranking features, followed by qualitative computed tomography variables and clinical/laboratory variables. ML model 3 exhibited the highest discriminatory performance to identify individuals who would experience RPP when compared with atherosclerotic cardiovascular disease risk score, the other ML models, and the statistical model (area under the receiver operating characteristic curve in ML model 3, 0.83 [95% CI 0.78-0.89], versus atherosclerotic cardiovascular disease risk score, 0.60 [0.52-0.67]; Duke coronary artery disease score, 0.74 [0.68-0.79]; ML model 1, 0.62 [0.55-0.69]; ML model 2, 0.73 [0.67-0.80]; all P<0.001; statistical model, 0.81 [0.75-0.87], P=0.128). Conclusions Based on a ML framework, quantitative atherosclerosis characterization has been shown to be the most important feature when compared with clinical, laboratory, and qualitative measures in identifying patients at risk of RPP
Rationale, design and methodology of APPROACH-IS II: International study of patient-reported outcomes and frailty phenotyping in adults with congenital heart disease.
In recent years, patient-reported outcomes (PROs) have received increasing prominence in cardiovascular research and clinical care. An understanding of the variability and global experience of PROs in adults with congenital heart disease (CHD), however, is still lacking. Moreover, information on epidemiological characteristics and the frailty phenotype of older adults with CHD is minimal. The APPROACH-IS II study was established to address these knowledge gaps. This paper presents the design and methodology of APPROACH-IS II.
APPROACH-IS II is a cross-sectional global multicentric study that includes Part 1 (assessing PROs) and Part 2 (investigating the frailty phenotype of older adults). With 53 participating centers, located in 32 countries across six continents, the aim is to enroll 8000 patients with CHD. In Part 1, self-report surveys are used to collect data on PROs (e.g., quality of life, perceived health, depressive symptoms, autonomy support), and explanatory variables (e.g., social support, stigma, illness identity, empowerment). In Part 2, the cognitive functioning and frailty phenotype of older adults are measured using validated assessments.
APPROACH-IS II will generate a rich dataset representing the international experience of individuals in adult CHD care. The results of this project will provide a global view of PROs and the frailty phenotype of adults with CHD and will thereby address important knowledge gaps. Undoubtedly, the project will contribute to the overarching aim of improving optimal living and care provision for adults with CHD
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