Effects of the changes between preand post-treatment 18F-FDG PET-CT volumetric parameters on overall survival in pleural mesothelioma

Introduction. This study aimed to examine the efficacy of positron emission tomography in fusion with computed tomography (PET-CT) parameters in predicting survival outcomes for patients with malignant pleural mesothelioma.  Material and methods. This study retrospectively evaluated the data of 250 patients who were followed up after a diagnosis of malignant pleural mesothelioma. The relationship of pre-treatment [maximum standardized uptake value (SUVmax1), metabolic tumor volume (MTV1), total lesion glycolysis (TLG1), tumor/background (TBR1), pleural thickness1), post-treatment (SUVmax2, MTV2, TLG2, TBR2, pleural thickness2], and DPET-CT parameters with survival was retrospectively evaluated in 36 patients whose pre- and post-treatment CT scan examinations were complete.  Results. The median age of the patients was 57.5 years, ranging from 35 to 76. Median follow-up time was 16 months, with a range of 7 to 42 months. Median survival was calculated as 18.8 months for all patients. Based on the determined cut-off values, overall survival was determined as 29.9 months in patients with TLG2 ≤ 158 compared to 16 months in patients with TLG2 > 158 (p = 0.009) and as 30.9 months in patients with DTLG ≤ –62.58 compared to 16 months in patients with DTLG > –62.58 (p = 0.001). In addition, median overall survival (OS) was determined as 29.9 months in patients with MTV2 ≤ 63.9 compared to 16 months in patients with MTV2 > 63.9 (p = 0.007) and as 29.9 months in patients with DMTV ≤ –54.03 compared to 16 months in patients with DMTV > –54.03 (p = 0.002). When evaluated with respect to TBR2; median OS was 29.9 months in patients with TBR2 ≤ 1.84 compared to 16 months in patients with TBR2 > 1.84 (p = 0.039).  Conclusions. Our research findings indicate a correlation between OS and volumetric PET-CT measures, specifically TLG and MTV

Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases

Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (Peer reviewe

A Multicenter, International Cohort Analysis of 1435 Cases to Support Clinical Trial Design in Acute Pancreatitis

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Trophic positioning among native and non-indigenous species in the eastern Mediterranean Sea

The substantial influx of non-indigenous species (NIS) into the eastern Mediterranean Sea from the Suez Canal has prompted questions about the mechanisms enabling their establishment and the resulting impacts on native species. We focus on the trophic level dynamics of the dominant native red mullet (Mullus barbatus) and the four NIS Pomadasys stridens, Upeneus moluccensis, U. pori, and Parupeneus forsskali. Using various methods, including trophic level estimations, intestine length analysis, and monthly trophic level variations, we assessed their trophic positions and flexibility. The results indicate that compared to M. barbatus, P. stridens occupies a lower trophic level due to its omnivorous nature, potentially facilitating its biomass increase. This lower trophic position is further supported by its lengthy intestine relative to size. Conversely, U. moluccensis, U. pori, and P. forsskali position themselves consistently at higher trophic levels than M. barbatus. Monthly trophic level variations suggest temporal dietary changes, which point to seasonal impacts on NIS success. M. barbatus’s resilience, including its preference for polychaetes, may explain its sustained dominance amid competition. This study sheds light on NIS-native species coexistence, further suggesting that NIS success could stem from exploitation of vacant niches and adaptation to new food sources