Estudio y propuesta de gestión integral de riesgos en la planta industrial Familia del Ecuador

Realizada una revisión histórica y bibliográfica de la Empresa; y concluido un estudio preliminar de identificación, medición y evaluación de los riesgos existentes en Familia del Ecuador S. A., se constata que la Empresa tiene una buena gestión de salud y seguridad; por tal razón se ha creído necesario tomar en cuenta aquello para sugerir algunos aspectos que optimicen el Sistema de Gestión Integral de riesgosDiplomado en Seguridad y Salud LaboralCuenc

Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae

The yeast Saccharomyces cerevisiae has developed specialized mechanisms that enable growth on suboptimal nitrogen sources. Exposure of yeast cells to poor nitrogen sources or treatment with the Tor kinase inhibitor rapamycin elicits activation of Gln3 and transcription of nitrogen catabolite-repressed (NCR) genes whose products function in scavenging and metabolizing nitrogen. Here, we show that mutations in class C and D Vps components, which mediate Golgi-to-endosome vesicle transport, impair nuclear translocation of Gln3, NCR gene activation, and growth in poor nitrogen sources. In nutrient-replete conditions, a significant fraction of Gln3 is peripherally associated with light membranes and partially colocalizes with Vps10-containing foci. These results reveal a role for Golgi-to-endosome vesicular trafficking in TORC1-controlled nuclear translocation of Gln3 and support a model in which Tor-mediated signaling in response to nutrient cues occurs in these compartments. These findings have important implications for nutrient sensing and growth control via mTor pathways in metazoans