Power loss of FZG gears lubricated with wind turbine gear oil using ionic liquid additive

This work presents a study of the tribological behaviour of a mineral fully-formulated wind turbine gear oil additised with [BMP][NTf2] ionic liquid. The target application are the wind turbine gearboxes, thus the fully formulated oil with and without ionic liquid additive was tested in a rolling bearings test rig to measure the thrust rolling bearing torque loss and was also tested in a FZG gear test rig to measure the gears torque loss at operating conditions similar to the observed in a wind turbine gearbox. The results show that a wind turbine gear oil additised with ionic liquid can reduce the torque loss and improve the gearbox efficiency while producing less wear particles as observed in the oil analysis.The authors thank to the Ministry of Science and Innovation (Spain) and to the Foundation for the Promotion in Asturias of the Applied Scientific Research and Technology (FICYT) for supporting this research within the framework of the Research Projects WINDTRIB (DPI2010-18166) and GRUPIN14-023, respectively. The authors thank to Repsol S.A. that provided the wind turbine gear oil. The authors gratefully acknowledge the funding supported by: National Funds through Fundação para a Ciência e a Tecnologia (FCT), under the project EXCL/SEMPRO/ 0103/2012; COMPETE and National Funds through Fundação para a Ciência e a Tecnologia (FCT), under the project Incentivo/EME/LA0022/2014; Quadro de Referência Estratégico Nacional (QREN), through Fundo Europeu de Desenvolvimento Regional (FEDER), under the project NORTE-07-0124-FEDER- 000009 - Applied Mechanics and Product Development; without whom this work would not be possible

Laboratory and telescope demonstration of the TP3-WFS for the adaptive optics segment of AOLI

AOLI (Adaptive Optics Lucky Imager) is a state-of-art instrument that combines adaptive optics (AO) and lucky imaging (LI) with the objective of obtaining diffraction limited images in visible wavelength at mid- and big-size ground-based telescopes. The key innovation of AOLI is the development and use of the new TP3-WFS (Two Pupil Plane PositionsWavefront Sensor). The TP3-WFS, working in visible band, represents an advance over classical wavefront sensors such as the Shack-Hartmann WFS (SH-WFS) because it can theoretically use fainter natural reference stars, which would ultimately provide better sky coverages to AO instruments using this newer sensor. This paper describes the software, algorithms and procedures that enabled AOLI to become the first astronomical instrument performing real-time adaptive optics corrections in a telescope with this new type of WFS, including the first control-related results at the William Herschel Telescope (WHT)This work was supported by the Spanish Ministry of Economy under the projects AYA2011-29024, ESP2014-56869-C2-2-P, ESP2015-69020-C2-2-R and DPI2015-66458-C2-2-R, by project 15345/PI/10 from the Fundación Séneca, by the Spanish Ministry of Education under the grant FPU12/05573, by project ST/K002368/1 from the Science and Technology Facilities Council and by ERDF funds from the European Commission. The results presented in this paper are based on observations made with the William Herschel Telescope operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Special thanks go to Lara Monteagudo and Marcos Pellejero for their timely contributions

Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout

NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore, there is high current interest in the clinical development of new NLRP3 inflammasome small inhibitors to treat these diseases. Novel N-sulfonylureas were obtained by the replacement of the hexahydroindacene moiety of the previously described NLRP3 inhibitor MCC950. These new derivatives show moderate to high potency in inhibiting IL-1β release in vitro. The greatest effect was observed for compound 4b, which was similar to MCC950. Moreover, compound 4b was able to reduce caspase-1 activation, oligomerization of ASC, and therefore, IL-1β processing. Additional in silico predictions confirmed the safety profile of compound 4b, and in vitro studies in AML12 hepatic cells confirmed the absence of toxicological effects. Finally, we evaluated in vivo anti-inflammatory properties of compound 4b, which showed a significant anti-inflammatory effect and reduced mechanical hyperalgesia at 3 and 10 mg/kg (i.p.) in an in vivo mouse model of gout.J.E. thanks Fondo de Investigaciones Sanitarias (ISCIII/ FEDER) (Programa Miguel Servet: CP19/00005 and PI19/ 00082) and Fundación Mutua Madrileñ a. D.D.-I. thanks the Spanish Ministry of Science, Innovation, and Universities for predoctoral FPU grant

High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4

[Abstract] Background and Aims. Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real‐world clinical practice, showed high rates of sustained virological response (SVR) in non‐cirrhotic genotype (GT)‐1 and GT‐4 patients. These results were slightly lower in cirrhotic patients. We investigated real‐life effectiveness and safety of SOF/SMV with or without ribavirin (RBV) in a large cohort of cirrhotic patients. Methods. This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV‐GT1 or 4, treated with SOF/SMV±RBV in 30 centres across Spain between January‐2014 and December‐2015. Demographic, clinical, virological and safety data were analysed. Results. Overall SVR was 92.3%; the majority of patients were treated with RBV (62%) for 12 weeks (92.4%). No significant differences in SVR were observed between genotypes (GT1a:94.3%; GT1b:91.7%; GT4:91.1%). Those patients with more advanced liver disease (Child B/C, MELD≥10) or portal hypertension (platelet count≤100×109/L, transient elastography≥21 Kpa) showed significantly lower SVR rates (84.4%‐91.9%) than patients with less advanced liver disease (93.8%‐95.9%, P<.01 in all cases). In the multivariate analysis, the use of RBV, female gender, baseline albumin≥35 g/L, MELD<10 and lack of exposure to a triple therapy regimen were independent predictors of SVR (P<.05). Serious adverse events (SAEs) and SAE‐associated discontinuation events occurred in 5.9% and 2.6%. Conclusions. In this large cohort of cirrhotic patients managed in the real‐world setting in Spain, SOF/SMV±RBV yielded to excellent SVR rates, especially in patients with compensated liver cirrhosis. In addition, this combination showed to be safe, with low rates of SAEs and early discontinuations.Instituto de Salud Carlos III; PI15/0015

Anisotropy of magnetic susceptibility of the Pyrenean granites

In this paper, we report on a compilation of more than 2200 sites (more than 10,000 individual measurements) where anisotropy of magnetic susceptibility (AMS) was studied in granites from the Variscan Pyrenees. The standardization and homogenization of this information has allowed us to produce three Main Maps that synthesize all the information related with the AMS of the Pyrenean granites. We also describe the problems found during the construction of the database (variable geo-positioning, different published information, etc.). The information derived from 21 granite bodies, the database, and the synthesis maps (magnetic susceptibility, Km, and the orientation of the magnetic foliation, plane perpendicular to k3, and of the magnetic lineation, k1) allow us to see for the first time a complete image of this important kinematic and petrographic indicator

Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART): study protocol.

BACKGROUND: Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances in early diagnosis and postnatal management have increased survival in CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, have emerged as a key prognostic factor in the counseling of these pregnancies. METHODS: Eligible participants are women presenting at 20 to < 37 weeks of gestation carrying a fetus with CHD. Maternal/neonatal recordings are performed at regular intervals, from the fetal period to 24 months of age, and include: placental and fetal hemodynamics, fetal brain magnetic resonance imaging (MRI), functional echocardiography, cerebral oxymetry, electroencephalography and serum neurological and cardiac biomarkers. Neurodevelopmental assessment is planned at 12 months of age using the ages and stages questionnaire (ASQ) and at 24 months of age with the Bayley-III test. Target recruitment is at least 150 cases classified in three groups according to three main severe CHD groups: transposition of great arteries (TGA), Tetralogy of Fallot (TOF) and Left Ventricular Outflow Tract Obstruction (LVOTO). DISCUSSION: The results of NEURO-HEART study will provide the most comprehensive knowledge until date of children's neurologic prognosis in CHD and will have the potential for developing future clinical decisive tools and improving preventive strategies in CHD

What pulmonologists think about the asthma–COPD overlap syndrome

Background: Some patients with COPD may share characteristics of asthma; this is the so-called asthma–COPD overlap syndrome (ACOS). There are no universally accepted criteria for ACOS, and most treatments for asthma and COPD have not been adequately tested in this population. Materials and methods: We performed a survey among pulmonology specialists in asthma and COPD aimed at collecting their opinions about ACOS and their attitudes in regard to some case scenarios of ACOS patients. The participants answered a structured questionnaire and attended a face-to-face meeting with the Metaplan methodology to discuss different aspects of ACOS. Results: A total of 26 pulmonologists with a mean age of 49.7 years participated in the survey (13 specialists in asthma and 13 in COPD). Among these, 84.6% recognized the existence of ACOS and stated that a mean of 12.6% of their patients might have this syndrome. In addition, 80.8% agreed that the diagnostic criteria for ACOS are not yet well defined. The most frequently mentioned characteristics of ACOS were a history of asthma (88.5%), significant smoking exposure (73.1%), and postbronchodilator forced expiratory volume in 1 second/forced vital capacity ,0.7 (69.2%). The most accepted diagnostic criteria were eosinophilia in sputum (80.8%), a very positive bronchodilator test (69.2%), and a history of asthma before 40 years of age (65.4%). Up to 96.2% agreed that first-line treatment for ACOS was the combination of a long-acting β2-agonist and inhaled steroid, with a long-acting antimuscarinic agent (triple therapy) for severe ACOS. Conclusion: Most Spanish specialists in asthma and COPD agree that ACOS exists, but the diagnostic criteria are not yet well defined. A previous history of asthma, smoking, and not fully reversible airflow limitation are considered the main characteristics of ACOS, with the most accepted first-line treatment being long-acting β2-agonist/inhaled corticosteroids

Autophagy and Apoptosis Have a Role in the Survival or Death of Stallion Spermatozoa during Conservation in Refrigeration

Apoptosis has been recognized as a cause of sperm death during cryopreservation and a cause of infertility in humans, however there is no data on its role in sperm death during conservation in refrigeration; autophagy has not been described to date in mature sperm. We investigated the role of apoptosis and autophagy during cooled storage of stallion spermatozoa. Samples from seven stallions were split; half of the ejaculate was processed by single layer centrifugation, while the other half was extended unprocessed, and stored at 5°C for five days. During the time of storage, sperm motility (CASA, daily) and membrane integrity (flow cytometry, daily) were evaluated. Apoptosis was evaluated on days 1, 3 and 5 (active caspase 3, increase in membrane permeability, phosphatidylserine translocation and mitochondrial membrane potential) using flow cytometry. Furthermore, LC3B processing was investigated by western blotting at the beginning and at the end of the period of storage. The decrease in sperm quality over the period of storage was to a large extent due to apoptosis; single layer centrifugation selected non-apoptotic spermatozoa, but there were no differences in sperm motility between selected and unselected sperm. A high percentage of spermatozoa showed active caspase 3 upon ejaculation, and during the period of storage there was an increase of apoptotic spermatozoa but no changes in the percentage of live sperm, revealed by the SYBR-14/PI assay, were observed. LC3B was differentially processed in sperm after single layer centrifugation compared with native sperm. In processed sperm more LC3B-II was present than in non-processed samples; furthermore, in non-processed sperm there was an increase in LC3B-II after five days of cooled storage. These results indicate that apoptosis plays a major role in the sperm death during storage in refrigeration and that autophagy plays a role in the survival of spermatozoa representing a new pro-survival mechanism in spermatozoa not previously described

New insights into asymmetric folding by means of the anisotropy of magnetic susceptibility, Variscan and Pyrenean folds (SW Pyrenees)

"This is a post-peer-review, pre-copyedit version of an article published in Studia Geophysica et Geodaetica. The final authenticated version is available online at DOI: http://doi.org/10.1007/s11200-017-0143-6"Magnetic fabric allows to unravel the petrofabrics of sedimentary rocks and to assess their deformational history. The use of this technique, in addition to classical structural field observations in the limbs of seven asymmetric folds in the Pyrenees, helps to determine the differences of internal deformation as well as the folding kinematics. Three folds developed during the Variscan Orogeny in Ordovician and Devonian rocks, and four folds developed during the Pyrenean Orogeny in Eocene rocks, are studied. Folds show a variety of structural locations, in different thrust sheets of the Southern Central Pyrenees, different cleavage development, age, geometry and lithology. Sampling follows an equivalent lithological layer in the two limbs, except for one case, of the selected folds. Results show a modified tectonic magnetic fabric in most sites with the magnetic lineation on the tectonic foliation plane. A larger scattering of the magnetic lineation (maximum magnetic anisotropy axis) and a higher intensity of the preferred orientation of minerals (eccentricity of the anisotropy of magnetic susceptibility - AMS ellipsoid) is better observed in the overturned (short) limb of the asymmetric Variscan folds than in the normal (long) limb. On the other hand, the shape parameter in Alpine folds is generally larger in the overturned (short) limb then in the normal (long) one. A good clustering of the minimum magnetic anisotropy axes is observed in all limbs. The combination of the AMS data with the structural data helps to understand and better constrain the deformation degree in these asymmetric folds and to unravel the deformational historyFinancial support came from the Spanish Ministry of Science and Innovation - FEDER Funds (MICINN) and from the National Parks Organism, Spain