Chapter El plano de Rivera Manescau y las cuatro colegiatas de Valladolid

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

Reforma de la legislación civil sobre el régimen jurídico de los animales y Derecho Internacional Privado.

The proposal for the reform of civil legislation on the legal status of animals provides for their consideration as living beings endowed with sensitivity. This will be reflected not only in the internal sphere but also in the international sphere in situations in which there is a conflict of laws. La propuesta de reforma de la legislación civil sobre el régimen jurídico de los animales prevé su consideración como seres vivos dotados de sensibilidad. Ello se reflejará no solo en el ámbito interno sino en el ámbito internacional en aquellas situaciones en las que se produzca un conflicto de leyes

Carprofen Permeation Test through Porcine Ex VivoMucous Membranes and Ophthalmic Tissues forTolerability Assessments: Validation andHistological Study

Carprofen (CP), a non-steroidal anti-inflammatory drug (NSAID), is profusely used in veterinary medicine for its analgesic and anti-inflammatory activity. Some undesirable effects are associated with its systemic administration. Alternative local routes are especially useful to facilitate its administration in animals. The main aim of this paper is to validate the suitability of ex vivo permeation experiments of CP with porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) intended to be representative of naïve in vivo conditions. Chromatographic analysis of CP in membrane-permeated samples and drug-retained have been validated following standard bioanalytical guidelines. Then, recovery levels of drugs in tissue samples were assessed with aqueous phosphate buffered saline (PBS) buffer to preserve the histological integrity. Finally, as a proof of concept, a series of CP permeation tests in vertical Franz diffusion cells has been performed to evaluate permeation flux and permeability constants in all tissues, followed by a histological study for critical evaluation. Furthermore, synthetic tissue retention-like samples were prepared to verify the value of this experimental study. Results show linear relationships with good determination coefficient (R2 > 0.998 and R2 > 0.999) in the range of 0.78 to 6.25 mg/mL and 3.125 mg/mL to 100 mg/mL, respectively. Low limits of quantification around 0.40 µg/mL were allowed to follow permeation levels until a minimum of 0.40% of the locally-applied dose. This method showed a good accuracy and precision with values lower than 2%. After the recovery technique, reproducible values below 30% were achieved in all tissues, suggesting it is a non-damaging method with low efficiency that requires the use of further solvents to enhance the extraction percentages. After permeation and histology tests, no relevant peak interferences were detected, and no cell or tissue damage was found in any tissue. In conclusion, results demonstrate the suitability of this test to quantify the distribution of CP with good histological tolerability

Multifunctional catalyst for maximizing NOx oxidation/storage/reduction: The role of the different active sites

A multifunctional catalyst/storage material has been prepared to maximize NOx removal. This material is based on mixed oxides derived from modified layered double hydrotalcites (LDH). A cobalt catalytic function oxidizes the NO to NO2. The NO2 is stored as nitrate in the basic sites of the material. The basic properties of the Co/Mg/Al mixed oxide derived from LDH were enhanced by doping with sodium, improving the storage capacity of the catalyst. Finally, the introduction of vanadium sites, enables the reduction¿decomposition of the nitrates. This multisite catalyst/storage material results in a well equilibrate formulation that maximizes catalyst conversion and regenerabilityFinancial support from the Spanish Ministry of Economy and Competitiveness through the Severo Ochoa program (SEV-2012-0267) as well as operating grants Consolider Ingenio Multicat (CSD-2009-00050) and MAT-2012-3856-C02-01 is gratefully acknowledged. Authors want to thank Maria Orti for her collaboration in the experiments.Palomares Gimeno, AE.; Uzcategui Paredes, A.; Franch Martí, C.; Corma Canós, A. (2013). Multifunctional catalyst for maximizing NOx oxidation/storage/reduction: The role of the different active sites. Applied Catalysis B: Environmental. 142-143:795-800. https://doi.org/10.1016/j.apcatb.2013.06.015S795800142-14

Análisis de redes sociales: un estudio de caso en Educación Física:

This study analyzes social networks in a physical education class in a public high school in Valencia during the COVID-19 pandemic. The main objective of this paper is to check the social status of the classroom and identify potentially problematic situations in the classroom, based on the analysis of dimensions such as pleasant interaction, emotional support, social support and co-study. To do this, a quantitative methodology was used through a questionnaire where students had to respond based on their perception of the rest of their classmates from various items corresponding to sociological dimensions. From this point, a social network analysis (SNA) was carried out and numerical and graphic values were extracted that exposed the social situation of the students. Integration problems were found, derived from the great differences in centrality between the most isolated students and the average of the class, as well as a large number of connections in the dimension “pleasant interaction”, and few connections in “emotional support”. Substantial leadership differences were also found depending on the dimension, so that the student leaders in some areas were not leaders in others. Finally, differences were found between face-to-face and digital connections, the latter being greater. This study encourages physical education teachers to use SNA to objectively know the social situation of the class, taking into account the great social component that surrounds a session of this subject.Este estudio analiza de forma gráfica las redes sociales en una clase de educación física de un centro público de secundaria de Valencia durante la pandemia del COVID-19, a partir de las conexiones que se producen entre los alumnos. El objetivo es comprobar el estado social del aula e identificar situaciones potencialmente problemáticas en el aula, a partir del análisis de dimensiones como la interacción agradable, el apoyo emocional, el apoyo social y el coestudio. Se utilizó una metodología cuantitativa mediante un cuestionario donde los estudiantes debían responder en función de su percepción del resto de compañeros a partir de varios ítems correspondientes a dimensiones sociológicas. Se realizó un análisis de redes sociales (SNA) y se extrajeron valores numéricos y gráficos que exponían la situación social del alumnado. Se hallaron problemas de integración, derivadas de las grandes diferencias de centralidad entre los alumnos más aislados y la media de la clase, así como una gran cantidad de conexiones en la dimensión “interacción agradable” y pocas conexiones en “apoyo emocional”. Se hallaron también diferencias sustanciales de liderazgo dependiendo de la dimensión de forma que los alumnos líderes en unos ámbitos, en otros no lo eran. Por último, se encontraron diferencias entre las conexiones cara a cara y digitales, siendo mayores estas últimas. Este estudio anima a los docentes de educación física a utilizar en SNA para conocer de forma objetiva la situación social de la clase, teniendo en cuenta el gran componente social que envuelve a una sesión de esta asignatura

The ballast pick-up problem. A theoretical approach and two experimental campaigns

The aim of this contribution is to present a theoretical approach and two experimental campaigns (on wind tunnel and on the track) concerning the research work about the ballast train-induced-wind erosion (BTIWE) phenomenon. When a high speed train overpasses the critical speed, it produces a wind speed close to the track large enough to start the motion of the ballast elements, eventually leading to the rolling of the stones (Kwon and Park, 2006) and, if these stones get enough energy, they can jump and then initiate a saltation-like chain reaction, as found in the saltation processes of soil eolian erosion (Bagnold, 1941). The expelled stones can reach a height which is larger than the lowest parts of the train, striking them (and the track surroundings) producing considerable damage that should be avoided. There is not much published work about this phenomenon, in spite of the great interest that exists due to its relevant applications in increasing the maximum operative train speed. Particularly, the initiation of flight of ballast due to the pass of a high speed train has been studied by Kwon and Park (2006) by performing field and wind tunnel experiments

Estudio histomorfológico de la capacidad de regeneración ósea del plasma rico en plaquetas, médula ósea y fosfato tricálcico. Estudio experimental en cerdos 'regeneración ósea en cirugía experimental en cerdos'

ABSTRACT Objetive: On numerous occasions after the oral surgery bone defects occur which may be difficult to repair. Objective: We assessed the histomorphologic bone regeneration capacity of platelet-rich plasma at different concentrations, and extract bone marrow platelet-rich, compared with β-tricalcium phosphate. Material and Methods: We performed an experimental study in 8 pigs, who are practicing trepanaciones jaw to move the materials to study. The samples obtained were observed through electronic microscope and systematic photographs were made to analyse them through a system of gray histogram. Results: Ossification Phenomena were seen in 96% of the defaults practiced with independance of the material used to fill them. It is appreciated that the platelet-rich plasma (PRP) and bone marrow (M) show an equivalent degree of osteogenesis, 12.3 and 13.4 respectively, more power than the control. The platelet-poor plasma (PPP) provides a capability similar to controls (C) with an average of 14.03 and 14.12 abduction respectively. Tricalcium phosphate (FT) is effective as an inducer of ossification, 3.03 times more potent than the control. Conclusions: The ossification occurs in most of the charged defects. The PRP and the M are the most osteogenic capacity and the PPP is no more effective than control

Etest® versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: results from PREMIUM, a European multicentre study

Objectives: To compare the concordance of ceftaroline MIC values 24 by reference broth microdilution (BMD) and Etest (BioMérieux, France) for MSSA and MRSA isolates, respectively, in isolates from PREMIUM (D372SL00001), a European multi-centre study.  Methods: Ceftaroline MICs were determined by reference BMD and by Etest for 1,242 MSSA and MRSA from adult patients with community-acquired pneumonia or complicated skin and soft tissue infections collected between February and May 2012; tests were performed across six European laboratories. Selected isolates with ceftaroline resistance in broth (MIC >1 mg/L) were retested in three central laboratories to confirm their behaviour.  Results: Overall concordance between BMD and Etest was good, with >97% essential agreement and >95% categorical agreement. Nevertheless, 12 of the 26 MRSA isolates found resistant by BMD scored as susceptible by Etest, with MICs ≤1 mg/L, thus counting as very major errors, whereas only five of 380 MRSA found ceftaroline susceptible in BMD were mis-categorised as resistant by Etest. Twenty-one of the 26 isolates with MICs of 2 mg/L by BMD were then re-tested twice by each of three central laboratories: BMD MICs of 2 mg/L were consistently found for 19 of the 21 isolates. Among 147 Etest results for these 21 isolates (original plus six repeats per isolate) 112 were >1 mg/L.  Conclusions: BMD and Etest have good overall agreement for ceftaroline against Staphylococcus aureus; nevertheless, reliable Etest-based discrimination of the minority of ceftaroline-resistant (MIC 2 mg/L) MRSA is extremely challenging, requiring careful reading of strips, ideally with duplicate testing

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections

IMPORTANCE The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these infections is critical, for which some neglected drugs may be an option. OBJECTIVE To determine whether fosfomycin is noninferior to ceftriaxone or meropenem in the targeted treatment of bacteremic urinary tract infections (bUTIs) due to MDR E coli. DESIGN, SETTING, AND PARTICIPANTS This multicenter, randomized, pragmatic, open clinical trial was conducted at 22 Spanish hospitals from June 2014 to December 2018. Eligible participants were adult patients with bacteremic urinary tract infections due to MDR E coli; 161 of 1578 screened patients were randomized and followed up for 60 days. Data were analyzed in May 2021. INTERVENTIONS Patients were randomized 1 to 1 to receive intravenous fosfomycin disodium at 4 g every 6 hours (70 participants) or a comparator (ceftriaxone or meropenem if resistant; 73 participants) with the option to switch to oral fosfomycin trometamol for the fosfomycin group or an active oral drug or pa renteral ertapenem for the comparator group after 4 days. MAIN OUTCOMES AND MEASURES The primary outcome was clinical and microbiological cure (CMC) 5 to 7 days after finalization of treatment; a noninferiority margin of 7% was considered. RESULTS Among 143 patients in the modified intention-to-treat population (median [IQR] age, 72 [62-81] years; 73 [51.0%] women), 48 of 70 patients (68.6%) treated with fosfomycin and 57 of 73 patients (78.1%) treated with comparators reached CMC (risk difference, -9.4 percentage points; 1-sided 95% CI, -21.5 to infinity percentage points; P = .10). While clinical or microbiological failure occurred among 10 patients (14.3%) treated with fosfomycin and 14 patients (19.7%) treated with comparators (risk difference, -5.4 percentage points; 1-sided 95% CI. -infinity to 4.9; percentage points; P = .19), an increased rate of adverse event-related discontinuations occurred with fosfomycin vs comparators (6 discontinuations [8.5%] vs 0 discontinuations; P = .006). In an exploratory analysis among a subset of 38 patients who underwent rectal colonization studies, patients treated with fosfomycin acquired a new ceftriaxone-resistant or meropenem-resistant gram-negative bacteria at a decreased rate compared with patients treated with comparators (0 of 21 patients vs 4 of 17 patients [23.5%]; 1-sided P = .01). CONCLUSIONS AND RELEVANCE This study found that fosfomycin did not demonstrate noninferiority to comparators as targeted treatment of bUTI from MDR E coli; this was due to an increased rate of adverse event-related discontinuations. This finding suggests that fosfomycin may be considered for selected patients with these infections

Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies

Background: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains un- known. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n = 168,287) and non-fatal (13 cohorts, n = 27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 10 0,0 0 0 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those esti- mated from cohorts in high-income countries