10 research outputs found
Variations in concerns reported on the Patient Concerns Inventory (PCI) in head and neck cancer patients from different health settings across the world
Background: The aim was to collate and contrast patient concerns from a range of different head and neck cancer follow-up clinics around the world. Also, we sought to explore the relationship, if any, between responses to the patient concerns inventory (PCI) and overall quality of life (QOL). Methods: Nineteen units participated with intention of including 100 patients per site as close to a consecutive series as possible in order to minimize selection bias. Results: There were 2136 patients with a median total number of PCI items selected of 5 (2-10). “Fear of the cancer returning” (39%) and “dry mouth” (37%) were most common. Twenty-five percent (524) reported less than good QOL. Conclusion: There was considerable variation between units in the number of items selected and in overall QOL, even after allowing for case-mix variables. There was a strong progressive association between the number of PCI items and QOL
Relación entre las propiedades mecánicas de los suelos y sus limites de atterberg
Tesis (Ingeniero Civil).--Universidad de Cartagena. Facultad de Ciencias E Ingeniería. Programa de Ingeniería Civil, 1998.El presente estudio tiene por objeto validar y/o adaptar la ecuación que relaciona el coeficiente de consolidación (Cv) y el limite liquido (LL) y completar el estudio relacionado en la Universidad de Cartagena sobre la correlación existente entre la cohesión, la máxima presión de consolidación y el indice de plasticidad para arcillas presentes en el área de Cartagena
Un tributo de reconocimiento, de admiración y de cariño a Pilar Franco-Rosselli. Sogamoso, septiembre 18-1950-Villavicencio, febrero 3-2000
Con el sentimiento de respeto por la muerte y la fundación de ritos a su alrededor, nuestra especie comenzó a diferenciarse de otros homínidos. Los recuerdos y la presencia permanente en nuestros corazones y mentes de quien ha dejado huella en nuestras vidas, es lo que hoy nos congrega. Han transcurrido 15 meses de tu absurda e incomprensible pérdida física, tiempo durante el cual te hemos aflorado cada vez más.</p
Un tributo de reconocimiento, de admiración y de cariño a pilar franco-rosselli. sogamoso, septiembre 18-1950-villavicencio, febrero 3-2000
Con el sentimiento de respeto por la muerte y la fundación de ritos a su alrededor, nuestra especie comenzó a diferenciarse de otros homínidos. Los recuerdos y la presencia permanente en nuestros corazones y mentes de quien ha dejado huella en nuestras vidas, es lo que hoy nos congrega. Han transcurrido 15 meses de tu absurda e incomprensible pérdida física, tiempo durante el cual te hemos aflorado cada vez más
Impact of learning English on cognitive processes in older adults. A preliminary study in Cuenca
Se realiza un estudio exploratorio descriptivo antes y después de un curso de seis meses de aprendizaje de inglés para adultos mayores, con el objetivo de evaluar el efecto del aprendizaje de otro idioma sobre la esfera cognitiva en este grupo de edad en la ciudad de Cuenca.
Material y Método: Se incluyeron 80 adultos de edad promedio 70.48 ± 4.9 años (31 hombres, 19 mujeres); quienes fueron sometidos a evaluación neurológica y neuropsicológica al inicio, seis y doce meses después del curso, incluyendo pruebas para funcionalidad ejecutiva (memoria de trabajo y procesos atencionales).
Resultados: Se encuentran datos de asociación estadística entre alteración de la percepción olfatoria con relación a la edad. Las pruebas neuropsicológicas muestran datos interesantes en relación con mantenimiento cognitivo e incluso mejoría en el rendimiento de las pruebas de series directas e inversas (WAIS III) y en el test de símbolos (SMDT) seis y doce meses luego de haber iniciado un curso de aprendizaje de inglés.
Conclusión: El estudio sugiere que el aprendizaje de inglés, incluso sin objetivo funcional del manejo de una nueva lengua, puede tener un efecto protector en las funciones ejecutivas, cuyas alteraciones constituyen los primeros hallazgos en pacientes con deterioro cognitivo. Se propone un seguimiento a largo plazo en la búsqueda de asociación estadística importante.A descriptive exploratory study, before and after a six-month english learning course for seniors is conducted to evaluate the cognitive effect of learning another language in this age group in the city of Cuenca.
Materials and Methods: 80 adults of average age 70.48 ± 4.9 years (31 men, 19 women) were included; who underwent neurological and neuropsychological evaluation at baseline, six and twelve months after the course; including tests for executive function (working memory and attention processes).
Results: Data show significant statistical association between impaired olfactory perception related to age. Neuropsychological tests show interesting data relating cognitive maintenance and even improvement in the Performance Testing Direct and inverse series (Wais III) and Symbol Digital Modality Test (SMDT) six and twelve months after initiating a learning course of English.
Conclusion: The study suggests that learning English, even without functional objective of a new language, may have protective effect on the executive functions and neuronal brain networks are claimed the first findings in patients with cognitive impairment. We suggest perform this follow up long term in time to find strongest evidence, related to international bibliography
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Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.
The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1α under genotoxic stress to modulate repair programs and sustain cell survival. DNA damage engages IRE1α signaling in the absence of an endoplasmic reticulum (ER) stress signature, leading to the exclusive activation of regulated IRE1α-dependent decay (RIDD) without activating its canonical output mediated by the transcription factor XBP1. IRE1α endoribonuclease activity controls the stability of mRNAs involved in the DNA damage response, impacting DNA repair, cell cycle arrest and apoptosis. The activation of the c-Abl kinase by DNA damage triggers the oligomerization of IRE1α to catalyze RIDD. The protective role of IRE1α under genotoxic stress is conserved in fly and mouse. Altogether, our results uncover an important intersection between the molecular pathways that sustain genome stability and proteostasis
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Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study
BackgroundPaediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition, which was designed and validated for adults. We aimed to determine the incidence and outcomes of children who meet the PALICC definition of PARDS.MethodsIn this international, prospective, cross-sectional, observational study, 145 paediatric intensive care units (PICUs) from 27 countries were recruited, and over a continuous 5 day period across 10 weeks all patients were screened for enrolment. Patients were included if they had a new diagnosis of PARDS that met PALICC criteria during the study week. Exclusion criteria included meeting PARDS criteria more than 24 h before screening, cyanotic heart disease, active perinatal lung disease, and preparation or recovery from a cardiac intervention. Data were collected on the PICU characteristics, patient demographics, and elements of PARDS (ie, PARDS risk factors, hypoxaemia severity metrics, type of ventilation), comorbidities, chest imaging, arterial blood gas measurements, and pulse oximetry. The primary outcome was PICU mortality. Secondary outcomes included 90 day mortality, duration of invasive mechanical and non-invasive ventilation, and cause of death.FindingsBetween May 9, 2016, and June 16, 2017, during the 10 study weeks, 23 280 patients were admitted to participating PICUs, of whom 744 (3·2%) were identified as having PARDS. 95% (708 of 744) of patients had complete data for analysis, with 17% (121 of 708; 95% CI 14-20) mortality, whereas only 32% (230 of 708) of patients met Berlin criteria with 27% (61 of 230) mortality. Based on hypoxaemia severity at PARDS diagnosis, mortality was similar among those who were non-invasively ventilated and with mild or moderate PARDS (10-15%), but higher for those with severe PARDS (33% [54 of 165; 95% CI 26-41]). 50% (80 of 160) of non-invasively ventilated patients with PARDS were subsequently intubated, with 25% (20 of 80; 95% CI 16-36) mortality. By use of PALICC PARDS definition, severity of PARDS at 6 h after initial diagnosis (area under the curve [AUC] 0·69, 95% CI 0·62-0·76) discriminates PICU mortality better than severity at PARDS diagnosis (AUC 0·64, 0·58-0·71), and outperforms Berlin severity groups at 6 h (0·64, 0·58-0·70; p=0·01).InterpretationThe PALICC definition identified more children as having PARDS than the Berlin definition, and PALICC PARDS severity groupings improved the stratification of mortality risk, particularly when applied 6 h after PARDS diagnosis. The PALICC PARDS framework should be considered for use in future epidemiological and therapeutic research among children with PARDS.FundingUniversity of Southern California Clinical Translational Science Institute, Sainte Justine Children's Hospital, University of Montreal, Canada, Réseau en Santé Respiratoire du Fonds de Recherche Quebec-Santé, and Children's Hospital Los Angeles, Department of Anesthesiology and Critical Care Medicine
Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021
1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano