Mechanism of Arctic amplification revealed from the energy flux analysis

第6回極域科学シンポジウム分野横断セッション：[IA] 急変する北極気候システム及びその全球的な影響の総合的解明―GRENE北極気候変動研究事業研究成果報告2015―11月19日（木）　国立極地研究所 2階 大会議

Dark Matter Search Using XMM-Newton Observations of Willman 1

We report the results of a search for an emission line from radiatively decaying dark matter in the ultra-faint dwarf spheroidal galaxy Willman 1 based on analysis of spectra extracted from XMM-Newton X-ray Observatory data. The observation follows up our analysis of Chandra data of Willman 1 that resulted in line flux upper limits over the Chandra bandpass and evidence of a 2.5 keV feature at a significance below the 99% confidence threshold used to define the limits. The higher effective area of the XMM-Newton detectors, combined with application of recently developing methods for extended-source analysis, allow us to derive improved constraints on the combination of mass and mixing angle of the sterile neutrino dark matter candidate. We do not confirm the Chandra evidence for a 2.5 keV emission line.Comment: 23 pages, including 17 figures; accepted for publication in Ap

Imaging in focus: An introduction to denoising bioimages in the era of deep learning

Fluorescence microscopy enables the direct observation of previously hidden dynamic processes of life, allowing profound insights into mechanisms of health and disease. However, imaging of live samples is fundamentally limited by the toxicity of the illuminating light and images are often acquired using low light conditions. As a consequence, images can become very noisy which severely complicates their interpretation. In recent years, deep learning (DL) has emerged as a very successful approach to remove this noise while retaining the useful signal. Unlike classical algorithms which use well-defined mathematical functions to remove noise, DL methods learn to denoise from example data, providing a powerful content-aware approach. In this review, we first describe the different types of noise that typically corrupt fluorescence microscopy images and introduce the denoising task. We then present the main DL-based denoising methods and their relative advantages and disadvantages. We aim to provide insights into how DL-based denoising methods operate and help users choose the most appropriate tools for their applications

Direct thrust measurement of a permanent magnet helicon double layer thruster

Direct thrust measurements of a permanent magnet helicon double layer thruster have been made using a pendulum thrust balance and a high sensitivity laser displacement sensor. At the low pressures used (0.08 Pa) an ion beam is detected downstream of the thruster exit, and a maximum thrust force of about 3 mN is measured for argon with an rf input power of about 700 W. The measured thrust is proportional to the upstream plasma density and is in good agreement with the theoretical thrust based on the maximum upstream electron pressure

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.

New strategies for visualizing self-assembly processes at the nanoscale give deep insights into the molecular origins of disease. An example is the self-assembly of misfolded proteins into amyloid fibrils, which is related to a range of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. Here, we probe the links between the mechanism of α-synuclein (AS) aggregation and its associated toxicity by using optical nanoscopy directly in a neuronal cell culture model of Parkinson's disease. Using superresolution microscopy, we show that protein fibrils are taken up by neuronal cells and act as prion-like seeds for elongation reactions that both consume endogenous AS and suppress its de novo aggregation. When AS is internalized in its monomeric form, however, it nucleates and triggers the aggregation of endogenous AS, leading to apoptosis, although there are no detectable cross-reactions between externally added and endogenous protein species. Monomer-induced apoptosis can be reduced by pretreatment with seed fibrils, suggesting that partial consumption of the externally added or excess soluble AS can be significantly neuroprotective.We thank Dr Q. Jeng and Dr A. Stephens for technical assistance and Dr J. Skepper for TEM imaging. This work was funded by grants from the U.K. Medical Research Council (MR/K015850/1 and MR/K02292X/1), Alzheimer’s Research UK (ARUK-EG2012A-1), U.K. Engineering and Physical Sciences Research Council (EPSRC) (EP/H018301/1) and the Wellcome Trust (089703/Z/09/Z). D.P. wishes to acknowledge support from the Swiss National Science Foundation and the Wellcome Trust through personal fellowships. A.K.B thanks Magdalene College, Cambridge and the Leverhulme Trust for support.This is the author accepted manuscript. The final version is available from the National Academy of Sciences via http://dx.doi.org/10.1073/pnas.1516546113

New Limits on Sterile Neutrinos from Suzaku Observations of the Ursa Minor Dwarf Spheroidal Galaxy

We present results of our search for X-ray line emission associated with the radiative decay of the sterile neutrino, a well-motivated dark matter candidate, in Suzaku Observatory spectra of the Ursa Minor dwarf spheroidal galaxy. These data represent the first deep observation of one of these extreme mass-to-light systems and the first dedicated dark matter search using an X-ray telescope. No such emission line is positively detected, and we place new constraints on the combination of the sterile neutrino mass and the active-sterile neutrino oscillation mixing angle. Line flux upper limits are derived using a maximum-likelihood-based approach that, along with the lack of intrinsic X-ray emission, enables us to minimize systematics and account for those that remain. The limits we derive match or approach the best previous results over the entire 1--20 keV mass range from a single Suzaku observation. These are used to place constraints on the existence of sterile neutrinos with given parameters in the general case and in the case where they are assumed to constitute all of the dark matter. The range allowed implies that sterile neutrinos remain a viable candidate to make up some -- or all -- of the dark matter and also explain pulsar kicks and various other astrophysical phenomena.Comment: revised to closely match version to be published in ApJ v. 69

Technology-Supported Guidance Models Stimulating the Development of Critical Thinking in Clinical Practice: Mixed Methods Systematic Review

publishedVersio

Understanding the ecology and evolution of host-parasite interactions across scales

Predicting the emergence, spread and evolution of parasites within and among host populations requires insight to both the spatial and temporal scales of adaptation, including an understanding of within-host up through community-level dynamics. Although there are very few pathosystems for which such extensive data exist, there has been a recent push to integrate studies performed over multiple scales or to simultaneously test for dynamics occurring across scales. Drawing on examples from the literature, with primary emphasis on three diverse host-parasite case studies, we first examine current understanding of the spatial structure of host and parasite populations, including patterns of local adaptation and spatial variation in host resistance and parasite infectivity. We then explore the ways to measure temporal variation and dynamics in host-parasite interactions and discuss the need to examine change over both ecological and evolutionary timescales. Finally, we highlight new approaches and syntheses that allow for simultaneous analysis of dynamics across scales. We argue that there is great value in examining interplay among scales in studies of host-parasite interactions.Peer reviewe

A dilemma of the uniqueness of weather and climate model closure parameters

Peer reviewe