CLÍNICA AMPLIADA À ESCOLA INCLUSIVA DURANTE A PANDEMIA DA COVID-19: RELATO DE EXPERIÊNCIA DE ESTÁGIO PROFISSIONALIZANTE EM PSICOLOGIA DA PUC MINAS BETIM

Em março de 2020 a comunidade escolar do país entrou em quarentena para evitar a proliferação do coronavírus. O isolamento social prolongado exigiu que a formação em Psicologia incluísse novas formas de transmissão do saber e de prestação de serviços, usando das tecnologias digitais. O estágio profissionalizante da ênfase voltada ao estudo e as práticas da Psicologia nas “Políticas Sociais” do curso de psicologia da PUC-MG unidade de Betim, tem uma parceria como Centro de Referência e Apoio à Educação Inclusiva Rafael Veneroso, visando qualificar as(os) professores das escolas da rede municipal para tratar da inclusão usando de metodologias lúdicas e coletivas. O presente artigo visa apresentar o que pudemos fazer de forma remota para não deixarmos de prestar nosso serviço a rede municipal da cidade de Betim

O processo neuroinflamatório e sintomatologia na doença de Alzheimer: Uma revisão bibliográfica: The neuroinflammatory process and symptomatology in Alzheimer's disease: a literature review

Este artigo buscou analisar a produção científica sobre o mecanismo da doença de Alzheimer abordando o processo neuroinflamatório e a sintomatologia gerada pelas alterações bioquímicas. A fisiopatologia da doença de Alzheimer é relacionada à síntese das placas de amiloides e à formação dos emaranhados neurofibrilares, que afetam as funções neuronais e podem culminar com a apoptose celular. Estes componentes atuam como fatores pró-inflamatórios, assim ocorrendo a ativação das células gliais e manutenção de um estado inflamatório neurodegenerativo crônico. Além disso, há outros participantes desse cenário, que produzem quimiocinas e citocinas, e atuam como fonte de proteínas do complemento e prostanóides derivados da COX-2. A progressão clínica tem relação direta com o avanço da neuroinflamação, que potencializa a degeneração e morte neuronal, a cada pico inflamatório ocorre a progressão sintomatológica, comprometendo a cognição e execução de atividades básicas de vida diária. O manejo ocorre nos fatores de risco cardiovascular, cuidados com a saúde cerebrovascular e na manutenção da qualidade de vida. A doença é multifatorial e complexa, é necessário o aprofundamento dos conhecimentos acerca do processo da doença e sua sintomatologia, e a investigação para a conjectura do declínio cognitivo e o estabelecimento de prognóstico

Antimicrobial and antileishmanial activity of essential oil from the leaves of Annona foetida (Annonaceae)

bicyclogermacrene (35.12%), (E)-caryophyllene (14.19%) and α-copaene (8.19%). The antimicrobial and antileishmanial activities were investigated. The oil showed potent antimicrobial activity against Candida albicans and Rhodococcus equi. The oil also showed significant antileishmanial activity, giving the best results against Leishmania guyanensis. A preliminary cytotoxicity assay for this oil was carried out on hamster and mice (Balb/c) peritoneal macrophages. The results obtained were similar to pentamidine and considered not to be cytotoxic to macrophages.7881Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

As particularidades clínicas da otite média: Clinical features of otitis media

A otite média é um processo inflamatório de evolução abrupta, acompanhado pelo quadro clínico típico de inflamação na orelha média, sendo sua incidência prevalente em crianças, culminando em leves repercussões clínicas, mas que deve ser adequadamente diagnosticada e tratada. Este evento clínico pode ser agudo, subagudo ou crônico com aparições típicas, evolução e manejo clínico diferenciados. O seguinte artigo é uma revisão narrativa de literatura que visa analisar a respeito das principais particularidades clínicas da Otite Média. Diante das informações coletadas, pode se elucidar que a otite média é o fator causal para implicações negativas e antibioticoterapia em crianças, logo é essencial medidas para diagnose precoce para evitar repercussões na saúde destes

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Cross-cutting principles for planetary health education

Since the 2015 launch of the Rockefeller Foundation Lancet Commission on planetary health,1 an enormous groundswell of interest in planetary health education has emerged across many disciplines, institutions, and geographical regions. Advancing these global efforts in planetary health education will equip the next generation of scholars to address crucial questions in this emerging field and support the development of a community of practice. To provide a foundation for the growing interest and efforts in this field, the Planetary Health Alliance has facilitated the first attempt to create a set of principles for planetary health education that intersect education at all levels, across all scales, and in all regions of the world—ie, a set of cross-cutting principles