La arquitectura ordinaria del siglo XX como patrimonio cultural: tres barrios de promoción oficial de Madrid

RESUMEN La incipiente construcción de la legitimidad de los barrios de vivienda pública de la segunda mitad del siglo XX como patrimonio ordinario de calidad requiere el desarrollo de medidas para su protección y rehabilitación. Estos barrios son innovadores arquitectónica y urbanísticamente, al tiempo que están sometidos a procesos de destrucción por la presión inmobiliaria ligada a su centralidad, y de degradación por las reformas individuales e incluso por políticas insuficientes o inadecuadas de rehabilitación estrictamente funcional. Se expone la evolución del concepto de patrimonio ordinario aplicado a los conjuntos de vivienda social, y cómo éste aparece recogido en las normativas y prácticas europeas y nacionales, para pasar a considerar la situación de los barrios de promoción oficial de Madrid como objeto patrimonializable a través del estudio de tres barrios representativos del Madrid de los años 1940, 1960 y 1980, de los que se extraen conclusiones generalizables a otros barrios de promoción oficial

The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics

[Abstract] Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy and the safety of the therapy. Here, we demonstrated that when formulating the biosystem, an adequate selection of osmolarity adjusting agents significantly contributes to the regulation of cell responses. Our data showed that these agents interact in the capsule formation process, influencing the alginate crosslinking degree. Therefore, when selecting inert or electrolyte-based osmolarity adjusting agents to encapsulate D1 multipotent mesenchymal stromal cells (MSCs), alginate microcapsules with differing mechanical properties were obtained. Since mechanical forces acting on cells influence their behavior, contrasting cell responses were observed both, in vitro and in vivo. When employing mannitol as an inert osmolarity adjusting agent, microcapsules presented a more permissive matrix, allowing a tumoral-like behavior. This resulted in the formation of enormous cell-aggregates that presented necrotic cores and protruding peripheral cells, rendering the therapy unpredictable, dysfunctional, and unsafe. Conversely, the use of electrolyte osmolarity adjusting agents, including calcium or sodium, provided the capsule with a suitable crosslinking degree that established a tight control over cell proliferation and enabled an adequate therapeutic regimen in vivo. The crucial impact of these agents was confirmed when gene expression studies reported pivotal divergences not only in proliferative pathways, but also in genes involved in survival, migration, and differentiation. Altogether, our results prove osmolarity adjusting agents as an effective tool to regulate cell behavior and obtain safer and more predictable therapies.Gobierno Vasco; IT-907-16Universidad del País Vasco; UFI11/3

Related Factors of Anemia in Critically Ill Patients: A Prospective Multicenter Study

Anemia; Blood; Practice managementAnemia; Sangre; Gestión prácticaAnèmia; Sang; Gestió pràcticaAnemia is common in critically ill patients; almost 95% of patients admitted to intensive care units (ICUs) have hemoglobin levels below normal. Several causes may explain this phenomenon as well as the tendency to transfuse patients without adequate cause: due to a lack of adherence to protocols, lack of supervision, incomplete transfusion request forms, or a lack of knowledge about the indications, risks, and costs of transfusions. Daily sampling to monitor the coagulation parameters and the acid–base balance can aggravate anemia as the main iatrogenic factor in its production. We studied the association and importance of iatrogenic blood loss and other factors in the incidence of anemia in ICUs. We performed a prospective, observational, multicenter study in five Spanish hospitals. A total of 142 patients with a median age of 58 years (IQI: 48–69), 71.83% male and 28.17% female, were admitted to ICUs without a diagnosis of iatrogenic anemia. During their ICU stay, anemia appeared in 66.90% of the sample, 95 patients, (95% CI: 58.51–74.56%). Risk factors associated with the occurrence of iatrogenic anemia were arterial catheter insertion (72.63% vs. 46.81%, p-value = 0.003), venous catheter insertion (87.37% vs. 72.34%, p-value = 0.023), drainages (33.68% vs. 12. 77%, p-value = 0.038), and ICU stay, where the longer the stay, the higher the rate of iatrogenic anemia (p-value < 0.001). We concluded that there was a statistical significance in the production of iatrogenic anemia due to the daily sampling for laboratory monitoring and critical procedures in intensive care units. The implementation of patient blood management programs could address these issues

Computación interactiva en la nube con JupyterHub y Kubernetes

El proyecto investiga el posible uso de Kubernetes para desplegar la plataforma de cuadernos de Python JupyterHu

In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation.

Autologous hematopoietic stem cell transplantation (autoHSCT) is a treatment option for hematological disorders and pediatric solid tumors. After an autoHSCT, natural killer (NK) cells are the first lymphocyte subset returning to normal levels. To uncover global changes during NK cell reconstitution after autoHSCT, we performed RNA-sequencing on NK cells before and after autoHSCT. Results showed profound changes in the gene expression profile of NK cells immediately after autoHSCT. Several biological processes including cell cycle, DNA replication and the mevalonate pathway were enriched. Significantly, we observed that following autoHSCT, NK cells acquired a decidual-like gene expression profile, including the expression of CD9. By using multiparametric flow cytometry, we confirmed the expansion of NK cells expressing CD9 immediately after autoHSCT, which exhibited higher granzyme B and perforin expression levels than CD9- NK cells. These results provide insights into the physiopathology of NK cells during their reconstitution after autoHSCT.Supported by the following grants: AECC-Spanish Association Against Cancer (PROYE16074- BORR) and Health Department, Basque Government (2021333006). GA-P is the recipient of a predoctoral contract funded by AECC-Spanish Association Against Cancer (PRDVZ21440ASTA). DP-A is a recipient of a fellowship from the AECC-Spanish Association Against Cancer (PPLAB212164POLA), AA-I and GA-P are recipient of a fellowship from the Jesús de Gangoiti Barrera Foundation (FJGB20/007, FJGB21/001 and FJBG21/005). IT is recipient of a predoctoral contract funded by the Department of Education, Basque Government (PRE_2021_2_0215). OZ is the recipient of a postdoctoral contract funded by ‘‘Instituto de Salud Carlos III-Contratos Sara Borrell 2017 (CD17/00128)’’ and the European Social Fund (ESF)-The ESF invests in your future. FB is an Ikerbasque Research Professor, Ikerbasque, Basque Foundation for Science.S

Lineal and cartesian graphics modes of representations in understanding of numerical sequence concept in secondary school students

Esta investigación forma parte de un trabajo cuyo objetivo es la compresión del concepto de sucesión numérica en los estudiantes de secundaria. El enfoque proporcionado por distintos investigadores en relación a los modos de representación y las aportaciones de Piaget y García en relación al desarrollo de un esquema a través de los niveles intra, inter y trans, nos proporciona información sobre el desarrollo de la comprensión del concepto de sucesión numérica a través del uso de los modos de representación gráficos, lineal y cartesiano, por parte de los estudiantes en la resolución de una tarea.The present paper is part of research that addresses the compression of the concept of numerical sequence in secondary school students. The perspective provided by the work of Piaget & Garcia related to the development of a scheme through several levels (intra, inter and trans), it provides empirical evidence of how the students’ use of the modes of representations when solving a task provides information of the development of understanding. This use allows us to go deep about the stages in the development of numerical sequence concep

Related Factors of Anemia in Critically Ill Patients : A Prospective Multicenter Study

Anemia is common in critically ill patients; almost 95% of patients admitted to intensive care units (ICUs) have hemoglobin levels below normal. Several causes may explain this phenomenon as well as the tendency to transfuse patients without adequate cause: due to a lack of adherence to protocols, lack of supervision, incomplete transfusion request forms, or a lack of knowledge about the indications, risks, and costs of transfusions. Daily sampling to monitor the coagulation parameters and the acid-base balance can aggravate anemia as the main iatrogenic factor in its production. We studied the association and importance of iatrogenic blood loss and other factors in the incidence of anemia in ICUs. We performed a prospective, observational, multicenter study in five Spanish hospitals. A total of 142 patients with a median age of 58 years (IQI: 48-69), 71.83% male and 28.17% female, were admitted to ICUs without a diagnosis of iatrogenic anemia. During their ICU stay, anemia appeared in 66.90% of the sample, 95 patients, (95% CI: 58.51-74.56%). Risk factors associated with the occurrence of iatrogenic anemia were arterial catheter insertion (72.63% vs. 46.81%, p -value = 0.003), venous catheter insertion (87.37% vs. 72.34%, p -value = 0.023), drainages (33.68% vs. 12. 77%, p -value = 0.038), and ICU stay, where the longer the stay, the higher the rate of iatrogenic anemia (p -value < 0.001). We concluded that there was a statistical significance in the production of iatrogenic anemia due to the daily sampling for laboratory monitoring and critical procedures in intensive care units. The implementation of patient blood management programs could address these issue

Evidence of association of the NLRP1 gene with giant cell arteritis

Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation

Identidad territorial : globalización y patrimonio

El presente libro analiza la relación entre los tres con¬ceptos que dan cuerpo a su nombre, con el fin parti¬cular de examinar los impactos que la globalización ha traído sobre el patrimonio construido. Con ello busca explorar los posibles caminos que, para la re¬flexión académica, la investigación aplicada o la polí¬tica pública, pudieran derivarse de las reflexiones que al respecto concentra aquí la mirada de numerosos investigadores provenientes de distintos países. Sobre el particular, el trabajo ofrece un marco con¬ceptual desde donde se ha abordado el fenóme¬no, y a partir del cual se analizan temas como el pensamiento en red; los conflictos socio espaciales que genera el turismo; la relación entre identidad y memoria histórica, así como entre patrimonio y de¬rechos humanos; las tensiones y dilemas que sobre la identidad y el patrimonio trae la globalización y, finalmente, el tema del, denominado en el trabajo, “pensar situado”, como condición a la hora de estu¬diar y entender lo que frente al tema ocurre en cada contexto. Enfoque desde el cual se analizan casos en España, Portugal, Italia, Colombia, Perú, Ecuador, Brasil, Uruguay, Argentina, México, Croacia y, entre otros, Turquía, país, este último, donde los investiga¬dores en pleno efectuaron un trabajo de campo que, junto con las exploraciones en otros contextos, per¬mitió contrastar la teoría con la práctica y extrapolar desde aquí sus conclusiones.Resumen-Abstract. CAPÍTULO 1. Identidad territorial: Elementos transversales y temas críticos, a manera de preámbulo y marco científico. CAPÍTULO 2. Identidad territorial y globalización: Pensar en red. Un reto y un compromiso. CAPÍTULO 3. Morir de éxito. Conflictos socioespaciales del turismo globalizado en ciudades patrimoniales. CAPÍTULO 4. El patrimonio industrial y su compleja puesta en valor: Identidades y memorias en disputa. CAPÍTULO 5. Patrimônio e direitos humanos: A ação do icomos no caso de Bento Rodrigues. CAPÍTULO 6. Tensiones y dilemas de la identidad y el patrimonio en tiempos de globalización CAPÍTULO 7. Identidad territorial, globalización y patrimonio en el valle del Colca, Arequipa, Perú. CAPÍTULO 8. O dilema da patrimonialização em tempos de globalização: Cidade de Paraty, Rio de Janeiro, Brasil. CAPÍTULO 9. Territorialización del paisaje cultural mexicano. Imaginarios y realidades ante la globalización. CAPÍTULO 10. Temas críticos en la relación entre identidad territorial, globalización y patrimonio. CAPÍTULO 11. Pensar situado, identidad territorial y patrimonio. CAPÍTULO 12. Tensiones y desafíos para las relaciones entre lo local y lo global1a