Eficácia do hidratante Regenèr emulsão em pacientes diabéticos

This study aimed to evaluate the effectiveness of Regenèr Emulsion moisturizer in the process of regeneration and maintenance of skin health in the lower limbs of patients with Diabetes Mellitus. Qualitative, exploratory, case-study research, carried out in a public hospital in Greater Florianópolis, Santa Catarina, between August and October 2020. The results reported by the patients were the reduction of dryness of the skin on the legs and/or feet or xerosis, improvement in skin color related to diabetic dermopathy lesions, improvement in skin sensitivity and resistance, reduction of itching, reduction of skin discomfort and discomfort, as well as improvement in the skin and its color, when compared to the initial day and the day end of treatment. It is concluded that the study has great relevance for the field of nursing, it presents an approach to preventive care and effective hydration for maintaining the quality of the skin of the lower limbs of diabetic patients.Objetivou-se avaliar a eficácia do hidratante Regenèr emulsão no processo de regeneração e manutenção da saúde da pele dos membros inferiores de pacientes com Diabetes Mellitus. Pesquisa qualitativa, exploratória, tipo estudo de caso, realizada em uma instituição hospitalar pública na Grande Florianópolis em Santa Catarina, entre agosto e outubro de 2020.   Os resultados relatados pelos pacientes foram à redução do ressecamento da pele das pernas e/ou pés ou xerose, melhora da coloração da pele referente às lesões da dermopatia diabética, melhora da sensibilidade e resistência da pele, redução do prurido, diminuição do incômodo e desconforto da pele assim como a melhora na pele e sua coloração, quando comparada ao dia inicial e o dia final do tratamento.  Conclui-se que o estudo possui grande relevância para a área da enfermagem, apresenta uma abordagem sobre os cuidados preventivos e de hidratação eficaz para a manutenção da qualidade da pele de membros inferiores dos pacientes diabéticos

The Joint Vienna Institute

"How does the intellectual role played by international training organisations fit into the contemporary architecture of global governance? The international diffusion of economic policy ideas represents one of the core dimensions of contemporary global governance, which has generated heated controversy in recent years with international institutions such as the International Monetary Fund (IMF) and the World Bank castigated for championing a ‘one-size-fits-all’ brand of neoliberal economic reform. Yet while substantial scholarly attention has focused on analysing the effects of the formal compliance mechanisms that the IMF and the World Bank rely on to implement neoliberal policy changes in borrowing countries, such as loan conditionality, less attention has been devoted to exploring the intermediate avenues through which neoliberal ideas travel from global governance institutions to national governance contexts. This article aims to address this gap in the study of contemporary global governance and neoliberal policy diffusion through critically examining the evolving role of the Joint Vienna Institute (JVI), an international training organisation set up after the end of the Cold War to transmit global ‘best practice’ economic policy ideas to national officials in post-communist economies.

Resveratrol derivatives as potential treatments for Alzheimer's and Parkinson's disease

Neurodegenerative diseases are characterized by the progressive loss of neurons in different regions of the nervous system. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most prevalent neurodegenerative diseases, and the symptoms associated with these pathologies are closely related to the regions that are most affected by the process of neurodegeneration. Despite their high prevalence, currently, there is no cure or disease-modifying drugs for the treatment of these conditions. In the last decades, due to the need for the development of new treatments for neurodegenerative diseases, several authors have investigated the neuroprotective actions of naturally occurring molecules, such as resveratrol. Resveratrol is a stilbene found in several plants, including grapes, blueberries, raspberries, and peanuts. Studies have shown that resveratrol presents neuroprotective actions in experimental models of AD and PD, however, its clinical application is limited due to its rapid metabolism and low bioavailability. In this context, studies have proposed that structural changes in the resveratrol molecule, including glycosylation, alkylation, halogenation, hydroxylation, methylation, and prenylation could lead to the development of derivatives with enhanced bioavailability and pharmacological activity. Therefore, this review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD

Source apportionment of size and time resolved trace elements and organic aerosols from an urban courtyard site in Switzerland

Time and size resolved data of trace elements were obtained from measurements with a rotating drum impactor (RDI) and subsequent X-ray fluorescence spectrometry. Trace elements can act as indicators for the identification of sources of particulate matter <10 μm (PM10) in ambient air. Receptor modeling was performed with positive matrix factorization (PMF) for trace element data from an urban background site in Zürich, Switzerland. Eight different sources were identified for the three examined size ranges (PM1-0.1, PM2.5-1 and PM 10-2.5): secondary sulfate, wood combustion, fire works, road traffic, mineral dust, de-icing salt, industrial and local anthropogenic activities. The major component was secondary sulfate for the smallest size range; the road traffic factor was found in all three size ranges. This trace element analysis is complemented with data from an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (AMS), assessing the PM1 fraction of organic aerosols. A separate PMF analysis revealed three factors related to three of the sources found with the RDI: oxygenated organic aerosol (OOA, related to inorganic secondary sulfate), hydrocarbon-like organic aerosol (HOA, related to road traffic) and biomass burning organic aerosol (BBOA), explaining 60 %, 22 % and 17 % of total measured organics, respectively. Since different compounds are used for the source classification, a higher percentage of the ambient PM10 mass concentration can be apportioned to sources by the combination of both methods. © 2011 Author(s)

Avaliação do perfil de mulheres atendidas em centros de referência em saúde de Porto Alegre/RS e relação de alterações citológicas detectadas no exame citopatológico e a presença do HPV

Justificativas e Objetivos: Câncer de colo de útero é considerado um problema de saúde pública mundial. Seu diagnóstico é realizado através do exame citopatológico (EC) e seu desenvolvimento relacionado à infecção pelo papilomavírus humano (HPV). Este estudo objetiva avaliar o perfil de mulheres atendidas em centros de referência em saúde de Porto Alegre, Rio Grande do Sul, assim como a relação de alterações observadas ao EC com presença do HPV. Métodos: Estudo transversal realizado em mulheres atendidas em unidades básicas de saúde e um ambulatório de referência de hospital público terciário, no período de julho de 2014 a janeiro de 2017. Coletaram-se amostras representativas da endo/ectocérvice para realização do EC e investigadas quanto à presença molecular do HPV. Resultados: Foram analisadas 169 mulheres com idade média entre 31 e 40 anos, das quais 125 (74%) informaram que a sexarca ocorreu na faixa de 15-20 anos e 37,9% relatou ter tido de três a cinco parceiros sexuais. Em relação ao EC, 71 (42%) apresentaram resultado negativo para lesão intraepitelial ou malignidade e 98 (58%) alguma anormalidade de células escamosas: 20 (11,8%) atipias; 22 (13%) lesão intraepitelial escamosa de baixo grau e 56 (32,6%) lesão intraepitelial de alto grau (HSIL). Cinquenta (29,6%) apresentaram positividade para HPV, destas 56,4% foram diagnosticadas com HSIL (

Aplicações de isótopos de oxigênio e carbono na reconstrução paleoambiental do interior da Lagoa dos Patos, RS, Brasil: um estudo de caso.

O trabalho apresenta uma reconstrução paleoambiental, a partir de um testemunho extraído da célula sul da Lagoa dos Patos (Rio Grande do Sul – Brasil), com base em análises de isotópos estáveis de carbono e de oxigênio, realizadas em conchas de moluscos. O testemunho está localizado entre a saída do rio Camaquã e o município de Bojuru. Três zonas distintas foram observadas: uma zona inferior marinha composta pelos moluscos Carycorbula tryoni, Acteocina bidentata e Tawera gayi, mostrando um comportamento espelhado com relação à profundidade entre os valores de δ18O e de δ13C,  uma temperatura média de 17°C e a idade do 14C é de 3876 – 4004 AP a 2,5 m. Uma zona de transição, onde não são encontrados moluscos fósseis, e uma zona superior mixohalina, com o molusco Erodona mactroides, de comportamento concordante entre os valores negativos de δ18O e de δ13C. Nesta zona, a temperatura aumenta em 5°C, chegando a 22°C. A 1,2m, a idade radiocarbono é de 3.054 ± 27 anos AP. A 0,3m de profundidade, o comportamento do δ13C e do δ18O passa a ser estável, refletindo o provável fechamento da Lagoa dos Patos (2.080 AP), pertencente a Série Meghalayan da parte Superior do Holoceno. Este estudo corrobora com a variação do nível do mar e com a história evolutiva da formação de ilhas barreira no litoral sul-brasileiro em função da presença de espécies marinhas na base do testemunho e de espécies mixohalinas no topo

DOENÇAS EXÓTICAS E EMERGENTES EM ANIMAIS DOMÉSTICOS – UMA PLATAFORMA ONLINE EM CONSTRUÇÃO

Doenças exóticas e emergentes são enfermidades pouco estudadas na graduação de Medicina Veterinária, devido a sua baixa ocorrência. Entretanto, o diagnóstico deve ser rápido para evitar a sua disseminação pelo país, mitigando, assim, os prejuízos econômicos consequentes. Este trabalho tem por objetivo difundir o conhecimento sobre doenças exóticas e emergentes através de uma plataforma online. Até o momento, foram traduzidas 95 doenças, das quais 40 já estão disponíveis em português. Com o trabalho, pretende-se promover o rápido reconhecimento de uma doença exótica ou emergente, com a instauração das medidas de emergência sanitária antes da disseminação da enfermidade no território nacional

Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins

The density of circulating hepatitis C virus (HCV) particles in the blood of chronically infected patients is very heterogeneous. The very low density of some particles has been attributed to an association of the virus with apolipoprotein B (apoB) positive and triglyceride rich lipoproteins (TRL) likely resulting in hybrid lipoproteins known as lipo-viro-particles (LVP) containing the viral envelope glycoproteins E1 and E2, capsid and viral RNA. The specific infectivity of these particles has been shown to be higher than the infectivity of particles of higher density. The nature of the association of HCV particles with lipoproteins remains elusive and the role of apolipoproteins in the synthesis and assembly of the viral particles is unknown. The human intestinal Caco-2 cell line differentiates in vitro into polarized and apoB secreting cells during asymmetric culture on porous filters. By using this cell culture system, cells stably expressing E1 and E2 secreted the glycoproteins into the basal culture medium after one week of differentiation concomitantly with TRL secretion. Secreted glycoproteins were only detected in apoB containing density fractions. The E1–E2 and apoB containing particles were unique complexes bearing the envelope glycoproteins at their surface since apoB could be co-immunoprecipitated with E2-specific antibodies. Envelope protein secretion was reduced by inhibiting the lipidation of apoB with an inhibitor of the microsomal triglyceride transfer protein. HCV glycoproteins were similarly secreted in association with TRL from the human liver cell line HepG2 but not by Huh-7 and Huh-7.5 hepatoma cells that proved deficient for lipoprotein assembly. These data indicate that HCV envelope glycoproteins have the intrinsic capacity to utilize apoB synthesis and lipoprotein assembly machinery even in the absence of the other HCV proteins. A model for LVP assembly is proposed

Advances in quantum metrology

The statistical error in any estimation can be reduced by repeating the measurement and averaging the results. The central limit theorem implies that the reduction is proportional to the square root of the number of repetitions. Quantum metrology is the use of quantum techniques such as entanglement to yield higher statistical precision than purely classical approaches. In this Review, we analyse some of the most promising recent developments of this research field and point out some of the new experiments. We then look at one of the major new trends of the field: analyses of the effects of noise and experimental imperfections

Genome-wide associations for birth weight and correlations with adult disease

Birth weight (BW) is influenced by both foetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease1. These lifecourse associations have often been attributed to the impact of an adverse early life environment. We performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where foetal genotype was associated with BW (P <5x10-8). Overall, ˜15% of variance in BW could be captured by assays of foetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (rg-0.22, P =5.5x10-13), T2D (rg-0.27, P =1.1x10-6) and coronary artery disease (rg-0.30, P =6.5x10-9) and, in large cohort data sets, demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P =1.9x10-4). We have demonstrated that lifecourse associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and have highlighted some of the pathways through which these causal genetic effects are mediated