CO J=2-1 line emission in cluster galaxies at z~1: fueling star formation in dense environments

We present observations of CO J=2-1 line emission in infrared-luminous cluster galaxies at z~1 using the IRAM Plateau de Bure Interferometer. Our two primary targets are optically faint, dust-obscured galaxies (DOGs) found to lie within 2 Mpc of the centers of two massive (>10^14 Msun) galaxy clusters. CO line emission is not detected in either DOG. We calculate 3-sigma upper limits to the CO J=2-1 line luminosities, L'_CO < 6.08x10^9 and < 6.63x10^9 K km/s pc^2. Assuming a CO-to-H_2 conversion factor derived for ultraluminous infrared galaxies in the local Universe, this translates to limits on the cold molecular gas mass of M_H_2 < 4.86x10^9 Msun and M_H_2 < 5.30x10^9 Msun. Both DOGs exhibit mid-infrared continuum emission that follows a power-law, suggesting that an AGN contributes to the dust heating. As such, estimates of the star formation efficiencies in these DOGs are uncertain. A third cluster member with an infrared luminosity, L_IR < 7.4x10^11 Lsun, is serendipitously detected in CO J=2-1 line emission in the field of one of the DOGs located roughly two virial radii away from the cluster center. The optical spectrum of this object suggests that it is likely an obscured AGN, and the measured CO line luminosity is L'_CO = (1.94 +/- 0.35)x10^10 K km/s pc^2, which leads to an estimated cold molecular gas mass M_H_2 = (1.55+/-0.28)x10^10 Msun. A significant reservoir of molecular gas in a z~1 galaxy located away from the cluster center demonstrates that the fuel can exist to drive an increase in star-formation and AGN activity at the outskirts of high-redshift clusters.Comment: 22 pages, 4 figures; accepted for publication in Ap

Star Formation and AGN Activity in Galaxy Clusters from z=1−2z=1-2: a Multi-wavelength Analysis Featuring HerschelHerschel/PACS

We present a detailed, multi-wavelength study of star formation (SF) and AGN activity in 11 near-infrared (IR) selected, spectroscopically confirmed, massive ($\gtrsim10^{14}\,\rm{M_{\odot}}$) galaxy clusters at $1<z<1.75$. Using new, deep $Herschel$/PACS imaging, we characterize the optical to far-IR spectral energy distributions (SEDs) for IR-luminous cluster galaxies, finding that they can, on average, be well described by field galaxy templates. Identification and decomposition of AGN through SED fittings allows us to include the contribution to cluster SF from AGN host galaxies. We quantify the star-forming fraction, dust-obscured SF rates (SFRs), and specific-SFRs for cluster galaxies as a function of cluster-centric radius and redshift. In good agreement with previous studies, we find that SF in cluster galaxies at $z\gtrsim1.4$ is largely consistent with field galaxies at similar epochs, indicating an era before significant quenching in the cluster cores ($r<0.5\,$Mpc). This is followed by a transition to lower SF activity as environmental quenching dominates by $z\sim1$. Enhanced SFRs are found in lower mass ($10.1< \log \rm{M_{\star}}/\rm{M_{\odot}}<10.8$) cluster galaxies. We find significant variation in SF from cluster-to-cluster within our uniformly selected sample, indicating that caution should be taken when evaluating individual clusters. We examine AGN in clusters from $z=0.5-2$, finding an excess AGN fraction at $z\gtrsim1$, suggesting environmental triggering of AGN during this epoch. We argue that our results $-$ a transition from field-like to quenched SF, enhanced SF in lower mass galaxies in the cluster cores, and excess AGN $-$ are consistent with a co-evolution between SF and AGN in clusters and an increased merger rate in massive haloes at high redshift.Comment: 26 pages, 14 figures, 6 tables with appendix, accepted for publication in the Astrophysical Journa

Infanticide and infant defence by males--modelling the conditions in primate multi-male groups

Infanticide by primate males was considered rare if groups contain more than one adult male because, owing to lower paternity certainty, a male should be less likely to benefit from infanticide. Guided by recent evidence for strong variation of infanticide in primate multi-male groups, we modelled the conditions for when infanticide should occur for a group with a resident and an immigrant male. Setting the parameters (e.g. infant mortality, reduction of interbirth interval, life-time reproductive success, genetic representation) to fit the conditions most commonly found in nature, we develop a game-theoretic model to explore the influence of age and dominance on the occurrence of infanticide and infant defence. Male age strongly impacts the likelihood of an attack which is modified by the father's defence. If the new male is dominant he is likely to attack under most circumstances whereas a subordinate male will only attack if the father does not defend. These model scenarios fit the conditions under which infanticide is known to occur in primate multi-male groups and offer an explanation why infanticide is common in some multi-male groups and rare in others. Overall, the benefits for infanticidal males are strongly governed by a reduced interbirth interval while advantages via improved genetic representation in the gene pool contribute but a minor fraction

The evolution of dust-obscured star formation activity in galaxy clusters relative to the field over the last 9 billion years

We compare the star formation (SF) activity in cluster galaxies to the field from z=0.3-1.5 using $Herschel$ SPIRE 250$\mu$m imaging. We utilize 274 clusters from the IRAC Shallow Cluster Survey (ISCS) selected as rest-frame near-infrared overdensities over the 9 square degree Bootes field . This analysis allows us to quantify the evolution of SF in clusters over a long redshift baseline without bias against active cluster systems. Using a stacking analysis, we determine the average star formation rates (SFRs) and specific-SFRs (SSFR=SFR/M$_{\star}$) of stellar mass-limited (M>1.3x10$^{10}$ M$_{\odot}$), statistical samples of cluster and field galaxies, probing both the star forming and quiescent populations. We find a clear indication that the average SF in cluster galaxies is evolving more rapidly than in the field, with field SF levels at z>1.2 in the cluster cores (r<0.5 Mpc), in good agreement with previous ISCS studies. By quantifying the SF in cluster and field galaxies as an exponential function of cosmic time, we determine that cluster galaxies are evolving ~2 times faster than the field. Additionally, we see enhanced SF above the field level at z~1.4 in the cluster outskirts (r>0.5 Mpc). These general trends in the cluster cores and outskirts are driven by the lower mass galaxies in our sample. Blue cluster galaxies have systematically lower SSFRs than blue field galaxies, but otherwise show no strong differential evolution with respect to the field over our redshift range. This suggests that the cluster environment is both suppressing the star formation in blue galaxies on long time-scales and rapidly transitioning some fraction of blue galaxies to the quiescent galaxy population on short time-scales. We argue that our results are consistent with both strangulation and ram pressure stripping acting in these clusters, with merger activity occurring in the cluster outskirts.Comment: 23 pages, 11 figures, 5 tables. Accepted for publication in MNRA

An Investigation of Performance Appraisal With Recommendations for White Collar and Blue Collar Workers

The accurate evaluation of an employee\u27s performance, whether it be a salary or wage worker, is one of the most challenging problems confronting any organization. According to Lazer (1977), which is still true today, performance appraisal is absolutely necessary if an organization is to prosper in the highly competitive world of modern business. Regardless of all that has been written about the how and why of performance appraisal, there still seems to be constant problems and areas of clear disagreement. Published writings about performance appraisal cover approximately the past 30 years and deal mostly with private corporations. Before that, performance appraisal systems were used in the public sector, but the guidelines for their development and use were not widely circulated. As organizations developed and became larger, a discreet and persistent ethic evolved. This ethic said that if we grow, we ought to know more about whom to select, how to supervise, and how to assess performance for promotion and salary decisions. What had once been an informal process, with a good amount of flexibility, had to be changed and standardized for use with more employees at all levels in the organization (Keil, 1977)

Hopf bifurcation in a gene regulatory network model:Molecular movement causes oscillations

Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse a mathematical model of a canonical gene regulatory network consisting of a single negative feedback loop between a protein and its mRNA (e.g. the Hes1 transcription factor system). The model consists of two partial differential equations describing the spatio-temporal interactions between the protein and its mRNA in a 1-dimensional domain. Such intracellular negative feedback systems are known to exhibit oscillatory behaviour and this is the case for our model, shown initially via computational simulations. In order to investigate this behaviour more deeply, we next solve our system using Green's functions and then undertake a linearized stability analysis of the steady states of the model. Our results show that the diffusion coefficient of the protein/mRNA acts as a bifurcation parameter and gives rise to a Hopf bifurcation. This shows that the spatial movement of the mRNA and protein molecules alone is sufficient to cause the oscillations. This has implications for transcription factors such as p53, NF-$\kappa$B and heat shock proteins which are involved in regulating important cellular processes such as inflammation, meiosis, apoptosis and the heat shock response, and are linked to diseases such as arthritis and cancer

Heterogeneity of State Stroke Center Certification and Designation Processes.

BACKGROUND: Stroke centers are critical for the timely diagnosis and treatment of acute stroke and have been associated with improved treatment and outcomes; however, variability exists in the definitions and processes used to certify and designate these centers. Our study categorizes state stroke center certification and designation processes and provides examples of state processes across the United States, specifically in states with independent designation processes that do not rely on national certification. METHODS: In this cross-sectional study from September 2022 to April 2023, we used peer-reviewed literature, primary source documents from states, and communication with state officials in all 50 states to capture each states process for stroke center certification and designation. We categorized this information and outlined examples of processes in each category. RESULTS: Our cross-sectional study of state-level stroke center certification and designation processes across states reveals significant heterogeneity in the terminology used to describe state processes and the processes themselves. We identify 3 main categories of state processes: No State Certification or Designation Process (category A; n=12), State Designation Reliant on National Certification Only (category B; n=24), and State Has Option for Self-Certification or Independent Designation (category C; n=14). Furthermore, we describe 3 subcategories of self-certification or independent state designation processes: State Relies on Self-Certification or Independent Designation for Acute Stroke Ready Hospital or Equivalent (category C1; n=3), State Has Hybrid Model for Acute Stroke Ready Hospital or Equivalent (category C2; n=5), and State Has Hybrid Model for Primary Stroke Center and Above (category C3; n=6). CONCLUSIONS: Our study found significant heterogeneity in state-level processes. A better understanding of how these differences may impact the rigor of each process and clinical performance of stroke centers is worthy of further investigation

A meta-analysis of long-term effects of conservation agriculture on maize grain yield under rain-fed conditions

Conservation agriculture involves reduced tillage, permanent soil cover and crop rotations to enhance soil fertility and to supply food from a dwindling land resource. Recently, conservation agriculture has been promoted in Southern Africa, mainly for maize-based farming systems. However, maize yields under rain-fed conditions are often variable. There is therefore a need to identify factors that influence crop yield under conservation agriculture and rain-fed conditions. Here, we studied maize grain yield data from experiments lasting 5 years and more under rain-fed conditions. We assessed the effect of long-term tillage and residue retention on maize grain yield under contrasting soil textures, nitrogen input and climate. Yield variability was measured by stability analysis. Our results show an increase in maize yield over time with conservation agriculture practices that include rotation and high input use in low rainfall areas. But we observed no difference in system stability under those conditions. We observed a strong relationship between maize grain yield and annual rainfall. Our meta-analysis gave the following findings: (1) 92% of the data show that mulch cover in high rainfall areas leads to lower yields due to waterlogging; (2) 85% of data show that soil texture is important in the temporal development of conservation agriculture effects, improved yields are likely on well-drained soils; (3) 73% of the data show that conservation agriculture practices require high inputs especially N for improved yield; (4) 63% of data show that increased yields are obtained with rotation but calculations often do not include the variations in rainfall within and between seasons; (5) 56% of the data show that reduced tillage with no mulch cover leads to lower yields in semi-arid areas; and (6) when adequate fertiliser is available, rainfall is the most important determinant of yield in southern Africa. It is clear from our results that conservation agriculture needs to be targeted and adapted to specific biophysical conditions for improved impact

Oral abstracts 1: SpondyloarthropathiesO1. Detecting axial spondyloarthritis amongst primary care back pain referrals

Background: Inflammatory back pain (IBP) is an early feature of ankylosing spondylitis (AS) and its detection offers the prospect of early diagnosis of AS. However, since back pain is very common but only a very small minority of back pain sufferers have ASpA or AS, screening of back pain sufferers for AS is problematic. In early disease radiographs are often normal so that fulfilment of diagnostic criteria for AS is impossible though a diagnosis of axial SpA can be made if MRI evidence of sacroiliitis is present. This pilot study was designed to indicate whether a cost-effective pick up rate for ASpA/early AS could be achieved by identifying adults with IBP stratified on the basis of age. Methods: Patients aged between 18 and 45 years who were referred to a hospital physiotherapy service with back pain of more than 3 months duration were assessed for IBP. All were asked to complete a questionnaire based on the Berlin IBP criteria. Those who fulfilled IBP criteria were also asked to complete a second short questionnaire enquiring about SpA comorbidities, to have a blood test for HLA-B27 and CRP level and to undergo an MRI scan of the sacroiliac joints. This was a limited scan, using STIR, diffusion-weighted, T1 and T2 sequences of the sacroiliac joints to minimize time in the scanner and cost. The study was funded by a research grant from Abbott Laboratories Ltd. Results: 50 sequential patients agreed to participate in the study and completed the IBP questionnaire. Of these 27 (54%) fulfilled criteria for IBP. Of these, 2 patients reported a history of an SpA comorbidity - 1 psoriasis; 1 ulcerative colitis - and 3 reported a family history of an SpA comorbidity - 2 psoriasis; 1 Crohn's disease. 4 were HLA-B27 positive, though results were not available for 7. Two patients had marginally raised CRP levels (6, 10 -NR ≤ 5). 19 agreed to undergo MRI scanning of the sacroiliac joints and lumbar spine; 4 scans were abnormal, showing evidence of bilateral sacroiliitis on STIR sequences. In all cases the changes met ASAS criteria but were limited. Of these 4 patients 3 were HLA-B27 positive but none gave a personal or family history of an SpA-associated comorbidity and all had normal CRP levels. Conclusions: This was a pilot study yielding only limited conclusions. However, it is clear that: Screening of patients referred for physiotherapy for IBP is straightforward, inexpensive and quick. It appears that IBP is more prevalent in young adults than overall population data suggest so that targeting this population may be efficient. IBP questionnaires could be administered routinely during a physiotherapy assessment. HLA-B27 testing in this group of patients with IBP is a suitable screening tool. The sacroiliac joint changes identified were mild and their prognostic significance is not yet clear so that the value of early screening needs further evaluation. Disclosure statement: C.H. received research funding for this study from Abbott. A.K. received research funding for this study, and speaker and consultancy fees, from Abbott. All other authors have declared no conflicts of interes