La percepción de padres y madres en el ejercicio del rol parental

In the so called Information and Knowledge Society, social and cultural capital are expected values. Despite the technological and scientific progres and the unstoppable development of Information and Communication Technologies, the doubts families feel about how to performe their parental role increases. Although the range of resources parents and children have at their disposal to get information to resolve those doubts is very wide (printed material, telephone, chats, social networks…), it seems that there is still lack of communication among the family members, which bring about conflicts which are not always solved in a constructive way. So, it is relevant to build nets which may support the educational and socialization role of the family. This paper analizes how 689 fathers and mothers perceive themselves regading communication strategies with their children. Variables related to communication styles with children, parental skills of emotional self-regulation, and strategies to solve conflicts have been analyzed. In order to collect qualitative and quantitative data, surveys, self-information, participative observation and focus groups techniques were used. The quantitative data was processed with descriptive and variables association statistics. The final conclusions indicate that parents demand information to better cope with their parental role, thus, parenting programms should be developed on a community base. Also, taking advantage of the wide scope the Net provides us, parents´ participation in Blogs and Virtual Learning Communities should be promoted. These resources may be understood as networks for social support, and ideal meeting places for exchanging concerns, experiences and worries. All in all, will promote the development of “Positive Parenting” as expected by the European Council.En la sociedad de la Información y del Conocimiento un valor cada vez más en alza es el capital cultural y social. A pesar del progreso científico-tecnológico y del avance de las Tecnologías de la Información y la Comunicación, se advierte que las familias manifiestan cada vez más dudas en el desarrollo del rol parental. Aún siendo muy amplio el abanico de recursos que tienen a su disposición los padres, madres e hijos para acceder a información que les permita resolverlas (material impreso, telefonía, chats, redes sociales...) parece existir un patrón comunicativo deficitario en el ámbito familiar que conlleva el surgimiento de conflictos y/o en el afrontamiento carencial de los mismos. Resulta por tanto relevante generar redes de apoyo social y comunitario que refuercen y complementen la labor educativa y de socialización familiar. Con este trabajo se pretende conocer cómo se perciben los padres y madres en el ejercicio del rol parental a fin de sugerir líneas de acción educativa con las familias. La muestra de estudio está constituida por 689 padres y madres participantes en diferentes Programas de Formación Familiar. Se han analizado variables referidas al estilo de comunicación con los hijos, habilidades parentales de autorregulación emocional y estrategias de resolución de conflictos. Para recabar datos de naturaleza cuantitativa y cualitativa se han empleado cuestionarios, autoinformes, observación participante y grupos de discusión. Los datos cuantitativos han sido procesados con procedimientos descriptivos y de asociación entre variables. Los resultados obtenidos sugieren fomentar la prevención en el ámbito familiar, promocionando la implementación comunitaria de Programas de Orientación Educativa Familiar que den respuesta a las demandas detectadas. Además, aprovechando las potencialidades de la Red se podría incentivar que las familias participen en Blogs o Comunidades Virtuales de Aprendizaje, recursos entendidos como redes de apoyo social y espacios ideales de encuentro, intercambio de preocupaciones, experiencias e inquietudes, así como de adquisición de información y formación específica para el ejercicio de una Parentalidad Positiva, como espera el Consejo de Europa

A new method for the preparation of biocompatible silica coated-collagen hydrogels

Silica-collagen scaffolds were obtained by covalent binding of an aminosilane to glutaraldehyde fixed collagen hydrogels, rendering a three dimensional network of silicon coated collagen fibrils. When compared to non silicified collagen, silica containing matrices exhibited a 60 fold increment in the rheological properties. Moreover, acellular degradation collagenase type I indicated that enzymatic digestion occurred at a slower rate for silica modified hydrogels, hence enabling a controlled degradation of the obtained material. In addition, fibroblastic cells seeded on silicified collagen matrices were able to adhere, proliferate and migrate within the scaffold for over 3 weeks as shown by MTT tests and hematoxylin-eosin staining. These results suggest that the herein described method could be useful in the design of materials for tissue engineering purposesFil: Diaz, Luis Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Foglia, María Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Camporotondi, Daniela Edhit. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Heinemann, Sascha. Technische Universitat Dresden. Max Bergmann Center of Biomaterials and Institute of Materials Science; AlemaniaFil: Hanke, Thomas. Technische Universitat Dresden. Max Bergmann Center of Biomaterials and Institute of Materials Science; AlemaniaFil: Pérez, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentin

Lidocaína endovenosa domiciliaria en cuidados paliativos

Introduction: Neuropathic pain is a often difficult to control pain and is suitable of different therapeutic approaches. Method: Lidocaine is a local anesthesic and its endovenous use is sometimes necessary to control neuropathic pain. There is no reported use of this drug at home. Results: We performed the lidocaine endovenous infusion in two patients with neuropathic pain achieving significant clinical improvement. Conclusions: Endovenous lidocaine infusion at home, is a safe and effective proceeding for patients with neuropathic pain.Introducción: El dolor neuropático es, en numerosas ocasiones, un dolor de difícil manejo que precisa la combinación de diferentes grupos terapéuticos para su control óptimo. Método: La lidocaína es un anestésico local y su uso endovenoso es necesario ocasionalmente para el tratamiento del dolor neuropático; no hay experiencia en su uso domiciliario. Resultados: Realizamos la infusión endovenosa domiciliaria con lidocaína en 2 pacientes con dolor neuropático refractario con mejoría clínica. Conclusiones: La infusión de lidocaína endovenosa en domicilio es una técnica segura y eficaz en pacientes con dolor neuropático

Propuesta Estratégica de Mejora en la Implementación de los Estándares Mínimos del Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST) en la empresa Gytrans para el primer semestre de 2019

Como opción de grado del Programa de Administración de Empresas, hemos elegido el Diplomado de Profundización en Gerencia del Talento Humano; que se constituye en una valiosa herramienta, primordial en la formación del profesional de las ciencias administrativas; la temática del curso se ha desarrollado mediante una investigación del Sistema de Gestión de la Seguridad y Salud en el Trabajo en la empresa Gytrans, con el propósito de fortalecer las competencias en la gestión del capital humano, que nos permita generar valor organizacional y que nos brinden los elementos esenciales para la formación integral en esta importante disciplina, y en esta medida, poder gestionar la acción del personal dentro del entorno laboral; y así mismo lograr desarrollar con total éxito nuestro propósito académico y graduarnos como Administradores de Empresas.Strategic proposal for improvement in the implementation of the Minimum Standards of the Occupational Health and Safety Management System (SG-SST) in the company Gytrans for the first semester of 201

Prognostic Value of D-dimer to Lymphocyte Ratio (DLR) in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients: A Validation Study in a National Cohort

Background: This study aimed to validate the role of the D-dimer to lymphocyte ratio (DLR) for mortality prediction in a large national cohort of hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: A retrospective, multicenter, observational study that included hospitalized patients due to SARS-CoV-2 infection in Spain was conducted from March 2020 to March 2022. All biomarkers and laboratory indices analyzed were measured once at admission. Results: A total of 10,575 COVID-19 patients were included in this study. The mean age of participants was 66.9 (+/- 16) years, and 58.6% (6202 patients) of them were male. The overall mortality rate was 16.3% (n = 1726 patients). Intensive care unit admission was needed in 10.5% (n = 1106 patients), non-invasive mechanical ventilation was required in 8.8% (n = 923 patients), and orotracheal intubation was required in 7.5% (789 patients). DLR presented a c-statistic of 0.69 (95% CI, 0.68-0.71) for in-hospital mortality with an optimal cut-off above 1. Multivariate analysis showed an independent association for in-hospital mortality for DLR > 1 (adjusted OR 2.09, 95% CI 1.09-4.04; p = 0.03); in the same way, survival analysis showed a higher mortality risk for DLR > 1 (HR 2.24; 95% CI 2.03-2.47; p < 0.01). Further, no other laboratory indices showed an independent association for mortality in multivariate analysis. Conclusions: This study confirmed the usefulness of DLR as a prognostic biomarker for mortality associated with SARS-CoV-2 infection, being an accessible, cost-effective, and easy-to-use biomarker in daily clinical practice

Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19 : a multicentre, randomised, double-blind, non-inferiority phase IIb trial

A SARS-CoV-2 protein-based heterodimer vaccine, PHH-1V, has been shown to be safe and well-tolerated in healthy young adults in a first-in-human, Phase I/IIa study dose-escalation trial. Here, we report the interim results of the Phase IIb HH-2, where the immunogenicity and safety of a heterologous booster with PHH-1V is assessed versus a homologous booster with BNT162b2 at 14, 28 and 98 days after vaccine administration. The HH-2 study is an ongoing multicentre, randomised, active-controlled, double-blind, non-inferiority Phase IIb trial, where participants 18 years or older who had received two doses of BNT162b2 were randomly assigned in a 2:1 ratio to receive a booster dose of vaccine-either heterologous (PHH-1V group) or homologous (BNT162b2 group)-in 10 centres in Spain. Eligible subjects were allocated to treatment stratified by age group (18-64 versus ≥65 years) with approximately 10% of the sample enrolled in the older age group. The primary endpoints were humoral immunogenicity measured by changes in levels of neutralizing antibodies (PBNA) against the ancestral Wuhan-Hu-1 strain after the PHH-1V or the BNT162b2 boost, and the safety and tolerability of PHH-1V as a boost. The secondary endpoints were to compare changes in levels of neutralizing antibodies against different variants of SARS-CoV-2 and the T-cell responses towards the SARS-CoV-2 spike glycoprotein peptides. The exploratory endpoint was to assess the number of subjects with SARS-CoV-2 infections ≥14 days after PHH-1V booster. This study is ongoing and is registered with , . From 15 November 2021, 782 adults were randomly assigned to PHH-1V (n = 522) or BNT162b2 (n = 260) boost vaccine groups. The geometric mean titre (GMT) ratio of neutralizing antibodies on days 14, 28 and 98, shown as BNT162b2 active control versus PHH-1V, was, respectively, 1.68 (p < 0.0001), 1.31 (p = 0.0007) and 0.86 (p = 0.40) for the ancestral Wuhan-Hu-1 strain; 0.62 (p < 0.0001), 0.65 (p < 0.0001) and 0.56 (p = 0.003) for the Beta variant; 1.01 (p = 0.92), 0.88 (p = 0.11) and 0.52 (p = 0.0003) for the Delta variant; and 0.59 (p ≤ 0.0001), 0.66 (p < 0.0001) and 0.57 (p = 0.0028) for the Omicron BA.1 variant. Additionally, PHH-1V as a booster dose induced a significant increase of CD4 + and CD8 + T-cells expressing IFN-γ on day 14. There were 458 participants who experienced at least one adverse event (89.3%) in the PHH-1V and 238 (94.4%) in the BNT162b2 group. The most frequent adverse events were injection site pain (79.7% and 89.3%), fatigue (27.5% and 42.1%) and headache (31.2 and 40.1%) for the PHH-1V and the BNT162b2 groups, respectively. A total of 52 COVID-19 cases occurred from day 14 post-vaccination (10.14%) for the PHH-1V group and 30 (11.90%) for the BNT162b2 group (p = 0.45), and none of the subjects developed severe COVID-19. Our interim results from the Phase IIb HH-2 trial show that PHH-1V as a heterologous booster vaccine, when compared to BNT162b2, although it does not reach a non-inferior neutralizing antibody response against the Wuhan-Hu-1 strain at days 14 and 28 after vaccination, it does so at day 98. PHH-1V as a heterologous booster elicits a superior neutralizing antibody response against the previous circulating Beta and the currently circulating Omicron BA.1 SARS-CoV-2 variants in all time points assessed, and for the Delta variant on day 98 as well. Moreover, the PHH-1V boost also induces a strong and balanced T-cell response. Concerning the safety profile, subjects in the PHH-1V group report significantly fewer adverse events than those in the BNT162b2 group, most of mild intensity, and both vaccine groups present comparable COVID-19 breakthrough cases, none of them severe. HIPRA SCIENTIFIC, S.L.U

Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson?s Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson?s Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor?patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.Funding This work is supported by AbbVie S.L.U, the Instituto de Salud Carlos III [DTS17/00195] and the European Fund for Regional Development, 'A way to make Europe'

Fostering English-taught higher education programs in a Spanish university: the "TechEnglish" innovative project

In recent years, coinciding with adjustments to the Bologna process, many European universities have attempted to improve their international profile by increasing course offerings in English. According to the Institute of International Education (IIE), Spain has notably increased its English-taught higher education programs, ranking fifth in the list of European countries by number of English-taught Master's programs in 2013. This article presents the goals and preliminary results of an on-going innovative education project (TechEnglish) that aims to promote course offerings in English at the Technical University of Madrid (Universidad Politécnica de Madrid, UPM). The UPM is the oldest and largest of all Technical Universities in Spain. It offers graduate and postgraduate programs that cover all the engineering disciplines as well as architecture. Currently, the UPM has no specific bilingual/multilingual program to promote teaching in English, although there is an Educational Model Whitepaper (with a focus on undergraduate degrees) that promotes the development of activities like an International Semester or a unique shared curriculum. The TechEnglish project is an attempt to foster courses taught in English at 7 UPM Technical Schools, including students and 80 faculty members. Four tasks were identified: (1) to design a university wide framework to increase course offerings, (2) to identify administrative difficulties, (3) to increase visibility of courses offered, and (4) to disseminate the results of the project. First, to design a program we analyzed existing programs at other Spanish universities, and other projects and efforts already under way at the UPM. A total of 13 plans were analyzed and classified according to their relation with students (learning), professors (teaching), administration, course offerings, other actors/institutions within the university (e.g., language departments), funds and projects, dissemination activities, mobility plans and quality control. Second, to begin to identify administrative and organizational difficulties in the implementation of teaching in English, we first estimated the current and potential course offerings at the undergraduate level at the UPM using a survey (student, teacher and administrative demand, level of English and willingness to work in English). Third, to make the course offerings more attractive for both Spanish and international students we examined the way the most prestigious universities in Spain and in Europe try to improve the visibility of their academic offerings in English. Finally, to disseminate the results of the project we created a web page and a workspace on the Moodle education platform and prepared conferences and workshops within the UPM. Preliminary results show that increasing course offerings in English is an important step to promote the internationalization of the University. The main difficulties identified at the UPM were related to how to acknowledge/certify the departments, teachers or students involved in English courses, how students should register for the courses, how departments should split and schedule the courses (Spanish and English), and the lack of qualified personnel. A concerted effort could be made to increase the visibility of English-taught programs offered on-line