216 research outputs found
Dynamic analysis of the moving mechanism of the reciprocating compressor with clearance joints
The clearance faults on joint of moving mechanism are most common in a reciprocating compressor. In order to investigate the relationship between the clearance faults and the dynamic behavior of the moving mechanism, a dynamic model with clearances of a reciprocating compressor is built via software ADAMS. We take into the clearance size and clearance number into consideration and set clearance fault on the joint between the crank and connecting rod, the joint between connecting rod and crosshead and both joints of connecting rod, exploring the effect of these factor on the dynamic response. Then we make a non-linear analysis to estimate the chaos behavior. In the end, we conclude that the clearance size and the number of clearance both strongly influence the dynamic behaviors of the moving mechanism, so do the position where clearance fault happens. As the clearance size increases or the number of clearance fault increase, the acceleration will oscillate more violent and have higher amplitude, furthermore, it is more possible to show chaotic behaviors
Comparing One with Many -- Solving Binary2source Function Matching Under Function Inlining
Binary2source function matching is a fundamental task for many security
applications, including Software Component Analysis (SCA). The "1-to-1"
mechanism has been applied in existing binary2source matching works, in which
one binary function is matched against one source function. However, we
discovered that such mapping could be "1-to-n" (one query binary function maps
multiple source functions), due to the existence of function inlining.
To help conduct binary2source function matching under function inlining, we
propose a method named O2NMatcher to generate Source Function Sets (SFSs) as
the matching target for binary functions with inlining. We first propose a
model named ECOCCJ48 for inlined call site prediction. To train this model, we
leverage the compilable OSS to generate a dataset with labeled call sites
(inlined or not), extract several features from the call sites, and design a
compiler-opt-based multi-label classifier by inspecting the inlining
correlations between different compilations. Then, we use this model to predict
the labels of call sites in the uncompilable OSS projects without compilation
and obtain the labeled function call graphs of these projects. Next, we regard
the construction of SFSs as a sub-tree generation problem and design root node
selection and edge extension rules to construct SFSs automatically. Finally,
these SFSs will be added to the corpus of source functions and compared with
binary functions with inlining. We conduct several experiments to evaluate the
effectiveness of O2NMatcher and results show our method increases the
performance of existing works by 6% and exceeds all the state-of-the-art works
Diurnal Temperature Variation and Plants Drive Latitudinal Patterns in Seasonal Dynamics of Soil Microbial Community
Seasonality, an exogenous driver, motivates the biological and ecological temporal dynamics of animal and plant communities. Underexplored microbial temporal endogenous dynamics hinders the prediction of microbial response to climate change. To elucidate temporal dynamics of microbial communities, temporal turnover rates, phylogenetic relatedness, and species interactions were integrated to compare those of a series of forest ecosystems along latitudinal gradients. The seasonal turnover rhythm of microbial communities, estimated by the slope (w value) of similarity-time decay relationship, was spatially structured across the latitudinal gradient, which may be caused by a mixture of both diurnal temperature variation and seasonal patterns of plants. Statistical analyses revealed that diurnal temperature variation instead of average temperature imposed a positive and considerable effect alone and also jointly with plants. Due to higher diurnal temperature variation with more climatic niches, microbial communities might evolutionarily adapt into more dispersed phylogenetic assembly based on the standardized effect size of MNTD metric, and ecologically form higher community resistance and resiliency with stronger network interactions among species. Archaea and the bacterial groups of Chloroflexi, Alphaproteobacteria, and Deltaproteobacteria were sensitive to diurnal temperature variation with greater turnover rates at higher latitudes, indicating that greater diurnal temperature fluctuation imposes stronger selective pressure on thermal specialists, because bacteria and archaea, single-celled organisms, have extreme short generation period compared to animal and plant. Our findings thus illustrate that the dynamics of microbial community and species interactions are crucial to assess ecosystem stability to climate variations in an increased climatic variability era
Untangling the drivers of energy reduction in the UK productive sectors: Efficiency or offshoring?
The UK has been one of the few countries that has successfully decoupled final energy consumption from economic growth over the past 15 years. This study investigates the drivers of final energy consumption in the UK productive sectors between 1997 and 2013 using a decomposition analysis that incorporates two novel features. Firstly, it investigates to what extent changes in thermodynamic efficiency have contributed to overall changes in sectoral energy intensities. Secondly, it analyses how much of the structural change in the UK economy is driven by the offshoring of energy-intensive production overseas. The results show that energy intensity reductions are the strongest factor reducing energy consumption. However, only a third of the energy savings from energy intensity reductions can be attributed to reductions in thermodynamic efficiency with re- ductions in the exergy intensity of production making up the reminder. In addition the majority of energy savings from structural change are a result of offshoring, which constitutes the second biggest factor reducing energy consumption. In recent years the contributions of all decomposition factors have been declining with very little change in energy consumption after 2009. This suggests that a return to the strong reductions in energy consumption observed between 2001 and 2009 in the UK productive sectors should not be taken for granted. Given that further reductions in UK final energy consumption are needed to achieve global targets for climate change mitigation, additional policy interventions are needed. Such policies should adopt a holistic approach, taking into account all sectors in the UK economy as well as the relationship between the structural change in the UK and in the global supply chains delivering the goods and service for consumption and investment in the UK
Surface skyrmions and dual topological Hall effect in antiferromagnetic topological insulator EuCdAs
In this work, we synthesized single crystal of EuCdAs, which exhibits
A-type antiferromagnetic (AFM) order with in-plane spin orientation below
= 9.5~K.Optical spectroscopy and transport measurements suggest its topological
insulator (TI) nature with an insulating gap around 0.1eV. Remarkably, a dual
topological Hall resistivity that exhibits same magnitude but opposite signs in
the positive to negative and negative to positive magnetic field hysteresis
branches emerges below 20~K. With magnetic force microscopy (MFM) images and
numerical simulations, we attribute the dual topological Hall effect to the
N\'{e}el-type skyrmions stabilized by the interactions between topological
surface states and magnetism, and the sign reversal in different hysteresis
branches indicates potential coexistence of skyrmions and antiskyrmions. Our
work uncovers a unique two-dimensional (2D) magnetism on the surface of
intrinsic AFM TI, providing a promising platform for novel topological quantum
states and AFM spintronic applications.Comment: 7 pages, 3 figure
The Effect of Temozolomide/Poly(lactide-co-glycolide) (PLGA)/Nano-Hydroxyapatite Microspheres on Glioma U87 Cells Behavior
In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells. The microspheres were fabricated by the âSolid/Water/Oilâ method, and they were characterized by using X-Ray diffraction, scanning electron microscopy and differential scanning calorimetry. The proliferation, apoptosis and invasion of glioma cells were evaluated by MTT, flow cytometry assay and Transwell assay. The presence of the key invasive gene, αVÎČ3 integrin, was detected by the RT-PCR and Western blot method. It was found that the temozolomide/PLGA/nano-hydroxyapatite microspheres have a significantly diminished initial burst of drug release, compared to the TMZ laden PLGA microspheres. Our results suggest they can significantly inhibit the proliferation and invasion of glioma cells, and induce their apoptosis. Additionally, αVÎČ3 integrin was also reduced by the microspheres. These data suggest that by inhibiting the biological behavior of glioma cells in vitro, the newly designed temozolomide/PLGA/nano-hydroxyapatite microspheres, as controlled drug release carriers, have promising potential in treating glioma
Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these drugs are widespread. As efforts to develop vaccines against parasitic nematodes have been largely unsuccessful, there is an increased focus on discovering new anthelmintic entities to combat drug resistant worms. Here, we employed thermal proteome profiling (TPP) to explore hit pharmacology and to support optimisation of a hit compound (UMW-868), identified in a high-throughput whole-worm, phenotypic screen. Using advanced structural prediction and docking tools, we inferred an entirely novel, parasite-specific target (HCO_011565) of this anthelmintic small molecule in the highly pathogenic, blood-feeding barber's pole worm, and in other socioeconomically important parasitic nematodes. The "hit-to-target" workflow constructed here provides a unique prospect of accelerating the simultaneous discovery of novel anthelmintics and associated parasite-specific targets
Arf6 regulates AP-1Bâdependent sorting in polarized epithelial cells
Activated Arf6 directs membrane recruitment of the clathrin adaptor AP-1B to maintain membrane polarization in epithelial cells
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