25 research outputs found
Autoclave modeling of corrosion processes occurring in a gas pipeline during transportation of an unprepared multiphase medium containing CO2
The problem of selecting a method for ensuring the reliability of the unprepared fluid transport facilities of
an unprepared fluid in the presence of carbon dioxide is considered. Carbon dioxide corrosion is one of the dangerous types of damage to field and main pipelines. It has been shown that dynamic autoclave tests should be carried out during staged laboratory tests in order to determine the intensity of carbon dioxide corrosion and to select the optimal method of protection.
A hypothesis about the imperfection of the existing generally accepted approaches to dynamic corrosion testing has been put forward and confirmed. A test procedure based on the use of an autoclave with an overhead stirrer, developed using elements of mathematical modeling, is proposed. The flows created in the autoclave provide corrosive wear of the sample surface similar to the internal surfaces elements wear of the pipelines piping of gas condensate wells. The autoclave makes it possible to simulate the effect of the organic phase on the flow rate and the nature of corrosion damage to the metal surface, as well
as the effect of the stirrer rotation speed and, accordingly, the shear stress of the cross section on the corrosion rate in
the presence/absence of a corrosion inhibitor. The given results of staged tests make it possible to judge the high efficiency
of the developed test procedure
Singularities in the optical response of cuprates
We argue that the detailed analysis of the optical response in cuprate
superconductors allows one to verify the magnetic scenario of superconductivity
in cuprates, as for strong coupling charge carriers to antiferromagnetic spin
fluctuations, the second derivative of optical conductivity should contain
detectable singularities at , , and
, where is the amplitude of the
superconducting gap, and is the resonance energy of spin
fluctuations measured in neutron scattering. We argue that there is a good
chance that these singularities have already been detected in the experiments
on optimally doped .Comment: 6 pages, 4 figure
Quantum Phase Transition in Frustrated Two-Dimensional Antiferromagnets
We study frustrated, two-dimensional, quantum antiferromagnets in the
vicinity of a quantum transition from a non-collinear, magnetically-ordered
ground state to a quantum disordered phase. The general scaling properties of
this transition are described. A detailed study of a particular field-theoretic
model of the transition, with bosonic spin-1/2 spinon fields, is presented.
Explicit universal scaling forms for a variety of observables are obtained and
the results are compared with numerical data on the spin-1/2 triangular
antiferromagnet. Universal properties of an alternative field-theory, with
confined spinons, are also briefly noted.Comment: 51 pages, REVTEX 3.0, 5 uuencoded EPS figures appended, YCTP-xxz
Theory of Two-Dimensional Quantum Heisenberg Antiferromagnets with a Nearly Critical Ground State
We present the general theory of clean, two-dimensional, quantum Heisenberg
antiferromagnets which are close to the zero-temperature quantum transition
between ground states with and without long-range N\'{e}el order. For
N\'{e}el-ordered states, `nearly-critical' means that the ground state
spin-stiffness, , satisfies , where is the
nearest-neighbor exchange constant, while `nearly-critical' quantum-disordered
ground states have a energy-gap, , towards excitations with spin-1,
which satisfies . Under these circumstances, we show that the
wavevector/frequency-dependent uniform and staggered spin susceptibilities, and
the specific heat, are completely universal functions of just three
thermodynamic parameters. Explicit results for the universal scaling functions
are obtained by a expansion on the quantum non-linear sigma model,
and by Monte Carlo simulations. These calculations lead to a variety of
testable predictions for neutron scattering, NMR, and magnetization
measurements. Our results are in good agreement with a number of numerical
simulations and experiments on undoped and lightly-doped .Comment: 81 pages, REVTEX 3.0, smaller updated version, YCTP-xxx
Suppressing quantum errors by scaling a surface code logical qubit
Practical quantum computing will require error rates that are well below what
is achievable with physical qubits. Quantum error correction offers a path to
algorithmically-relevant error rates by encoding logical qubits within many
physical qubits, where increasing the number of physical qubits enhances
protection against physical errors. However, introducing more qubits also
increases the number of error sources, so the density of errors must be
sufficiently low in order for logical performance to improve with increasing
code size. Here, we report the measurement of logical qubit performance scaling
across multiple code sizes, and demonstrate that our system of superconducting
qubits has sufficient performance to overcome the additional errors from
increasing qubit number. We find our distance-5 surface code logical qubit
modestly outperforms an ensemble of distance-3 logical qubits on average, both
in terms of logical error probability over 25 cycles and logical error per
cycle ( compared to ). To investigate
damaging, low-probability error sources, we run a distance-25 repetition code
and observe a logical error per round floor set by a single
high-energy event ( when excluding this event). We are able
to accurately model our experiment, and from this model we can extract error
budgets that highlight the biggest challenges for future systems. These results
mark the first experimental demonstration where quantum error correction begins
to improve performance with increasing qubit number, illuminating the path to
reaching the logical error rates required for computation.Comment: Main text: 6 pages, 4 figures. v2: Update author list, references,
Fig. S12, Table I
Non-Abelian braiding of graph vertices in a superconducting processor
Indistinguishability of particles is a fundamental principle of quantum
mechanics. For all elementary and quasiparticles observed to date - including
fermions, bosons, and Abelian anyons - this principle guarantees that the
braiding of identical particles leaves the system unchanged. However, in two
spatial dimensions, an intriguing possibility exists: braiding of non-Abelian
anyons causes rotations in a space of topologically degenerate wavefunctions.
Hence, it can change the observables of the system without violating the
principle of indistinguishability. Despite the well developed mathematical
description of non-Abelian anyons and numerous theoretical proposals, the
experimental observation of their exchange statistics has remained elusive for
decades. Controllable many-body quantum states generated on quantum processors
offer another path for exploring these fundamental phenomena. While efforts on
conventional solid-state platforms typically involve Hamiltonian dynamics of
quasi-particles, superconducting quantum processors allow for directly
manipulating the many-body wavefunction via unitary gates. Building on
predictions that stabilizer codes can host projective non-Abelian Ising anyons,
we implement a generalized stabilizer code and unitary protocol to create and
braid them. This allows us to experimentally verify the fusion rules of the
anyons and braid them to realize their statistics. We then study the prospect
of employing the anyons for quantum computation and utilize braiding to create
an entangled state of anyons encoding three logical qubits. Our work provides
new insights about non-Abelian braiding and - through the future inclusion of
error correction to achieve topological protection - could open a path toward
fault-tolerant quantum computing
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
[3+3]-Annulation of Cyclic Nitronates with Vinyl Diazoacetates: Diastereoselective Synthesis of Partially Saturated [1,2]Oxazino[2,3-<i>b</i>][1,2]oxazines and Their Base-Promoted Ring Contraction to Pyrrolo[1,2-<i>b</i>][1,2]oxazine Derivatives
A rhodium(II)-catalyzed reaction of cyclic nitronates (5,6-dihydro-4H-1,2-oxazine N-oxides) with vinyl diazoacetates proceeds as a [3+3]-annulation producing bicyclic unsaturated nitroso acetals (4a,5,6,7-tetrahydro-2H-[1,2]oxazino[2,3-b][1,2]oxazines). Optimization of reaction conditions revealed the use of Rh(II) octanoate as the preferred catalyst in THF at room temperature, which allows the preparation of target products in good yields and excellent diastereoselectivity. Under basic conditions, namely, the combined action of DBU and alcohol, these nitroso acetals undergo ring contraction of an unsaturated oxazine ring into the corresponding pyrrole. Both transformations can be performed in a one-pot fashion, thus constituting a quick approach to oxazine-annulated pyrroles from available starting materials, such as nitroalkenes, olefins, and diazo compounds
Diels-Alder Reaction of β-Fluoro-β-nitrostyrenes with Cyclic Dienes
The
Diels-Alder reaction of β-fluoro-β-nitrostyrenes with cyclic 1,3-dienes was
investigated. A series of novel monofluorinated norbornenes was prepared in up
to 97% yield. The reaction with 1,3‑cyclohexadiene permits the preparation of
monofluorinated bicyclo[2.2.2]oct-2-enes. The kinetic data of the reaction with
cyclopentadiene and cyclohexadiene-1,3
were used to calculate activation parameters. Furthermore, the synthetic
utility of the cycloadducts obtained was demonstrated
Six-Membered Cyclic Nitronates as 1,3-Dipoles in Formal [3 + 3]-Cycloaddition with Donor–Acceptor Cyclopropanes. Synthesis of New Type of Bicyclic Nitrosoacetals
The first formal [3 + 3]-cycloaddition of nitronates with donor–acceptor cyclopropanes is reported. The reaction is catalyzed by ytterbium trifluoromethanesulfonate and leads to hitherto unknown bicyclic nitrosoacetals, possessing two annelated six-membered rings