Temperature modulates compensatory responses to food limitation at metamorphosis in a marine invertebrate

Under climate change, increased temperatures combined with food limitation may be critical for species with complex life cycles, if high growth rates characterise the larval development. We studied the effect of increased temperature and food limitation on larval survival and on functional traits (developmental time, body mass, elemental composition, growth) at moulting and metamorphosis in the crab Carcinus maenas collected in the North Sea (Helgoland, Germany). We followed the approach of models of metamorphosis integrating responses of body mass and developmental time to increased temperature and food limitation. We also evaluated if body mass decreased with temperature (according to the temperature-size rule) and if developmental time followed an inverse exponential reduction (expected from some metabolic theories), as both trends are relevant for modelling effects of climate change on fitness and population connectivity. Larvae produced by four females during the reproductive period (i.e. spring-summer 2016) were reared separately from hatching to metamorphosis to the megalopa at two food conditions (ad libitum and low food availability), and at four temperatures covering the range experienced in the field (20°C). Survival and developmental rates were obtained by daily monitoring of the experiments. Biomass data (body mass and elemental composition) were obtained by sampling larvae at the zoea IV and megalopa stages and further processed with standard methods (see Torres & Giménez 2020 for details). We propose that integrative studies of traits at metamorphosis could be a basis to develop a mechanistic understanding of how species with complex life cycles will respond to climate change. Such models could eventually include hormonal and metabolic regulation of development as drivers of responses to environmental change

Egg development, hatching rhythm and moult patterns in Paralomos spinosissima (Decapoda: Anomura: Paguroidea: Lithodidae) from South Georgia waters (Southern Ocean)

Larval release, hatching rhythms and moult patterns were examined in a captive population of the subantarctic lithodid, Paralomis spinosissima from the South Georgia and Shag Rocks region. Larvae hatched throughout the year with the majority of females starting to release larvae at the end of the austral summer and beginning of autumn. Larval release continued over a period of up to 9 weeks with high variability in the numbers that hatched each day. A similar seasonal pattern to hatching was evident in the moulting of females. Intermoult period for two adult females (CL = 63 and 85 mm) ranged from 894 to 1,120 days while an intermoult period for males was estimated to be in excess of 832 days. The results are consistent with other species of Paralomis and are discussed in relation to physiological and environmental adaptations to the cold-water conditions south of the Antarctic Convergence

The morbidity of urethral stricture disease among male Medicare beneficiaries

<p>Abstract</p> <p>Background</p> <p>To date, the morbidity of urethral stricture disease among American men has not been analyzed using national datasets. We sought to analyze the morbidity of urethral stricture disease by measuring the rates of urinary tract infections and urinary incontinence among men with a diagnosis of urethral stricture.</p> <p>Methods</p> <p>We analyzed Medicare claims data for 1992, 1995, 1998, and 2001 to estimate the rate of dual diagnoses of urethral stricture with urinary tract infection and with urinary incontinence occurring in the same year among a 5% sample of beneficiaries. Male Medicare beneficiaries receiving co-incident ICD-9 codes indicating diagnoses of urethral stricture and either urinary tract infection or urinary incontinence within the same year were counted.</p> <p>Results</p> <p>The percentage of male patients with a diagnosis of urethral stricture who also were diagnosed with a urinary tract infection was 42% in 2001, an increase from 35% in 1992. Eleven percent of male Medicare beneficiaries with urethral stricture disease in 2001 were diagnosed with urinary incontinence in the same year. This represents an increase from 8% in 1992.</p> <p>Conclusions</p> <p>Among male Medicare beneficiaries diagnosed with urethral stricture disease in 2001, 42% were also diagnosed with a urinary tract infection, and 11% with incontinence. Although the overall incidence of stricture disease decreased over this time period, these rates of dual diagnoses increased from 1992 to 2001. Our findings shed light into the health burden of stricture disease on American men. In order to decrease the morbidity of stricture disease, early definitive management of strictures is warranted.</p

Developing SOEPsurvey and SOEPservice: The (Near) Future of the German Socio-Economic Panel Study (SOEP)

Das Sozio-oekonomische Panel (SOEP) ist als multidisziplinäres Haushaltspanel, das Informationen zu allen Personen, die in einem Panel-Haushalt leben, erhebt und damit alle Altersjahrgänge abdeckt, nach 25 Jahren Laufzeit auch zu einer Kohorten- Studie geworden. Der zunehmende Erfolg der Forschungsinfrastruktur-Einrichtung SOEP speist sich in erster Linie daraus, dass die Analysekraft von Längsschnittstudien mit jedem weiteren Erhebungsjahr zunimmt. Hinzu kommen im Falle des SOEP seit Beginn an eine lange Reihe von Innovationen bei der Erhebung, Datenaufbereitung und Nutzer-Service. Deswegen gilt es zu überlegen, wie die wissenschaftliche Power des SOEP weiter gestärkt werden kann. Nicht zuletzt auch, da es für neue, spezialisierte Panel-Studien (wie das Nationale Bildungspanel oder das DFG-geförderte Familienpanel PAIRFAM) eine Referenz und ggf. Verankerung der Hochrechnung darstellt. Zudem kann das SOEP künftig eine größere Rolle als ,,Kontroll-Stichprobe" für Interventions-Studien spielen; etwa im Bereich der Kindheitsentwicklung. Auf diese neuen Rollen muss es vorbereitet sein. Die im SOEP in den letzten Jahren realisierten Erhebungsinnovationen wie z. B. die Inkorporation psychologischer Konzepte, physische Gesundheitsmessungen (Greifkraft), die Messung kognitiver Fähigkeiten und die Erprobung von Verhaltens- Experimenten werden in anderen Panel-Studien aufgegriffen und auf eine größere Stichprobenbasis gestellt. Im UK wird mit ,,Understanding Society" ein Haushaltspanel mit 40.000 Haushalten begonnen; in den Niederlanden wird mit MESS ein Haushaltspanel von über 5.000 Haushalten für innovative Messmethoden zur Verfügung gestellt. Die Erhebungsinhalte des SOEP werden von den Forschungs- und Politikberatungs-Communities unverändert stark nachgefragt. In UK hat ein für ,,Understanding Society" breit angelegter Konsultationsprozess keine grundsätzlich neuen Befragungsinhalte zu Tage gefördert, die das SOEP nicht bereits enthält oder die für das SOEP ohnehin im Gespräch sind. Wichtiger als die ,,Entdeckung" völlig neuer Erhebungsinhalte ist das thematische wie zeitliche ,,Zuschneiden" der Details von Befragungsinhalten auf (zugespitzte) neue (theoretische) Fragestellungen und dabei gleichzeitig bewährte sowie viel genutzte zentrale Befragungsinhalte und deren Befragungsrhythmen beizubehalten. Das ,,Maßschneidern" von Erhebungsinhalten wird in den nächsten Jahren die eigentliche Herausforderung für Infrastruktur- Erhebungen wie die PSID, ,,Understanding Society" und das SOEP sein. Bei den Erhebungsinhalten sollten die ,,Ränder" des Lebenslaufs eine größere Rolle spielen, da diese von Haushalts-Panels besonders gut erfasst werden können. Diese Verbesserungen der Erhebungen beziehen sich einerseits auf die fötale Phase von in das SOEP hineingeborenen Kindern und die (frühe) Kindheit, andererseits auf die letzte Lebensphase und das Sterben. In der Mitte des Lebenslaufs werden verbesserte Fragen zum Einkommen, Sparen und Vermögen sowie auch psychologische Konstrukte eine zentrale Rolle spielen, außerdem gezielte Fragen (event triggered questionnaires) in Verbindung mit zentralen Lebensereignissen wie z. B. Eheschließung, Scheidung, Eintritt in und Austritt aus Arbeitslosigkeit. Es wird die Etablierung einer SOEP-"Innovations-Stichprobe" vorbereitet, um theoriegeleitete Forschungsfragen gezielter unterstützen zu können. Dazu wird es auch notwendig sein, neue Messkonzepte zu erproben (z. B. die Erhebung von Biomarkern, qualitative Erhebungen, aber auch Experimente und gezielte Interventionsstudien). Um die Power von Längsschnittdaten von Anfang an für die Innovations-Stichprobe ausnutzen zu können, ist geplant, zwei kleinere Teilstichproben des SOEP, die seit 1998 bzw. 2006 laufen (Subsamples E und H), in die Innovationsstichprobe zu überführen. Um die statistische Power langlaufender Längsschnittdaten entscheidend zu verbessern, schätzen wir eine Mindestfallzahl von etwa 500 Personen pro Geburtsund Alterskohorte für ausreichend ein. Um dieses Ziel zu erreichen, muss die Fallzahl des SOEP-Standard-Samples erhöht werden. Als ,,Nebeneffekt" werden dadurch wesentlich bessere Analysen für relativ kleine Gruppen in der Bevölkerung möglich; etwa für allein Erziehende oder bestimme Immigrantengruppen. Außerdem verbessern sich als weiterer ,,Nebeneffekt" auch regionale Analysemöglichkeiten, z. B. für die meisten Bundesländer und in großen Bundesländern bis hin zu Regierungsbezirken (oder ähnlich abgegrenzten regionalen Einheiten). In letzter Zeit wird immer deutlicher, welche große Bedeutung das SOEP als ,,Referenz-Datensatz" für spezialisierte und vom SOEP völlig unabhängige Erhebungen hat (neben Beobachtungsstudien, wie etwa Zwillings-Studien, auch Labor- und Interventions-Studien). Zur Unterstützung dieser Funktion ist eine neue Art von Service, der in Deutschland bislang nicht vorgehalten wird, notwendig (Beratung von Spezial-Erhebungen; ggf. Datenaufbereitung von längsschnittlichen Spezial-Erhebungen), der auch in ein Datenservicezentrum eingebracht werden könnte. After 25 years as a multidisciplinary household panel containing information on all individuals residing in panel households and thus covering all age cohorts, the German Socio-Economic Panel (SOEP) has become a true cohort study as well. The increasing success of the SOEP research infrastructure comes above all from the increasing analytical power that longitudinal studies attain with each successive survey year. In the case of SOEP, a long series of innovations in surveying, data preparation, and user service have also played a major role. For this reason, it is important to consider how the scientific capacity of SOEP can be further enhanced-- not least of all since the SOEP can form a key point of reference (or "anchor") for new, specialized panel studies (such as the National Educational Panel and the family panel PAIRFAM, funded by the German Research Foundation). Furthermore SOEP can become a kind of "control sample" for intervention studies, for example, in the field of child development. The SOEP survey and its governance structures must be prepared for these new tasks. The numerous innovations introduced into SOEP in recent years--questions dealing with psychological concepts, physical health measures (grip strength), measures of cognitive capabilities, and behavioral experiments--have been incorporated into other panel studies as well, and thus provided with a larger sample base. In the UK, the "Understanding Society" household panel study was launched with 40,000 households; in the Netherlands, the MESS household panel study of over 5,000 households offered a new basis for testing innovative measurement methods. The results of the SOEP survey are in continuing high demand in the research and policy advisory community. From our point of view, the large-scale consultation process conducted to define the content of the UK survey "Understanding Society" failed to identify any fundamentally new survey content that the SOEP either did not already contain or that was not already being discussed for the SOEP. More important than "discovering" entirely new survey areas is "tailoring" the details of existing survey content to address new, more specific (theoretical) questions, and thus maintaining proven and widely used elements of survey content. The "tailoring" of survey content will be the real challenge facing infrastructure surveys like PSID, "Understanding Society," and the SOEP in the coming years. In the future, the "margins" of the life course should play a stronger role in survey content, since household panels are able to provide outstanding data of these life phases. The SOEP, and other household panel surveys, can be improved, on the one hand, by including the fetal phase of life and early childhood for children born into the panel, and on the other, by including late life and death. In the middle of the life course, improved questions on income, savings, and wealth as well as psychological constructs will play a central role, as will specific questions (in "eventtriggered" questionnaires) on central life occurrences such as marriage, divorce, and entry into and exit from unemployment. Current plans for SOEP foresee the addition of an "Innovation Sample" that will make it possible to better address theory-based research questions required for testing new measurement concepts (e.g., the surveying of biomarkers, qualitative surveys, but also experiments and targeted intervention studies). In order to exploit the power of longitudinal data from the outset, we plan to incorporate two smaller SOEP subsamples that have been running since 1998 and 2006 (Subsamples E and H, respectively) into the Innovation Sample. In order to decisively improve the statistical power of long-term longitudinal data, we believe that a minimum case number of about 500 persons per birth and age cohort is required. In order to reach this goal, the case number in the SOEP standard samples needs to be increased. A positive side-effect of this enlargement would be a significantly improved potential for analyses of relatively small groups within the population: for example, lone parents or specific immigrant groups. Another positive side-effect would be an improved potential for regional analyses: for example, for the majority of federal states. In recent times, the importance of SOEP as a "reference dataset" for specialized surveys which are independent from SOEP (observational studies such as twin studies, and laboratory and intervention studies) has become strikingly evident. To enhance this important function, new types of service are needed (advice on special surveys, possibly also data preparation for special surveys), which could become part of a Data Service Center.Household Panels, German Socio-Economic Panel Study, SOEP

Neurobehavioral Evaluation for a Community with Chronic Exposure to Hydrogen Sulfide Gas

In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H2S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in an area with repeated exposure to H2S showed poorer performance on neurobehavioral tests than unexposed residents. Study participants were required to meet age (≥16 years of age) and length of residency (2 years) eligibility requirements. A battery of computer-assisted standardized neurobehavioral tests was administered in English or Spanish. A questionnaire was used to collect information about participants, demographic and health status. Three hundred forty-five people agreed to participate. After the exclusion of 10 persons, analyses were conducted on 335 participants; 171 residents in the target area and 164 residents in the comparison area. The two groups were comparable in demographic characteristics and various health conditions. Overall, neurobehavioral test results for the target and comparison groups were similar. Residence in the H2S-exposed area was associated with marginally poorer performance on a test of memory, namely, match to sample score, and a test of grip strength. However, these differences were not significant. Deficits in overall neurobehavioral performance were not associated with exposure to H2S in this study

Larval dispersal in a changing ocean with an emphasis on upwelling regions

Dispersal of benthic species in the sea is mediated primarily through small, vulnerable larvae that must survive minutes to months as members of the plankton community while being transported by strong, dynamic currents. As climate change alters ocean conditions, the dispersal of these larvae will be affected, with pervasive ecological and evolutionary consequences. We review the impacts of oceanic changes on larval transport, physiology, and behavior. We then discuss the implications for population connectivity and recruitment and evaluate life history strategies that will affect susceptibility to the effects of climate change on their dispersal patterns, with implications for understanding selective regimes in a future ocean. We find that physical oceanographic changes will impact dispersal by transporting larvae in different directions or inhibiting their movements while changing environmental factors, such as temperature, pH, salinity, oxygen, ultraviolet radiation, and turbidity, will affect the survival of larvae and alter their behavior. Reduced dispersal distance may make local adaptation more likely in well-connected populations with high genetic variation while reduced dispersal success will lower recruitment with implications for fishery stocks. Increased dispersal may spur adaptation by increasing genetic diversity among previously disconnected populations as well as increasing the likelihood of range expansions. We hypothesize that species with planktotrophic (feeding), calcifying, or weakly swimming larvae with specialized adult habitats will be most affected by climate change. We also propose that the adaptive value of retentive larval behaviors may decrease where transport trajectories follow changing climate envelopes and increase where transport trajectories drive larvae toward increasingly unsuitable conditions. Our holistic framework, combined with knowledge of regional ocean conditions and larval traits, can be used to produce powerful predictions of expected impacts on larval dispersal as well as the consequences for connectivity, range expansion, or recruitment. Based on our findings, we recommend that future studies take a holistic view of dispersal incorporating biological and oceanographic impacts of climate change rather than solely focusing on oceanography or physiology. Genetic and paleontological techniques can be used to examine evolutionary impacts of altered dispersal in a future ocean, while museum collections and expedition records can inform modern-day range shifts

Neurobehavioral Evaluation for a Community with Chronic Exposure to Hydrogen Sulfide Gas

In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H2S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in an area with repeated exposure to H2S showed poorer performance on neurobehavioral tests than unexposed residents. Study participants were required to meet age (≥16 years of age) and length of residency (2 years) eligibility requirements. A battery of computer-assisted standardized neurobehavioral tests was administered in English or Spanish. A questionnaire was used to collect information about participants, demographic and health status. Three hundred forty-five people agreed to participate. After the exclusion of 10 persons, analyses were conducted on 335 participants; 171 residents in the target area and 164 residents in the comparison area. The two groups were comparable in demographic characteristics and various health conditions. Overall, neurobehavioral test results for the target and comparison groups were similar. Residence in the H2S-exposed area was associated with marginally poorer performance on a test of memory, namely, match to sample score, and a test of grip strength. However, these differences were not significant. Deficits in overall neurobehavioral performance were not associated with exposure to H2S in this study

Spontaneous emission enhancement of a single molecule by a double-sphere nanoantenna across an interface

We report on two orders of magnitude reduction in the fluorescence lifetime when a single molecule placed in a thin film is surrounded by two gold nanospheres across the film interface. By attaching one of the gold particles to the end of a glass fiber tip, we could control the modification of the molecular fluorescence at will. We find a good agreement between our experimental data and the outcome of numerical calculations

Recent developments for beam intensity increase operation

International audienceThe aim of the beam intensity increase operation (THI project) is to multiply the present intensities for lightest ions by a factor of fifteen in order to reach maximum power of six kilowatts [1]. The main objective is the production of large amounts of rare isotopes, either with SISSI (device intended for producing radioactive beams), or with SPIRAL (production and acceleration of radioactive ion beams). As part of this THI project, new developments have been required such as spiral scanners, for beanl profile measurements, and safety system to protect equipments against beam losses. Other developments are being carried on to improve the high intensity beam operation