Levantamiento arquitectónico y estudio físico-constructivo del "Molí Paperer"

El molino papelero de Martorell data del 1739. Desde su origen hasta la actualidad, ha sufrido una serie de cambios provocados tanto por las necesidades industriales de cada momento, como por las constantes riadas que se sucedían en Martorell. Por estos motivos el edificio presenta cierta dificultad a la hora de estudiarlo. Las ampliaciones y pequeñas intervenciones que se le han realizado, crean conflicto para establecer la tipología constructiva correspondiente a cada época. El molino cesa su producción definitivamente en 1964 y desde entonces no ha recibido el mantenimiento adecuado, mostrando en la actualidad un avanzado estado de degradación constructiva con el agotamiento de sus elementos estructurales y constructivos. Los objetivos del proyecto se centran en: - un estudio histórico de la evolución del molino - un levantamiento gráfico - un estudio de los elementos constructivos - un análisis de las lesiones existentes con sus propuestas de actuación - un estudio de la maquinaria propia del molino papelero. Siguiendo estas directrices, se pretende estudiar el estado actual del edificio y que sirva de base para una futura rehabilitación y cambio de uso

Remote Teaching of Chemistry Laboratory Courses during COVID-19

This paper describes the transfer from face-to-face education toemergency remote teaching of chemistry laboratory courses in a bachelor's degree inPharmacy during the COVID-19 pandemic. The virtualization was carried out usingvideos of each experimental practice and questionnaires containing the experimentaldata needed. The contents were integrated into the virtual platform BlackboardCollaborate, where tutorials and remote support from the teachers were provided tosolve the issues raised. The didactic strategy was very positive: it turned the studentsinto active learners, fostering knowledge sharing and promoting the self-management of their learning process. The teachers acted as guides, raisingquestions, and provided continuous feedback to the students that contributed toknowledge assimilation and competence acquisition. The teaching-learning processwas evaluated through a rubric that graded the reports delivered by the students andafinal online test. The impact of this teaching methodology was assessed bycomparing the students'marks with those obtained in the conventional on-site education before the pandemic and feedback fromthe students via surveys. This study provides a unique experience on how a traditional instruction can be adapted to remote teachingin analytical chemistry laboratories, providing new tools that can be used in future pandemics or in other setting

Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides

Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, solomonamide A exhibits anti-inflammatory activity, showing potent reduction (60%) of inflammation at a very low concentration of 100 µg/kg in animal models. However, the scarcity of these compounds from their natural sources has been a drawback for further pharmacological assays. In fact, the anti-inflammatory activity of solomonamide B was not evaluated due to the limited amounts. This difficulty to access large amounts of these compounds makes quite difficult to gain insight into their biological profiles and mechanism of action and justifies the chemical synthesis of this new class of cyclic peptides. As a consequence, the solomonamides have been the subject of several synthetic efforts [2] notably by the Reddy group who has recently reported the first total synthesis of solomonamide B based on a intramolecular Heck reaction, which led to a revision of the initially proposed structure for 2 [3].Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Valoración de la herramienta Dolceta: una herramienta de aprendizaje electrónico para primaria y secundaria

El objeto del presente trabajo es describir la valoración efectuada sobre Dolceta, una herramienta en línea para la alfabetización financiera de alumnos de primaria, secundaria y bachillerato. Tras realizar un grupo de discusión, se han llevado a cabo once entrevistas a profesores de secundaria conocedores de esta herramienta. Los resultados del análisis de estas entrevistas y del grupo de discusión ponen de manifiesto el interés mostrado por este recurso virtual, que es visto, a su vez, como un medio y como una oportunidad, tanto para emplear herramientas audiovisuales en línea en el aula que permiten el learning by doing, como para aportar una cultura financiera a los estudiantes que en la situación actual de crisis financiera se percibe como un activo más que necesario. Asimismo, se demuestra también su utilidad para los adultos. El presente trabajo aporta opiniones profesionales sobre la aplicabilidad práctica de una herramienta de formación en línea. Al tratarse de una plataforma de aprendizaje electrónico de libre acceso, se evitan restricciones de tipo económico o espacial, y todos los ciudadanos pueden acceder a ella libremente. Como conclusión, se constata la posibilidad real de utilizar el módulo de «Alfabetización financiera» de la plataforma Dolceta, especialmente, en un entorno educativo de primaria y secundaria, tanto en España como en el resto de estados de la Unión Europea

Collagen and chitosan blends for 3D bioprinting: A rheological and printability approach

Collagen and chitosan are widely employed as biomaterials, including for 3D-bioprinting. However, the use of collagen and chitosan (col:chi) blends as bioinks is still scarce. In this work, the rheology of different hydrogel precursors (0.5–1.50% w/v chi: 0.18–0.54% w/v col) was analyzed through frequency and strain sweeps, as well as at different shear rates. Col:chi blends showed a shear-thinning behavior, with viscosity values at low shear rates between 0.35 and 2.80 Pa s. Considering the strain rate determined by the applied flow in a 3D-bioprinter, precursor viscosities during the extrusion were in the interval 0.5–0.8 Pa s. Printability (Pr) was measured comparing images of the printed meshes and the corresponding CAD grid design, using photograph analysis. Col:chi 0.36:1.00 was chosen to print mono-layered scaffolds for tissue engineering (TE) because of its suitable viscosity, printability and polymer ratio content. Hydrogels were obtained through NaHCO3 nebulization and 37° incubation, and NHS/EDC were added to obtain scaffolds with improved mechanical behavior. They were stable after 44 h in PBS with collagenase at physiological level and showed no cytotoxic effect in NIH-3T3 fibroblasts.Fil: Heidenreich, Ana Carolina. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Laboratorio de Biomateriales, Biomecanica y Bioinstrumentacion.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pérez Recalde, Mercedes. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Laboratorio de Biomateriales, Biomecanica y Bioinstrumentacion.; ArgentinaFil: González Sánchez Wusener, Ana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Hermida, Elida Beatriz. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Laboratorio de Biomateriales, Biomecanica y Bioinstrumentacion.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Antitumor and antiangiogenic potential of solomonamide synthesis intermediates

Es comunicación (formato panel) a congreso internacionalIn this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ring contained in these natural products. During the synthetic process, a diverse set of analogues was generated and we evaluated their potential antitumor activity in vitro. For this purpose we performed in vitro proliferation assays, determining the IC50 values of the compounds in a panel of tumor cell lines. In addition, we evaluated the possible antiangiogenic effects of these solomonamide analogues by using in vitro endothelial cell differentiation assays. Our results showed that the potential antitumor and antiangiogenic activity of the studied analogues depended on their chemical structure, suggesting that the presence of specific functional groups could be responsible of their biological activity. Further studies are needed to understand the basis of the observed activities in endothelial and tumor cells.Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors

New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized systems, and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core. The described synthetic strategies toward the solomonamides are well suited for the subsequent access to the natural products and represent flexible and diversityoriented routes that allow for the generation of a variety of analogues via oxidative transformations. In addition, preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines.This work was financially supported by the Ministerio de Economía y Competitividad (MINECO) (ref BIO2014-56092-R, CTQ2014-60223-R and CTQ2016-76311-R) and Junta de Andalucía and “Fondo Europeo de Desarrollo Regional-FEDER” (P12 CTS-1507). I.C.-S. thanks Ministerio de Educación, Cultura y Deporte for a predoctoral fellowship (FPU programme)

Thyroid hormone-mediated activation of the ERK/dual specificity phosphatase 1 pathway augments the apoptosis of GH4C1 cells by down-regulating nuclear factor-κB activity

14 pages, 5 figures.Thyroid hormone (T3) plays a crucial role in processes such as cell proliferation and differentiation, whereas its implication on cellular apoptosis has not been well documented. Here we examined the effect of T3 on the apoptosis of GH4C1 pituitary cells and the mechanisms underlying this effect. We show that T3 produced a significant increase in apoptosis in serum-depleted conditions. This effect was accompanied by a decrease in nuclear factor-kappaB (NF-kappaB)-dependent transcription, IkappaBalpha phosphorylation, translocation of p65/NF-kappaB to the nucleus, phosphorylation, and transactivation. Moreover, these effects were correlated with a T3-induced decrease in the expression of antiapoptotic gene products, such as members of the inhibitor of apoptosis protein and Bcl-2 families. On the other hand, ERK but not c-Jun N-terminal kinase or MAPK p38, was activated upon exposure to T3, and inhibition of ERK alone abrogated T3-mediated apoptosis. In addition, T3 increased the expression of the MAPK phosphatase, dual specificity phosphatase 1 (DUSP1), in an ERK-dependent manner. Interestingly, the suppression of DUSP1 expression abrogated T3-induced inhibition of NF-kappaB-dependent transcription and p65/NF-kappaB translocation to the nucleus, as well as T3-mediated apoptosis. Overall, our results indicate that T3 induces apoptosis in rat pituitary tumor cells by down-regulating NF-kappaB activity through a mechanism dependent on the ERK/DUSP1 pathway.This work was supported by grants from the Fundación Mutua Madrileña (2005X0615), from Fondo de Investigaciones Sanitarias (PI070832), from Ministerio de Educación y Ciencia (BFU2004 3465), from Fondo de Investigaciones Sanitarias (RD06/0020/0036), and the European grant CRESCENDO (FP-018652). A.S.-P. and M.L. are recipients of grants from the Spanish MEC (“Ramón y Cajal” Program).Peer reviewe

Innovación, una estrategia de competitividad de las empresas colombianas en los mercados internacionales

Esta investigación fue desarrollada con el objetivo de verificar que la innovación es una herramienta valiosa para agregar valor a productos y servicios que incursionan en nuevos mercados y que compiten globalmente, según lo han demostrado compañías internacionales, que actualmente generan productos y servicios novedosos no solo en presentación, sino también en funcionalidad. Aunque no se puede afirmar, que la innovación es la única estrategia a aplicar, si se puede convertir en la mejor, pues es un factor determinante para la generación de competitividad en los paíse

Aprendizaje basado en problemas en el diseño de prácticas de laboratorio online

[EN] This communication describes the use of problem-based learning methodology for remote teaching of laboratory practices of Chemistry subjects in the Bachelor's Degree in Pharmacy. The virtualization was carried out using explanatory videos of each laboratory practice and questionnaires with queries and fictitious data equivalent to those the students would obtain in the laboratory to carry out the resolution of the laboratory practices. The contents were integrated into the virtual platform Blackboard Collaborate, where tutorials and remote support from the teacher were combined to solve the problems raised.The evaluation of the impact of this teaching methodology was carried out by comparing the marks with those obtained in the full presential model and questionnaires to the students. The degree of satisfaction was very high, 100% percentage of passing students as compared to the 70% obtained in the full presential model. It can be concluded that the introduction of problem-based learning methodologies increased the interest of the students, favoring the assimilation of knowledge, as is also demonstrated in the general improvement of grades, satisfaction surveys and a higher number of students passing the exams.[ES] En esta comunicación se describe el empleo de la metodología de aprendizaje basado en problemas para la docencia remota de prácticas de laboratorio de asignaturas de Química en el Grado en Farmacia. La virtualización se llevó a cabo empleando vídeos explicativos de cada práctica de laboratorio y cuestionarios con datos ficticios equivalentes a los que los alumnos obtendrían en el laboratorio para llevar a cabo la resolución de los casos prácticos. Los contenidos se integraron en la plataforma virtual Blackboard Collaborate, donde se llevaron a cabo tutorías y apoyo remoto del docente para la resolución de los problemas planteados. La evaluación del impacto de esta metodología en la docencia se llevó a cabo mediante comparación de las calificaciones con las obtenidas en el modelo presencial y cuestionarios a los alumnos. El grado de satisfacción fue muy elevado, con un porcentaje de aprobados del 100 % frente al 70 % obtenido en el modelo presencial. Se puede concluir que la introducción de las metodologías de aprendizaje basadas en problemas aumentó el interés del alumno, favoreciendo la asimilación de conocimientos como se demuestra además en la mejora general de las calificaciones, encuestas de satisfacción y mayor número de aprobados.Jurado Sánchez, B.; Díez Pascual, A. (2021). Aprendizaje basado en problemas en el diseño de prácticas de laboratorio online. En IN-RED 2021: VII Congreso de Innovación Edicativa y Docencia en Red. Editorial Universitat Politècnica de València. 339-346. https://doi.org/10.4995/INRED2021.2021.13720OCS33934