Obtención de nanopartículas metálicas soportadas o embebidas en matrices oxídicas: Alúmina - Sepiolita

Tesis Doctoral inédita de la Universidad Autónoma de Madrid. Facultad de Ciencias, Departamento de Química Inorgánica. Fecha de lectura: 13-04-200

The genuine sumak kawsay as Ecuadorian Amazonian social phenomenon

En este artículo se indaga sobre el origen del concepto de sumak kawsay. Partiendo de la constatación de su existencia como fenómeno social: se muestra cómo surgió como alternativa al desarrollo sustentable en la Organización de Pueblos Indígenas de Pastaza en los años noventa; se explica cómo su emergencia en el ámbito intelectual occidental es consecuencia de la divulgación que realizó Carlos Viteri a finales del siglo XX y comienzos del siglo XXI; se explica que dicho fenómeno es la forma de vida cotidiana y la aspiración vital de los pueblos indígenas amazónicos; y se describe cómo el concepto llegó a las constituciones de Ecuador y Bolivia referido ya a las sociedades andino-amazónicas.In this article we investigate the origin of the concept of sumak kawsay. Based on the finding of existence of sumak kawsay as a social phenomenon, we show how this emerged as an alternative to sustainable development in the Organization of Indigenous Peoples of Pastaza in the nineties. We also show how this emerged in the Western academic-intellectual scope by the disclosure that Carlos Viteri made during late twentieth and early twenty-first century. We explained that this phenomenon is the everyday way of life and vital aspiration of Amazonian indigenous peoples too. And we describe how the concept came to the constitutions of Ecuador and Bolivia but referred to the Andean-Amazonian societies

Comparación de las Propiedades Elásticas Dinámicas para Edificios Tipo Marco con Base Fija y Base Aislada: Caso Concreto Reforzado

Proyecto de graduación (Licenciatura en Ingeniería en Construcción) Instituto Tecnológico de Costa Rica, Escuela de Ingeniería en Construcción, 2015.In the following report a research is carried out in order to determine trends in the dynamic behavior and their seismic response in frame structures. This research aims to analyze and correlate the dynamic properties of three buildings in reinforced concrete and frame structure with different number of flats (10, 15, 20), with fixed base and isolated basis. The three buildings were analyzed in the 4types of soils present in the seismic zone III, according to the CSCR 2010 and with three different ductility (μ of 1.0, 3.0, and 6.0) to determine the dynamic contribution of each building. Concludes that as you increase the height of this type of structure the dynamic contribution decreases in fundamental mode and in modes 2, 3, 4 and 5 are presented bigger dynamic contributions. This project is obtained that the variation of soil, generates higher modes showing the biggest dynamic contributions and increasing the height, generates a bigger flexibility in this type of structure that causes decrease in its dynamic contribution. Also with the use of seismic isolators, the dynamic contribution of the fundamental mode falls significantly, being more effective in lower height model.Instituto Tecnológico de Costa Rica. Escuela de Ingeniería en Construcción

Multidisciplinary Approach of Malignant Tumors of the Biliary Tree

Biliary tract carcinomas are aggressive tumors that arise from epithelial cells of bile ducts. They present several difficulties in their clinical management. A late initial diagnosis (frequently in the form of locally advanced disease), jaundice, cholangitis, or poor performance status of patients are some of the medical issues that arise in this setting. Another clinical limitation is the lack of robust evidence for many of the standard procedures in this particular scenario. Biliary tumors are lethal tumors, and most of them present in the form of advanced disease or during late evolution. However, we are witnessing some exciting changes in clinical management of tumors of the biliary tract, such as the development of new radiological techniques and novel interventional radiology procedures, the emergence of new radiotherapy modalities, the establishment of standardized chemotherapy regimens, the advance in molecular knowledge, and the development of new treatments directed against therapeutic targets. On the other hand, the most important step for advancing the treatment of these complex diseases is the appearance of multidisciplinary management teams integrating qualified specialists to resolve appropriate treatment challenges. In this chapter, we summarize the most relevant advances in clinical management and new oncologic treatment in biliary tract carcinomas

Tumor Treating Fields Concomitant with Sorafenib in Advanced Hepatocellular Cancer: Results of the HEPANOVA Phase II Study

Liver cancer; Solid tumor; SorafenibCàncer de fetge; Tumor sòlid; SorafenibCáncer de hígado; Tumor sólido; SorafenibAdvanced hepatocellular carcinoma (HCC) is an aggressive disease associated with poor prognosis. Tumor Treating Fields (TTFields) therapy is a non-invasive, loco-regional treatment approved for glioblastoma and malignant pleural mesothelioma. HCC preclinical and abdominal simulation data, together with clinical results in other solid tumors, provide a rationale for investigating TTFields with sorafenib in this patient population. HEPANOVA was a phase II, single arm, historical control study in adults with advanced HCC (NCT03606590). Patients received TTFields (150 kHz) for ≥18 h/day concomitant with sorafenib (400 mg BID). Imaging assessments occurred every 12 weeks until disease progression. The primary endpoint was the overall response rate (ORR). Safety was also evaluated. Patients (n = 27 enrolled; n = 21 evaluable) had a poor prognosis; >50% were Child–Turcotte–Pugh class B and >20% had a baseline Eastern Clinical Oncology Group performance status (ECOG PS) of 2. The ORR was higher, but not statistically significant, for TTFields/sorafenib vs. historical controls: 9.5% vs. 4.5% (p = 0.24), respectively; all responses were partial. Among patients (n = 11) with ≥12 weeks of TTFields/sorafenib, ORR was 18%. Common adverse events (AEs) were diarrhea (n = 15/27, 56%) and asthenia (n = 11/27, 40%). Overall, 19/27 (70%) patients had TTFields-related skin AEs; none were serious. TTFields/sorafenib improved response rates vs. historical controls in patients with advanced HCC, with no new safety concerns or related systemic toxicity.This study was funded by Novocure Inc

Rise and Decline of Good Living in the National Development Planning in Ecuador (2007-2021)

This article presents a hermeneutical analysis of the last four development plans of Ecuador that cover the period 2007-2021. The objective of this analysis is to assess the variable real importance that the concept of good living has had as a guide for development public policies in Ecuador, in the context of the Citizen Revolution implemented by Alianza pais under the leadership of Rafael Correa (2007-2017) and Lenin Moreno (2017-2021).En este artículo se presenta un análisis hermenéutico de los cuatro últimos planes nacionales de desarrollo del Ecuador que abarcan el período 2007-2021. El objetivo de este análisis es valorar la variable importancia real que el concepto de buen vivir ha tenido como orientador de las políticas públicas de desarrollo en Ecuador, en el contexto de la Revolución Ciudadana implementada por Alianza pais bajo el liderazgo de Rafael Correa (2007-2017) y Lenin Moreno (2017-2021)

Seis debates abiertos sobre el sumak kawsay

This essay seeks to shed light on six open debates about sumak kawsay: Its meaning, translation, origin, cultural referent, relation with development, and direction. Such debates are analyzed from the premise that the authors who participate in them do so from different cultural paradigms (Andean worldview, modernism, or post-modernism) and from different schools of thought (socialist and statist, indigenist and “pachamamista”, or ecologist and post-developmentalist).Este ensayo trata de arrojar luz sobre seis debates abiertos en torno al sumak kawsay: sobre su significado, su traducción, su origen, su referente cultural, su relación con el desarrollo y su dirección de destino. Dichos debates son analizados a partir de la premisa de que los autores que participan en ellos lo hacen desde diferentes paradigmas culturales (cosmovisión andina, modernismo o post-modernismo) y desde distintas corrientes de pensamiento (socialista y estatista, indigenista y “pachamamista” o ecologista y post-desarrollista)