60 research outputs found
Measurement agreement between a newly developed sensing insole and traditional laboratory-based method for footstrike pattern detection in runners
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
This study introduced a novel but simple method to continuously measure footstrike patterns in runners using inexpensive force sensors. Two force sensing resistors were firmly affixed at the heel and second toe of both insoles to collect the time signal of foot contact. A total of 109 healthy young adults (42 males and 67 females) were recruited in this study. They ran on an instrumented treadmill at 0˚, +10˚, and -10˚ inclinations and attempted rearfoot, midfoot, and forefoot landings using real time visual biofeedback. Intra-step strike index and onset time difference between two force sensors were measured and analyzed with univariate linear regression. We analyzed 25,655 footfalls and found that onset time difference between two sensors explained 80–84% of variation in the prediction model of strike index (R-squared = 0.799–0.836, p<0.001). However, the time windows to detect footstrike patterns on different surface inclinations were not consistent. These findings may allow laboratory-based gait retraining to be implemented in natural running environments to aid in both injury prevention and performance enhancement
Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma
- Author
- A Gamboa-Dominguez
- A Keirsebilck
- A Mialhe
- A Valizadeh
- AK Lam
- Alfred K. Y. Lam
- AO Chan
- AU Jawhari
- BM Ghadimi
- BP Wijnhoven
- CM Franz
- D Fujimoto
- D Sarrio
- DI Bellovin
- F Sato
- FX Bosch
- G Berx
- G Karatzas
- HJ van
- HX Si
- I Grosheva
- John M. Luk
- John Wong
- K Tomita
- KS Nair
- Kwok-Wah Chan
- KY Lam
- L Nakopoulou
- M Feith
- M Takeichi
- M Yanagisawa
- MA Davis
- MA Thoreson
- MT Nieman
- NK Noren
- O Montonen
- Ping-Yin Lee
- PZ Anastasiadis
- Q Lu
- RB Hazan
- RC Ireton
- RM Bremnes
- S Aho
- S Inada
- Simon Law
- XJ Zhao
- Y Fukudome
- Y Ishizaki
- Y Uchikado
- YC Lin
- Yvonne Chung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
Background: E-cadherin is a well-known tumor suppressor and its dysregulated expression correlates with tumor differentiation, metastasis and survival in esophageal squamous cell carcinoma (ESCC). p120 catenin is an Armadillo protein normally bound to E-cadherin in the cadherin-catenin complex at the adherens junction. Dysregulated expression and mislocalization of p120ctn affect the protective function of the complex. The objective of the present study was to evaluate the clinical significance of E-cadherin and p120ctn expression in ESCC. Methods: Immunohistochemistry was performed to investigate the expression of E-cadherin and p120ctn proteins in 71 patients with ESCC. The relationships between protein expression and clinicopathological characteristics were analyzed. Results: Reduced E-cadherin and p120ctn expressions were observed in 42.3% and 8.5% of ESCC cases, respectively. Reduction of membranous p120ctn was observed in 33.8% of cases. Membranous E-cadherin was preserved when p120ctn co-localized on the membrane of tumor cells (72.3%, P = 0.001). High level E-cadherin expression and membranous p120ctn preservation positively correlated with tumor differentiation (P = 0.001 and P = 0.008, respectively). p120ctn expression was also significantly related to lymph node metastasis (P = 0.003). Heterogeneous expression of both E-cadherin and p120ctn was observed in dysplasia. Conclusions: Altered E-cadherin expression and p120ctn localization were related to tumor differentiation, indicating their important roles in the pathogenesis of ESCC. © 2007 The Society of Surgical Oncology, Inc.postprin
Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines
- Author
- A Guo
- A Jemal
- A Tyybakinoja
- Adi F. Gazdar
- AF Gazdar
- AF Gazdar
- Alfred Lewin
- B Everit
- BA Helfrich
- BP Coe
- C Rosenberg
- DA Eberhard
- E Galanis
- EK Rowinsky
- F Cappuzzo
- F Cappuzzo
- FA Shepherd
- FA Shepherd
- FR Hirsch
- H Lyng
- H Shigematsu
- H Shigematsu
- H Shigematsu
- H Uramoto
- H Yamamoto
- Hiromasa Yamamoto
- Hisayuki Shigematsu
- I Bieche
- IK Mellinghoff
- J Netter
- J Soh
- J Zhang
- Jeet Gandhi
- JG Paez
- Jianling Zhang
- JL Marks
- John D. Minna
- Junichi Soh
- K Jong
- K Naoki
- LP Gondek
- Luc Girard
- M Fukuoka
- M Nomura
- M Varella-Garcia
- Marileila Varella-Garcia
- MG Kris
- Michael Peyton
- RD Ramirez
- RI Nicholson
- RM Phelps
- S Sun
- SH Jung
- SV Sharma
- T Pawson
- TJ Lynch
- W Pao
- W Pao
- Wan L. Lam
- Wei Zhang
- William W. Lockwood
- WS Chen
- WW Lockwood
- X Tang
- Y Samuels
- Y Yatabe
- Yang Xie
- YH Soung
- Z Zhang
- Publication venue
- Public Library of Science
- Publication date
- Field of study
Deregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC) and this finding led to the development of tyrosine kinase inhibitors (TKIs) that are highly effective in a subset of NSCLC. Mutations of EGFR (mEGFR) and copy number gains (CNGs) of EGFR (gEGFR) and HER2 (gHER2) have been reported to predict for TKI response. Mutations in KRAS (mKRAS) are associated with primary resistance to TKIs.We investigated the relationship between mutations, CNGs and response to TKIs in a large panel of NSCLC cell lines. Genes studied were EGFR, HER2, HER3 HER4, KRAS, BRAF and PIK3CA. Mutations were detected by sequencing, while CNGs were determined by quantitative PCR (qPCR), fluorescence in situ hybridization (FISH) and array comparative genomic hybridization (aCGH). IC50 values for the TKIs gefitinib (Iressa) and erlotinib (Tarceva) were determined by MTS assay. For any of the seven genes tested, mutations (39/77, 50.6%), copy number gains (50/77, 64.9%) or either (65/77, 84.4%) were frequent in NSCLC lines. Mutations of EGFR (13%) and KRAS (24.7%) were frequent, while they were less frequent for the other genes. The three techniques for determining CNG were well correlated, and qPCR data were used for further analyses. CNGs were relatively frequent for EGFR and KRAS in adenocarcinomas. While mutations were largely mutually exclusive, CNGs were not. EGFR and KRAS mutant lines frequently demonstrated mutant allele specific imbalance i.e. the mutant form was usually in great excess compared to the wild type form. On a molar basis, sensitivity to gefitinib and erlotinib were highly correlated. Multivariate analyses led to the following results: 1. mEGFR and gEGFR and gHER2 were independent factors related to gefitinib sensitivity, in descending order of importance. 2. mKRAS was associated with increased in vitro resistance to gefitinib.Our in vitro studies confirm and extend clinical observations and demonstrate the relative importance of both EGFR mutations and CNGs and HER2 CNGs in the sensitivity to TKIs
An investigation in the correlation between Ayurvedic body-constitution and food-taste preference
- Author
- Abdullah M. Al-Beda
- Abolali Mohagheghzadeh
- Adriana Macchi
- Agnete E. Kristoffersen
- Alejandra Ribas
- Aleksandar Vcev
- Alfred Längler
- Ali M. Tamaddon
- Ali Tavakoli
- Amie Steel
- Amir M. Jaladat
- Amir M. Jaladat
- Ana C. Moreno Mazini
- Ana C. Viana Valle
- Ana P. Simões-Wüst
- Ana P. Simões-Wüst
- Ana P. Simões-Wüst
- Andre Tsai
- Anette L. Larsen
- Angelika Eggert
- Anita Rose
- Anita Salamonsen
- Anita Salamonsen
- Anja Thronicke
- Anjali Bhagra
- Anna Nietlispach
- Anne Majumdar
- Anne Ponstein
- Anne Ponstein
- Annemarie Abbing
- Annemarie Abbing
- Antonella Traversi
- Ashry Gad Mohamed
- Ava Lorenc
- Ava Lorenc
- Awais Mian
- Awais Mian
- Ayda Hosseinkhani
- Babak Daneshfard
- Babak Daneshfard
- Beatriz Jimenez
- Benedikt Huber
- Benno Brinkhaus
- Bjørg Evjen
- Bo-Hyung Jang
- Bradley McEwen
- Britta Rutert
- Carel Thijs
- Carmelo Guido
- Carmelo Guido
- Carmen J. Cerda
- Carmen Rocha
- Carolina Moltó-Puigmartí
- Carolyn Szuter
- Carolyn Szuter
- Charlene H. L. Wong
- Chen Bai
- Chiara Cervino
- Chin Lin
- Christine Holmberg
- Christine Lam
- Claudia Iachino
- Cornelia Herbstreit
- Cornelia Kaspar
- Cosette Pharisa
- Daiva Jakubonienė
- Damiano Zemp
- Daniel Krüerke
- Daniela Navarrete Heckersdorf
- Darong Wu
- Darong Wu
- Deja Ostrowski
- Deja Ostrowski
- Diego Lanaro
- Dora Tsui
- Edith Chan
- Eduardo D’Alessandro
- Elham Behmanesh
- Elham Behmanesh
- Elham Behmanesh
- Elham Behmanesh
- Elio Rossi
- Elio Rossi
- Elio Rossi
- Elio Rossi
- Elio Rossi
- Eny Márcia Ruggerini
- Eric T. C. Ziea
- Eric Ziea
- Erik Baars
- Erik Baars
- Ethel Doyle
- Eunji Choi
- Eva Tihanyi
- Evgeniya Sovershaeva
- Fabian Lotz
- Fabiana Quattrone
- Fabio Firenzuoli
- Fabio Firenzuoli
- Fabio Firenzuoli
- Faith Warner
- Farhad Handjani
- Fatemeh Amini
- Fatemeh Amini
- Fatemeh Tabatabaei
- Fatemeh Tabatabei
- Fatemeh Tavakoli
- Federica Sabatini
- Fei Zhen
- Fei Zhen
- Fenna Heyning
- Fernanda Mulinari Fontana
- Filippo Bosco
- Francesco Cerritelli
- Francesco Macrì
- Francislete Melo
- Frauke Musial
- Friedemann Schad
- Gabriele Rotter
- Gabriella Hegyi
- Georg Seifert
- Gerhard Florschutz
- Gholamreza Hatam
- Gianfranco Trapani
- Giuseppe Peloni
- Gokarna Dahal
- Gregor Kaczala
- Guoyan Yang
- Hakima Amri
- Hans de Goeij
- Hans Jeekel
- Harald Gruber
- Harald Matthes
- Harald Walach
- Hasan Sadeghi
- He Yu
- Heike Gerhardt
- Helen Parsons
- Henny Hui
- Hilde Risvoll
- Holger Pelz
- Hye L. Woo
- Hyunchul Jang
- Hyunho Kim
- Héctor Jorquera
- Ingo Bolliger
- Irene Schlingensiepen
- Iva Selke-Krulichova
- Ivna M. Fuchigami
- Jacques Kopferschmitt
- Jafar Abolghasemi
- Jafar Hasanzadeh
- Jan Smit
- Jan Vagedes
- Janet Schloss
- Jang W. Lee
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianxiong Cai
- Jianxiong Cai
- Jin M. Lee
- Jingnan Xu
- Jinhyang Ahn
- Jinsoon Seo
- Jitka Pokladnikova
- Johannes Wildhaber
- Joyce Hsieh
- Justin C. Y. Wu
- Justin C. Y. Wu
- Kamran Bagheri-Lankarani
- Katharina Schnabel
- Katherine Beaven
- Katherine Burke
- Katia Belvedere
- Katia Belvedere
- Katia Vuono
- Kealoha Fox
- Kealoha Fox
- Kjell H. Halvorsen
- Li Zhou
- Li Zhou
- Lily Chan
- Lina Chen
- Linda Nurra
- Lingjia Yin
- Livia Waeber
- Lixin Wang
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Luigi Ciullo
- Luisella Zanino
- Lynda Balneaves
- Mahmood R. Moein
- Mahsa rostami
- Majid Nimrouzi
- Majid Nimrouzi
- Marco Picchi
- Marco Picchi
- Marco Picchi
- Margit Cree
- Maria C. Torri
- Maria T. Borges Neres
- Maria T. Mangini
- Maria Waldenez Oliveira
- Marialessandra Panozzo
- Mariella Di Stefano
- Mariella Di Stefano
- Marisa Gaioli
- Marit Waaseth
- Marta Dell’Orso
- Martien van Dongen
- Martin Schnelle
- Martine Busch
- Maryam Mosaffa-Jahromi
- María L. Alcázar Saldivia
- Matthias Kröz
- Megan Steele
- Mehdi Pasalar
- Mehdi Pasalar
- Mehdi Pasalar
- Meiling Li
- Meng Zhao
- Meng Zhao
- Mia Li
- Michael Heinrich
- Michael Heinrich
- Michael Munday
- Michael Teut
- Min K. Hyun
- Miranda Rodrigo Jacobsen
- Miriam Ortiz
- Mohadeseh Ostovar
- Mohammad E. Zohalinezhad
- Mohammad M. Parvizi
- Mohammad M. Parvizi
- Mohammad M. Zarshenas
- Mohammad R. Namazi
- Mohemmed K. M. Khalil
- Mojgan Tansaz
- Mojtaba Heydari
- Mojtaba Heydari
- Momir Dunjic
- Momir Dunjic
- Monica E. Winnubst
- Morgana Masetti
- Márcia da Silva Jacobsen
- Mónica Galanti
- Mónica Galanti
- Mónica Galanti
- Mónica Mennet
- Namgyeong Go
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nasrin Hamidizadeh
- Nicola Brough Phil
- Nicola Robinson
- Nicola Robinson
- Norma Barraza
- Olja Njaradi
- Olja Njaradi
- Pak K. Chan
- Palitha Serasingh
- Pantea Shirooye
- Paolo Fedi
- Patricia Ronan
- Patricia Ronan
- Paulo Caceres Guido
- Pavel Sidorov
- Penny Agent
- Penny Agent
- Petar Papuga
- Peter Heusser
- Pholtan Rajamanoharan
- Pierluigi Quadri
- Pieter Dagnelie
- Po-Hsu Chen
- Raid A. Abutalib
- Ralf Suhr
- Razie N. Meybodi
- Renate Oepen
- Ricardo Monezi
- Ricardo Monezi
- Ricardo Monezi
- Ricardo Monezi
- Robert Kempenich
- Roberto Cardarelli
- Robin S. T. Ho
- Romy Schneider
- Roshanak Mokaberinejad
- Rui M. Da Cunha Faria
- Sam Watts
- Sandra Burnside
- Sarah Croke
- Sarah Stewart-Brown
- Saravanan Sathasivampillai
- Sathyanarayana Badekila
- Sebastian Weiss
- Sebo Damir
- Seyyedali Mozaffarpour
- Seyyedali Mozaffarpour
- Seyyedali Mozaffarpour
- Seyyedali Mozaffarpour
- Shelley Dorazio
- Siaw M. Liew
- Sicheng Wang
- Silvia Villanueva
- Siobhan Carr
- Siobhan Carr
- Solveig Wiesener
- Sonia Baccetti
- Sonia Baccetti
- Sonia Baccetti
- Su Madge
- Su Madge
- Sulaiman AlEidi
- Suleiman Afsharypuor
- Susanne Metzner
- Suzanne Hanser
- Sylvia Binting
- Taoying Lu
- Tido von Schoen-Angerer
- Tiegang Liu
- Tiziana Di Giampietro
- Tommaso Bellandi
- Tommaso Conti
- Torunn Hamran
- Trine Stub
- Trude Giverhaug
- Tu-Hsing Wu
- Ursula von Mandach
- Vahid Tafazoli
- Vahid Tafazoli
- Vincent C. H. Chung
- Vincent C. H. Chung
- Viola Heckel
- Volker Perlitz
- Weiwei Li
- Weiwei Li
- Wendy Wong
- Wiebke Stritter
- William Elder
- Wilma Sanzeni
- Wonmo Jung
- Xaver Frauenknecht
- Xia Wang
- Xiaohong Gu
- Xiaolin Tong
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xin Y. Wu
- Xin Y. Wu
- Xuan Wang
- Xufang Wu
- Xun Li
- Xun Li
- Ying Zhang
- Ying Zhang
- Ying Zhang
- Yongho Lee
- Younghee Yun
- Younghee Yun
- Yuhao Wu
- Yumin Cho
- Yutong Fei
- Yutong Fei
- Yuxiang Wan
- Yvonne M. Scherrer
- Zahra Parvizi
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhi X. Lin
- Zian Zheng
- Ziomara Balbarrey
- Zulj Marinko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2017
- Field of study
Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses
- Author
- A Bruning
- A Hemminki
- A Jemal
- A Kanerva
- A Kanerva
- A Kanerva
- A Kanerva
- A Ristimaki
- AH Baker
- Akseli Hemminki
- Alfred Lewin
- Anna Kanerva
- Ari Ristimäki
- C Benckert
- C Tordjman
- D Kirn
- D Walsh
- DM Parkin
- DT Rein
- E Casado
- EJ Small
- FR Khuri
- G Eibl
- G Ferrandina
- GE Blair
- Gerd J. Bauerschmitz
- GJ Bauerschmitz
- GJ Bauerschmitz
- H Fechner
- H zur Hausen
- HF Dvorak
- I Dmitriev
- J Fujimoto
- JA Loncaster
- JG Wesseling
- JT Lam
- K Binley
- K Suzuki
- Koichi Takayama
- Lotta Kangasniemi
- M Moriuchi
- M Rajecki
- M Raki
- M Sarkioja
- M Yamamoto
- M Yamamoto
- Mari Raki
- MM Hitt
- NH Chow
- P Nagi
- PA Insel
- Renee A. Desmond
- RJ Gralla
- S Kulkarni
- SD Barker
- Sergio Lavilla-Alonso
- TL Symensma
- V Krasnykh
- W Pruzanski
- W Yu
- WC Russell
- WF Cheng
- XM Xu
- Y Cao
- Y Manome
- YJ Jung
- Publication venue
- Publication date
- 01/01/2008
- Field of study
Peer reviewe
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni Frascà
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
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- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
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- Attwood John
- Aubin Keith
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- Bell George I.
- Bellard Terell M.
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- Belter Edward A., Jr.
- Bemrose Richard
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- Campo Kevin
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- Chain Patrick
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- Chi Cheng
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- Jia Jia
- Jia Jia
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- Jin Jian
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- Jong Pieter De
- Jordan Yun
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- Joy Ann
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- Luo Chunqing
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- Mangum Brian
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- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt Anne H
- Aamodt Anne H
- Abedi Vida
- Adams Hieab
- Adebajo Olayinka J
- Adeoye Abiodun M
- Afzal Shoaib
- Ago Tetsuro
- Agunloye Atinuke
- Akinyemi Joshua
- Akinyemi Rufus
- Akpa Onoja
- Akpa Onoja
- Akpalu Albert
- Almgren Peter
- Alvarez-Sabin Jose
- Amin Najaf
- Amouyel Philippe
- Anderson Christopher D
- Anderson Christopher D
- Anderson Christopher D
- Aparicio Hugo J
- Arenillas Juan Francisco
- Armasu Sebastian M
- Armstrong Nicole D
- Arnett Donna K
- Arulogun Oyedunni
- Attia John
- Ay Hakan
- Bae Hee-Joon
- Bakker Mark K
- Bammler Theo K
- Bartz Traci M
- Bastarache Lisa
- Beiser Alexa S
- Beiser Alexa S
- Bell Steven
- Benavente Oscar R
- Benn Marianne
- Bennett David A
- Berr Claudine
- Bevan Steve
- Bis Joshua C
- Bis Joshua C
- Bis Joshua C
- Blay Natalia
- Boerwinkle Eric
- Boncoraglio Giorgio B
- Bordes Constance
- Borte Sigrid
- Braekkan Sigrid K
- Brody Jennifer A
- Brouwers Paul JAM
- Brown Robert D
- Brumpton Ben M
- Brumpton Ben M
- Buring Julie E
- Bustamante Mariana
- Butterworth Adam S
- Cain Anael
- Campos Francisco
- Camps-Renom Pol
- Carcel-Marquez Jara
- Caro Ilana
- Carrera Caty
- Carty Cara L
- Caso Valeria
- Castillo Jose
- Chasman Daniel I
- Chauhan Ganesh
- Chen Junshi
- Chen Junshi
- Chen Ming-Huei
- Chen Pei-Hsin
- Chen Wei Min
- Chen Wei-Min
- Chen Yiping
- Chen Zhengming
- Cheng Yu-Ching
- Cho Kelly
- Choi Seung Hoan
- Chong Michael R
- Chowhan Ayesha
- Christensen Kaare
- Clarke Robert
- Cole John W
- Collins Rory
- Correa Adolfo
- Cotlarciuc Ioana
- Cruchaga Carlos
- Cullell Natalia
- Curtze Sami
- Curtze Sami
- Cushman Mary
- Damrauer Scott M
- Danesh John
- Dartigues Jean-Francois
- de Andrade Mariza
- de Bakker Paul IW
- de Cid Rafael
- de Cid Rafael
- de Jager Phil L
- de Jager Phil L
- de Jager Phil L
- de Kort Paul L
- de Laat Karlijn F
- de Laat Karlijn F
- de Leeuw Frank-Erik
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran Hossein
- Deleuze Jean-Francois
- Delgado Pilar
- Delgado Pilar
- Delgado-Mederos Raquel
- den Heijer Tom
- den Hoed Marcel
- DeStefano Anita L
- Dhar Rajat
- Diaz-Navarro Rosa
- Dichgans Martin
- Dorr Marcus
- Duan Qing
- Ellekjaer Hanne
- Endres Matthias
- Engelter Stefan T
- Engstrom Gunnar
- Esko Tonu
- Esko Tonu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Fakunle Adekunle G
- Falcone Guido J
- Fernandez-Cadenas Israel
- Ferreira Leslie E
- Ferreira Leslie E
- Fongang Bernard
- Ford Ian
- Fornage Myriam
- Franca Paulo HC
- Frantz Stefan
- Frazer Kelly A
- Freijo Marimar
- Frikke-Schmidt Ruth
- Fritsche Lars G
- Furie Karen L
- Gabrielsen Maiken E
- Gabrielsen Maiken E
- Gallego-Fabrega Cristina
- Gallego-Fabrega Cristina
- Gasca Natalie C
- Gasca Natalie C
- Geerlings Mirjam I
- Geerlings Mirjam I
- Geerlings Mirjam I
- Georgakis Marios K
- Germain Marine
- Ghanbari Mohsen
- Gieger Christian
- Giese Anne-Katrin
- Giese Anne-Katrin
- Giulianini Franco
- Gons Rob AR
- Gordon William
- Gottesman Rebecca F
- Gottesman Rebecca F
- Gottesman Rebecca F
- Grabe Hans J
- Gravel Simon
- Gretarsdottir Solveig
- Grewal Raji P
- Gudnason Vilmundur
- Gudnason Vilmundur
- Guo Yu
- Gurpreet Wander S
- Gustafsson Stefan
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler Jeffrey
- Haessler Jeffrey
- Haeusler Karl Georg
- Hagen Knut
- Hamsten Anders
- Hansen John-Bjarne
- Harris Tamara B
- Hassan Ahamad
- Hata Jun
- Havulinna Aki S
- He Jing
- He Yunye
- Heath Alicia K
- Heath Alicia K
- Heckbert Susan R
- Heit John A
- Heitsch Laura
- Heuch Ingrid
- Heuschmann Peter Ulrich
- Hill Michael
- Ho Yuk-Lam
- Holliday Elizabeth G
- Hopewell Jemma C
- Howard George
- Howson Joanna MM
- Hozawa Atsushi
- Hsu Fang-Chi
- Huffman Jennifer E
- Hveem Kristian
- Hveem Kristian
- Hyacinth Hyacinth I
- Ibanez Laura
- Ibrahim Manal
- Ikram Mohammad A
- Ikram Mohammad K
- Ilinca Andreea
- Ingelsson Erik
- Ingelsson Martin
- Inouye Michael
- Irvin Marguerite R
- Irvin Marguerite R
- Irvin Marguerite R
- Iwasaki Motoki
- Jackson Rebecca D
- Jackson Rebecca D
- Jacob Mina A
- Jee Yon Ho
- Jenkins Carolyn
- Jensen Gorm B
- Jeon Christina E
- Jern Christina
- Jian Xueqiu
- Jimenez-Conde Jordi
- Johnson Andrew D
- Johnson Julie A
- Jood Katarina
- Jousilahti Pekka
- Judy Renae L
- Jukema J Wouter
- Jung Keum Ji
- Jurgenson Tuuli
- Kabrhel Christopher
- Kaffashian Sara
- Kalra Lalit
- Kamanu Frederick K
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup Pia R
- Kanai Masahiro
- Kappelle L Jaap
- Keene Keith L
- Kim Bong-Jo
- Kim Bong-Jo
- Kim Jihye
- Kim Young Jin
- Kinnunen Janne
- Kissela Brett M
- Kitazono Takanari
- Kittner Steven J
- Kjartansson Olafur
- Kleindorfer Dawn O
- Kleinschnitz Christoph
- Kleinschnitz Christoph
- Kloss Manja
- Knol Maria J
- Koido Masaru
- Komolafe Morenikeji
- Konuma Takahiro
- Kooperberg Charles
- Kooperberg Charles
- Kooperberg Charles
- Korv Janika
- Koudstaal Peter J
- Kraft Peter
- Krebs Kristi
- Kristoffersen Espen S
- Krupinski Jerzy
- Kubo Michiaki
- Kumar Amit
- Labovitz Daniel L
- Lacaze Paul
- Lange Leslie A
- Langefeld Carl D
- Langenberg Claudia
- Lathrop G Mark
- Launer Lenore J
- Laurie Cathy C
- Le Grand Quentin
- Le Grand Quentin
- Le Grand Quentin
- Lee Jin-Moo
- Lee Keon-Joo
- Lee Tsong-Hai
- Lemmens Robin
- Lemmons Robin
- Leonard Hampton L
- Lepik Kaido
- Levi Christopher R
- Lewis Adam J
- Lewis Cathryn M
- Leys Didier
- Li Jiang
- Li Liming
- Li Linxin
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin Wei-Yu
- Lind Lars
- Lindgren Arne G
- Lindgren Cecilia M
- Lindstrom Sara
- Linkohr Birgit
- Lioutas Vasileios
- Liu Yong Mei
- Lledos Miquel
- Llucia-Carol Laia
- Longstreth WT
- Lopez Oscar L
- Lopez-Cancio Elena
- Lorentzen Erik
- Luijckx Gert-Jan
- Lv Jun
- MacDonald James
- Magi Reedik
- Magnusson Patrik K
- Maguire Jane
- Makoto Hirata
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S
- Marston Nicholas A
- Marti-Fabregas Joan
- Martinez-Majander Nicolas
- Martinsen Amy E
- Matsuda Koichi
- Mayerhofer Ernst
- McArdle Patrick F
- McCauley Bryan M
- McDonough Caitrin W
- McKnight Barbara
- Meitinger Thomas
- Melander Olle
- Menon Vilas
- Menon Vilas
- Meschia James F
- Metspalu Andres
- Milani Lili
- Millan Monica
- Millwood Iona Y
- Minegishi Naoko
- Mishra Aniket
- Mitchell Braxton D
- Molina Carlos A
- Montaner Joan
- Montellano Felipe A
- Morange Pierre-Emmanuel
- Morisaki Takayuki
- Morris Andrew P
- Mosley Thomas H
- Muino Elena
- Muller-Nurasyid Martina
- Munoz-Narbona Lucia
- Murakami Yoishinori
- Nagai Akiko
- Nagai Akiko
- Nalls Mike A
- Namba Shinichi
- Nederkoorn Paul J
- Nederkoorn Paul J
- Nelis Mari
- Nielsen Jonas B
- Nielsen Jonas B
- Niiranen Teemu J
- Ninomiya Toshiharu
- Nordestgaard Borge G
- Nordestgaard Borge G
- Norrving Bo
- Nygaard Marianne
- O'Donnell Chris J
- O'Donnell Martin J
- Obach Victor
- Obiako Reginald
- Ogbole Godwin
- Ogishima Soichi
- Okada Yukinori
- Olalere Abimbola
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Osaigbovo Godwin
- Ovbiagele Bruce
- Owolabi Lukman
- Owolabi Mayowa O
- Pankow James S
- Pankratz Nathan
- Parati Eugenio A
- Pare Guillaume
- Parodi Livia
- Pattee Jack W
- Peddareddygari Leema Reddy
- Pedersen Linda M
- Pedersen Nancy L
- Pera Joanna
- Perola Markus
- Peters Annette
- Peto Richard
- Pezzini Alessandro
- Pileggi Silvana
- Posner Daniel C
- Pozarickij Alfred
- Prasad Kameshwar
- Prats-Sanchez Luis
- Psaty Bruce M
- Pulit Sara L
- Putaala Jukka
- Puurunen Marja K
- Rabionet Raquel
- Rannikmae Kristiina
- Reiner Alexander
- Reiner Alexander P
- Rexrode Kathryn M
- Riaz Moeen
- Riba-Llena Iolanda
- Ribases Marta
- Ribo Marc
- Rice Kenneth
- Rich Stephen S
- Ridker Paul M
- Rissanen Ina L
- Rolfs Arndt
- Romero Jose R
- Roquer Jaume
- Rosand Jonathan
- Rosendaal Frits R
- Roshchupkin Gennady V
- Ross Owen A
- Rost Natalia S
- Rothwell Peter M
- Rotter Jerome I
- Rudd Anthony G
- Ruff Christian T
- Ruigrok Ynte M
- Rundek Tatjana
- Rutten-Jacobs Loes
- Sabatine Marc S
- Sacco Ralph L
- Saillour-Glenisson Florence
- Sakaue Saori
- Sale Michele M
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera Dharambir K
- Sapkota Bishwa R
- Sarfo Fred S
- Sargurupremraj Muralidharan
- Sargurupremraj Muralidharan
- Sarin Antti-Pekka
- Sarju Ralhan
- Sarnowski Chloe
- Sasaki Makoto
- Satizabal Claudia L
- Satoh Mamoru
- Sattar Naveed
- Sawada Norie
- Schmidt Carsten O
- Schmidt Dan
- Schmidt Reinhold
- Schminke Ulf
- Schnohr Peter
- Schnohr Peter
- Segura Tomas
- Serrano-Heras Gemma
- Seshadri Sudha
- Sharma Pankaj
- Shi Mingyang
- Shimizu Atsushi
- Shiroma Eric J
- Sibolt Gerli
- Sigurdsson Asgeir
- Sigurdsson Sigurdur
- Simonsick Eleanor M
- Skogholt Anne H
- Sloane Kelly L
- Slowik Agnieszka
- Smith Albert
- Smith Erin N
- Smith Nicholas L
- Sobrino Tomas
- Sobue Kenji
- Soderholm Martin
- Soriano-Tarraga Carolina
- Srinivasasainagendra Vinodh
- Stanne Tara M
- Stefansson Kari
- Stevens Becky
- Stine O Colin
- Stott David J
- Strauch Konstantin
- Strbian Daniel
- Suchon Pierre
- Sudlow Cathie LM
- Sumoy Lauro
- Sun Yan V
- Sung Yun Ju
- Sutoh Yoichi
- Takai Takako
- Tanaka Hideo
- Tang Weihong
- Tanislav Christian
- Tanno Kozo
- Tatlisumak Turgut
- Taylor Kent D
- Taylor Kent D
- Teumer Alexander
- Thijs Vincent NS
- Thomas Laurent F
- Thomassen Jesper Qvist
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tiainen Marjaana
- Tiedt Steffen
- Tiwari Hemant K
- Tomppo Liisa
- Torres-Aguila Nuria P
- Touze Emmanuel
- Traylor Matthew
- Tregouet David-Alexandre
- Trompet Stella
- Tsugane Shoichiro
- Tuladhar Anil Man
- Turman Constance
- Turnbull Iain
- Tybjaerg-Hansen Anne
- Tzourio Christophe
- Uitterlinden Andre G
- Ungethum Kathrin
- Uvere Ezinne
- Valdimarsson Einar M
- van der Laan Sander W
- van der Lee Sven J
- van Dijk Ewoud J
- van Dijk Ewoud J
- van Dijk Gert W
- van Duijn Cornelia M
- van Hylckama Vlieg Astrid
- van Norden Anouk GW
- van Oostenbrugge Robert J
- van Rooij Frank GW
- van Setten Jessica
- van Setten Jessica
- van Vugt Marion
- van Vugt Marion
- Vaura Felix C
- Verma Shefali S
- Verma Shefali S
- Vermeer Sarah E
- Vibo Riina
- Visser Marieke C
- Vives-Bauza Cristofol
- Volker Uwe
- Volzke Henry
- Vonk Jet MJ
- Wahab Kolawole
- Wakai Kenji
- Walters Matthew
- Walters Robin G
- Wang Chen
- Wang Lu
- Wang Ruiqi
- Wareham Nicholas J
- Wassertheil-Smoller Sylvia
- Weir David
- Wennberg Patrik
- Wermer Marieke JH
- Wiggins Kerri L
- Willer Cristen J
- Williams Stephen R
- Wilson James G
- Wilson Peter WF
- Winsvold Bendik Slagsvold
- Wolfe Charles DA
- Wong Quenna
- Woo Daniel
- Worrall Bradford B
- Xu Huichun
- Yaffe Kristine
- Yamaji Taiki
- Yang Chaojie
- Yang Chengran
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu Canqing
- Yusuf Salim
- Zand Ramin
- Zhou Wei
- Zonderman Alan B
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries
Modelling human choices: MADeM and decision‑making
- Author
- Abbasi Samira
- Abbasi Samira
- Ahmad Subutai
- Ahn Sungwoo
- Aldrovandi Silvio
- Alexander William
- Ali Rehman
- Amaducci Rodrigo
- Andermann Martin
- Anderson William S.
- Andras Peter
- Andreassen Ole A
- Andreassen Ole A.
- Angulo Sergio L
- Antic Srdjan D
- Antolík Jan
- Arleo Angelo
- Asada Minoru
- Ashby Michael C
- Azizi Amir Hossein
- Babaie Tahereh
- Bakker Rembrandt
- Balaguer-Ballester Emili
- Barkat Tania R.
- Barri Alessandro
- Bauermeister Christoph
- Bayati Mehdi
- Beeman David
- Beggs John
- Beier Julia
- Belić Jovana J.
- Berdondini Luca
- Berg Rune W.
- Bernard Christophe
- Bernard Christophe
- Bernardi Davide
- Bernardi Davide
- Bettella Francesco
- Blackwell Kim T.
- Blumberger Daniel M.
- Boahen Frank
- Boatman-Reich Dana
- Boi Fabio
- Boothe David L.
- Boothe David L.
- Braun Jochen
- Bridger Emma
- Brochier Thomas
- Brunel Nicolas
- Bryson Alexander
- Buchin Anatoly
- Buhry Laure
- Burkitt Anthony N.
- Butera Robert
- Bächle Johanna
- Calabrese Ronald L.
- Campo Adria Tauste
- Canals Santiago
- Carrillo Richard R.
- Casali Stefano
- Casellato Claudia
- Cazé Romain D
- Chauhan Ankur
- Chen Nan-yow
- Chen Nan-Yow
- Cheng Sen
- Chiappalone Michela
- Chien Shih-Cheng
- Chizhov Anton
- Chizhov Anton V.
- Choi Woochul
- Christensen Rasmus K.
- Chuang Chao-Chun
- Coca Daniel
- Cohen Charles C.
- Courtiol Julie
- Covolan Roberto J. M.
- Crone Joshua C.
- Crone Joshua C.
- Cronin Joseph T
- Cui Yuwei
- Cumming Ben
- Curio Gabriel
- Cymbalyuk Gennady
- Dabrovska Paulina
- Dahmen David
- Dale Anders M.
- Daskalakis Zafiris J.
- Daun Silvia
- Dave Austin I.
- Davey Catherine E
- Davison Andrew P.
- De Curtis Marco
- De Weerd Peter
- Deco Gustavo
- Deeba Farah
- Denker Michael
- Deraeve James
- Desrosiers Patrick
- Destexhe Alain
- Devor Anna
- Di Marco Stefano
- Diaz-Pier Sandra
- Diba Kamran
- Diesmann Markus
- Diggelmann Roland
- DiGregorio David A.
- Dijkstra Tjeerd M.H.
- Dimitrov Alexander G.
- Ditlevsen Susanne
- Djurovic Srdjan
- Doloc-Mihu Anca
- Doncieux Stéphane
- Dorman Daniel B.
- Dornas João V.
- Doyon Nicolas
- Doyon Nicolas
- Drach Andrew
- Drakesmith Mark
- Dubé Louis J.
- Dumont Grégory
- Dura-Bernal Salvador
- Durstewitz Daniel
- D’Angelo Egidio
- Einevoll Gaute T.
- Eipert Peter
- Eleonora Russo
- Eriksson Olivia
- Ernst Udo
- Ernst Udo A
- Etienne Benjamin Xavier
- Farzan Faranak
- Fedorov Leonid A.
- Fellin Tommaso
- Felton Jr Melvin A.
- Felton Melvin A.
- Feng Yeqian
- Fink Gereon R.
- Fiscella Michele
- Florescu Dorian
- Forlim Caroline Garcia
- Formisano Elia
- Franaszczuk Piotr
- Franke Felix
- Franke Felix
- Frohlich Flavio
- Frègnac Yves
- Fuchs Marie
- Furber Steve
- Gallinat Jürgen
- Garrido Jesús A.
- Geminiani Alice
- Genovesio Aldo
- Gentiletti Damiano
- Giaffar Hamza
- Giemsa Patrick
- Giese Martin A
- Gilson Matthieu
- Giovannini Francesco
- Girard Benoît
- Giugliano Michele
- Glomb Katharina
- Gnatkovski Vadym
- Goedeke Sven
- Goedeke Sven
- Gong Pulin
- Graham Joe W.
- Grayden David B
- Grayden David B.
- Grefkes Christian
- Gros Claudius
- Grzymisch Axel
- Grün Sonja
- Grün Sonja
- Gu Yifan
- Guarino Domenico
- Guillamon Antoni
- Gunay Cengiz
- Gutkin Boris
- Gutkin Boris S
- Hadjinicolaou Alex
- Hadrava Michal
- Hagen Espen
- Halgren Eric
- Halnes Geir
- Halnes Geir
- Harnack Daniel
- Hatano Naomichi
- Havela Riikka
- Hawkins Jeff
- Heck Detlef H.
- Helias Moritz
- Helms Jessica
- Henderson James A.
- Hennig Matthias H.
- Heuer Katja
- Hierlemann Andreas
- Hierlemann Andreas
- Hill Sean
- Hlinka Jaroslav
- Hock Howard
- Hopkins Michael
- Horner Marc
- Hosaka Ryosuke
- Houghton Conor
- Huberfeld Gilles
- Hudson Amber E.
- Hunt C. Anthony
- Huth Jacob
- Iannella Nicolangelo
- Iavarone Elisabetta
- Iavarone Elisabetta
- Ibbotson Michael R
- Ichinose Koki
- Ikeda Kazushi
- Imperatore Julia
- Inkpen Felicity H.
- Inoue Katsuma
- Inoue Takao
- Insabato Andrea
- Isope Philippe
- Jaeger Dieter
- Jang Hyun Jae
- Jang Jaeson
- Janušonis Skirmantas
- Jauhiainen Alexandra
- Jenssen Jörg
- Jirsa Viktor K
- Jones Derek K
- Jędrzejewska-Szmek Joanna
- Kadir Kanar
- Kambhampati Chandra
- Kameneva Tatiana
- Kameneva Tatiana
- Kamps Marc de
- Karakasis Vasileios
- Karbowski Jan
- Karnitzki Adrian
- Kawai Yuji
- Kaya Zeynep Gokcen
- Kempter Richard
- Kepple Daniel
- Keren Hanna
- Kerr Cliff C.
- Kerr Clifford Charles
- Keup Christian
- Kheradpisheh Saeed Reza
- Kida Hiroyuki
- Kim Chang Sub
- Kim Hojeong
- Kiselnikov Andrey A
- Kitano Katsunori
- Klijn Wouter
- Klishko Alexander N.
- Klock Leonie
- Klooster Jan
- Klünker Ann-Christin
- Knock Stuart A.
- Knösche Thomas R.
- Kole Maarten H.P.
- Kopell Nancy J
- Korvasová Karolína
- Kotaleski Jeanette H
- Kotaleski Jeanette Hellgren
- Kotsakidis Rebecca
- Koulakov Alex
- Kozlovskiy Stanislav A
- Kramer Andrei
- Krull Florian
- Kubo Takatomi
- Kuch Lena
- Kudela Pawel
- Kuhn Bernd
- Kulvicius Tomas
- Kumar Arvind
- Kuniyoshi Yasuo
- Kwag Jeehyun
- Kühn Simone
- Kühn Tobias
- Lai Yi Ming
- Lakretz Yair
- Lam K. P.
- Lamb Damon
- Langlet Clément
- Launey Thomas
- Laurence Edward
- Lavin Antonieta
- Lee Hyeonsu
- Lee Joel
- Lee Ray X.
- Lefebvre Jérémie
- Lepora Nathan F
- Lessmann Felix
- Lester David R
- Lewis John E.
- Li Lily W.
- Li Yinyun
- Lillo Davide
- Lim Sukbin
- Lindner Benjamin
- Lindén Henrik
- Linne Marja-Leena
- Lizier Joseph
- Lonardoni Davide
- Longtin Andre
- Lu Huanxiang
- Luque Niceto R.
- Lytton William W.
- López-Madrona Víctor J.
- Maccione Alessandro
- Maess Burkhard
- Mana PierGianLuca
- Maninen Tiina
- Marakshina Julia A
- Marcos Encarni
- Markram Henry
- Masoli Stefano
- Masoli Stefano
- Masquelier Timothée
- Matias Fernanda S.
- Mattia Maurizio
- Mavritsaki Eirini
- Mayberg Helen
- Meffin Hamish
- Meffin Hamish
- Meinhardt Jennifer
- Melchior Jan
- Metzner Christoph
- Miles Richard
- Mirasso Claudio R.
- Moerel Michelle
- Molano-Mazón Manuel
- Montag Christiane
- Mori Hiroki
- Morrison Tina
- Muddapu Vignayanandam R
- Mulugeta Lealem
- Muñiz Carlos
- Myers Jr. Jerry G.
- Mäki-Marttunen Tuomo
- Mäki-Marttunen Tuomo
- Nakamura Mari
- Naveros Francisco
- Naveros Francisco
- Neklyudova Anastasia A.
- Ness Torbjørn V
- Neymotin Samuel A
- Novikov Nikita A.
- Næss Solveig
- Ohmura Yoshiyuki
- Oie Kelvin
- Oie Kelvin S.
- Olenik Mark
- Oprisan Sorinel A.
- O’Reilly Christian
- Paik Se-Bum
- Pallarés Vicente
- Panzeri Stefano
- Park Jihoon
- Park Youngjin
- Parker Jessica
- Pasquale Valentina
- Pedrocchi Alessandra
- Pena Rodrigo F. O.
- Pereda Ernesto
- Perin Rodrigo
- Persike Malte
- Petkoski Spase
- Pettersen Klas H
- Peyser Alexander
- Pica Giuseppe
- Ponce-Alvarez Adrián
- Popovic Marko A.
- Popovych Svitlana
- Powanwe Arthur
- Prilutsky Boris I.
- Qin Wei
- Reyes-Sánchez Manuel
- Riehle Alexa
- Rinberg Dima
- Ritter Petra
- Rizza Martina
- Rizza Martina Francesca
- Roberts Erik A.
- Robinson P. A.
- Robinson Peter
- Rodríguez Francisco B
- Roque Antonio C
- Ros Eduardo
- Rosjat Nils
- Rowley Andrew
- Rubchinsky Leonid L.
- Rupp André
- Ruß Frauke
- Rössert Christian
- Rössert Christian
- Saggio Maria Luisa
- Salvadé Stefano
- Santos Filipa dos
- Santos Joao
- Sanz-Leon Paula
- Saudargiene Ausra
- Schiffer Alina
- Schmidt Dominik
- Schmidt Maximilian
- Schmitt Oliver
- Schoofs Nikola
- Schuecker Jannis
- Schwanke Sebastian
- Sellner Linda
- Senk Johanna
- Shi Ying
- Shi Ying
- Shifman Aaron R.
- Shih Chi-Tin
- Shimono Masanori
- Silveira Rava Azeredo da
- Smirnova Elena Y.
- Soman Karthik
- Song Jun Ho
- Song Min
- Soriano Jaymar
- Spencer Martin J.
- Spiegler Andreas
- Spiegler Andreas
- Srinivasa Chakravarthy V.
- Stacey William C.
- Steele Martin
- Stephens Greg J.
- Sting Louisa
- Stokes Alan B
- Stoll Laura
- Suffczynski Piotr
- Sun Yinming
- Suzuki Junichi
- Suzuki Michiyasu
- Sándor Bulcsú
- Sætra Marte J.
- Tabas Alejandro
- Tam Nicoladie
- Taniguchi Kanako
- Tao Liangyu
- Tauffer Luiz
- Teleńczuk Bartosz
- Tetzlaff Christian
- Tetzlaff Tom
- Tewatia Parul
- Thiele Alexander
- Tiesinga Paul
- Tiruvadi Vineet
- Tomen Nergis
- Tompa Tamas
- Toro Roberto
- Tosi Zach
- Treves Alessandro
- Vadigepalli Rajanikanth
- van Albada Sacha J.
- Van Geit Werner
- Varona Pablo
- Vartanov Alexander V
- Vassena Eliana
- Vellmer Sebastian
- Verbist Christophe
- Vich Catalina
- Viswanathan Shivakumar
- Voges Nicole
- Walton Marlei
- Wernecke Hendrik
- Wiechert Martin T.
- Wiskott Laurenz
- Wong Willy
- Woodman Marmaduke
- Wree Andreas
- Yakimova Elena G
- Yamakawa Toshitaka
- Yates Stuart
- Yi Jane
- Yonekura Shogo
- Yu Alfred B.
- Zadeh Ali Sadegh
- Zandt Bas-Jan
- Zandt Bas-Jan
- Zhang Zhong
- Zucca Stefano
- Zulfiqar Isma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
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- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-Carrascón Víctor
- Cesareni Gianni
- Cha John
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- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
- Chang Alfred E
- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
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- Chen Yu
- Chen Yu
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- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
- Conwell Darwin
- Corrales Leticia P
- Corrales Leticia P
- Coukos George
- Coukos George
- Coussens Lisa M
- Coussens Lisa M
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R
- Cronstein Bruce N
- Crooks James
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- Crowder Robert
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- Dai Fu
- Dai Jie
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- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
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- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
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- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J
- Dietz Allan B
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Donahue Renee
- Dorsey Frank C
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G
- Drake Charles G
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J
- Dubensky Thomas W
- Dubensky Thomas W
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dunai Cordelia
- Dutcher Janice P
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- D’Apuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P
- Edwards Robert P
- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
- Eles Klara
- Ellies Lesley
- Elnaggar Omar
- Elvecrog James
- Emberley Ethan
- Emerling Daniel
- Eng Charis
- Engelhard Victor H
- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
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- Fantini Massimo
- Farkas Emil
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- Faustman Denise
- Fa’ak Faisal
- Fa’ak Faisal
- Femel Julia
- Feng JunLi
- Feng Yan
- Feng Zipei
- Feola Sara
- Fernandez Christian
- Fernando Ingrid
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Fesenkova Valentyna
- Field Jessica J
- Fisher Kerry
- Fisher Terry
- Fitzharris Bernie
- Flano Emilio
- Flechtner Jessica B
- Flies Dallas B
- Flynn Patrick
- Fogler William
- Fong Lawrence
- Formenti Silvia C
- Formenti Silvia C
- Foster Cathie
- Foster Rosemary
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- Frangou Costa
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- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
- Früh Martin
- Fu Yang-Xin
- Fu Yichun
- Fu Yichun
- Fuertes Marraco Silvia A
- Fugle Caroline W
- Fuhrmann Steven
- Fukaya Satoshi
- Fulton Noreen
- Fuoco Claudia
- Fusciello Manlio
- Fuseri Nicolas
- Gabitzsch Elizabeth
- Gabrail Nashat
- Gabrilovich Dmitry
- Gajewski Thomas
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Galeassi Nadejda
- Gamble Alicia
- Gamble Alicia
- Gameiro Sofia
- Gameiro Sofia R
- Gandhi Anita
- Gao Chan
- Gardai Shyra J
- Gardner Kellie
- Gartrell Robyn
- Gartrell Robyn
- Gartrell Robyn
- Gasmi Billel
- Gastineau Dennis A
- Gaughan Elizabeth
- Gauthier Audrey
- Gauthier Kelsey S
- Geissler Michael
- Gergel Ivan
- Geukens Nick
- Gfeller David
- Ghadially Hormas
- Ghamsari Lila
- Ghandi Leena
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- Giaccia Amato
- Gibney Geoffrey
- Giffin Louise
- Gillies Stephen D
- Giri Sanjeev
- Gladstone Douglas
- Glickman Laura H
- Gnad-Vogt Ulrike
- Godwin John
- Gomes Bruno
- Gong Jian
- Gong Jian
- Gonzales Rodney J M
- Gooding William
- Gooding William
- Goodman Reid
- Gopal Ajay
- Gordon Keith
- Gordon Nancy
- Gottschalk Stephen
- Gough Michael
- Gowda Nagaraj
- Goyal Sharad
- Graff Jeremy
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- Graves Edward
- Gray Michael
- Gray Michael
- Greasley Samantha
- Greenberg Norman
- Greiff Lennart
- Greiner John W
- Grenga Italia
- Grenga Italia
- Gressett Monica M
- Griesinger Frank
- Grigoryeva Olga
- Grigsby Iwen
- Grivas Petros
- Grogan Elizabeth W
- Grogan Jane
- Grose Mark
- Grose Mark
- Grose Mark
- Grosh William
- Gross Matt
- Gross Matt
- Grossenbacher Steven K
- Grossmann Kenneth
- Gruber Harry
- Gu Xuemin
- Guenther Garret
- Guerriero Jennifer
- Gugel Elena G
- Guiducci Cristina
- Guirado Elizabeth
- Gulley James L
- Gunatilaka Leslie A A
- Guo Jie
- Guo Zeng-qing
- Gupta Ravi
- Gupta Sachin
- Gupta Sumati
- Gustafson Michael P
- Gutierrez Andres A
- Guttridge Denis
- Guy Emily I
- Guzman Wilson
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- Hallmeyer Sigrun
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- Hardwick James
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- Harris-Bookman Sarah
- Hart Philip
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- Hassan Raffit
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- Havunen Riikka
- Havunen Riikka
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- Haymaker Cara
- Haynes Heather
- Heinze Clinton
- Hellmann Matthew D
- Hellmann Matthew D
- Hellmann Matthew D
- Hellström Ann-Charlotte
- Helming Laura
- Hemmi Silvio
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- Hendrickx Wouter
- Hendrickx Wouter
- Henrich Ian
- Heo Dae S
- Herbert Garth S
- Herbst Ronald
- Heron Dwight
- Herranz Mireia U
- Hess Kenneth R
- Heymach John
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- Hilbe Wolfgang
- Hill Adrian
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- Hill Jonathan A
- Hillringhaus Lars
- Hipp Madeleine
- Hirschhorhn-Cymerman Daniel
- Ho Po
- Hoch Ute
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- Hodge James
- Hodge James
- Hodge James W
- Hodi F. S
- Hodi F. S
- Hodi F. S
- Hofmeister Robert
- Holland Pamela M
- Hollevoet Kevin
- Hollingsworth Robert E
- Hollingsworth Robert E
- Holmgaard Rikke
- Holtzhausen Alisha
- Honarmand Somayeh
- Hong Bang-Xing
- Hong David
- Hong Henoch S
- Hong Peter
- Horst Basil
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- Horvath Szabolcs
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- Huang Fei
- Huang Jing
- Huang Shiang
- Huang Shiang
- Huang Tony
- Huang Yuanhiu
- Huang Yuanhiu
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- Huelsmann Erica
- Huffman Austin P
- Humeau Laurent
- Hunt Donald F
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- Hurt Elaine
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- Hurwitz Michael
- Hutchins Jeff
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- Hwu Wen-Jen
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- Illingworth Sam
- Infante Jeffrey
- Ioffe Ella
- Irmler Martin
- Irving Bryan A
- Irving Bryan A
- Izaki Daisuke
- Jablons David
- Jablonski Sandra
- Jackson Doreen O
- Jackson Natalie
- Jacobson Caron
- Jacques Judy
- Jaen Juan C
- Jaen Juan C
- Jahan Naznin
- Jahan Thierry
- Jaini Ritika
- Jaiswal Ashvin
- Jameson Michael B
- Jang Dadi
- Janku Filip
- Janne Pasi A
- Janssen Louise
- Jarblad-Leja Justyna
- Jeraj Robert
- Jessen Katti
- Jhawar Sachin
- Jhawar Sachin
- Jia Dan T
- Jin Ming
- Johnson Brian
- Johnson Bruce D
- Johnson Karen
- Johnson Melissa L
- Jolly Douglas
- Joly Nathalie
- Jonas Adria
- Jones Frank
- Jones Jeremy
- Jones Sian
- Joshi Bharat H
- Ju Xiaoming
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- Kaiser Stephen
- Kalinski Pawel
- Kalinski Pawel
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- Kallen Karl-Josef
- Kalos Michael
- Kane Lawrence P
- Kanerva Anna
- Kang Kai
- Kangas Takashi O
- Kanne David B
- Kantrowitz Joel
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- Karpathy Roberta
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- Kasler Miklos
- Katibah George
- Katibah George
- Kaufman David R
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
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- Kauh John S
- Kavanaugh W. M
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- Keam Bhumsuk
- Kern Jeffrey
- Khalil Danny N
- Khong Hiep
- Khong Hung
- Khuat Lam T
- Khuat Lam T
- Kibel Adam S
- Kidder Koby
- Kim Chul-Ho
- Kim Dong-Wan
- Kim Dongkyoon
- Kim Seulki
- Kim Seungwon
- Kim Soyeon
- Kim Tae M
- Kindler Hedy L
- Kindt Erick
- Kirk Peter
- Kirksey Yolanda
- Kitaura Kazutaka
- Kleinerman Eugenie S
- Kler Jasdeep
- Kline Justin
- Klinke David J
- Klinkhardt Ute
- Klippel Anke
- Kluger Harriet
- Knapp Alyssa
- Knudson Karin M
- Knudson Karin M
- Koch Sven D
- Kodumudi Krithika
- Kohanbash Gary
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- Komarov Andrey
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- Kortylewski Marcin
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- Kotlan Beatrix
- Koziol Marie E
- Kradjian Giorgio
- Krasovskaia Liudmila
- Kraus Manfred
- Kraynyak Kim
- Krejsa Cecile M
- Krishnan Monica
- Krishnan Suba
- Krisko John
- Kuai Rui
- Kumai Takumi
- Kumar Sushil
- Kumar Sushil
- Kumar Vikas
- Kumar Vikas
- Kung Andrew L
- Kunk Paul R
- Kuo Peiwen
- Kuppen Peter
- Kyruk Lukasz
- Laderas Ted
- Lai Venus
- Lake Andrew C
- Lamble Adam
- Lan Yan
- Lane Ryan
- Langowski John L
- Laport Ginna
- Lauer Peter
- Law Che-Leung
- Lazo Suzan
- Lazorchak Adam S
- Le Dung T
- Lee Dean
- Lee Jessica
- Lee Yu S
- Lehmann Paul
- Leidner Rom
- Leland Pamela
- Leleti Manmohan R
- Leleux Jardin
- Lemmens Edward E
- Lemmens Edward E
- Leonard John E
- Leonard John P
- Leonardo Steven
- Leong Justin L
- Leong Meredith L
- Leong Meredith L
- Lepone Lauren
- Lepone Lauren
- Leshem Jasmin
- Lesinski Gregory B
- Lesinski Gregory B
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- Lessey-Morillon Elizabeth
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- Lifke Alexander
- Lifke Valeria
- Lin Jing
- Lind Evan F
- Lindstedt Malin
- Lipson Evan
- Liszkay Gabriella
- Litton Jennifer
- Liu Bei
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- Lo Kin-Ming
- Loibner Hans
- Long Georgina V
- Longo Dan
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- Loskog Angelica
- Loskog Angelica
- Loskog Angelica
- Lossos Izidore S
- Lowe David
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- Lu Bo
- Lu Shanhong
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- Lu Yan
- Lu Yan
- Lu Yan
- Ludwig Dale
- Ludwug Thomas
- Luke Jason
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- Zeng Xue
- Zha Yuanyuan
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- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
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