Autoestima y trastorno de déficit de atención en estudiantes de cinco y seis años EBR, San Juan de Lurigancho

Esta investigación tuvo como objetivo en que medida se relaciona la autoestima y trastornos de déficit de atención en estudiantes de cinco y seis años EBR, San Juan de Lurigancho. La presente investigación es de tipo básica y diseño no experimental de alcance correlacional, su muestra estuvo conformada por 54 estudiantes de cinco y seis años, se utilizó muestreo no probabilístico de tipo intencionado. Se utilizaron dos instrumentos de recolección de datos como el Cuestionario para la evaluación de la autoestima en la infancia (EDINA) y la Escala para la evaluación del Trastorno por Déficit de Atención con Hiperactividad (EDAH). Los resultados más relevantes que se pueden nombrar es que, 66.7% muestran sin riesgo algún trastorno por déficit de atención y el 11.1% en alto riesgo; respecto a la autoestima el 50% posee un rango medio y el otro 50% en porcentajes similares entre el rango bajo y alto. Respecto al objetivo de la presente investigación en la prueba de hipótesis se concluyó que existe relación directa y significativa de nivel moderado entre las variables Autoestima y Trastorno de Déficit de Atención, al obtener Rho de Spearman es de (0.478, p= .000 < .05). Aceptándose la hipótesis alterna

Antitumor and antiangiogenic potential of solomonamide synthesis intermediates

Es comunicación (formato panel) a congreso internacionalIn this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ring contained in these natural products. During the synthetic process, a diverse set of analogues was generated and we evaluated their potential antitumor activity in vitro. For this purpose we performed in vitro proliferation assays, determining the IC50 values of the compounds in a panel of tumor cell lines. In addition, we evaluated the possible antiangiogenic effects of these solomonamide analogues by using in vitro endothelial cell differentiation assays. Our results showed that the potential antitumor and antiangiogenic activity of the studied analogues depended on their chemical structure, suggesting that the presence of specific functional groups could be responsible of their biological activity. Further studies are needed to understand the basis of the observed activities in endothelial and tumor cells.Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Ectomicorrizas presentes en la plantación trufera “Los Quejigares” (Soria)

En este trabajo se describen las ectomicorrizas presentes en 16 plantas de Quercus ilex L. subsp. ballota (Desf.) Samp. de 22 años, de la finca de 600 ha que gestiona AROTZ-CATESA en el término municipal de Villaciervos (Soria). Además se presentan los porcentajes de micorrización de las ectomicorrizas más interesantes. Este estudio se incluye dentro del proyecto LIFE 99 ENV/E/000356 “Revalorización de bosques productores de trufa: un ejemplo de gestión sostenible”. SUMMARY: This study describes the ectomycorrhiza occurring in 16 twenty-two years old seedlings of Quercus ilex L. subsp. ballota (Desf.) Samp., in the plot of 600 ha that AROTZ-CATESA manages in of Villaciervos (Soria). Mycorrhization percentages of the most interesting ectomycorrhiza are also reported. This study is included in the project LIFE 99 ENV/E/000356 "Truffled Mediterranean forest improvement: an example of sustanaible management”

Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes

Proyecto de investigación que describe la presencia de diversos factores de riesgo para desarrollar diabetes mellitus tipo 2 en adolescentes.Liver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. Mexican-American adolescents are disproportionately affected by T2DM, while in Mexico its prevalence is emerging. We assessed liver biomarkers and lipid profiles among Mexican and Mexican-American adolescents 10–14 years old with high/low risk of T2DM through a cross-sectional, descriptive study (Texas n = 144; Mexico n = 149). We included family medical histories, anthropometry, and blood pressure. Obesity was present in one-third of subjects in both sites. ALT (UL) was higher (p < 0 001) in high-risk adolescents (23.5 ± 19.5 versus 17.2 ± 13.4 for males, 19.7 ± 11.6 versus 15.1 ± 5.5 for females), in Toluca and in Texas (26.0 ± 14.7 versus 20.0 ± 13.2 for males, 18.2 ± 13.4 versus 14.6 ± 10.1 for females), as well as GGT (UL) (p < 0 001) (18.7 ± 11.1 versus 12.4 ± 2.3 for males, 13.6 ± 5.8 versus 11.5 ± 3.9 for Mexican females; 21.0 ± 6.8 versus 15.4 ± 5.5 for males, 14.3 ± 5.0 versus 13.8 ± 5.3 for females in Texas). We found no differences by sex or BMI. Total cholesterol and HDL were higher among Mexican-Americans (p < 0 001). In conclusion, multiple risk factors were present in the sample. We found differences by gender and between high and low risk for T2DM adolescents in all liver enzymes in both sites.Fondo Semilla UAEM-UNTHS

Estimating human leishmaniasis burden in Spain using the capture-recapture method, 2016-2017

Leishmaniasis is endemic and a mandatory reporting disease in Spain since 1982. However, between 1996 and 2014, surveillance on public health was decentralized and only some autonomous regions monitored the disease. The aim of this study is to estimate the incidence of leishmaniasis and to evaluate the extent of underreporting in Spain. A capture-recapture (CRC) study was conducted to calculate the incidence of human leishmaniasis using reports from the National Surveillance Network (RENAVE) and the Hospital Discharge Records of the National Health System (CMBD) for 2016 and 2017. During the study period, 802 cases were reported to RENAVE and there were 1,149 incident hospitalizations related to leishmaniasis. The estimated incidence rates through the CRC study were 0.79 per 100,000 inhabitants for visceral leishmaniasis (VL), 0.88 (cutaneous leishmaniasis (CL)) and 0.12 (mucocutaneous leishmaniasis (MCL)) in 2016 and 0.86 (VL), 1.04 (CL) and 0.12 (MCL) in 2017. An underreporting of 14.7-20.2% for VL and 50.4-55.1% for CL was found. The CRC method has helped us to assess the sensitivity and representativeness of leishmaniasis surveillance in Spain, being a useful tool to assess whether the generalization of leishmaniasis surveillance throughout the Spanish territory achieves a reduction in underreporting.S

SiSOB data extraction and codification: A tool to analyze scientific careers

AbstractThis paper describes the methodology and software tool used to build a database on the careers and productivity of academics, using public information available on the Internet, and provides a first analysis of the data collected for a sample of 360 US scientists funded by the National Institute of Health (NIH) and 291 UK scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC). The tool’s structured outputs can be used for either econometric research or data representation for policy analysis. The methodology and software tool is validated for a sample of US and UK biomedical scientists, but can be applied to any countries where scientists’ CVs are available in English. We provide an overview of the motivations for constructing the database, and the data crawling and data mining techniques used to transform webpage-based information and CV information into a relational database. We describe the database and the effectiveness of our algorithms and provide suggestions for further improvements. The software developed is released under free software GNU General Public License; the aim is for it to be available to the community of social scientists and economists interested in analyzing scientific production and scientific careers, who it is hoped will develop this tool further

Alpine forbs rely on different photoprotective strategies during spring snowmelt

Snowmelt in alpine ecosystems brings ample water, and together with above-freezing temperatures, initiates plant growth. In this scenario, rapid activation of photosynthesis is essential for a successful life-history strategy. But, strong solar radiation in late spring enhances the risk of photodamage, particularly before photosynthesis is fully functional. We compared the photoprotective strategy of five alpine forbs: one geophyte not particularly specialised in subnival life (Crocus albiflorus) and four wintergreens differing in their degree of adaptation to subnival life, from least to most specialised: Gentiana acaulis, Geum montanum, Homogyne alpina and Soldanella alpina. We used distance to the edge of snow patches as a proxy to study time-dependent changes after melting. We postulated that the photoprotective response of snowbed specialists would be stronger than of more-generalist alpine meadow species. F-v/F-m was relatively low across wintergreens and even lower in the geophyte C. albiflorus. This species also had the largest xanthophyll-cycle pool and lowest tocopherol and flavonoid glycoside contents. After snow melting, all the species progressively activated ETR, but particularly the intermediate snowbed species G. acaulis and G. montanum. The photoprotective responses after snowmelt were idiosyncratic: G. montanum rapidly accumulated xanthophyll-cycle pigments, tocopherol and flavonoid glycosides; while S. alpina showed the largest increase in plastochromanol-8 and chlorophyll contents and the greatest changes in optical properties. Climate warming scenarios might shift the snowmelt date and consequently alter the effectiveness of photoprotection mechanisms, potentially changing the fitness outcome of the different strategies adopted by alpine forbs.Peer reviewe

A Methodology to Create 3D Body Models in Motion

[EN] Size, shape and posture are fundamental features of digital human models (DHM) to obtain accurate virtual simulations of the ergonomics of products and environments. Research on 3D body scanning, processing and modelling have enabled the generation of avatars representing specific populations and morphotypes in standing and seated postures being the basis to define size and shape of DHM. Posture is implemented with biomechanical models of the human movement. Most of the research is focused on posture control and movement tracking to analyze the variability in different contexts (e.g. driving, performing a working task). Motion capture technology used for this purpose, requires a limited number of sensors or reflective markers attached to the body according to the definition of body segments. 3D body scanning and motion capture are both technologies currently used to analyze human body shape and biomechanics to apply it to enhance digital human models. These technologies may converge on the so-called temporal 3D scanners or 4D scanners, a new technology recently developed to scan the body in motion. With this technology, it is possible to obtain sequences of dense 3D point clouds representing the movement of the body. In this paper, a novel methodology to create realistic 3D body models in motion is proposed. This method is supported by a new 4D scanning system (Move 4D) and a data driven-model. Move4D is a modular photogrammetry-based 4D scanning system. It consists of a set of 12 synchronized modules to scan full bodies with texture in motion. It can capture up to 180 fps with a resolution of 2 mm. The algorithms have been conceived and optimized to automatically process the series of raw point clouds captured. They rely on a data-driven body model including shape, pose and soft-tissue deformation trained with a large database and a deep learning model. The process is fully automatic and does not require any interactive landmarking or revision. The 3D outcome of this methodology is one noise-and artefact-free watertight mesh per frame and a model of shape, pose and soft-tissue that can be rigged with a 23-joint skeleton. This type of outcome permits their use for many applications such as simulations, augmented and virtual reality (AR/VR) or biomechanical analysis purposes.The research presented in this paper have been developed within the projects IMDEEA/2020/85 and MDEEA/2020/87. Funding requested to Instituto Valenciano de Competitividad Empresarial (IVACE), call for proposals 2020 for Technology Centers of the Comunitat Valenciana, co-funded by ERDF Funds, EU Operational Program of the Comunitat Valenciana 2014-2020.Parrilla Bernabé, E.; Ruescas, A.; Solves, J.; Ballester Fernandez, A.; Nacher Fernandez, B.; Alemany Mut, MS.; Garrido Jaen, JD. (2020). A Methodology to Create 3D Body Models in Motion. Springer. 309-314. https://doi.org/10.1007/978-3-030-51064-0_39S309314Scataglini, S., Paul, G.: DHM and Posturography. Academic Press, London (2019)Zakaria, N., Gupta, D.: Anthropometry, Apparel Sizing and Design. Woodhead Publishing, Cambridge (2019)Liberadzki, P., Adamczyk, M., Witkowski, M., Sitnik, R.: Structured-light-based system for shape measurement of the human body in motion. Sensors 18, 2827 (2018). https://doi.org/10.3390/s18092827Parrilla, E., Ballester, A., Parra, P., Ruescas, A., Uriel, J., Garrido, D., Alemany, S.: MOVE 4D: accurate high-speed 3D body models in motion. In: Proceedings of 3DBODY.TECH 2019, Lugano, Switzerland, 22–23 October 2019, pp. 30–32 (2019). https://doi.org/10.15221/19.03

MAP3K kinases and kidney injury

Mitogen-activated protein kinases (MAP kinases) are functionally connected kinases that regulate key cellular process involved in kidney disease such as all survival, death, differentiation and proliferation. The typical MAP kinase module is composed by a cascade of three kinases: a MAP kinase kinase kinase (MAP3K) that phosphorylates and activates a MAP kinase kinase (MAP2K) which phosphorylates a MAP kinase (MAPK). While the role of MAPKs such as ERK, p38 and JNK has been well characterized in experimental kidney injury, much less is known about the apical kinases in the cascade, the MAP3Ks. There are 24 characterized MAP3K (MAP3K1 to MAP3K21 plus RAF1, BRAF and ARAF). We now review current knowledge on the involvement of MAP3K in non-malignant kidney disease and the therapeutic tools available. There is in vivo interventional evidence clearly supporting a role for MAP3K5 (ASK1) and MAP3K14 (NIK) in the pathogenesis of experimental kidney disease. Indeed, the ASK1 inhibitor Selonsertib has undergone clinical trials for diabetic kidney disease. Additionally, although MAP3K7 (MEKK7, TAK1) is required for kidney development, acutely targeting MAP3K7 protected from acute and chronic kidney injury; and targeting MAP3K8 (TPL2/Cot) protected from acute kidney injury. By contrast MAP3K15 (ASK3) may protect from hypertension and BRAF inhibitors in clinical use may induced acute kidney injury and nephrotic syndrome. Given their role as upstream regulators of intracellular signaling, MAP3K are potential therapeutic targets in kidney injury, as demonstrated for some of them. However, the role of most MAP3K in kidney disease remains unexploredLas proteínas quinasas activadas por mitógenos (MAP quinasas) son quinasas conectadas funcionalmente que regulan procesos celulares clave involucrados en la enfermedad renal como la supervivencia, la muerte, la diferenciación y la proliferación. El típico módulo MAP quinasa está compuesto por una cascada de 3 quinasas: una MAP quinasa quinasa quinasa (MAP3K) que fosforila y activa una MAP quinasa quinasa (MAP2K) que, a su vez, fosforila una MAP quinasa (MAPK). Si bien el papel de las MAPK como ERK, p38 y JNK se ha caracterizado bien en las lesiones renales experimentales, se sabe mucho menos acerca de las quinasas apicales en la cascada, las MAP3K. Hay 24 MAP3K (MAP3K1 a MAP3K21, más RAF1, BRAF y ARAF). En este trabajo revisamos el conocimiento actual sobre la participación de MAP3K en la enfermedad renal no maligna y las herramientas terapéuticas disponibles. Existe evidencia intervencionista experimental in vivo que respalda claramente el papel de MAP3K5 (ASK1) y MAP3K14 (NIK) en la patogenia de la enfermedad renal experimental. De hecho, el inhibidor de ASK1, selonsertib, ha sido estudiado en ensayos clínicos en la enfermedad renal diabética. Además, aunque la MAP3K7 (MEKK7, TAK1) es necesaria para el desarrollo renal, la inhibición de MAP3K7 en el adulto protegió de la lesión renal aguda y crónica experimental; e inhibir MAP3K8 (TPL2/Cot) protegió de la lesión renal aguda. Por el contrario, MAP3K15 (ASK3) puede proteger de la hipertensión y los inhibidores de BRAF, en uso clínico, pueden inducir lesión renal aguda y síndrome nefrótico. Dado su papel como reguladores de los primeros pasos de la señalización intracelular, las MAP3K son posibles dianas terapéuticas en la lesión renal, como se ha demostrado para algunas de ellos. Sin embargo, el papel de la mayoría de las MAP3K en la enfermedad renal no ha sido exploradoGrant support: Instituto de Salud Carlos III (ISCIII) and FEDER– Fonds Européen de Développement Économique et Régional (FEDER) funds EUTOX, CP14/00133, PI15/00298, PI16/01900,PI16/02057, PI18/01366, Sociedad Española de Nefrologia, Fun-dación Renal Iñigo Alvarez de Toledo (FRIAT), ISCIII Red de Investigacion Renal (REDinREN) RD016/009, Salary support: ISCIII Miguel Servet to MDSN, Universidad Autónoma deMadrid to LC