Tietoarkiston arkistointiprosessi antaa tutkimusaineistoille lisäarvoa

Informaatiotutkimuksen päivät 2016

Work Disability among Employees with Diabetes : Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies

Background Studies of work disability in diabetes have examined diabetes as a homogeneous disease. We sought to identify subgroups among persons with diabetes based on potential risk factors for work disability. Methods Participants were 2,445 employees with diabetes from three prospective cohorts (the Finnish Public Sector study, the GAZEL study, and the Whitehall II study). Work disability was ascertained via linkage to registers of sickness absence and disability pensions during a follow-up of 4 years. Study-specific latent class analysis was used to identify subgroups according to prevalent comorbid disease and health-risk behaviours. Study-specific associations with work disability at follow-up were pooled using fixed-effects meta-analysis. Results Separate latent class analyses for men and women in each cohort supported a two-class solution with one subgroup (total n = 1,086; 44.4%) having high prevalence of chronic somatic diseases, psychological symptoms, obesity, physical inactivity and abstinence from alcohol and the other subgroup (total n = 1,359; 55.6%) low prevalence of these factors. In the adjusted meta-analyses, participants in the 'high-risk' group had more work disability days (pooled rate ratio = 1.66, 95% CI 1.38-1.99) and more work disability episodes (pooled rate ratio = 1.33, 95% CI 1.21-1.46). These associations were similar in men and women, younger and older participants, and across occupational groups. Conclusions Diabetes is not a homogeneous disease in terms of work disability risk. Approximately half of people with diabetes are assigned to a subgroup characterised by clustering of comorbid health conditions, obesity, physical inactivity, abstinence of alcohol, and associated high risk of work disability; the other half to a subgroup characterised by a more favourable risk profile.Peer reviewe

Avoin tiede ja tutkimusaineistot -kysely 2015 : Raportti terveystieteiden ja humanististen alojen tutkijoille suunnatun kyselyn tuloksista

Tietoarkisto toteutti toukokuussa 2015 tutkijakyselyn, jonka tarkoituksena oli selvittää, miten humanistit, terveystieteilijät ja lääketieteilijät suhtautuvat aineistonhallintaan ja aineistojen arkistoimiseen. Sähköpostikysely lähetettiin historiantutkijoille ja valikoidulle joukolle terveys- ja lääketieteen tutkijoita. Kysymykset koskivat muun muassa tutkimusyksiköiden vallitsevia arkistointikäytäntöjä ja tutkijoiden omia avoimeen tieteeseen liittyviä tietoja, toiveita ja huolia. Raportti on osa Suomen Akatemian rahoittamaa FSD ja CESSDA -hanketta

Hoitoonpääsytietojen kirjaaminen ja raportointi perusterveydenhuollossa ja suun terveydenhuollossa

Materiaalissa kerrotaan, miten hoitoonpääsytietoja kirjataan ja raportoidaan kiireettömässä perusterveydenhuollon avohoidossa ja perusterveydenhuollon suun terveydenhuollossa, kun hoitoonpääsyä koskevat terveydenhuoltolain muutokset tulevat voimaan 1.9.2023. Tavoitteena on vahvistaa hoitoonpääsytietojen yhtenäistä kirjaamista ja edistää tietojen kattavuutta sekä hyödyntämistä

Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up.

OBJECTIVE: The purpose of the present study was to analyze the associations between specific genetic markers and early disc degeneration (DD) or early disc degeneration progression (DDP) defined by magnetic resonance imaging (MRI). METHODS: We selected eleven of the most promising single nucleotide polymorphisms (SNP) and compared the distributions of these genetic markers between groups defined by MRI in a Danish adolescent population (N=166) over a three-year follow-up period. RESULTS: We observed a ten-fold higher annual incidence of endplate changes than previously reported in adults. The gender difference in IL1A rs1800587 association with DD remained significant and another association with DDP emerged in follow-up assessment. Among girls, the rs1800587 T-allele was associated both with DD (OR 2.82 [95% CI 1.29-6.16]) and with DDP (OR 2.45 [95% CI 1.03-5.82]). Among boys, the IL6 rs1800795 genotype G/C was protective in both DD (OR 0.26 [95% CI 0.09-0.72]) and DDP (OR 0.32 [95% CI 0.12-0.88]) with the IL6 rs1800797 genotype G/A was associated with a decreased likelihood of DD (OR 0.27 [95% CI 0.10-0.77]). Gender-genotype interactions were significant for polymorphisms in both IL1A and IL6. Correction for multiple testing weakened the associations for IL6 polymorphisms. CONCLUSION: We conclude that gender specific effects in lumbar disc degeneration and its progression are possible. However, further evaluations in larger populations are needed. Our results provide some support to the hypothesis that early disc degeneration is an especially important phase in the cascade of degenerative disc disease

Correction of leg-length discrepancy among meat cutters with low back pain:a randomized controlled trial

Abstract Background: The etiology of non-specific low back pain (LBP) is complex and not well understood. LBP is common and causes a remarkable health burden worldwide. Leg-length discrepancy (LLD) is potentially a risk factor for development of LBP, although this relationship has been questioned. Yet only one randomized controlled study (RCT) has been performed. The objective of our study was to evaluate the effect of insoles with leg-length discrepancy (LLD) correction compared to insoles without LLD correction among meat cutters in a RCT-design. Methods: The study population consisted 387 meat cutters who were over 35 years old and had been working 10 years or more. The LLD measurement was done by a laser ultrasound technique. All workers with an LLD of at least 5 mm and an LBP intensity of at least 2 on a 10-cm Visual Analog Scale were eligible. The LLD of all the participants in the intervention group was corrected 70%, which means that if the LLD was for example 10 mm the correction was 7 mm. The insoles were used at work for eight hours per day. The control group had insoles without LLD correction. The primary outcome was between-group difference in LBP intensity. Secondary outcomes included sciatic pain intensity, disability (Roland Morris), RAND-36, the Oswestry Disability Index, physician visits and days on sick leave over the first year. We used a repeated measures regression analysis with adjustments for age, gender and BMI. The hurdle model was used for days on sick leave. Results: In all, 169 workers were invited and 114 (67%) responded. Of them, 42 were eligible and were randomized to the intervention (n = 20) or control group (n = 22). The workers in the intervention group had a higher improvement in LBP intensity (−2.6; 95% confidence intervals −3.7–−1.4), intensity of sciatic pain (−2.3; −3.4–−1.07) and RAND-36 physical functioning (9.6; 1.6–17.6) and a lesser likelihood of sick leaves (OR −3.7; −7.2–−0.2). Conclusions: Correction of LLD with insoles was an effective intervention among workers with LBP and a standing job