Rostros de un artista sin rostro: Me Bes. Aproximación a su figura.

El grafiti, el arte urbano y el muralismo son expresiones artísticas que nos rodean en nuestro día a día, aunque en ocasiones no lo apreciemos o percibamos. En el presente trabajo fin de máster se ha trazado una escueta historia sobre los comienzos del grafiti, el postgraffiti, su llegada a nuestro país y cómo se ha desarrollado en la ciudad de Zaragoza gracias a diferentes instituciones que favorecieron este tipo de expresiones artísticas carentes de aceptación. Este contexto nos facilita situar a Me Bes, artista urbano que realiza stencil por céntricas calles de Zaragoza y a cuya personalidad nos aproximaremos a través de su trayectoria, de su modo de trabajo y del análisis de sus obras. <br /

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling

BACKGROUND: The androgen receptor (AR) plays a central role in the oncogenesis of different tumors, as is the case in prostate cancer. In triple negative breast cancer (TNBC) a gene expression classification has described different subgroups including a luminal androgen subtype. The AR can be controlled by several mechanisms like the activation of membrane tyrosine kinases and downstream signaling pathways. However little is known in TNBC about how the AR is modulated by these mechanisms and the potential therapeutic strategists to inhibit its expression. METHODS: We used human samples to evaluate the expression of AR by western-blot and phospho-proteomic kinase arrays that recognize membrane tyrosine kinase receptors and downstream mediators. Western-blots in human cell lines were carried out to analyze the expression and activation of individual proteins. Drugs against these kinases in different conditions were used to measure the expression of the androgen receptor. PCR experiments were performed to assess changes in the AR gene after therapeutic modulation of these pathways. RESULTS: AR is present in a subset of TNBC and its expression correlates with activated membrane receptor kinases-EGFR and PDGFRβ in human samples and cell lines. Inhibition of the PI3K/mTOR pathway in TNBC cell lines decreased notably the expression of the AR. Concomitant administration of the anti-androgen bicalutamide with the EGFR, PDGFRβ and Erk1/2 inhibitors, decreased the amount of AR compared to each agent given alone, and had an additive anti-proliferative effect. Administration of dihydrotestosterone augmented the expression of AR that was not modified by the inhibition of the PI3K/mTOR or Erk1/2 pathways. AR expression was posttranscriptionally regulated by PI3K or Erk1/2 inhibition. CONCLUSION: Our results describe the expression of the AR in TNBC as a druggable target and further suggest the combination of bicalutamide with inhibitors of EGFR, PDGFRβ or Erk1/2 for future development

Raynaud's syndrome

Esta entidad de variable frecuencia en la población general, adquiere mayor relevancia dentro de las enfermedades del tejido conectivo puede ser causa importante de morbilidad. Su presentación es de amplio espectro y aunque se han descrito factores que influyen en su fisiopatología no se ha dicho la última palabra. En este artículo se revisan estos aspectos y se presentan las herramientas disponibles actualmente para su diagnóstico y manejoThis entity of variable frequency in the general population, acquires greater relevance within connective tissue diseases and can be an important cause of morbidity. Its presentation is broad spectrum and although factors that influence its pathophysiology have been described, the last word has not been said. This article reviews these aspects and presents the tools currently available for its diagnosis and management

Influence of age, gender and obesity on pressure discomfort threshold of the foot: A cross-sectional study

[EN] Background: Foot pain is a highly prevalent health problem for which measures such as a pattern of Pressure Discomfort Threshold of the foot plantar surface can provide valuable information for orthosis design. This study aimed to describe such pattern as a tool for the assessment of painful conditions of the feet and to analyse how it modifies according to age, gender and obesity. Methods: A cross-sectional study was performed with participants allocated in: Group 1 people aged 20 to 35 years, Group 2 aged 50 to 65 years and Group 3 aged over 65. Pressure Discomfort Threshold on twelve points of the foot plantar surface was measured with an adapted manual dynamometer. Inferential analyses of the data were performed using one-way analysis of variance (ANOVA) considering foot areas, age group, gender and obesity. Findings: 36 participants were analysed. The pattern of Pressure Discomfort Threshold for all individuals showed a significantly higher threshold on the heel and external foot (P < 0.001, eta(2) = 0.124) and was statistical significantly influenced by age (P < 0.001, eta(2) = 0.17), especially in participants aged over 65; by gender, with women having higher values (P < 0.001, eta(2) = 0.13), and by obesity (P < 0.001, eta(2) = 0.19). Interpretation: A Pressure Discomfort Threshold pattern exists in the foot plantar surface. The characteristics of the discomfort pattern of the foot and its association with aging, gender and obesity may have considerable implications for orthosis and footwear design.Dueñas, L.; Arnal-Gómez, A.; Aparicio, I.; Balasch-Bernat, M.; López-Bueno, L.; Gonzalez Garcia, JC.; Solves Camallonga, C.... (2021). Influence of age, gender and obesity on pressure discomfort threshold of the foot: A cross-sectional study. 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A new portable method for the measurement of pressure discomfort threshold on the foot plant. Fourth symposium of the Technical Group on Footwear Biomechanics. 5–7 August 1999. Canmore, Canada. International Society of Biomechanics.Gorter, K., Kuyvenhoven, M., & de Melker, R. (2000). Nontraumatic foot complaints in older people. A population-based survey of risk factors, mobility, and well-being. Journal of the American Podiatric Medical Association, 90(8), 397-402. doi:10.7547/87507315-90-8-397Greenspan, J. D., Craft, R. M., LeResche, L., Arendt-Nielsen, L., Berkley, K. J., Fillingim, R. B., … Traub, R. J. (2007). Studying sex and gender differences in pain and analgesia: A consensus report. Pain, 132(Supplement 1), S26-S45. doi:10.1016/j.pain.2007.10.014Hennig, E. M., & Sterzing, T. (2009). Sensitivity Mapping of the Human Foot: Thresholds at 30 Skin Locations. Foot & Ankle International, 30(10), 986-991. doi:10.3113/fai.2009.0986Hill, C. L., Gill, T. K., Menz, H. B., & Taylor, A. W. (2008). Prevalence and correlates of foot pain in a population-based study: the North West Adelaide health study. Journal of Foot and Ankle Research, 1(1). doi:10.1186/1757-1146-1-2Hills, A., Hennig, E., McDonald, M., & Bar-Or, O. (2001). Plantar pressure differences between obese and non-obese adults: a biomechanical analysis. International Journal of Obesity, 25(11), 1674-1679. doi:10.1038/sj.ijo.0801785Hong, W.-H., Lee, Y.-H., Chen, H.-C., Pei, Y.-C., & Wu, C.-Y. (2005). Influence of Heel Height and Shoe Insert on Comfort Perception and Biomechanical Performance of Young Female Adults During Walking. Foot & Ankle International, 26(12), 1042-1048. doi:10.1177/107110070502601208Le Johansson, L., Kjellberg, A., Kilbom, A., & Hagg, G. M. (1999). Perception of surface pressure applied to the hand. Ergonomics, 42(10), 1274-1282. doi:10.1080/001401399184947Kwan, R. L.-C., Zheng, Y.-P., & Cheing, G. L.-Y. (2010). The effect of aging on the biomechanical properties of plantar soft tissues. Clinical Biomechanics, 25(6), 601-605. doi:10.1016/j.clinbiomech.2010.04.003Machado, Á. S., Bombach, G. D., Duysens, J., & Carpes, F. P. (2016). Differences in foot sensitivity and plantar pressure between young adults and elderly. Archives of Gerontology and Geriatrics, 63, 67-71. doi:10.1016/j.archger.2015.11.005McPoil, T. G., & Cornwall, M. W. (2006). Plantar tactile sensory thresholds in healthy men and women. The Foot, 16(4), 192-197. doi:10.1016/j.foot.2006.07.001Messing, K., & Kilbom, Å. (2001). Standing and very slow walking: foot pain-pressure threshold, subjective pain experience and work activity. Applied Ergonomics, 32(1), 81-90. doi:10.1016/s0003-6870(00)00030-2Mickle, K. J., & Steele, J. R. (2015). Obese older adults suffer foot pain and foot-related functional limitation. Gait & Posture, 42(4), 442-447. doi:10.1016/j.gaitpost.2015.07.013Mickle, K. J., Munro, B. J., Lord, S. R., Menz, H. B., & Steele, J. R. (2010). Foot Pain, Plantar Pressures, and Falls in Older People: A Prospective Study. Journal of the American Geriatrics Society, 58(10), 1936-1940. doi:10.1111/j.1532-5415.2010.03061.xOkifuji, A., Bradshaw, D. H., & Olson, C. (2009). Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions. Clinical Rheumatology, 28(4), 475-478. doi:10.1007/s10067-009-1094-2Redmond, A. C., Landorf, K. B., & Keenan, A.-M. (2009). Contoured, prefabricated foot orthoses demonstrate comparable mechanical properties to contoured, customised foot orthoses: a plantar pressure study. Journal of Foot and Ankle Research, 2(1). doi:10.1186/1757-1146-2-20Shrout, P. E., & Fleiss, J. L. (1979). Intraclass correlations: Uses in assessing rater reliability. Psychological Bulletin, 86(2), 420-428. doi:10.1037/0033-2909.86.2.420Veves, A., Murray, H. J., Young, M. J., & Boulton, A. J. M. (1992). The risk of foot ulceration in diabetic patients with high foot pressure: a prospective study. Diabetologia, 35(7), 660-663. doi:10.1007/bf00400259Weerasinghe, T. W., Goonetilleke, R. S., & Reischl, U. (2016). Pressure thresholds and stiffness on the plantar surface of the human foot. Ergonomics, 60(7), 985-996. doi:10.1080/00140139.2016.1229042Xiong, S., Goonetilleke, R. S., Witana, C. P., & Rodrigo, W. D. A. S. (2010). An indentation apparatus for evaluating discomfort and pain thresholds in conjunction with mechanical properties of foot tissue in vivo. The Journal of Rehabilitation Research and Development, 47(7), 629. doi:10.1682/jrrd.2009.09.0152Xiong, S., Goonetilleke, R. S., & Jiang, Z. (2011). Pressure thresholds of the human foot: measurement reliability and effects of stimulus characteristics. Ergonomics, 54(3), 282-293. doi:10.1080/00140139.2011.552736Xu, R., Wang, Z., Ma, T., Ren, Z., & Jin, H. (2019). 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Factores de riesgo psicosociales que influyen en el comportamiento suicida en las personas privadas de la libertad en Colombia

Objetivo: Identificar los factores de riesgo psicosocial y las características que los componen; que a su vez repercuten en el comportamiento suicida, en los privados de la libertad de Colombia, para mejorar la atención psicológica que se lleva a cabo en los centros penitenciarios. Método: Articulo de revisión documental, de tipo cualitativo, realizado a través de una recolección, revisión y análisis de 55 documentos; de los cuales se seleccionaron 13 artículos que cumplían con los criterios de inclusión y exclusión previamente establecidos. Durante la investigación se tiene en cuenta la elaboración y distinción del documento, de acuerdo a la recolección y organización de la información obtenida a través de bases de datos como Scielo, Scopus, Oxford, Science Direct, Redalyc, Pubmed, entre otros, por lo tanto, se discriminaron las categorías y subcategorías desarrolladas durante la indagación correspondientes al tema a trabajar. Resultados: Se identificaron los factores de riesgo psicosociales fundamentales como: prisionización, vínculo familiar o afectivo, consumo de sustancias psicoactivas, proyecto de vida, problemas psicológicos y tiempo de condena; que presenta la población penitenciaria a nivel mundial, los cuales se tienen en cuenta para reducir las tasas de comportamiento suicida en el ámbito carcelario. Conclusiones: En la revisión documental se logró identificar cuáles son los factores de riesgo que permitan detectar a tiempo el comportamiento suicida en las personas privadas de la libertad, teniendo en cuenta que la población carcelaria a nivel mundial va en aumento y el comportamiento suicida es catalogado como un problema grave de salud pública; se evidenció la falta de existencia de información para la investigación con base a la atención psicosocial que se le brinda a las personas privadas de la libertad alrededor de los factores de riesgos psicosociales que influyen en el comportamiento suicida; por tal razón es importante investigar a profundidad acerca de los factores protectores que pueden prevenir el suicidio en la población

Synthesis and chromatographic-separation of the stereoisomers of furnidipine

The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase. Enantiomeric purity of stereoisomers is determined by HPLC-CSP technique and configurations deduced via X-ray crystallography

On the Combination of Remote Sensing and Geophysical Methods for the Digitalization of the San Lázaro Middle Paleolithic Rock Shelter (Segovia, Central Iberia, Spain)

This paper is focused on the Middle Paleolithic rock shelter called “Abrigo de San Lázaro”, placed in the Eresma River valley (Segovia, Spain). In this area, a multisource geomatic approach is used. On the one hand, the external envelope of the shelter has been digitalized by the means of an efficient combination between aerial photogrammetry and laser scanning (static and mobile). On the other hand, the ground penetrating radar and the electric tomography were used with the aim of evaluating the inner disposition of the shelter. The combination of both digitalization (external and internal) has allowed for improving the knowledge of the site characteristics that, in turn, will facilitate the future excavation works. The results of these studies allow archaeologists to know new data for a better understanding of the site formation (geology of the site, sedimentary potential, rock shelter dimensions, etc.) and the events that took place in it (knowing its historical evolution, especially the interaction between man and the environment). Additionally, the information obtained from these studies is very useful to plan future excavation works on the site

Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection.

Atrial fibrillation (AF) is common in patients admitted with severe COVID-19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19. We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleeding, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death. 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%), p=0.003; 52 (34.4%) vs 35 (23.2%), p=0.03, respectively]. The multivariate analysis showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as independent predictor of in-hospital major bleeding. AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk.S

Red para la coordinación y el seguimiento del grado en Arquitectura Técnica en la Universidad de Alicante

La investigación docente se centrará en el seguimiento y coordinación de las acciones de mejora que se pretenden implantar en la titulación del grado en Arquitectura Técnica. El interés de esta red radica en la realización de un seguimiento eficaz de la implementación, la coordinación, evaluación y mejora del Grado que permita proponer acciones de mejora en la calidad del título. Para ello ha sido necesario analizar el desarrollo del plan de estudios y las dificultades metodológicas detectadas, así como su coherencia. Se realiza una investigación y estudio de los diferentes indicadores de calidad que utilizan las agencias de acreditación. Para ello se analizan las tasas relacionadas con el profesorado para valorar si los recursos son suficientes o podrían ser mejorables. Después se analizan las tasas de rendimiento para valorar si los resultados y su evolución son adecuados o requieren de acciones de mejora. A partir del informe de la acreditación realizado por la AVAP, se elaboran unas medidas de mejora a implantar en el título, como se viene haciendo en cada curso académico con el plan de acciones de mejora del SGIC