Propuestas didácticas de carácter interdisciplinar para la enseñanza/Aprendizaje del espacio y el tiempo en la educación infantil

En este artículo se desarrollan propuestas didácticas de carácter interdisciplinar que el maestro de educación infantil puede aplicar en su práctica educativa para conseguir que niños y niñas interioricen las nociones de espacio y tiempo. Estas propuestas se enmarcan en el ámbito del conocimiento del entorno natural y social, que en esta etapa educativa no se configura como un área independiente. Se parte de la idea de que el propio cuerpo es el primer punto de referencia de la percepción y que desde la percepción del propio esquema corporal se llegará a dominar la percepción del espacio representativo. En la segunda parte, ampliamos el horizonte espacial e introducimos las nociones temporales, en base a la percepción que el niño tiene de los cambios que se producen en su entorno cercano, especialmente de los cambios rítmicos (rutinas en el día, cambios estacionales, cambios en la familia…). Por último, en la tercera parte, se plantea el descubrimiento, correcta percepción y comprensión por parte del niño, de un espacio más amplio: en la calle, el barrio, el pueblo o la ciudad. Cada uno de los tres apartados se acompaña de propuestas didácticas que permiten implementar y llevar a la práctica con facilidad, las argumentaciones teóricasIn this article we present interdisciplinary educational proposals that young children teachers could apply in their educational practice to ensure that children internalize the notions of space and time. These proposals concern the natural and the social environments, which in this level of education are not considered independent areas but one complex field. Each proposal contains specific activities with a theoretical basis which justifies them. We start in the first part from the concept that for human beings the body is the first benchmark of perception. From the perception of the body scheme itself, we finally acknowledge representative space. Then, in the second part, we expand the field and introduce temporal notions, taking into account the perception that children have of changes that occur in their immediate environment, especially recurrent changes (routines during the day, seasonal changes, within the family...). Finally, in the third part, we elaborate on the discovery, correct perception and understanding by the child, of a wider space: the street, the neighborhood, the town or cit

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis

EducaFarma 11.0

Memoria ID2022-036. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2022-2023

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Aspects of gauged/massive supergravity and its origin from eleven dimensions

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Física Teórica, Fecha de lectura 20-06-200

Clinical guidelines for endoscopic mucosal resection of non-pedunculated colorectal lesions

This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions

Clinical guidelines for endoscopic mucosal resection of non-pedunculated colorectal lesions.

This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions

Guía clínica para la resección mucosa endoscópica de lesiones colorrectales no pediculadas.

This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions