Design Analysis of Hybrid Vehicles and Use of Possible Improvements in Future Designs

Hybrid vehicles seem to be, for the foreseeable future, the only way forward in lowering CO2 emissions of private transport. The objective of this project is to analyze the two forms of hybridization: The series and the parallel hybrids, and compare their advantages and disadvantages. On sale today, the Toyota Pruis, a parallel hybrid, is the best selling hybrid. Its main competitor is the Honda Civic Hybrid, recognized as a series hybrid. These two examples were studied and compared in different everyday driving situations. The Prius has the better fuel economy and emissions. However, for its lower drag coefficient, less powerful petrol engine and more powerful electric motor, it only gains minimal drop in CO2 emissions over the Civic. Improvements to the Civic should include emission free operation at low speeds. A hybrid system for the Prius should be developed that has lower weight; at present, it has two electric motors and two batteries. Further analysis should still be carried out in an attempt to improve hybrid vehicles further. Performance at low speeds (<40km/h) should be investigated further, concentrating on prolonged periods of city driving

F-18-FDG and C-11-choline positron emission tomography in human esophago-gastric cancer : prediction of response to therapy

Peer reviewedPublisher PD

Transdimensional Love-wave tomography of the British Isles and shear-velocity structure of the East Irish Sea Basin from ambient-noise interferometry

We present the first Love-wave group velocity and shear velocity maps of the British Isles obtained from ambient noise interferometry and fully non-linear inversion. We computed interferometric inter-station Green's functions by cross-correlating the transverse component of ambient noise records retrieved by 61 seismic stations across the UK and Ireland. Group velocity measurements along each possible inter-station path were obtained using frequency-time analysis and converted into a series of inter-station traveltime datasets between 4 and 15 seconds period. Traveltime uncertainties estimated from the standard deviation of dispersion curves constructed by stacking randomly-selected subsets of daily cross-correlations, were observed to be too low to allow reasonable data fits to be obtained during tomography. Data uncertainties were therefore estimated again during the inversion as distance-dependent functionals. We produced Love-wave group velocity maps within 8 different period bands using a fully non-linear tomography method which combines the transdimensional reversible-jump Markov chain Monte Carlo (rj-McMC) algorithm with an eikonal raytracer. By modelling exact raypaths at each step of the Markov chain we ensured that the non-linear character of the inverse problem was fully and correctly accounted for. Between 4 and 10 seconds period, the group velocity maps show remarkable agreement with the known geology of the British Isles and correctly identify a number of low-velocity sedimentary basins and high-velocity features. Longer period maps, in which most sedimentary basins are not visible, are instead mainly representative of basement rocks. In a second stage of our study we used the results of tomography to produce a series of Love-wave group velocity dispersion curves across a grid of geographical points focussed around the East Irish Sea sedimentary basin. We then independently inverted each curve using a similar rj-McMC algorithm to obtain a series of one-dimensional shear velocity profiles. By merging all 1D profiles, we created a fully three-dimensional model of the crust beneath the East Irish Sea. The depth to basement in this model compares well with that averaged from seismic reflection profiles. This result is the first 3-dimensional model in the UK with fully quantified uncertainties: it shows basin depths and basement structures, and their concomitant uncertainties

Nutritional significance of a winter-flowering succulent for opportunistic avian nectarivores

The winter-flowering succulent Aloe marlothii provides nectar for many opportunistic avian nectarivores in southern African savannas. We assessed the importance of A. marlothii nectar sugar for opportunistic nectarivores by analysing temporal changes in stable carbon isotope ratios (d13C) in the tissues of birds in Suikerbosrand Nature Reserve, South Africa. The blood of the 11 most common non-granivorous opportunistic nectarivores at our site was enriched in 13C by 3.4 ± 1.5& during the flowering period of A. marlothii, reflecting the enriched crassulacean acid metabolism (CAM) isotopic signature of nectar ()12.6 ± 0.5&). This relatively small contribution of A. marlothii nectar to assimilated carbon in whole blood contrasted with that of exhaled CO2 in African Red-eyed Bulbuls Pycnonotus nigricans and Cape White-eyes Zosterops capensis. In both these species, the d13C of breath samples was significantly enriched compared with blood and feathers, and closely resembled that of the nectar, revealing combustion of ingested nectar rather than assimilation. Although our analysis was complicated by the presence of C4 grasses, whose d13C values are similar to those of CAM photosynthesizers, when considered with previously published feeding observations our data reveal that opportunistic nectarivores feeding on A. marlothii nectar obtain a relatively small fraction of their assimilated carbon, but most of their metabolized carbon, from this seasonally available carbohydrate food resource. Because the d13C values of insects associated with C3 plants also became enriched during the flowering season, some insect-eating opportunistic nectarivores may have assimilated A. marlothii carbon indirectly from insects. This study highlights the importance of understanding isotopic routing when assessing the nutritional significance of specific dietary items to consumer communities.The National Research Foundation of South Africahttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1474-919X/ab201

The long-term outcomes of epilepsy surgery

<div><p>Objective</p><p>Despite modern anti-epileptic drug treatment, approximately 30% of epilepsies remain medically refractory and for these patients, epilepsy surgery may be a treatment option. There have been numerous studies demonstrating good outcome of epilepsy surgery in the short to median term however, there are a limited number of studies looking at the long-term outcomes. The aim of this study was to ascertain the long-term outcome of resective epilepsy surgery in a large neurosurgery hospital in the U.K.</p><p>Methods</p><p>This a retrospective analysis of prospectively collected data. We used the 2001 International League Against Epilepsy (ILAE) classification system to classify seizure freedom and Kaplan-Meier survival analysis to estimate the probability of seizure freedom.</p><p>Results</p><p>We included 284 patients who underwent epilepsy surgery (178 anterior temporal lobe resections, 37 selective amygdalohippocampectomies, 33 temporal lesionectomies, 36 extratemporal lesionectomies), and had a prospective median follow-up of 5 years (range 1–27). Kaplan-Meier estimates showed that 47% (95% CI 40–58) remained seizure free (apart from simple partial seizures) at 5 years and 38% (95% CI 31–45) at 10 years after surgery. 74% (95% CI 69–80) had a greater than 50% seizure reduction at 5 years and 70% (95% CI 64–77) at 10 years. Patients who had an amygdalohippocampectomy were more likely to have seizure recurrence than patients who had an anterior temporal lobe resection (p = 0.006) and temporal lesionectomy (p = 0.029). There was no significant difference between extra temporal and temporal lesionectomies. Hippocampal sclerosis was associated with a good outcome but declined in relative frequency over the years.</p><p>Conclusion</p><p>The vast majority of patients who were not seizure free experienced at least a substantial and long-lasting reduction in seizure frequency. A positive long-term outcome after epilepsy surgery is possible for many patients and especially those with hippocampal sclerosis or those who had anterior temporal lobe resections.</p></div

Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report

<p>Abstract</p> <p>Introduction</p> <p>Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneuropathy has occasionally been reported in acute Immunodeficiency Virus infection but little data exists on frequency, management and outcome.</p> <p>Case presentation</p> <p>We describe an episode of Guillain-Barré syndrome presenting as acute inflammatory demyelinating polyneuropathy in a 30-year-old man testing positive for Immunodeficiency Virus, probably during acute seroconversion. Clinical suspicion was confirmed by cerebrospinal fluid analysis and nerve conduction studies. Rapid clinical deterioration prompted intravenous immunoglobulin therapy and early commencement of highly active anti-retroviral therapy. All symptoms resolved within nine weeks.</p> <p>Conclusion</p> <p>Unusual neurological presentations in previously fit patients are an appropriate indication for Immunodeficiency-Virus testing. Highly active anti-retroviral therapy with adequate penetration of the central nervous system should be considered as an early intervention, alongside conventional therapies such as intravenous immunoglobulin.</p

Rationale and study design of the MINERVA study: Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction-UK multicentre collaboration

Introduction The purpose of this study is to assess the ability of two new ECG markers (Regional Repolarisation Instability Index (R2I2) and Peak Electrical Restitution Slope) to predict sudden cardiac death (SCD) or ventricular arrhythmia (VA) events in patients with ischaemic cardiomyopathy undergoing implantation of an implantable cardioverter defibrillator for primary prevention indication. Methods and analysis Multicentre Investigation of Novel Electrocardiogram Risk markers in Ventricular Arrhythmia prediction is a prospective, open label, single blinded, multicentre observational study to establish the efficacy of two ECG biomarkers in predicting VA risk. 440 participants with ischaemic cardiomyopathy undergoing routine first time implantable cardioverter-defibrillator (ICD) implantation for primary prevention indication are currently being recruited. An electrophysiological (EP) study is performed using a non-invasive programmed electrical stimulation protocol via the implanted device. All participants will undergo the EP study hence no randomisation is required. Participants will be followed up over a minimum of 18 months and up to 3 years. The first patient was recruited in August 2016 and the study will be completed at the final participant follow-up visit. The primary endpoint is ventricular fibrillation or sustained ventricular tachycardia >200 beats/min as recorded by the ICD. The secondary endpoint is SCD. Analysis of the ECG data obtained during the EP study will be performed by the core lab where blinding of patient health status and endpoints will be maintained. Ethics and dissemination Ethical approval has been granted by Research Ethics Committees Northern Ireland (reference no. 16/NI/0069). The results will inform the design of a definitive Randomised Controlled Trial (RCT). Dissemination will include peer reviewed journal articles reporting the qualitative and quantitative results, as well as presentations at conferences and lay summaries

Mycorrhizal fungal abundance is affected by long-term climatic manipulations in the field

Climate change treatments - winter warming, summer drought and increased summer precipitation - have been imposed on an upland grassland continuously for 7 years. The vegetation was surveyed yearly. In the seventh year, soil samples were collected on four occasions through the growing season in order to assess mycorrhizal fungal abundance. Mycorrhizal fungal colonisation of roots and extraradical mycorrhizal hyphal (EMH) density in the soil were both affected by the climatic manipulations, especially by summer drought. Both winter warming and summer drought increased the proportion of root length colonised (RLC) and decreased the density of external mycorrhizal hyphal. Much of the response of mycorrhizal fungi to climate change could be attributed to climate-induced changes in the vegetation, especially plant species relative abundance. However, it is possible that some of the mycorrhizal response to the climatic manipulations was direct - for example, the response of the EMH density to the drought treatment. Future work should address the likely change in mycorrhizal functioning under warmer and drier conditions