STRUCTURAL CHARACTERISATION OF 5-HYDROXYTRYPTAMINE2A RECEPTOR IN HOMO SAPIENS BY IN - SILICO METHOD

Objective: Structural characterization of 5-hydroxytryptamine (5-HT)2A receptor in homo sapiens using in silico method.Methods: In silico approach has particularly providing a realistic representation needed to understand the fundamental molecular structure of a serotonin receptor. The structure has been generated using Swiss model, Modeller 9.14, Phyre2, and Geno three-dimensional, which was visualized using PyMol, and validated by Procheck and ERRAT analysis along with the values of different secondary structures mapping to diverse sections of the Ramachandran plot.Results: We compared all different models. Further structural analysis suggested that the structure of 5-HT2A is a monomer with 18 alpha helices, seven beta sheets, and one disulfide bridge. There is no signal peptide region in the protein sequence. The structure contains mostly polar and aromatic amino acid as suggested by using hydropathy plot. However, in both partitioning systems bilayer to water and water to bilayer, there are some hydropathy predicted segments, which are also transmembrane segments. Finally, the pore features, including diameter profile, size, and shape, were determined by porewalker, and the shape of the pore was found to be UDSD.Conclusion: This study suggested that 5-HT2A receptor interaction with its natural ligand serotonin and other inhibitor compounds would further additional information about G protein-coupled receptors. The 5-HT2A receptor could be an important target for therapeutics development

Near-Field Nanopatterning and Associated Energy Transport Analysis with Thermoreflectance

Laser nano-patterning with near-field optical microscope (NSOM) and the associated energy transport analysis are achieved in this study. Based on combined experimental/theoretical analyses, it is found that laser nano-patterning with a NSOM probes strongly depend on the laser conditions and material properties of the target: the energy transport from the NSOM probes to the targets changes from pure optical to a combination of thermal and optical transport when the pulse duration of laser is increased from femtosecond to nanosecond. As a result, the mechanisms of nano-pattern formation on targets changes from nano-ablation to nano-oxidation/ recrystallization when the laser pulse duration is increased from femtosecond to nanosecond. Also, with the laser nano-patterning experiments, thermal damage of NSOM probes is observed which can be attributed to the low transport efficiency (10-4 – 10-6) and associated heating of the metal cladding of NSOM probes. The heating of NSOM probes are studied with developed time harmonic and transient thermoreflectance (TR) imaging. From time harmonic TR when the NSOM probes are driven with continuous laser, it is found that the location of heating of NSOM probes is ~20-30µm away from the NSOM tip. The strength of the heating is determined by the laser power (linear dependence), wavelength of the laser (stronger with short A), and aperture size of NSOM probes (stronger when aperture size < A/2). From the transient TR imaging when the NSOM probes are driven with pulsed laser, it is found that the peak temperature of the NSOM probe shifts much closer to the tip. The possible reason for the change in the location of peak temperature when continuous laser is changed to pulsed laser can be attributed to the competition between the heat generation and dissipation rates at different location of the probe: the tip experiences highest temperature with pulsed heating as the entire heating processes is adiabatic. The tip also experiences highest heat dissipation rate due to its large surface-to-volume ratio which overcomes the heat generation at the tip under quasi-steady state resulting in shift of the hot spot. The knowledge obtained in this study can be important in the future design of more efficient NSOM probes and other nano-optic devices

Mechanical and Explosive Properties of Plastic Bonded Explosives Based on Mixture of HMX and TATB

This paper describes formulation of plastic bonded explosives (PBXs) compositions based on 2,4,6- triamino-1,3,5-trinitrobenzene (TATB), Octahydro l,3,5,7-tetranitro- 1,3,5,7-tetrazocine (HMX) by varying their relative amounts with Viton A as polymeric binder by slurry coating technique. These PBXs compositions are studied for mechanical and detonic properties. It has been observed that sensitivity and explosive performance of PBXs based on mixture of HMX and TATB were varied over a wide considerable range by varying relative amounts of TATB and HMX. The detonation study revealed there was increased in velocity of detonation (VOD) and detonation pressure with increasing amount of HMX from 10-80 % by weight. The sensitivity test results exhibited that insensitivity to impact for PBXs compositions was found to decrease with increasing HMX amount.  Friction sensitivity study showed that no reactions were observed upto 36 kg load for PBXs compositions namely HT6030, HT5040, HT4050, HT3060, HT2070 and HT1080. The compressive strength of these PBXs compositions was found within the range of 9-11 MPa.Defence Science Journal, 2013, 63(6), pp.622-629, DOI:http://dx.doi.org/10.14429/dsj.63.576

Assessment Of Purisha At Laboratory Level- A Review

Ahara is panchabhautika, each element of ahara is not used by thebody, thus it is eliminated in the form of waste(Mala). The importanceof by products, produced during the digestion process, is as importantas food consumption in terms of nutrition for every body segment andthese phenomena are unavoidable. The proper formation of these malasis a reflection of the normal metabolic function and regular dhatuproduction, with good characteristics. Mala have the samephysiological value as dosha or dhatu, since they are considered to bebody moola. The metabolism will be affected if malas are not removedfrom the body, eventually leading to a malformation of tissues anddisease

Anomalous single production of fourth generation t′t' quarks at ILC and CLIC

We present a detailed study of the anomalous single fourth generation $t'$ quark production within the dominant Standard Model(SM) decay modes at future $e^+e^-$ colliders. We calculate the signal and background cross sections in the mass range 300-800 GeV. We also discuss the limits of $t'q\gamma$ and $t'qZ$ ($q=u,c$) anomalous couplings as well as values of attainable integrated luminosity for 3$\sigma$ observation limit.Comment: 12 pages, 14 figures, version to be published on Nucl.Phys.

Pair Production of Fourth Family Charged Sleptons at e+e−e^{+}e^{-} Colliders

We study the pair production of $\tilde{l}_{4}$, which is the supersymmetric partner of the fourth family charged lepton, at the $e^{+}e^{-}$ colliders. It is shown that the investigation of this process at ILC/CLIC will give opportunity to differentiate the MSSM with three and four families.Comment: 6 pages, 2 figure

SM with four generations: Selected implications for rare B and K decays

We extend our recent work and study implications of the Standard Model with four generations (SM4) for rare B and K decays. We again take seriously the several 2-3 $\sigma$ anomalies seen in B, $B_s$ decays and interpret them in the context of this simple extension of the SM. SM4 is also of course of considerable interest for its potential relevance to dynamical electroweak symmetry breaking and to baryogenesis. Using experimental information from processes such as $B \to X_s \gamma$, $B_d$ and $B_s$ mixings, indirect CP-violation from $K_L \to \pi \pi$ etc along with oblique corrections, we constrain the relevant parameter space of the SM4, and find $m_{t'}$ of about 400-600 GeV with a mixing angle $| V_{t'b}^*V_{t's}|$ in the range of about (0.05 to 1.4)$\times 10^{-2}$ and with an appreciable CP-odd associated phase, are favored by the current data. Given the unique role of the CP asymmetry in $B_s \to \psi \phi$ due to its gold-plated nature, correlation of that with many other interesting observables, including the semileptonic asymmetry ($A_{SL}$) are studied in SM4. We also identify several processes, such as $B \to X_s \nu \bar\nu$, $K_L \to \pi^0 \nu \bar \nu$ etc, that are significantly different in SM4 from the SM. Experimentally the very distinctive process $B_s\to \mu^+\mu^-$ is also discussed; the branching ratio can be larger or smaller than in SM, $(3.2 \to 4.2)\times 10^{-9}$, by a factor of ${\cal{O}}(3)$.Comment: v2: 49 pages, 20 eps figures, Corrected some typos, added few references and minor changes with regard to direct CP in K pi. Also some added information to facilitate direct comparison with Buras et al, arXiv:1002.2126

New Physics in b -> s mu+ mu-: CP-Conserving Observables

We perform a comprehensive study of the impact of new-physics operators with different Lorentz structures on decays involving the b -> s mu+ mu- transition. We examine the effects of new vector-axial vector (VA), scalar-pseudoscalar (SP) and tensor (T) interactions on the differential branching ratios and forward-backward asymmetries (A_{FB}'s) of Bsbar -> mu+ mu-, Bdbar -> Xs mu+ mu-, Bsbar -> mu+ mu- gamma, Bdbar -> Kbar mu+ mu-, and Bdbar -> K* mu+ mu-, taking the new-physics couplings to be real. In Bdbar -> K* mu+ mu-, we further explore the polarization fraction f_L, the angular asymmetry A_T^{(2)}, and the longitudinal-transverse asymmetry A_{LT}. We identify the Lorentz structures that would significantly impact these observables, providing analytical arguments in terms of the contributions from the individual operators and their interference terms. In particular, we show that while the new VA operators can significantly enhance most of the asymmetries beyond the Standard Model predictions, the SP and T operators can do this only for A_{FB} in Bdbar -> Kbar mu+ mu-.Comment: 54 pages, JHEP format, 45 figures (included). 5/6/2013: typos in K* mu mu angular coefficients corrected, typos in Eq. (D.12) corrected, added a missing term in I3LT in Eq. (D.16). Numerical analysis unchange

Bounds on fourth generation induced Lepton Flavour Violating double insertions in Supersymmetry

We derive bounds on leptonic double mass insertions of the type $\delta^{l}_{i4} \delta^{l}_{4j}$ in four generational MSSM, using the present limits on $l_i \to l_j + \gamma$. Two main features distinguish the rates of these processes in MSSM4 from MSSM3 : (a) tan$\beta$ is restricted to be very small $\lesssim 3$ and (b) the large masses for the fourth generation leptons. In spite of small $\tan\beta$, there is an enhancement in amplitudes with $llrr$($\delta_{i4}^{ll}\delta_{4j}^{rr}$) type insertions which pick up the mass of the fourth generation lepton, $m_{\tau'}$. We find these bounds to be at least two orders of magnitude more stringent than those in MSSM3.Comment: Latex, 15 pages and 7 figures, Published versio

The Need for New Search Strategies for Fourth Generation Quarks at the LHC

Most limits on the fourth generation heavy top quark (the t') are based on the assumed dominance of t' -> Wb, which is expected to be case in the minimal fourth generation framework with a single Higgs (the so called SM4). Here we show, within a variant of a Two Higgs Doublet Model with four generations of fermions, that, in general, a different t' detection strategy is required if the physics that underlies the new heavy fermionic degrees of freedom goes beyond the "naive" SM4. We find that the recent CMS lower bounds: m_{t'}< 450 GeV in the semi-leptonic channel pp -> t't' -> l\nu qqbb and m_{t'}< 557 GeV in the dilepton channel pp -> t't' ->ll\nu \nu bb, that were obtained using the customary (SM4-driven) detection strategies, do not apply. In particular, we demonstrate that if the decay t' -> ht dominates, then applying the "standard" CMS search tools leads to a considerably relaxed lower bound: m_{t'} >~350 GeV. We, therefore, suggest an alternative search strategy that is more sensitive to beyond SM4 dynamics of the fourth generation fermions.Comment: 12 pages, 8 figure