Programming the attitude control of a CubeSat for simulation of LEO orbit space missions

Primarily, this work is part of the PLATHON project, which is an integrated simulation platform with hardware in the loop of space missions for communications between ground stations and nanosatellites, where these missions can be designed, analyzed, and evaluated by a constellation of CubeSats in LEO orbits. This project is centered on the implementation of a 1DoF attitude control of a CubeSat laboratory prototype based on a reaction wheel from a certain angle transmitted wirelessly to an electronic board based on the STM32 microcontroller, in particular, a development board known as Blue Pill. It should be noted that this work is based on Daniel Castillo Bonillo’s [1], Adrià Pérez Fernández’s [2], Yi Qiang Ji Zhang’s [3], and Joan Serrano’s [4] previous work. This project’s major goal is to add new innovations, such as a new motor to drive the wheel more steadily, precisely, and with less vibration. This goal requires a new motor driver as well as the development of new control algorithms

Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children

The uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism and a decline in renal excretion. Despite of solid experimental evidence for nephrotoxic effects, the impact of uremic toxins on the progression of CKD has not been investigated in representative patient cohorts. In this analysis, IS and pCS serum concentrations were measured in 604 pediatric participants (mean eGFR of 27 ± 11 ml/min/1.73m2) at enrolment into the prospective Cardiovascular Comorbidity in Children with CKD study. Associations with progression of CKD were analyzed by Kaplan-Meier analyses and Cox proportional hazard models. During a median follow up time of 2.2 years (IQR 4.3-0.8 years), the composite renal survival endpoint, defined as 50% loss of eGFR, or eGFR <10ml/min/1.73m2 or start of renal replacement therapy, was reached by 360 patients (60%). Median survival time was shorter in patients with IS and pCS levels in the highest versus lowest quartile for both IS (1.5 years, 95%CI [1.1,2.0] versus 6.0 years, 95%CI [5.0,8.4]) and pCS (1.8 years, 95%CI [1.5,2.8] versus 4.4 years, 95%CI [3.4,6.0]). Multivariable Cox regression disclosed a significant association of IS, but not pCS, with renal survival, which was independent of other risk factors including baseline eGFR, proteinuria and blood pressure. In this exploratory analysis we provide the first data showing a significant association of IS, but not pCS serum concentrations with the progression of CKD in children, independent of other known risk factors. In the absence of comorbidities, which interfere with serum levels of uremic toxins, such as diabetes, obesity and metabolic syndrome, these results highlight the important role of uremic toxins and accentuate the unmet need of effective elimination strategies to lower the uremic toxin burden and abate progression of CKD

The Amsterdam Declaration on Fungal Nomenclature

The Amsterdam Declaration on Fungal Nomenclature was agreed at an international symposium convened in Amsterdam on 19–20 April 2011 under the auspices of the International Commission on the Taxonomy of Fungi (ICTF). The purpose of the symposium was to address the issue of whether or how the current system of naming pleomorphic fungi should be maintained or changed now that molecular data are routinely available. The issue is urgent as mycologists currently follow different practices, and no consensus was achieved by a Special Committee appointed in 2005 by the International Botanical Congress to advise on the problem. The Declaration recognizes the need for an orderly transitition to a single-name nomenclatural system for all fungi, and to provide mechanisms to protect names that otherwise then become endangered. That is, meaning that priority should be given to the first described name, except where that is a younger name in general use when the first author to select a name of a pleomorphic monophyletic genus is to be followed, and suggests controversial cases are referred to a body, such as the ICTF, which will report to the Committee for Fungi. If appropriate, the ICTF could be mandated to promote the implementation of the Declaration. In addition, but not forming part of the Declaration, are reports of discussions held during the symposium on the governance of the nomenclature of fungi, and the naming of fungi known only from an environmental nucleic acid sequence in particular. Possible amendments to the Draft BioCode (2011) to allow for the needs of mycologists are suggested for further consideration, and a possible example of how a fungus only known from the environment might be described is presented

Impact de la ténascine-C sur l’immunité anti-tumorale dans un modèle de progression tumoral mammaire

La ténascine-C (TNC) est une protéine matricielle favorisant la progression tumorale et le développement de métastases, et son expression élevée chez les patients atteints de cancer est corrélée à un mauvais pronostic. Durant ma thèse j’ai étudié l’impact de la TNC sur l’immunité anti-tumorale en utilisant le modèle murin MMTV-NeuNT et le modèle de greffe orthotopique syngénique de cellules cancéreuses mammaires NT193. Nos résultats ont montré que la TNC empêche une action efficace de la réponse anti-tumorale en séquestrant les lymphocytes T CD8+ dans les réseaux de matrice, ceci en faisant intervenir la voie de signalisation CXCL12/CXCR4. L’inhibition de CXCR4 permet l’infiltration des lymphocytes T CD8+ dans la niche tumorale et augmente le nombre de cellules cancéreuses en apoptose menant ainsi à une régression tumorale. D’autre part, l’établissement d’une nouvelle lignée de cellules tumorales mammaires nous a permis de montrer que la TNC peut également avoir un rôle opposé et favoriser le rejet des cellules tumorales dans la phase initiale du développement tumoral post greffe. Les mécanismes sous-jacents restent cependant à être élucider. Enfin, nos premiers résultats sur cette lignée cellulaire montre que la TNC induit l’expression de NKG2DL dans cette lignée suggérant ainsi que la TNC a un lien avec l’axe NKG2D/NKG2DL dont l’impact sur le développement tumoral reste à établir.Tenascin-C is an extracellular matrix protein promoting tumor progression and metastasis development, and its expression in cancer patients correlates with poor prognosis. During my thesis I studied the impact of TNC on anti-tumor immunity using the MMTV-NeuNT mouse model and a syngeneic orthotopic grafting model based on the NT193 breast cancer cell line. Our results showed that TNC impairs the anti-tumor immune response by sequestrating CD8+ T lymphocytes in the tumor matrix tracks involving CXCL12/CXCR4 signaling. Inhibition of CXCR4 enables the infiltration of CD8+ T lymphocytes into the tumor cell nest and increases tumor cell death. Moreover, the establishment of a novel breast cancer cell line enabled us to show that TNC can also have an opposite effect inducing tumor cell rejection in the early phase of tumor development after engraftment. The underlying mechanisms remain to be elucidated. Finally, our first results show that TNC regulates NKG2DL in this new cancer cell line suggesting that TNC has a link with the NKG2D/NKG2DL whose impact on tumor development has to be further studied

Impact de la ténascine-C sur l’immunité anti-tumorale dans un modèle de progression tumoral mammaire

La ténascine-C (TNC) est une protéine matricielle favorisant la progression tumorale et le développement de métastases, et son expression élevée chez les patients atteints de cancer est corrélée à un mauvais pronostic. Durant ma thèse j’ai étudié l’impact de la TNC sur l’immunité anti-tumorale en utilisant le modèle murin MMTV-NeuNT et le modèle de greffe orthotopique syngénique de cellules cancéreuses mammaires NT193. Nos résultats ont montré que la TNC empêche une action efficace de la réponse anti-tumorale en séquestrant les lymphocytes T CD8+ dans les réseaux de matrice, ceci en faisant intervenir la voie de signalisation CXCL12/CXCR4. L’inhibition de CXCR4 permet l’infiltration des lymphocytes T CD8+ dans la niche tumorale et augmente le nombre de cellules cancéreuses en apoptose menant ainsi à une régression tumorale. D’autre part, l’établissement d’une nouvelle lignée de cellules tumorales mammaires nous a permis de montrer que la TNC peut également avoir un rôle opposé et favoriser le rejet des cellules tumorales dans la phase initiale du développement tumoral post greffe. Les mécanismes sous-jacents restent cependant à être élucider. Enfin, nos premiers résultats sur cette lignée cellulaire montre que la TNC induit l’expression de NKG2DL dans cette lignée suggérant ainsi que la TNC a un lien avec l’axe NKG2D/NKG2DL dont l’impact sur le développement tumoral reste à établir.Tenascin-C is an extracellular matrix protein promoting tumor progression and metastasis development, and its expression in cancer patients correlates with poor prognosis. During my thesis I studied the impact of TNC on anti-tumor immunity using the MMTV-NeuNT mouse model and a syngeneic orthotopic grafting model based on the NT193 breast cancer cell line. Our results showed that TNC impairs the anti-tumor immune response by sequestrating CD8+ T lymphocytes in the tumor matrix tracks involving CXCL12/CXCR4 signaling. Inhibition of CXCR4 enables the infiltration of CD8+ T lymphocytes into the tumor cell nest and increases tumor cell death. Moreover, the establishment of a novel breast cancer cell line enabled us to show that TNC can also have an opposite effect inducing tumor cell rejection in the early phase of tumor development after engraftment. The underlying mechanisms remain to be elucidated. Finally, our first results show that TNC regulates NKG2DL in this new cancer cell line suggesting that TNC has a link with the NKG2D/NKG2DL whose impact on tumor development has to be further studied

Grammatical, lexical and phonological control by adults learning Turkish : a corpus-based approach to expanding the Can Do descriptors in the Common European Framework of Reference for Languages

THESIS 11073.1THESIS 11073.2This thesis investigates the grammatical, lexical and phonological control of adult Turkish students in order to provide better understanding of the Turkish language development in second language learners. It aims to investigate how the scaled descriptors for spoken production in the Common European Framework of Languages (Council of Europe, 2001) for grammatical lexical and phonological control could be expanded specifically for learning Turkish at A1 and A2 beginner proficiency levels. Finally, in turn it suggests an adapted set of learning scales specifically designed for Turkish language learners regarding grammatical lexical and phonological control based on the empirical data collected amongst Turkish language learners over an academic year

Orthodontic Treatment of a Bilateral Mandibuar Latera Incisor-Canine Transposition

Transposition is a form of ectopia, in which two adjacent feeth change positions in the dental arch. It can be partial or complete. Transpositions are a challenge to orthodontics, especially if treatment aims to correct the order of the teeth. The aim of this case report was to present the treatment of a patient who had bilaterfly transposed mandibular lateral incisor and canine teeth