Relationship between Lung Functions and Extent of Emphysema in Patients with Chronic Obstructive Pulmonary Disease

Objective: A study was undertaken to investigate whether the extent of emphysema, visually confirmed by high-resolution computed tomography (HRCT), in patients with COPD was associated with different indices of lung function and health-related life quality of patients with COPD. Methods: Eighty-two patients with COPD underwent HRCT scanning; visual assessment of HRCT scan was used in the calculation of the assessment of the severity and extent of emphysematous destruction. The patients were clinically stable at the time of the evaluation. For all subjects, a detailed interview of disease history and symptoms, health-related quality of life (HRQL) measurement, and pulmonary function tests were performed. Results: The mean visual emphysema score in all patients was 2.10 +/- 1.26. While the mean emphysema score in patients with COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 3 was 2.88 +/- 1.01, it was 1.54 +/- 1.13 in patients with COPD GOLD stage 2 (p<0.001). There was a significant correlation between the percentage of pulmonary emphysema and the numbers of pack-years smoked (r=0.58, p<0.001). The visual emphysema score was inversely correlated with FEV1 (r=-0.56, p<0.0001), FVC (r=-0.38, p<0.001), FEV1/FVC (r=-0.43, p<0.001), PEF (r=-0.44, p<0,001) and with carbon monoxide diffusion capacity (DLCO) (r=-0.50, p<0.001). There was no correlation between emphysema score and SGRQ. Conclusion: These data suggest that HRCT visual scores correlate with functional indices of airflow obstruction and impaired lung diffusing capacity in patients with stable chronic obstructive pulmonary disease of varying severity, and the presence of pulmonary emphysema is best represented by FEV1 and DLCO

Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model

Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity. Here, we investigated the possible effects of 2 boron-containing compounds-sodium borate decahydrate and boric acid-against amyloid-beta toxicity. In our in vitro amyloid-beta toxicity model, we showed that these 2 compounds increase the survival of the SH-SY5Y cells. Furthermore, boron in these 2 forms increases the expression of Sirt1, which has protective functions against cellular stress. The compounds also change the expressions of GSK-3 alpha/beta; by doing so, boron may contribute to the stimulation of intracellular prosurvival pathways. This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model

Franchismo

We aimed to obtain information about the characteristics of the ICUs in our country via a point prevalence study