2-Hy­droxy-N′-[2-(6-meth­oxy­naphthalen-2-yl)propano­yl]benzohydrazide

In the title compound, C21H20N2O4, the naphthalene ring system makes a dihedral angle of 84.5 (3)° with the benzene ring, and the –C(=O)–N(H)–N(H)–C(=O)– torsion angle is 70.7 (7)°, so that the mol­ecule is twisted. An S(6) ring motif is formed via an intra­molecular O—H⋯O hydrogen bond. In the crystal, mol­ecules are linked by N—H⋯O and C–H⋯O hydrogen bonds into supra­molecular layers in the ab plane

Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

A Series Of Potential Biologically Active Compounds Have Been Synthesized Through The Derivatization of Carboxyl Group In Naproxen Core Structure Involving The Conversion The Naproxen To Its Methyl Ester Then To TheAcid Hydrazide. The Acid Hydrazide Of Naproxen Was Incorporated With Hydrazones, Diamide Linkage, Oxadiazole, Pyrazolone, Triazole, Quinazoline And Indole Containing Motifs. The Targeted Compounds Have Been Achieved In A Very Good Yield Under Conventional Heat And Irradiation Conditions. All Compounds Have Been Characterized By Ir, 1h-Nmr, 13c-Nmr And Mass Spectra.Keywords: Naproxen; Anti-Inflammatory; Nsaid's

Crystal structure of 4,6-diamino-2- sulfanylidene-1,2-dihydropyridine-3- carbonitrile

The title compound, C 6 H 6 N 4 S, crystallizes with two independent molecules, A and B, in the asymmetric unit. Both independent molecules are almost planar [maximum deviations of 0.068 (6) Å in molecule A and 0.079 (6) Å in molecule B]. In the crystal, molecules A and B are linked by N-HÁ Á ÁS, N-HÁ Á ÁN and C-HÁ Á ÁS hydrogen bonds, forming a threedimensional network

Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

A Series of Potential Biologically Active Compounds Have Been Synthesized Through the Derivatization of Carboxyl Group in Naproxen Core Structure Involving the Conversion the Naproxen to its Methyl Ester then to the Acid Hydrazide. The Acid Hydrazide of Naproxen was incorporated with Hydrazones, Diamide Linkage, Oxadiazole, Pyrazolone, Triazole, Quinazoline and Indole Containing Motifs. The Targeted Compounds have been achieved in a very good yield under Conventional Heat and Irradiation Conditions. All Compounds have been characterized by Ir, 1h-Nmr, 13c-Nmr and Mass Spectra

N-(2-Hydroxyphenyl)-4-methylbenzenesulfonamide

In the title compound, C13H13NO3S, the dihedral angle between the benzene rings is 64.15 (7)° and the C-S-N-C torsion angle is -57.18 (12)°. An intra­molecular N-H...O hydrogen bond closes an S(5) ring. In the crystal, O-H...O hydrogen bonds link the mol­ecules into C(8) chains propagating in [100]. Weak C-H...[pi] inter­actions are also observed

2-(4-Isobutyl­phen­yl)-N′-[(3Z)-2-oxoindolin-3-yl­idene]propano­hydrazide

In the title compound, C21H23N3O2, the indolin-2-one group is essentially planar, with a maximum deviation of 0.016 (2) Å for the N atom, and makes a dihedral angle of 84.38 (14)° with the benzene ring. The =N—N(H)—C(=O)—C– torsion angle is 0.9 (3)°. In the crystal, mol­ecules are linked into a three-dimensional network via N—H⋯O and C—H⋯O hydrogen bonds. In addition, a C—H⋯π inter­action was observed

N′-[(E)-2-chlorobenzylidene]-2-(6-methoxynaphthalen-2-yl) propanohydrazide

In the title compound, C21H19ClN2O2, the benzene ring and the naphthalene ring system are oriented at a dihedral angle of 65.24 (10)°. In the crystal, N—H⋯O, C—H⋯N and C—H⋯O hydrogen bonds link the mol­ecules, forming chains along the b-axis direction. Further C—H⋯O hydrogen bonds link the chains, forming corrugated sheets lying parallel to (10-1)