Projeto da estrutura de um edifício residencial em concreto armado e protendido e a influência do processo construtivo

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Tecnologia, Departamento de Engenharia Civil e Ambiental, 2017.Este trabalho constitui-se em um memorial descritivo e de cálculo do projeto estrutural de um edifício de concreto armado e protendido, desenvolvido a partir da arquitetura de um prédio residencial construído em Milão nos anos 1980. Para fins de cálculo será considerada a execução do edifício em Brasília – DF. Neste trabalho o objetivo é apresentar o projeto executivo da estrutura da edificação, com todas as dimensões finais e detalhamento dos elementos estruturais, incluindo plantas de armações. Além disso, apresentar as soluções estruturais adotadas para resolver as adversidades de projeto encontradas durante o dimensionamento da edificação

Quark Hadron Phase Transition and Hybrid Stars

We investigate the properties of hybrid stars consisting of quark matter in the core and hadron matter in outer region. The hadronic and quark matter equations of state are calculated by using nonlinear Walecka model and chiral colour dielectric (CCD) model respectively. We find that the phase transition from hadron to quark matter is possible in a narrow range of the parameters of nonlinear Walecka and CCD models. The transition is strong or weak first order depending on the parameters used. The EOS thus obtained, is used to study the properties of hybrid stars. We find that the calculated hybrid star properties are similar to those of pure neutron stars.Comment: 25 pages in LaTex and 9 figures available on request, IP/BBSR/94-3

Liderança internacional em enfermagem relacionada ao fenômeno das drogas: um estudo de caso da experiência de colaboração entre a Comissão Interamericana para o Controle do Abuso das Drogas (CICAD) e a Universidade de Alberta - Faculdade de Enfermagem

In this article, the authors discuss the value of international health in advancing the nursing profession through the development of strong leadership in the area of drug demand reduction. Paradigms for nursing leadership are briefly reviewed and linked to the development of the "International Nursing Leadership Institutes" organized by the Inter-American Commission for the Control of Drug Abuse (CICAD). The "International Nursing Leadership Institutes" have facilitated the implementation of Phase III of the CICAD Schools of Nursing Project: a) planning and implementing the first "International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in Latin America", b) development of Regional and National Strategic Plans for Nursing Professionals in the Area of Demand Reduction in Latin America, and c) preparation of a document that provides guidelines on how to include drug content into undergraduate and graduate nursing curricula. The article also brings reflections directly from several of the participants in the first International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in the Americas, offered in collaboration with the Faculty of Nursing at the University of Alberta in Edmonton, Canada. These reflections demonstrate the multiplicity of ways in which this capacity-building program has made it easier for these members of Latin American Schools of Nursing to show leadership in the area of drug demand reduction.En este artículo, los autores debaten el valor de la salud internacional para el avance de la profesión de enfermería a través del desarrollo de un sólido liderazgo en el área de reducción de la demanda de drogas. Los paradigmas de liderazgo de enfermería son brevemente revisados y tiene apoyado el desarrollo de la serie de "Institutos Internacionales de Liderazgo de Enfermería", organizados por la Comisión Interamericana para el Control del Abuso de Drogas (CICAD). Los "Institutos Internacionales de Liderazgo de Enfermería" han servido como facilitadores de la implementación de la Fase III del Proyecto de la CICAD de las Escuelas de Enfermería: a) planeamiento e implementación del primer "Programa Internacional de Capacitación de Enfermeras(os) para Estudiar el Fenómeno de las Drogas en América Latina", b) desarrollo de los Planes Estratégicos Regionales y Nacionales para la Profesión de Enfermería en el Área de la Reducción de la Demanda de Drogas y c) preparación de un documento directriz de como incluir el contenido de drogas en los currículos de pregrado y postgrado de enfermería. El articulo presenta también las consideraciones de los diversos participantes del primer Programa Internacional de Capacitación para Enfermeras(os), realizado en colaboración con la Facultad de Enfermería de la Universidad de Alberta, Edmonton, Canadá. Estas consideraciones demuestran la multiplicidad de maneras que el programa de capacitación ha presentado a los miembros de las Escuelas de Enfermería de América Latina para avanzar el liderazgo en el área de Reducción de la demanda de drogas.Neste artigo, os autores discutem o valor da saúde internacional para o avanço da profissão de enfermagem através do desenvolvimento de uma sólida Liderança na área de redução da demanda de drogas. Os paradigmas de Liderança em enfermagem são brevemente revisados e têm apoiado o desenvolvimento de uma série de "Institutos Internacionais de Liderança em Enfermagem", organizados pela Comissão Interamericana para o Controle do Abuso de Drogas (CICAD). Os "Institutos Internacionais de Liderança em Enfermagem" têm servido como facilitadores da implementação da Fase III do Projeto da CICAD das Escolas de Enfermagem: a) planejamento e implementação do primeiro "Programa Internacional de Capacitação de Enfermeiros no Estudo do Fenômeno das Drogas na América Latina", b) desenvolvimento de Planos Estratégicos Regionais e Nacionais para a Profissão de Enfermagem na Área da Redução da Demanda de Drogas e c) preparação de um documento de diretrizes de como incluir o conteúdo de drogas nos currículos de graduação e pós-graduação em enfermagem. O artigo apresenta também as considerações dos diversos participantes do primeiro Programa Internacional de Capacitação para Enfermeiras(os), realizado com a colaboração da Faculdade de Enfermagem da Universidade de Alberta, Edmonton, Canadá. Estas considerações demonstram a multiplicidade de maneiras que o programa de capacitação trouxe para os membros das Escolas de Enfermagem da América Latina para avançar a Liderança na área de redução da demanda de drogas

Emerging Role of HMGB1 in the Pathogenesis of Schistosomiasis Liver Fibrosis

In chronic schistosomiasis, liver fibrosis is linked to portal hypertension, which is a condition associated with high mortality and morbidity. High mobility group box 1 (HMGB1) was originally described as a nuclear protein that functions as a structural co-factor in transcriptional regulation. However, HMGB1 can also be secreted into the extracellular milieu under appropriate signal stimulation. Extracellular HMGB1 acts as a multifunctional cytokine that contributes to infection, injury, inflammation, and immune responses by binding to specific cell-surface receptors. HMGB1 is involved in fibrotic diseases. From a clinical perspective, HMGB1 inhibition may represent a promising therapeutic approach for treating tissue fibrosis. In this study, we demonstrate elevated levels of HMGB1 in the sera in experimental mice or in patients with schistosomiasis. Using immunohistochemistry, we demonstrated that HMGB1 trafficking in the hepatocytes of mice suffering from acute schistosomiasis was inhibited by Glycyrrhizin, a well-known HMGB1 direct inhibitor, as well as by DIC, a novel and potential anti-HMGB1 compound. HMGB1 inhibition led to significant downregulation of IL-6, IL4, IL-5, IL-13, IL-17A, which are involved in the exacerbation of the immune response and liver fibrogenesis. Importantly, infected mice that were treated with DIC or GZR to inhibit HMGB1 pro-inflammatory activity showed a significant increase in survival and a reduction of over 50% in the area of liver fibrosis. Taken together, our findings indicate that HMGB1 is a key mediator of schistosomotic granuloma formation and liver fibrosis and may represent an outstanding target for the treatment of schistosomiasis

Diabetogenic viruses: linking viruses to diabetes mellitus

Diabetes Mellitus (DM) is a group of chronic metabolic diseases distinguished by elevated glycemia due to the alterations in insulin metabolism. DM is one of the most relevant diseases of the modern world, with high incidence and prevalence worldwide, associated with severe systemic complications and increased morbidity and mortality rates. Although genetic factors and lifestyle habits are two of the main factors involved in DM onset, viral infections, such as enteroviruses, cytomegalovirus, hepatitis C virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, among others, have been linked as triggers of type 1 (T1DM) and type 2 (T2DM) diabetes. Over the years, various groups identified different mechanisms as to how viruses can promote these metabolic syndromes. However, this field is still poorly explored and needs further research, as millions of people live with these pathologies. Thus, this review aims to ex-plore the different processes of how viruses can induce DM and their contribution to the prevalence and incidence of DM worldwide

Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner.

Dengue constitutes a global health concern. The clinical manifestation of this disease varies from mild febrile illness to severe hemorrhage and/or fatal hypovolemic shock. Flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein that is displayed on the surface of infected cells but is absent in viral particles. NS1 accumulates at high levels in the plasma of dengue virus (DENV)-infected patients, and previous reports highlight its involvement in immune evasion, dengue severity, liver dysfunction and pathogenesis. In the present study, we performed a yeast two-hybrid screen to search for DENV2 NS1-interacting partners using a human liver cDNA library. We identified fifty genes, including human complement component 1 (C1q), which was confirmed by coimmunoprecipitation, ELISA and immunofluorescence assays, revealing for the first time the direct binding of this protein to NS1. Furthermore, the majority of the identified genes encode proteins that are secreted into the plasma of patients, and most of these proteins are classified as acute-phase proteins (APPs), such as plasminogen, haptoglobin, hemopexin, α-2-HS-glycoprotein, retinol binding protein 4, transferrin, and C4. The results presented here confirm the direct interaction of DENV NS1 with a key protein of the complement system and suggest a role for this complement protein in the pathogenesis of DENV infection