12 research outputs found
A proposal for a semantic change in the current diagnostic criteria of Parkinsonâs disease Psychosis
Psychosis may emerge as part of Parkinsonâs disease (PD) process but is also associated with PD treatment. When the NINDS-NIMH criteria were applied to a cross-sectional PD cohort, the prevalence of PD psychosis in PD patients reached 60% [1].The most frequent symptoms in PD-associated psychosis (PDAP) are related to sensory perception areas, especially hallucinations. Graham et al. [2], reported that 70% of their patients with hallucinations had retained insight. This seems a contradiction because psychosis is a mental disorder characterized by symptoms, such as delusions or hallucinations that indicate an impaired contact with reality [3]. If we adhere to this definition, which is in fact the common and accepted one, those patients who retained insight about abnormal sensory perceptive phenomena should not be diagnosed as âpsychoticâ. Moreover, FĂ©nelon and Alves reviewed the epidemiology of psychosis across different centers worldwide, showing that although psychosis could be diagnosed at that point of time, visual hallucinations were not always present for diagnosis: other features were taken into account to make this diagnosis for example the presence of delusions or illusions [4].</p
Efficacy and safety of opioid therapy guided by pharmacogenetics: A systematic review
Aim: To perform a systematic review to determine the efficacy/safety of PGx-guided opioid therapy for chronic/postoperative pain. Materials & methods: We searched PubMed and other specialized databases. Articles were considered if they compared the efficacy/safety of PGx-guided opioid therapy versus usual care. The risk of bias assessment was performed using Cochrane tools. Results: A total of 3794 records were retrieved. Only five were included for data extraction. A lower requirement of analgesics during postoperative in the PGx-guided intervention arm was reported in two studies. Also, two studies reported significant pain improvement in favor of the PGx-guided therapy when analyzing the subgroup of patients with a high-risk CYP2D6 phenotype. Conclusion: Despite the findings described, information on the efficacy/safety of this intervention is scarce.Fil: Rodriguez Cairoli, Federico. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; Argentina. Instituto de Efectividad ClĂnica y Sanitaria; ArgentinaFil: Appiani, Francisco. Universidad de Buenos Aires. Facultad de Medicina. Hospital de ClĂnicas General San MartĂn; ArgentinaFil: Sambade, Juan Manuel. Provincia de Buenos Aires. Municipalidad de Vicente LĂłpez. Hospital Municipal Doctor Bernardo Houssay; ArgentinaFil: ComandĂ©, Daniel. Instituto de Efectividad ClĂnica y Sanitaria; ArgentinaFil: Camacho Arteaga, Lina. Universidad AutĂłnoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Ciapponi, AgustĂn. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Centro de Investigaciones en EpidemiologĂa y Salud PĂșblica. Instituto de Efectividad ClĂnica y Sanitaria. Centro de Investigaciones en EpidemiologĂa y Salud PĂșblica; Argentin
Memorias del segundo coloquio de lenguas extranjeras
1 archivo PDF (156 pĂĄginas)"La CoordinaciĂłn de Lenguas Extranjeras y el Grupo de investigaciĂłn en LingĂŒĂstica Aplicada de la Universidad AutĂłnoma Metropolitana de Azcapotzalco presenta en este ejemplar, algunos de los trabajos que formaron parte del "2° Coloquio de Lenguas Extranjeras" que se llevĂł a cabo en septiembre de 1999 en el campus Azcapotzalco. Las lĂneas de investigaciĂłn presentadas fueron las siguientes: El autoaprendizaje en Lenguas Extranjeras; EvaluaciĂłn del Aprendizaje en Lenguas Extranjeras; Aspectos interculturales en el Aprendizaje de Lenguas Extranjeras"
Catatonia in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [Editorial]
Registry of neurological manifestations due to coronavirus-19 (COVID-19)
La enfermedad por COVID-19 se ha extendido por el mundo desde diciembre de 2019. Los sĂntomas neurolĂłgicos forman parte de su espectro clĂnico. Objetivo: Conocer las manifestaciones neurolĂłgicas en pacientes infectados por COVID-19 en Argentina. MĂ©todos: Estudio multicĂ©ntrico realizado en adultos, desde mayo de 2020 a enero de 2021, con COVID-19 confirmado y sĂntomas neurolĂłgicos. Se consignaron variables demogrĂĄficas, existencia de comorbilidades sistĂ©micas o neurolĂłgicas, la forma de comienzo de la infecciĂłn, alteraciĂłn en estudios complementarios y el grado de severidad de los sĂntomas neurolĂłgicos. Resultados: Se incluyeron 817 pacientes de todo el paĂs, 52% varones, edad promedio 38 anos. Ë La mayorĂa sin comorbilidades ni patologĂa neurolĂłgica previa. El primer sĂntoma de la infecciĂłn fue neurolĂłgico en 56,2% de los casos, predominando la cefalea (69%), luego anosmia/ageusia (66%). TambiĂ©n se reportaron mialgias (52%), alodinia/hiperalgesia (18%), astenia (6%). Un 3,2% mostrĂł compromiso difuso del SNC como encefalopatĂa o convulsiones. Un 1,7% tuvo complicaciones cerebrovasculares. Los trastornos del suenoË se observaron en 3,2%. Se reportaron seis pacientes con sĂndrome de Guillain-BarrĂ© (GBS), neuropatĂa perifĂ©rica (3,4%), parestesias en lengua (0,6%), hipoacusia (0,4%), plexopatĂa (0,3%). La severidad de sĂntomas neurolĂłgicos se correlacionĂł con la edad y la existencia de comorbilidades. Conclusiones: Nuestros resultados, similares a los de otros paĂses, muestran dos tipos de sĂntomas neurolĂłgicos asociados a COVID-19: algunos potencialmente incapacitantes o mortales como el GBS o la encefalitis, y otros menos devastadores, pero mĂĄs frecuentes, como cefalea o anosmia que demandan en forma creciente atenciĂłn a largo plazo.COVID-19 disease has spread around the world since December 2019. Neurological symptoms are part of its clinical spectrum. Objective: To know the neurological manifestations in patients infected by COVID-19 in Argentina. Methods: Multicenter study conducted in adults, from May 2020 to January 2021, with confirmed COVID-19 and neurological symptoms. Demographic variables, existence of systemic or neurological comorbidities, the form of onset of the infection, alteration in complementary studies and the degree of severity of neurological symptoms were recorded. Results: 817 patients from all over the country were included, 52% male, mean age 38 years, most of them without comorbidities or previous neurological pathology. The first symptom of the infection was neurological in 56.2% of the cases, predominantly headache (69%), then anosmia/ageusia (66%). Myalgias (52%), allodynia/hyperalgesia (18%), and asthenia (6%) were also reported. 3.2% showed diffuse CNS involvement such as encephalopathy or seizures. 1.7% had cerebrovascular complications. Sleep disorders were observed in 3.2%. 6 patients were reported with Guillain BarrĂ© (GBS), peripheral neuropathy (3.4%), tongue paresthesia (0.6%), hearing loss (0.4%), plexopathy (0.3%). The severity of neurological symptoms was correlated with age and the existence of comorbidities. Conclusions: Our results, similar to those of other countries, show two types of neurological symptoms associated with COVID-19: some potentially disabling or fatal such as GBS or encephalitis, and others less devastating, but more frequent such as headache or anosmia that demand increasingly long-term care.Fil: Alessandro, Lucas. FundaciĂłn para la Lucha contra las Enfermedades NeurolĂłgicas de la Infancia; ArgentinaFil: Appiani, Franco. FundaciĂłn Favaloro; ArgentinaFil: Bendersky, Mariana. Universidad de Buenos Aires; ArgentinaFil: Borrego Guerrero, Brenda. Sanatorio Tandil; ArgentinaFil: Bruera, Guadalupe. Hospital Privado de Rosario; ArgentinaFil: Cairola, Patricia. Gobierno de la Ciudad AutĂłnoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Calandri, Ismael. FundaciĂłn para la Lucha contra las Enfermedades NeurolĂłgicas de la Infancia; ArgentinaFil: Cardozo Oliver, Juan MartĂn. Sanatorio Finochietto; ArgentinaFil: ClĂ©ment, MarĂa Emilia. Hospital Privado de la Comunidad; ArgentinaFil: Di Egidio, Marianna. Tornu Hospital; ArgentinaFil: Di Pace, JosĂ© Luis. Gobierno de la Ciudad AutĂłnoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Diaconchuk, Melina Alejandra. Hospital San Luis; ArgentinaFil: Esliman, Celeste. FundaciĂłn para la Lucha contra las Enfermedades NeurolĂłgicas de la Infancia; ArgentinaFil: Esnaola y Rojas, MarĂa Martha. Universidad de Buenos Aires; ArgentinaFil: FernĂĄndez Boccazzi, JuliĂĄn. Sanatorio de la Trinidad; ArgentinaFil: Franco, Andrea Fabiana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones MĂ©dicas e Investigaciones ClĂnicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Giardino, Daniela Laura. Centro de EducaciĂłn Medica E Invest.clinicas; ArgentinaFil: GĂłmez, CĂ©sar. No especifĂca;Fil: Guevara, Ana Karina. No especifĂca;Fil: GutiĂ©rrez, Natalia. Sanatorio Julio MĂ©ndez; ArgentinaFil: Hryb, Javier. Gobierno de la Ciudad AutĂłnoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Ibarra, Viviana. Sanatorio Julio MĂ©ndez; ArgentinaFil: Janota, Franco. Universidad de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Larcher, Luis Alfredo. Sanatorio del Norte; ArgentinaFil: Leone, Fernando. Centro MĂ©dico Roca; ArgentinaFil: Luetic, Geraldine. No especifĂca;Fil: Medina, Claudia Andrea. Sanatorio Las Lomas; ArgentinaFil: Menichini, MarĂa Laura. No especifĂca;Fil: Nieto, Gonzalo. Hospital General de Agudos Bernardino Rivadavia ; Gobierno de la Ciudad Autonoma de Buenos Aires;Fil: PĂĄez, MarĂa Fernanda. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. FernĂĄndez"; ArgentinaFil: Peñalver, Francisco. No especifĂca;Fil: Perassolo, MĂłnica. Universidad de Buenos Aires; Argentina. Gobierno de la Ciudad AutĂłnoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Persi, Gabriel. Universidad de Buenos Aires; ArgentinaFil: Pestchanker, Claudia. Hospital San Luis; ArgentinaFil: Porta, Oscar. Gobierno de la Ciudad AutĂłnoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Rey, Roberto Daniel. Universidad de Buenos Aires; ArgentinaFil: RodrĂguez, Gabriel Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Romano, Marina. Centro de EducaciĂłn Medica E Invest.clinicas; ArgentinaFil: Rugiero, Marcelo. Hospital Italiano; ArgentinaFil: SaidĂłn, Patricia. Universidad de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Sica, MarĂa Florencia. Hospital Privado de la Comunidad; ArgentinaFil: Stankievich, Erica. No especifĂca;Fil: Tarulla, Adriana. No especifĂca;Fil: Zalazar, Guillermo. Hospital San Luis; Argentin
Frontline bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in transplantation-ineligible patients with newly diagnosed mantle cell lymphoma: final overall survival results of a randomised, open-label, phase 3 study
Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
BackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.MethodsA multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled after the first cohort was accomplished, was used as a secondary validation dataset. The two cohorts were evaluated jointly in an exploratory multivariable logistic regression model to assess prognostic variables on survival.ResultsIn the primary intention-to-treat (ITT) phase 2 population, 180/301 (59.8%) subjects received tocilizumab, and 67 deaths were observed overall. Lethality rates were equal to 18.4% (97.5% CI: 13.6-24.0, P=0.52) and 22.4% (97.5% CI: 17.2-28.3, P<0.001) at 14 and 30 days, respectively. Lethality rates were lower in the validation dataset, that included 920 patients. No signal of specific drug toxicity was reported. In the exploratory multivariable logistic regression analysis, older age and lower PaO2/FiO2 ratio negatively affected survival, while the concurrent use of steroids was associated with greater survival. A statistically significant interaction was found between tocilizumab and respiratory support, suggesting that tocilizumab might be more effective in patients not requiring mechanical respiratory support at baseline.ConclusionsTocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory support at baseline.Registration EudraCT (2020-001110-38); clinicaltrials.gov (NCT04317092)