Modelo para la medición del riesgo de insolvencia empresarial : un caso de estudio en las empresas PYME de Colombia

CD-T 658.155 A94; 85 pEste informe relata de manera concisa los resultados obtenidos en el desarrollo del proyecto "Modelo para la medición del riesgo de insolvencia para empresas PYME en Colombia"; así como también se muestra le metodología empleada para el desarrollo y es comparada con el diseño metodológico planificado con antelación al inicio de actividades investigativas.Universidad Libre Seccional Pereir

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Las organizaciones desde una mirada del desarollo sostenible

En el presente libro se articulan en dos líneas, a saber, las organizaciones desde la región y las organizaciones desde el emprendimiento y la gestión. En la primera se analizan diferentes temáticas que dejan ver el uso adecuado de la ciencia y la tecnología, reconociendo el rol de los sectores tanto público como privado y de la sociedad civil en el desarrollo, productividad y competitividad de las organizaciones, por lo que se tienen temáticas como normas internacionales, emprendimiento, tasa representativa del mercado, direccionamiento estratégico en el sector de obras civiles, precios internos y externos del tipo de cambio, que permitan comprender la dinámica contemporánea de las organizaciones, a partir de las experiencias de los diferentes actores que participan en escenarios inclusivos, con el propósito de evidenciar los elementos de competitividad y perdurabilidad que contribuyen a la internacionalización organizacional.La segunda línea trata de las organizaciones en la región, donde se muestran resultados de investigaciones, como las tendencias mundiales en el sector funerario, estrategias de innovación empresarial y responsabilidad social empresarial para Mipymes. Usos agroindustriales de la hoja de coca, factores de competitividad en la ganadería, en el sector metalmecánico, redes socio institucionales en el sector lácteo, imagen comercial de empresario, estrategia de encadenamiento, patios productivos, aplicación del modelo desing thinking, gestión del conocimiento en Mipymes industriales, ecosistema de emprendimiento, microempresas sostenibles, territorios de paz que dejan ver las nuevas tendencias y temáticas de creatividad e innovación para fortalecer la pedagogía, las competencias, las redes de emprendimiento a través de las herramientas, modelos y estructuras de los esquemas emprendedores, que permitan la continua evolución de los mercados emergentes y sus diferentes actores

Clinical characterization of data-driven diabetes subgroups in Mexicans using a reproducible machine learning approach

Introduction Previous reports in European populations demonstrated the existence of five data-driven adult-onset diabetes subgroups. Here, we use self-normalizing neural networks (SNNN) to improve reproducibility of these data-driven diabetes subgroups in Mexican cohorts to extend its application to more diverse settings.Research design and methods We trained SNNN and compared it with k-means clustering to classify diabetes subgroups in a multiethnic and representative population-based National Health and Nutrition Examination Survey (NHANES) datasets with all available measures (training sample: NHANES-III, n=1132; validation sample: NHANES 1999–2006, n=626). SNNN models were then applied to four Mexican cohorts (SIGMA-UIEM, n=1521; Metabolic Syndrome cohort, n=6144; ENSANUT 2016, n=614 and CAIPaDi, n=1608) to characterize diabetes subgroups in Mexicans according to treatment response, risk for chronic complications and risk factors for the incidence of each subgroup.Results SNNN yielded four reproducible clinical profiles (obesity related, insulin deficient, insulin resistant, age related) in NHANES and Mexican cohorts even without C-peptide measurements. We observed in a population-based survey a high prevalence of the insulin-deficient form (41.25%, 95% CI 41.02% to 41.48%), followed by obesity-related (33.60%, 95% CI 33.40% to 33.79%), age-related (14.72%, 95% CI 14.63% to 14.82%) and severe insulin-resistant groups. A significant association was found between the SLC16A11 diabetes risk variant and the obesity-related subgroup (OR 1.42, 95% CI 1.10 to 1.83, p=0.008). Among incident cases, we observed a greater incidence of mild obesity-related diabetes (n=149, 45.0%). In a diabetes outpatient clinic cohort, we observed increased 1-year risk (HR 1.59, 95% CI 1.01 to 2.51) and 2-year risk (HR 1.94, 95% CI 1.13 to 3.31) for incident retinopathy in the insulin-deficient group and decreased 2-year diabetic retinopathy risk for the obesity-related subgroup (HR 0.49, 95% CI 0.27 to 0.89).Conclusions Diabetes subgroup phenotypes are reproducible using SNNN; our algorithm is available as web-based tool. Application of these models allowed for better characterization of diabetes subgroups and risk factors in Mexicans that could have clinical applications

Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021

1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano