Aportes de Miguel Rodríguez Ferrer a la Antropología cubana

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Vuelta a los orígenes: reintroducción de la naturaleza en los centros educativos

La recuperación de la naturaleza en los centros educativos favorece el desarrollo integral del alumnado, tanto a nivel físico como psicológico, gracias a la influencia transversal de la naturaleza en la consecución del resto de áreas del currículum. Con el rescate de este contacto se logrará la adquisición de rutinas orientadas hacia el apego a la naturaleza, la alimentación sana, la realización de ejercicio y actividades al aire libre, y nos ayudará a reorganizar nuestras mentes a través del efecto relajante al que la naturaleza contribuye. Este proyecto se encuentra orientado hacia una acción docente, buscando como objetivo principal devolverle al alumnado el perdido contacto con la naturaleza. El objetivo es la introducción del contacto con la naturaleza en los centros, en las aulas, en los patios y en las rutinas diarias de los niños. Se trata de devolver a la Naturaleza su lugar, ya que esta quedó relegada en lugares a zonas localizadas rodeadas de asfalto y plástico. La situación actual supone un alejamiento de nuestro modo de vida natural como seres humanos: vivir por la naturaleza, en la naturaleza y disfrutar del medio ambiente que nos rodea, fomentando su respeto y cuidado. Para el logro de este objetivo, necesitamos un equipo directivo que alienten, inspiren y motiven a los docentes hacia el crecimiento profesional y personal mediante la aproximación a metodologías alternativas. A su vez se buscará la implicación de las familias, creando nuevas costumbres desde las raíces más profundas del seno familiar. Para ello no necesitaremos grandes inversiones económicas o costosas modificaciones de los centros educativos, sino dar uso a los espacios exteriores que ya se poseen, la introducción de materiales naturales en el aula, así como la creación de espacios exteriores donde se pueda impartir docencia. De esta manera conseguiremos fomentar el cariño, respeto y cuidado por la naturaleza desde las primeras etapas de infantil.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Creciendo en el autocontrol en educación infantil

La sociedad actual vive a un ritmo trepidante, con poco tiempo para poder pararse y pensar en lo que sucede en el interior del individuo y el porqué de sus actos y decisiones. Formar ciudadanos que tengan un pensamiento crítico y unos valores que les permitan vivir en sociedad es un objetivo común a cualquier programa educativo, aportando recursos y herramientas a aquellos que más lo necesitan. Así, los centros deberían ofrecer la posibilidad de adquirir aquellas habilidades necesarias para su convivencia social y crecimiento personal. Por tanto, será preciso que el alumnado sea capaz de controlar y prevenir su comportamiento no deseado. Este hecho implica un aprendizaje del autoconocimiento y de la autorregulación, conceptos intrínsecamente ligados al autoconcepto y a la autoestima y que influyen en su desarrollo global. En este caso, se implementó un proyecto en una clase de Educación Infantil de 25 niños y niñas de 5 años en un colegio público de Málaga. Posteriormente se analizaron las actuaciones llevadas a cabo y los resultados finales, planteando diversas posibilidades de mejora y modificaciones que buscaban subsanar los posibles errores localizados. Como resultado podemos afirmar que es posible potenciar el autocontrol en el aula de infantil, consiguiendo que alcancen su bienestar social y emocional. Cabría resaltar la idea de que la metodología de trabajo por proyectos puede presentarse como un método idóneo para conseguir los objetivos iniciales propuestos, siempre en un ambiente de trabajo lúdico, inclusivo, adaptado, respetuoso y abierto. En este contexto, el alumnado es el creador de su propio aprendizaje y el docente un guía y apoyo para la consecución de este. Con este trabajo se intenta aportar una solución sencilla a problemas de mal comportamiento y falta de autocontrol, basándose en destacar los potenciales individuales de cada uno de los niños, los cuales profundizan en el autoconocimiento para derivar en el autocontrol.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET

This work was supported by the following sources: Fondo de Investigacion Sanitaria (Ministry of Health, Spain; numbers FIS PI10/0288, FIS PI13/00430, FIS PI 11/00616, CPII14/00005 and FIS PI14/00860; the first two awarded to MQF and the last three to MD), and "Fondo Europeo de Desarrollo Regional (FEDER) - Una manera de hacer Europa". MQF is a recipient of a 2010 Beca-Retorno from the AECC Scientific Foundation. Rosae Foundation and AVON Espana S.A.U. contributed to this work with unrestricted donations. Dovitinib was kindly provided by Novartis.BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with (18)F-misonidazole ([18F]-FMISO, a probe that detects hypoxia) PET, in response to window-of-opportunity (WoO) treatment with the antiangiogenic dovitinib. METHODS: Two patient-derived pancreas xenografts (PDXs; Panc215 and Panc286) and the spontaneous breast cancer model MMTV-PyMT were used. Animals were treated during 1 week of WoO treatment with vehicle or dovitinib, preceded and followed by [18F]-FMISO-PET, [18F]-FDG-PET, and histologic assessment (dextran extravasation, hypoxia and microvessel staining, and necrosis, cleaved caspase-3 and Ki67 measurements). After WoO treatment, gemcitabine (pancreas)/adriamycin (breast) or vehicle was added and animals were treated until the humane endpoint. Tumor growth inhibition (TGI) and survival were the parameters studied. RESULTS: [18F]-FMISO SUV did not change after dovitinib-WoO treatment compared to vehicle-WoO (0.54 vs. 0.6) treatment in Panc215, but it decreased significantly in Panc286 (0.58 vs. 1.18; P < 0.05). In parallel, 10-KDa perivascular dextran extravasation was not reduced with dovitinib or vehicle-WoO treatment in Panc215, but it was reduced in Panc286. Whereas the addition of dovitinib to gemcitabine was indifferent in Panc215, it increased TGI in Panc286 (TGI switched from -59% to +49%). [18F]-FMISO SUV changes were accompanied by an almost 100% increase in interstitial gemcitabine delivery (665-1260 ng/mL). The results were validated in the PyMT model. CONCLUSIONS: [18F]-FMISO accurately monitored vascular re-normalization and improved interstitial chemotherapy delivery.This work was supported by the following sources: Fondo de Investigacion Sanitaria (Ministry of Health, Spain; numbers FIS PI10/0288, FIS PI13/00430, FIS PI 11/00616, CPII14/00005 and FIS PI14/00860; the first two awarded to MQF and the last three to MD), and "Fondo Europeo de Desarrollo Regional (FEDER) - Una manera de hacer Europa". MQF is a recipient of a 2010 Beca-Retorno from the AECC Scientific Foundation. Rosae Foundation and AVON Espana S.A.U. contributed to this work with unrestricted donations. Dovitinib was kindly provided by Novartis.S

A crowdsourcing database for the copy-number variation of the Spanish population

Background: Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especially at the level of the local population, is a critical factor for distinguishing pathogenic from non-pathogenic variation in the discovery of new disease variants. Results: Here, we present the SPAnish Copy Number Alterations Collaborative Server (SPACNACS), which currently contains copy number variation profiles obtained from more than 400 genomes and exomes of unrelated Spanish individuals. By means of a collaborative crowdsourcing effort whole genome and whole exome sequencing data, produced by local genomic projects and for other purposes, is continuously collected. Once checked both, the Spanish ancestry and the lack of kinship with other individuals in the SPACNACS, the CNVs are inferred for these sequences and they are used to populate the database. A web interface allows querying the database with different filters that include ICD10 upper categories. This allows discarding samples from the disease under study and obtaining pseudo-control CNV profiles from the local population. We also show here additional studies on the local impact of CNVs in some phenotypes and on pharmacogenomic variants. SPACNACS can be accessed at: http://csvs.clinbioinfosspa.es/spacnacs/. Conclusion: SPACNACS facilitates disease gene discovery by providing detailed information of the local variability of the population and exemplifies how to reuse genomic data produced for other purposes to build a local reference database

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

In Vivo Ectopic Implantation Model to Assess Human Mesenchymal Progenitor Cell Potential

Clinical interest on human mesenchymal progenitor cells (hMPC) relies on their potential applicability in cell-based therapies. An in vitro characterization is usually performed in order to define MPC potency. However, in vitro predictions not always correlate with in vivo results and thus there is no consensus in how to really assess cell potency. Our goal was to provide an in vivo testing method to define cell behavior before therapeutic usage, especially for bone tissue engineering applications. In this context, we wondered whether bone marrow stromal cells (hBMSC) would proceed in an osteogenic microenvironment. Based on previous approaches, we developed a fibrin/ceramic/BMP-2/hBMSCs compound. We implanted the compound during only 2 weeks in NOD-SCID mice, either orthotopically to assess its osteoinductive property or subcutaneously to analyze its adequacy as a cell potency testing method. Using fluorescent cell labeling and immunohistochemistry techniques, we could ascertain cell differentiation to bone, bone marrow, cartilage, adipocyte and fibrous tissue. We observed differences in cell potential among different batches of hBMSCs, which did not strictly correlate with in vitro analyses. Our data indicate that the method we have developed is reliable, rapid and reproducible to define cell potency, and may be useful for testing cells destined to bone tissue engineering purposes. Additionally, results obtained with hMPCs from other sources indicate that our method is suitable for testing any potentially implantable mesenchymal cell. Finally, we propose that this model could successfully be employed for bone marrow niche and bone tumor studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12015-013-9464-1) contains supplementary material, which is available to authorized users

La historia natural en la expedición geodésica al Perú: las aportaciones de Jorge Juan y Antonio de Ulloa

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