Scott William Sloan 1954–2019

Scott Sloan (1954–2019) was a leader of academic engineering in Australia and beyond, as evidenced by his numerous professional accolades and important research achievements, which have had significant impact on his chosen profession of geotechnical engineering. Educated in Australia and the United Kingdom, he returned to Australia in 1984 and developed a large and active research group at the University of Newcastle, and tackled a wide range of important problems in civil and mining engineering. These include the development of computational methods to predict the mechanical behaviour of soil and rock masses, and his pioneering methods to predict the collapse states of structures made of, on, and in, earth materials, allowing engineers to design cheaper and safer civil infrastructure around the globe. Sloan established long-standing international collaborations and was awarded many honours for his research achievements. He was also a keen and skilful fisherman and a more than competent blues guitar player.Postprint (published version

Experimental and numerical characterization of metallic studs

In this paper, the characterization of metallic studs used to mount lightweight double wall systems is studied both experimentally and numerically. The metallic studs are usually considered by introducing translational and rotational springs to couple the plasterboards composing the double wall. Therefore, the characterization involves determining these spring characteristics. The performance of this type of lightweight double wall in terms of sound transmission is presented in a companion paper. Different experimental setups have been investigated to determine the equivalent translational and rotational spring values. These experimental setups are described and involve the measurement of an input mobility. A finite element model of the laboratory tests has been developed. Shell and massive finite elements are employed in order to reproduce the experimental setups. A comparison of the measured and numerical results is shown. The FEM modelling is intended to help in developing new type of studs for double walls in order to obtain better sound transmission performance.Peer ReviewedPostprint (published version

Soybean seed yield response to plant density by yield environment in north america

Inconsistent soybean [Glycine max (L.) Merr.] seed yield response to plant density has been previously reported. Moreover, recent economic and productive circumstances have caused interest in within-field variation of the agronomic optimal plant density (AOPD) for soybean. Thus, the objectives of this study were to: (i) determine the AOPD by yield environments (YE) and (ii) study variations in yield components (seed number and weight) related to the changes in seed yield response to plant density for soybean in North America. During 2013 and 2014, a total of 78 yield-to-plant density responses were evaluated in different regions of the United States and Canada. A soybean database evaluating multiple seeding rates ranging from 170,000 to 670,000 seeds ha–1 was collected, including final number of plants, seed yield, and its components (seed number and weight). The data was classified in YEs: Low (LYE, 4.3 Mg ha–1). The main outcomes were: (i) AOPD increased by 24% from HYE to LYE, (ii) per-plant yield increased due to a decrease in plant density: HYE > MYE > LYE, and (iii) per-plant yield was mainly driven by seed number across plant densities within a YE, but both yield components influenced per-plant yield across YEs. This study presents the first attempt to investigate the seed yieldto- plant density relationship via the understanding of plant establishment and yield components and by exploring the influence of weather variables defining soybean YEs.Fil: Carciochi, Walter Daniel. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Schwalbert, Rai. Kansas State University; Estados UnidosFil: Andrade, Fernando Héctor. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Corassa, Geomar M.. Kansas State University; Estados UnidosFil: Carter, Paul. Kansas State University; Estados UnidosFil: Gaspar, Adam P.. Kansas State University; Estados UnidosFil: Schmidt, John. Kansas State University; Estados UnidosFil: Ciampitti, Ignacio Antonio. Kansas State University; Estados Unido

Characteristics of patients making serious inhaler errors with a dry powder inhaler and association with asthma-related events in a primary care setting

Acknowledgements The iHARP database was funded by unrestricted grants from Mundipharma International Ltd and Research in Real-Life Ltd; these analyses were funded by an unrestricted grant from Teva Pharmaceuticals. Mundipharma and Teva played no role in study conduct or analysis and did not modify or approve the manuscript. The authors wish to direct a special appreciation to all the participants of the iHARP group who contributed data to this study and to Mundipharma, sponsors of the iHARP group. In addition, we thank Julie von Ziegenweidt for assistance with data extraction and Anna Gilchrist and Valerie L. Ashton, PhD, for editorial assistance. Elizabeth V. Hillyer, DVM, provided editorial and writing support, funded by Research in Real-Life, Ltd.Peer reviewedPublisher PD

Appendiceal-sigmoid fistula presenting in a man with ulcerative colitis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Ulcerative colitis is a chronic disease characterized by diffuse mucosal inflammation limited to the colon. It mostly affects young adults, yet a large number of middle-aged and older patients with ulcerative colitis have also been reported.</p> <p>Case presentation</p> <p>A 58-year-old Caucasian man presented to our hospital in August 2006 with continuous and diffuse abdominal pain, meteorism, fever and bloody diarrhea. He had a two-year history of ulcerative colitis. Our patient was treated with intravenous medical therapy. As his condition worsened, he underwent surgery. An explorative laparotomy revealed that the entire colon was distended and pus was found around an appendiceal-sigmoid fistula.</p> <p>Conclusions</p> <p>Therapy for ulcerative colitis <b/>is a rapidly evolving field, with many new biological agents under investigation that are likely to change therapeutic strategies radically in the next decade. Indications for surgery are intractability (49%), stricture, dysplasia, toxic colitis, hemorrhage and perforation. To the best of our knowledge, this is the first case of an appendiceal-sigmoid fistula in a patient affected by ulcerative colitis reported in the literature. Fistulae between the appendix and the sigmoid tract are rarely reported in cases of diverticular disease and appendicitis.</p

About Bianchi I with VSL

In this paper we study how to attack, through different techniques, a perfect fluid Bianchi I model with variable G,c and Lambda, but taking into account the effects of a $c$-variable into the curvature tensor. We study the model under the assumption,div(T)=0. These tactics are: Lie groups method (LM), imposing a particular symmetry, self-similarity (SS), matter collineations (MC) and kinematical self-similarity (KSS). We compare both tactics since they are quite similar (symmetry principles). We arrive to the conclusion that the LM is too restrictive and brings us to get only the flat FRW solution. The SS, MC and KSS approaches bring us to obtain all the quantities depending on \int c(t)dt. Therefore, in order to study their behavior we impose some physical restrictions like for example the condition q<0 (accelerating universe). In this way we find that $c$ is a growing time function and Lambda is a decreasing time function whose sing depends on the equation of state, w, while the exponents of the scale factor must satisfy the conditions $\sum_{i=1}^{3}\alpha_{i}=1$ and $\sum_{i=1}^{3}\alpha_{i}^{2}<1,$ $\forall\omega$, i.e. for all equation of state$,$ relaxing in this way the Kasner conditions. The behavior of $G$ depends on two parameters, the equation of state $\omega$ and $\epsilon,$ a parameter that controls the behavior of $c(t),$ therefore $G$ may be growing or decreasing.We also show that through the Lie method, there is no difference between to study the field equations under the assumption of a $c-$var affecting to the curvature tensor which the other one where it is not considered such effects.Nevertheless, it is essential to consider such effects in the cases studied under the SS, MC, and KSS hypotheses.Comment: 29 pages, Revtex4, Accepted for publication in Astrophysics & Space Scienc

Cosmic acceleration from asymmetric branes

We consider a single 3-brane sitting in between two different five dimensional spacetimes. On each side of the brane, the bulk is a solution to Gauss-Bonnet gravity, although the bare cosmological constant, funda mental Planck scale, and Gauss-Bonnet coupling can differ. This asymmetry leads to weighted junction conditions across the brane and interesting brane cosmology. We focus on two special cases: a generalized Randall-Sundrum model without any Gauss-Bonnet terms, and a stringy model, without any bare cosmological constants, and positive Gauss-Bonnet coupling. Even though we assume there is no vacuum energy on the brane, we find late time de Sitter cosmologies can occur. Remarkably, in certain parameter regions, this acceleration is preceded by a period of matter/radiation domination, with $H^2 \propto \rho$, all the way back to nucleosynthesis.Comment: Version appearing in CQ

Carbohydrate mouth rinse: does it improve endurance exercise performance?

It is well known that carbohydrate (CHO) supplementation can improve performance in endurance exercises through several mechanisms such as maintenance of glycemia and sparing endogenous glycogen as well as the possibility of a central nervous-system action. Some studies have emerged in recent years in order to test the hypothesis of ergogenic action via central nervous system. Recent studies have demonstrated that CHO mouth rinse can lead to improved performance of cyclists, and this may be associated with the activation of brain areas linked to motivation and reward. These findings have already been replicated in other endurance modalities, such as running. This alternative seems to be an attractive nutritional tool to improve endurance exercise performance

The vulnerability, impacts, adaptation and climate services advisory board (VIACS AB v1.0) contribution to CMIP6

This paper describes the motivation for the creation of the Vulnerability, Impacts, Adaptation and Climate Services (VIACS) Advisory Board for the Sixth Phase of the Coupled Model Intercomparison Project (CMIP6), its initial activities, and its plans to serve as a bridge between climate change applications experts and climate modelers. The climate change application community comprises researchers and other specialists who use climate information (alongside socioeconomic and other environmental information) to analyze vulnerability, impacts and adaptation of natural systems and society in relation to past, ongoing and projected future climate change. Much of this activity is directed toward the co-development of information needed by decision-makers for managing projected risks. CMIP6 provides a unique opportunity to facilitate a two-way dialogue between climate modelers and VIACS experts who are looking to apply CMIP6 results for a wide array of research and climate services objectives. The VIACS Advisory Board convenes leaders of major impact sectors, international programs, and climate services to solicit community feedback that increases applications relevance of the CMIP6-Endorsed Model Intercomparison Projects (MIPs). As an illustration of its potential, the VIACS community provided CMIP6 leadership with a list of prioritized climate model variables and MIP experiments of greatest interest to the climate model applications community, indicating the applicability and societal relevance of climate model simulation outputs. The VIACS Advisory Board also recommended an impacts version of Obs4MIPs, and indicated user needs for the gridding and processing of model output

A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus causing vesicular oral or genital skin lesions, meningitis and other diseases particularly harmful in immunocompromised individuals. To comprehensively investigate the complex interaction between HSV-1 and its host we combined two genome-scale screens for host factors (HFs) involved in virus replication. A yeast two-hybrid screen for protein interactions and a RNA interference (RNAi) screen with a druggable genome small interfering RNA (siRNA) library confirmed existing and identified novel HFs which functionally influence HSV-1 infection. Bioinformatic analyses found the 358 HFs were enriched for several pathways and multi-protein complexes. Of particular interest was the identification of Med23 as a strongly anti-viral component of the largely pro-viral Mediator complex, which links specific transcription factors to RNA polymerase II. The anti-viral effect of Med23 on HSV-1 replication was confirmed in gain-of-function gene overexpression experiments, and this inhibitory effect was specific to HSV-1, as a range of other viruses including Vaccinia virus and Semliki Forest virus were unaffected by Med23 depletion. We found Med23 significantly upregulated expression of the type III interferon family (IFN-λ) at the mRNA and protein level by directly interacting with the transcription factor IRF7. The synergistic effect of Med23 and IRF7 on IFN-λ induction suggests this is the major transcription factor for IFN-λ expression. Genotypic analysis of patients suffering recurrent orofacial HSV-1 outbreaks, previously shown to be deficient in IFN-λ secretion, found a significant correlation with a single nucleotide polymorphism in the IFN-λ3 (IL28b) promoter strongly linked to Hepatitis C disease and treatment outcome. This paper describes a link between Med23 and IFN-λ, provides evidence for the crucial role of IFN-λ in HSV-1 immune control, and highlights the power of integrative genome-scale approaches to identify HFs critical for disease progression and outcome