Extinction in Lotka-Volterra model

Competitive birth-death processes often exhibit an oscillatory behavior. We investigate a particular case where the oscillation cycles are marginally stable on the mean-field level. An iconic example of such a system is the Lotka-Volterra model of predator-prey competition. Fluctuation effects due to discreteness of the populations destroy the mean-field stability and eventually drive the system toward extinction of one or both species. We show that the corresponding extinction time scales as a certain power-law of the population sizes. This behavior should be contrasted with the extinction of models stable in the mean-field approximation. In the latter case the extinction time scales exponentially with size.Comment: 11 pages, 17 figure

Projected sensitivity to sub-GeV dark matter of next-generation semiconductor detectors

We compute the projected sensitivity to dark matter (DM) particles in the sub-GeV mass range of future direct detection experiments using germanium and silicon semiconductor targets. We perform this calculation within the dark photon model for DM-electron interactions using the likelihood ratio as a test statistic, Monte Carlo simulations, and background models that we extract from recent experimental data. We present our results in terms of DM-electron scattering cross section values required to reject the background only hypothesis in favour of the background plus DM signal hypothesis with a statistical significance, $\mathcal{Z}$, corresponding to 3 or 5 standard deviations. We also test the stability of our conclusions under changes in the astrophysical parameters governing the local space and velocity distribution of DM in the Milky Way. In the best-case scenario, when a high-voltage germanium detector with an exposure of $50$ kg-year and a CCD silicon detector with an exposure of $1$ kg-year and a dark current rate of $1\times10^{-7}$ counts/pixel/day have simultaneously reported a DM signal, we find that the smallest cross section value compatible with $\mathcal{Z}=3$ ($\mathcal{Z}=5$) is about $8\times10^{-42}$ cm$^2$ ($1\times10^{-41}$ cm$^2$) for contact interactions, and $4\times10^{-41}$ cm$^2$ ($7\times10^{-41}$ cm$^2$) for long-range interactions. Our sensitivity study extends and refine previous works in terms of background models, statistical methods, and treatment of the underlying astrophysical uncertainties.Comment: 17 pages, 4 figure

4,5,6,7-Tetra­bromo-1,1,3-trimethyl-3-(2,3,4,5-tetra­bromo­phen­yl)indane

The title compound (OctaInd), C18H12Br8, is a commercial brominated flame retardant (BFR). In the mol­ecule, the five-membered ring has a slight envelope conformation, with a deviation of 0.317 (9) Å for the flap C atom from four essentially planar C atoms. The dihedral angle between the two benzene rings is 74.00 (16) Å

Toward Unbiased Galaxy Cluster Masses from Line of Sight Velocity Dispersions

We study the use of red sequence selected galaxy spectroscopy for unbiased estimation of galaxy cluster masses. We use the publicly available galaxy catalog produced using the semi-analytic model of De Lucia & Blaizot (2007) on the Millenium Simulation (Springel et al. 2005). We explore the impacts on selection using galaxy color, projected separation from the cluster center, and galaxy luminosity. We study the relationship between cluster mass and velocity dispersion and identify and characterize the following sources of bias and scatter: halo triaxiality, dynamical friction of red luminous galaxies and interlopers. We show that due to halo triaxiality the intrinsic scatter of estimated line of sight dynamical mass is about three times larger (30-40%) than the one estimated using the 3D velocity dispersion (~12%) and a small bias (~1%) is induced. We find evidence of increasing scatter as a function of redshift and provide a fitting formula to account for it. We characterize the amount of bias and scatter introduced by dynamical friction when using subsamples of red-luminous galaxies to estimate the velocity dispersion. We study the presence of interlopers in spectroscopic samples and their effect on the estimated cluster dynamical mass. Our results show that while cluster velocity dispersions extracted from a few dozen red sequence selected galaxies do not provide precise masses on a single cluster basis, an ensemble of cluster velocity dispersions can be combined to produce a precise calibration of a cluster survey mass observable relation. Currently, disagreements in the literature on simulated subhalo velocity dispersion mass relations place a systematic floor on velocity dispersion mass calibration at the 15% level in mass. We show that the selection related uncertainties are small by comparison, providing hope that with further improvements this systematic floor can be reduced.Comment: submitted to Ap

Phase 1 Trial With the Cell-Based Immune Primer Ilixadencel, Alone, and Combined With Sorafenib, in Advanced Hepatocellular Carcinoma

Several lines of evidence support immunotherapy in hepatocellular carcinoma (HCC). We have shown that intratumoral injections of the immune primer ilixadencel (pro-inflammatory allogeneic dendritic cells) are safe in renal-cell carcinoma. Here, we assessed ilixadencel as a single agent and combined with sorafenib in advanced HCC. Of 17 HCC patients enrolled, 12 patients received ilixadencel at the dose of 10 × 106 cells (six as monotherapy and six in combination with sorafenib), and five received ilixadencel at the dose of 20 × 106 cells as monotherapy. The primary objective was to evaluate tolerability. All patients had at least one adverse event, with 30% of such events considered as treatment-related, with one single treatment-related grade three event. The most common toxicity was grade 1 and 2 fever and chills. Eleven of 15 evaluable patients (73%) showed increased frequency of tumor-specific CD8+ T cells in peripheral blood. Overall one patient had a partial response (with ilixadencel as monotherapy), and five had stable disease as overall best response per mRECIST. The median time to progression was 5.5 months, and overall survival ranged from 1.6 to 21.4 months. Our study confirms the safety of ilixadencel as single agent or in combination with sorafenib and indicates tumor-specific immunological responses in advanced HCC.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT0197466

Propuesta de un prototipo de vivienda sustentable y sismo resistente en asentamiento humano Nueva Esperanza, Nuevo Chimbote, 2021

El distrito de Nuevo Chimbote, la mayor parte de viviendas fueron construidas con materiales poco duraderos y esto aumenta cada día debido al bajo nivel socioeconómico de las poblaciones vulnerables lo que los conlleva a no poder construir una vivienda duradera y siguiendo los protocolos establecidos; nuestro proyecto fue útil para brindar propuestas con bases teóricas para construir viviendas económicas y seguras de una manera rápida y confiable. Nuestro proyecto es descriptivo comparativo porque realizaremos la comparación con respecto a una vivienda tradicional. Nuestro proyecto permitió comparar en términos de economía que tipo de vivienda es más viable destinada hacia nuestra población a estudiar. Una vivienda sostenible planteada en nuestro proyecto posee las siguientes características: Económico, seguro, viable, basado en normas RNE, de menor tiempo de construcción. Con nuestro proyecto esperamos proponer una vivienda económica y confiable utilizando las normas correspondientes. Por lo cual presento este proyecto para abarcar lo máximo posible en base teórica y por consiguiente brindar un producto económico y rentable socialmente para dichas zonas de expansión urbana en nuestra localidad

Wave function recombination instability in cold atom interferometers

Cold atom interferometers use guiding potentials that split the wave function of the Bose-Einstein condensate and then recombine it. We present theoretical analysis of the wave function recombination instability that is due to the weak nonlinearity of the condensate. It is most pronounced when the accumulated phase difference between the arms of the interferometer is close to an odd multiple of PI and consists in exponential amplification of the weak ground state mode by the strong first excited mode. The instability exists for both trapped-atom and beam interferometers.Comment: 4 pages, 5 figure

Optimal simultaneous measurements of incompatible observables of a single photon

The ultimate limits of measurement precision are dictated by the laws of quantum mechanics. One of the most fascinating results is that joint or simultaneous measurements of noncommuting quantum observables are possible at the cost of increased unsharpness or measurement uncertainty. Many different criteria exist for determining what an “optimal” joint measurement is, with corresponding different trade-off relations for the measurements. It is generally a nontrivial task to devise or implement a strategy that minimizes the joint-measurement uncertainty. Here, we implement the simplest possible technique for an optimal four-outcome joint measurement and demonstrate a type of optimal measurement that has not been realized before in a photonic setting. We experimentally investigate a joint-measurement uncertainty relation that is more fundamental in the sense that it refers only to probabilities and is independent of values assigned to measurement outcomes. Using a heralded single-photon source, we demonstrate quantum-limited performance of the scheme on single quanta. Since quantum measurements underpin many concepts in quantum information science, this study is both of fundamental interest and relevant for emerging photonic quantum technologies

Estimating the frequency of Asian cytochrome B haplotypes in standard European and local Spanish pig breeds

Mitochondrial DNA has been widely used to perform phylogenetic studies in different animal species. In pigs, genetic variability at the cytochrome B gene and the D-loop region has been used as a tool to dissect the genetic relationships between different breeds and populations. In this work, we analysed four SNP at the cytochrome B gene to infer the Asian (A1 and A2 haplotypes) or European (E1 and E2 haplotypes) origins of several European standard and local pig breeds. We found a mixture of Asian and European haplotypes in the Canarian Black pig (E1, A1 and A2), German Piétrain (E1, A1 and A2), Belgian Piétrain (E1, A1), Large White (E1 and A1) and Landrace (E1 and A1) breeds. In contrast, the Iberian (Guadyerbas, Ervideira, Caldeira, Campanario, Puebla and Torbiscal strains) and the Majorcan Black pig breeds only displayed the E1 haplotype. Our results show that the introgression of Chinese pig breeds affected most of the major European standard breeds, which harbour Asian haplotypes at diverse frequencies (15–56%). In contrast, isolated local Spanish breeds, such as the Iberian and Majorcan Black pig, only display European cytochrome B haplotypes, a feature that evidences that they were not crossed with other Chinese or European commercial populations. These findings illustrate how geographical confinement spared several local Spanish breeds from the extensive introgression event that took place during the 18th and 19th centuries in Europe

PRISM: A Non-Equilibrium, Multiphase Interstellar Medium Model for Radiation Hydrodynamics Simulations of Galaxies

We introduce the PRISM interstellar medium (ISM) model for thermochemistry and its implementation in the RAMSES-RTZ code. The model includes a non-equilibrium primordial, metal, and molecular chemistry network for 115 species coupled to on-the-fly multifrequency radiation transport. PRISM accurately accounts for the dominant ISM cooling and heating processes in the low-density regime (i.e. $\rho<10^5\ {\rm cm^{-3}}$), including photoheating, photoelectric heating, H$_2$ heating/cooling, cosmic-ray heating, H/He cooling, metal-line cooling, CO cooling, and dust cooling (recombination and gas-grain collisions). We validate the model by comparing 1D equilibrium simulations across six dex in metallicity to existing 1D ISM models in the literature. We apply PRISM to high-resolution (4.5 pc) isolated dwarf galaxy simulations that include state-of-the-art models for star formation and stellar feedback to take an inventory of which cooling and heating processes dominate each different gas phase of a galaxy and to understand the importance of non-equilibrium effects. We show that most of the ISM gas is either close to thermal equilibrium or exhibits a slight cooling instability, while from a chemical perspective, the non-equilibrium electron fraction is often more than three times higher or lower than the equilibrium value, which impacts cooling, heating, and observable emission lines. Electron enhancements are attributed to recombination lags while deficits are shown to be due to rapid cosmic-ray heating. The PRISM model and its coupling to RAMSES-RTZ is applicable to a wide variety of astrophysical scenarios, from cosmological simulations to isolated giant molecular clouds, and is particularly useful for understanding how changes to ISM physics impact observable quantities such as metallic emission lines.Comment: 21 pages, 16 figures, submitted to MNRA