Development of Silicon Strip Detectors for a Medium Energy Gamma-ray Telescope

We report on the design, production, and testing of advanced double-sided silicon strip detectors under development at the Max-Planck-Institute as part of the Medium Energy Gamma-ray Astronomy (MEGA) project. The detectors are designed to form a stack, the "tracker," with the goal of recording the paths of energetic electrons produced by Compton-scatter and pair-production interactions. Each layer of the tracker is composed of a 3 x 3 array of 500 micron thick silicon wafers, each 6 cm x 6 cm and fitted with 128 orthogonal p and n strips on opposite sides (470 micron pitch). The strips are biased using the punch-through principle and AC-coupled via metal strips separated from the strip implant by an insulating oxide/nitride layer. The strips from adjacent wafers in the 3 x 3 array are wire-bonded in series and read out by 128-channel TA1.1 ASICs, creating a total 19 cm x 19 cm position-sensitive area. At 20 degrees C a typical energy resolution of 15-20 keV FWHM, a position resolution of 290 microns, and a time resolution of ~1 microsec is observed.Comment: 9 pages, 13 figures, to appear in NIM-A (Proceedings of the 9th European Symposium on Semiconductor Detectors

The MEGA Advanced Compton Telescope Project

The goal of the Medium Energy Gamma-ray Astronomy (MEGA) telescope is to improve sensitivity at medium gamma-ray energies (0.4-50 MeV) by at least an order of magnitude over that of COMPTEL. This will be achieved with a new compact design that allows for a very wide field of view, permitting a sensitive all-sky survey and the monitoring of transient and variable sources. The key science objectives for MEGA include the investigation of cosmic high-energy particle accelerators, studies of nucleosynthesis sites using gamma-ray lines, and determination of the large-scale structure of galactic and cosmic diffuse background emission. MEGA records and images gamma-ray events by completely tracking both Compton and pair creation interactions in a tracker of double-sided silicon strip detectors and a calorimeter of CsI crystals able to resolve in three dimensions. We present initial laboratory calibration results from a small prototype MEGA telescope.Comment: 7 pages LaTeX, 5 figures, to appear in New Astronomy Reviews (Proceedings of the Ringberg Workshop "Astronomy with Radioactivities III"

MEGA: A Medium-Energy Gamma-ray Astronomy mission concept

The Medium Energy Gamma-ray Astronomy (MEGA) telescope concept will soon be proposed as a MIDEX mission. This mission would enable a sensitive all-sky survey of the medium-energy gamma-ray sky (0.4 - 50 MeV) and bridge the huge sensitivity gap between the COMPTEL and OSSE experiments on the Compton Gamma Ray Observatory, the SPI and IBIS instruments on INTEGRAL, and the visionary Advanced Compton Telescope (ACT) mission. The scientific goals include, among other things, compiling a much larger catalog of sources in this energy range, performing far deeper searches for supernovae, better measuring the galactic continuum and line emissions, and identifying the components of the cosmic diffuse gamma-ray emission. MEGA will accomplish these goals using a tracker made of Si strip detector (SSD) planes surrounded by a dense high-Z calorimeter. At lower photon energies (below ∼ 30 MeV), the design is sensitive to Compton interactions, with the SSD system serving as a scattering medium that also detects and measures the Compton recoil energy deposit. If the energy of the recoil electron is sufficiently high (\u3e 2 MeV) its momentum vector can also be measured. At higher photon energies (above ∼10 MeV), the design is sensitive to pair production events, with the SSD system measuring the tracks of the electron and positron. A prototype instrument has been developed and calibrated in the laboratory and at a gamma-ray beam facility. We present calibration results from the prototype and describe the proposed satellite mission

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens

Systematic genetic perturbation screening in human cells remains technically challenging. Typically, large libraries of chemically synthesized siRNA oligonucleotides are used, each designed to degrade a specific cellular mRNA via the RNA interference (RNAi) mechanism. Here, we report on data from three genome-wide siRNA screens, conducted to uncover host factors required for infection of human cells by two bacterial and one viral pathogen. We find that the majority of phenotypic effects of siRNAs are unrelated to the intended “on-target” mechanism, defined by full complementarity of the 21-nt siRNA sequence to a target mRNA. Instead, phenotypes are largely dictated by “off-target” effects resulting from partial complementarity of siRNAs to multiple mRNAs via the “seed” region (i.e., nucleotides 2–8), reminiscent of the way specificity is determined for endogenous microRNAs. Quantitative analysis enabled the prediction of seeds that strongly and specifically block infection, independent of the intended on-target effect. This prediction was confirmed experimentally by designing oligos that do not have any on-target sequence match at all, yet can strongly reproduce the predicted phenotypes. Our results suggest that published RNAi screens have primarily, and unintentionally, screened the sequence space of microRNA seeds instead of the intended on-target space of protein-coding genes. This helps to explain why previously published RNAi screens have exhibited relatively little overlap. Our analysis suggests a possible way of identifying “seed reagents” for controlling phenotypes of interest and establishes a general strategy for extracting valuable untapped information from past and future RNAi screens

The eROSITA X-ray telescope on SRG

eROSITA (extended ROentgen Survey with an Imaging Telescope Array) is the primary instrument on the Spectrum-Roentgen-Gamma (SRG) mission, which was successfully launched on July 13, 2019, from the Baikonour cosmodrome. After the commissioning of the instrument and a subsequent calibration and performance verification phase, eROSITA started a survey of the entire sky on December 13, 2019. By the end of 2023, eight complete scans of the celestial sphere will have been performed, each lasting six months. At the end of this program, the eROSITA all-sky survey in the soft X-ray band (0.2-2.3 keV) will be about 25 times more sensitive than the ROSAT All-Sky Survey, while in the hard band (2.3-8 keV) it will provide the first ever true imaging survey of the sky. The eROSITA design driving science is the detection of large samples of galaxy clusters up to redshifts z > 1 in order to study the large-scale structure of the universe and test cosmological models including Dark Energy. In addition, eROSITA is expected to yield a sample of a few million AGNs, including obscured objects, revolutionizing our view of the evolution of supermassive black holes. The survey will also provide new insights into a wide range of astrophysical phenomena, including X-ray binaries, active stars, and diffuse emission within the Galaxy. Results from early observations, some of which are presented here, confirm that the performance of the instrument is able to fulfil its scientific promise. With this paper, we aim to give a concise description of the instrument, its performance as measured on ground, its operation in space, and also the first results from in-orbit measurements