Der Einsatz einer neuartigen Peroxidase aus dem Basidiomyceten Agrocybe aegerita am Beispiel der enantioselektiven Sulfoxidation

Die neuartige Agrocybe aegerita Peroxidase (AaP) konnte erfolgreich als enantioselektiver Biokatalysator in der Synthese optisch aktiver Sulfoxide charakterisiert und etabliert werden. Das (R)-Enantiomer entsteht dabei im hohen Überschuss (ee-Wert > 99 %). Das hohe Potential der AaP für den Einsatz in der industriellen Biokatalyse konnte durch die Verwendung organischer Lösungsmittel, durch die Immobilisierung des Enzyms und die Stabilität gegenüber seinem Kosubstrat bestätigt werden.In this dissertation the novel Agrocybe aegerita peroxidase (AaP) has been successfully characterized and established as an enantioselective biocatalyst in the synthesis of optically active alkyl aryl sulfoxides. The oxidation of the alkyl aryl sulfides yielding in high enantiomeric excess of the (R)-enantiomer (e.e. > 99 %). The application of organic solvent, the immobilization of the AaP and a better operational stability towards the peroxide demonstrates the great potential of this novel oxidative enzyme for the industrial biocatalysis

Gesundheitskompetenz - verständlich informieren und beraten: Material- und Methodensammlung zur Verbraucher- und Patientenberatung für Zielgruppen mit geringer Gesundheitskompetenz

Schmidt-Kaehler S, Vogt D, Berens E-M, Horn A, Schaeffer D. Gesundheitskompetenz - verständlich informieren und beraten: Material- und Methodensammlung zur Verbraucher- und Patientenberatung für Zielgruppen mit geringer Gesundheitskompetenz. Bielefeld: Universität Bielefeld, Fakultät für Gesundheitswissenschaften; 2017

Gesundheitsforderung in der stationaren Altenbetreuung Forderliche und hinderliche Faktoren bei der Implementation eines Mobilitatsprogramms

Marent B, Wieczorek CC, Schmied H, et al. Gesundheitsförderung in der stationären Altenbetreuung. Prävention und Gesundheitsförderung. 2014;9(4):298-304

Age-Related Attenuation of Dominant Hand Superiority

The decline of motor performance of the human hand-arm system with age is well-documented. While dominant hand performance is superior to that of the non-dominant hand in young individuals, little is known of possible age-related changes in hand dominance. We investigated age-related alterations of hand dominance in 20 to 90 year old subjects. All subjects were unambiguously right-handed according to the Edinburgh Handedness Inventory. In Experiment 1, motor performance for aiming, postural tremor, precision of arm-hand movement, speed of arm-hand movement, and wrist-finger speed tasks were tested. In Experiment 2, accelerometer-sensors were used to obtain objective records of hand use in everyday activities

When and How to Provide Feedback and Instructions to Athletes?—How Sport Psychology and Pedagogy Insights Can Improve Coaching Interventions to Enhance Self-Regulation in Training

In specialist sports coaching, the type and manner of augmented information that the coach chooses to use in communicating and training with individual athletes can have a significant impact on skill development and performance. Informed by insights from psychology, pedagogy, and sport science, this position paper presents a practitioner-based approach in response to the overarching question: When, why, and how could coaches provide information to athletes during coaching interventions? In an ecological dynamics rationale, practice is seen as a search for functional performance solutions, and augmented feedback is outlined as instructional constraints to guide athletes’ self-regulation of action in practice. Using the exemplar of team sports, we present a Skill Training Communication Model for practical application in the context of the role of a specialist coach, using a constraints-led approach (CLA). Further based on principles of a non-linear pedagogy and using the recently introduced Periodization of Skill Training (PoST) framework, the proposed model aims to support practitioners’ understanding of the pedagogical constraints of feedback and instruction during practice. In detail, the PoST framework’s three skill development and training stages work to (1) directly impact constraint manipulations in practice designs and (2) indirectly affect coaches’ choices of external (coach-induced) information. In turn, these guide practitioners on how and when to apply different verbal instruction methodologies and aim to support the design of effective skill learning environments. Finally, several practical guidelines in regard to sports coaches’ feedback and instruction processes are proposed

Evaluation der Patienteninformation und -​beratung für türkisch-​ und russischsprachige Migrantinnen und Migranten

Schaeffer D, Horn A. Evaluation der Patienteninformation und -​beratung für türkisch-​ und russischsprachige Migrantinnen und Migranten. Veröffentlichungsreihe des Instituts für Pflegewissenschaft an der Universität Bielefeld. Vol P13-150. Bielefeld: Institut für Pflegewissenschaft an der Universität Bielefeld; 2013

Patienten- und Nutzerorientierung. Konzepte zur Optimierung der Pflege. Abschlussbericht für den Zeitraum 01.05.2007 - 31.03.2011

Schaeffer D, Horn A. Patienten- und Nutzerorientierung. Konzepte zur Optimierung der Pflege. Abschlussbericht für den Zeitraum 01.05.2007 - 31.03.2011. Bielefeld: Pflegeforschungsverbund NRW; 2011