5,229 research outputs found
Deciphering the spin of new resonances in Higgsless models
We study the potential of the CERN Large Hadron Collider (LHC) to probe the
spin of new massive vector boson resonances predicted by Higgsless models. We
consider its production via weak boson fusion which relies only on the coupling
between the new resonances and the weak gauge bosons. We show that the LHC will
be able to unravel the spin of the particles associated with the partial
restoration of unitarity in vector boson scattering for integrated luminosities
of 150-560 fb^-1, depending on the new state mass and on the method used in the
analyses.Comment: 7 pages, 4 figures. Version published in Physical Review
Polychronous Interpretation of Synoptic, a Domain Specific Modeling Language for Embedded Flight-Software
The SPaCIFY project, which aims at bringing advances in MDE to the satellite
flight software industry, advocates a top-down approach built on a
domain-specific modeling language named Synoptic. In line with previous
approaches to real-time modeling such as Statecharts and Simulink, Synoptic
features hierarchical decomposition of application and control modules in
synchronous block diagrams and state machines. Its semantics is described in
the polychronous model of computation, which is that of the synchronous
language Signal.Comment: Workshop on Formal Methods for Aerospace (FMA 2009
The fluctuation energy balance in non-suspended fluid-mediated particle transport
Here we compare two extreme regimes of non-suspended fluid-mediated particle
transport, transport in light and heavy fluids ("saltation" and "bedload",
respectively), regarding their particle fluctuation energy balance. From direct
numerical simulations, we surprisingly find that the ratio between collisional
and fluid drag dissipation of fluctuation energy is significantly larger in
saltation than in bedload, even though the contribution of interparticle
collisions to transport of momentum and energy is much smaller in saltation due
to the low concentration of particles in the transport layer. We conclude that
the much higher frequency of high-energy particle-bed impacts ("splash") in
saltation is the cause for this counter-intuitive behavior. Moreover, from a
comparison of these simulations to Particle Tracking Velocimetry measurements
which we performed in a wind tunnel under steady transport of fine and coarse
sand, we find that turbulent fluctuations of the flow produce particle
fluctuation energy at an unexpectedly high rate in saltation even under
conditions for which the effects of turbulence are usually believed to be
small
Rifampicin: biotransformation study using the fungus Cunninghamella elegans and monitoring through UHPLC-MS
Drug biotransformation studies appear as an alternative to pharmacological investigations of metabolites, development of new drug candidates with reduced investment and most efficient production. The objective of this study was to evaluate the capacity of biotransformation of Rifampicin (RIF) by the filamentous fungus Cunninghamella elegans as a microbial model of mammalian metabolism. In 120 h, C. elegans transformed the drug into the following two metabolites: rifampicin quinone and novel metabolite. The products of rifampicin formed in vitro were monitored by HPLC-PDA, being identified through UHPLC–QTOF/MS. Metabolites were characterized according to their chromatographic profile, mass fragments and UV spectral data. The major metabolic pathways of rifampicin transformed by the fungus were oxidation, demethylation and mono-oxidation. The microbial transformation of RIF showed the potential of Cunninghamella species to produce RIF metabolites. This process can be used for a cost effective method for both known and unknown metabolite production
Cotiarinase is a novel prothrombin activator from the venom of Bothrops cotiara
Snake venom serine proteinases (SVSPs) may affect hemostatic pathways by specifically activating components involved in coagulation, fibrinolysis and platelet aggregation or by unspecific proteolytic degradation. in this study, we purified and characterized an SVSP from Bothrops cotiara venom, named cotiarinase, which generated thrombin upon incubation with prothrombin. Cotiarinase was isolated by a two-step procedure including gel-filtration and cation-exchange chromatographies and showed a single protein band with a molecular mass of 29 kDa by SDS-polyacrylamide gel electrophoresis under reducing conditions. Identification of cotiarinase by mass spectrometric analysis revealed peptides that matched sequences of viperid SVSPs. Cotiarinase did not show fibrinogen-clotting, platelet-aggregating, fibrino-genolytic and factor X activating activities. Upon incubation with prothrombin the generation of thrombin was detected using the peptide substrate D-Phe-Pip-Arg-pNA. Moreover, mass spectrometric identification of prothrombin fragments generated by cotiarinase in the absence of co-factors (phospholipids, factor Va, factor Xa and Ca2+ ions), indicated the limited proteolysis of this protein to release prothrombin 1, fragment 1 and thrombin. Cotiarinase is a novel SVSP that acts on prothrombin to release active thrombin that does not match any group of the current classification of snake venom prothrombin activators. (C) 2013 Elsevier Masson SAS. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Inst Butantan, CAT Cepid, Lab Especial Toxinol Aplicada, BR-05503000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, São Paulo, BrazilFAPESP: 98/14307-9FAPESP: 11/08514-8FAPESP: 2011/11308-0Web of Scienc
Алгоритм проведення попередньої дегазації методом гравітаційного знещільнення вуглепородного масиву
Приводится алгоритм проведения предварительной дегазации при применении нового способа гравитационной разгрузки на угольных месторождениях Донбасса и Львовско-Волынского бассейнов. Среди главных эффектов, которые будут получены при внедрении способа – обеспечение безопасности работ на шахтах и промышленная добыча метана.The algorithm of realization of pre-degassing with using new way of gravitational unloading on coal fields of Donbas and Lviv-Volyn basins is given in this article. Guaranteeing of safety works in mines and industrial methane-mining are between main effects which will be got on conditions of application of this method
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