Systém pro automatický překlad prstové znakové abecedy do mluvené řeči

Tento článek popisuje systém, který umožňuje vzájemnou komunikaci sluchově a zrakově postižených osob, s využitím konverze mluvené řeči do animace prstové znakové abecedy a naopak. V tomto článku je uvažováno využití několika jazyků: angličtina, ruština, turečtina a čeština.The aim of this paper is to help the communication of two people, one hearing impaired and one visually impaired by converting speech to fingerspelling and fingerspelling to speech. Fingerspelling is a subset of sign language, and uses finger signs to spell letters of the spoken or written language. We aim to convert finger spelled words to speech and vice versa. Different spoken languages and sign languages such as English, Russian, Turkish and Czech are considered

Recessive Lamc3 Mutations Cause Malformations of Occipital Cortical Development

The biological basis for regional and inter-species differences in cerebral cortical morphology is poorly understood. We focused on consanguineous Turkish families with a single affected member with complex bilateral occipital cortical gyration abnormalities. By using whole-exome sequencing, we initially identified a homozygous 2-bp deletion in LAMC3, the laminin. 3 gene, leading to an immediate premature termination codon. In two other affected individuals with nearly identical phenotypes, we identified a homozygous nonsense mutation and a compound heterozygous mutation. In human but not mouse fetal brain, LAMC3 is enriched in postmitotic cortical plate neurons, localizing primarily to the somatodendritic compartment. LAMC3 expression peaks between late gestation and late infancy, paralleling the expression of molecules that are important in dendritogenesis and synapse formation. The discovery of the molecular basis of this unusual occipital malformation furthers our understanding of the complex biology underlying the formation of cortical gyrations.Wo

Time-dependent analysis of extra length of stay and mortality due to ventilator-associated pneumonia in intensive-care units of ten limited-resources countries: findings of the International Nosocomial Infection Control Consortium (INICC)

Ventilator-associated pneumonias (VAPs) are a worldwide problem that significantly increases patient morbidity, mortality, and length of stay (LoS), and their effects should be estimated to account for the timing of infection. The purpose of the study was to estimate extra LoS and mortality in an intensive-care unit (ICU) due to a VAP in a cohort of 69 248 admissions followed for 283 069 days in ICUs from 10 countries. Data were arranged according to the multi-state format. Extra LoS and increased risk of death were estimated independently in each country, and their results were combined using a random-effects meta-analysis. VAP prolonged LoS by an average of 2.03 days (95% CI 1.52-2.54 days), and increased the risk of death by 14% (95% CI 2-27). The increased risk of death due to VAP was explained by confounding with patient morbidity