Testing the WEAP Hydrologic Model for Awash Basin, Ethiopia “Soil Moisture Module with Watershed Demand Approach”

The research is financed by the Egyptian Government through the Nile Sector bilateral cooperation project Abstract Currently, there are several hydrological simulation models in use worldwide. Prior to adoption of a model to a specific basin, its feasibility and practicality should be tested. This study highlights on the application of Water Evaluation and Planning system (WEAP) model for hydrologic simulation of Awash river basin in Ethiopia. A monthly time step hydrologic model was developed using the soil moisture rainfall-runoff method incorporated in WEAP with an aim to check the suitability of the model for Awash river basin. For this purpose five selected flow gauge stations located at the upper, middle and lower Awash basin were used as control stations. The model is configured taking into account the effects of development and hence the water abstractions, storage, loss rate, etc. are estimated using the data provided through various kinds of research and survey in Ethiopia. Standard methods are also used to prepare the hydro-metrological and landuse input data for each sub-catchment. Based on data availability, the time period 1986-2005 was selected for the hydrologic simulation. The observed data were split for calibration (1986–1995) and validation (1996–2005) purposes. Initially, the model was set up using the default model parameters. Then, manual calibration is performed to reproduce the observed streamflow. The model-simulated values are compared with those obtained from observations using standard statistical tests on monthly and monthly average basis. From the performance test results, it is observed that the coefficient of determination (R2) and the Index of Agreement (IA) show a good fit. Furthermore, the Nash-Sutcliffe Efficiency (NSE) and the Percent Bias (PBIAS) calibration and validation results show good performance for Upper Awash stations and satisfactory results for the middle and lower Awash control stations. As a conclusion, the main modelling constraints were discussed and possible solutions were also suggested in order to improve the performance of water resources simulation models for the Awash basin. Keywords: Awash Basin, Hydrologic Simulation, Calibration, Validation, Model Performance, WEAP DOI: 10.7176/CER/12-3-07 Publication date:March 31st 202

Planning for Environmental Water Allocations: Hydrology - Based Assessment in the Awash River Basin, Ethiopia

The research is financed by the Egyptian Government through the Nile Sector bilateral cooperation project Abstract With expanding water demand due to rapid socio-economic growth and shrinking supplies due to pollution and climate change impact, there is an increasing strain on the water resources of the Awash river basin. Furthermore, flow alterations due to the existing and the ongoing water resources infrastructure projects may adversely impact the natural life cycle of aquatic ecosystems in the river basin. In order to manage these consequences, compensation releases or allocation of environmental flows may be mandatory and calls for the establishment of environmental flows framework in Ethiopia. In this study, the environmental flows at selected five existing and proposed dam sites in the Awash river basin were investigated using six worldwide used hydrology-based methods, viz.: Desktop Reserve Model (DRM), Global Environmental Flow Calculator (GEFC), Tennant, Tessman, 7Q10 and Q95. The environmental flow volumes from the six methods were compared on mean annual, monthly average and monthly basis and it is found that the predictions from the DRM and GEFC are more reliable than the others. Comparative results indicate that minimum annual average flow rates of 4.4 m3/s (15 % of Mean Annual Flow (MAF)), 10.5 m3/s (19 % of MAF), 16.4 m3/s (22 % of MAF), 2.5 m3/s (17 % of MAF) and 24.2 m3/s (26 % of MAF) are required at the immediate downstream reaches of Melka kuntre, Koka, Awash Compensation, Kesem and Tendaho dams respectively. Accordingly, the annual average environmental flow throughout the basin varies from 15-26 % of the natural MAF. Although preliminary, being the first attempt in the Awash river basin, this study is expected to stimulate dialogue among experts and decision makers in Ethiopia. Keywords: EFR, EFA, Tennant, Tessman, Q95, 7Q10, DRM, GEFC Software, Awash DOI: 10.7176/JEES/9-11-08 Publication date: November 30th 201

The Biomechanical Effect of Different Denture Base Materials on the Articular Disc in Complete Denture Wearers: A Finite Element Analysis

AIM: The objective of the present study was to evaluate the effect of different denture base materials on the stress distribution in TMJ articular disc (AD) in complete denture wearers.MATERIAL AND METHODS: Two three dimensional Finite Element (FEA) models of an individual temporomandibular joint (TMJ) were built on the basis CT scan. The FEA model consisted of four parts: the condyle, the articular disc, the denture base, and the articular eminence skull. Acrylic resin and chrome-cobalt denture base materials were studied. Static loading of 300N was vertically applied to the central fossa of the mandibular second premolar. Stress and strain were calculated to characterize the stress/strain patterns in the disc.RESULTS: The maximum tensile stresses were observed in the anterior and posterior bands of (AD) on load application with the two denture base materials. The superior boundaries of the glenoid fossa showed lower stress than those on the inferior boundaries facing the condyle.CONCLUSIONS: Within the limitations of the present study it may be concluded that: The denture base material may a have an effect in stress-strain pattern in TMJ articular disc. The stiffer denture base material, the better the distribution of the load to the underling mandibular supporting structures & reducing stresses induced in the articular disc

In Vivo Visualization of Hair Follicles by Ultrasound Biomicroscopy in Alopecia Areata and its Correlation with Histopathology

Ultrasound biomicroscopy (UBM) is a non-invasive imaging technique used in examination of several skin diseases but never in imaging hair and scalp diseases.  Main objective of this investigation was assessment of the efficacy of UBM for in vivo visualization of hair follicles in cases of alopecia areata (AA) and correlation of findings with histopathological findings. This study included 30 patients with AA. Two areas, one with AA and a control area, were marked, examined by UBM and then biopsied for histopathological examination. In patients with alopecia totalis (AT) or universalis (AU) only an AA area was examined. Non-echogenic conical shadows reaching the epidermal entrance echo (probably corresponding to the hair follicles) were seen and were wider and fewer in number in areas of AA than in normal control areas. No significant difference was found regarding number and width of hair follicles between UBM and histopathological examination. However, a significant increase in length of follicles in histopathology was detected, indicating that the UBM image was probably unable to reach the deepest part of the follicle. Main limitation of the study is small number of cases. No significant difference was found between UBM and histological measurements of hair follicle number and width in patients with AA, making UBM a useful tool for in vivo visualization of hair follicles. </p

Nucleophilic Addition of Reactive Dyes on Amidoximated Acrylic Fabrics

Seven reactive dyes judiciously selected based on chemical structures and fixation mechanisms were applied at 2% owf of shade on amidoximated acrylic fabrics. Amidoximated acrylic fabric has been obtained by a viable amidoximation process. The dyeability of these fabrics was evaluated with respect to the dye exhaustion, fixation, and colour strength under different conditions of temperature and dyeing time. Nucleophilic addition type reactive dyes show higher colour data compared to nucleophilic substitution ones. FTIR studies further implicate the binding of reactive dyes on these fabrics. A tentative mechanism is proposed to rationalize the high fixation yield obtained using nucleophilic addition type reactive dyes. Also, the levelling and fastness properties were evaluated for all dyes used. Excellent to good fastness and levelling properties were obtained for all samples irrespective of the dye used. The result of investigation offers a new method for a viable reactive dyeing of amidoximated acrylic fabrics

In Vivo Visualization of Hair Follicles by Ultrasound Biomicroscopy in Alopecia Areata and its Correlation with Histopathology

Ultrasound biomicroscopy (UBM) is a non-invasive imaging technique used in examination of several skin diseases but never in imaging hair and scalp diseases.  Main objective of this investigation was assessment of the efficacy of UBM for in vivo visualization of hair follicles in cases of alopecia areata (AA) and correlation of findings with histopathological findings. This study included 30 patients with AA. Two areas, one with AA and a control area, were marked, examined by UBM and then biopsied for histopathological examination. In patients with alopecia totalis (AT) or universalis (AU) only an AA area was examined. Non-echogenic conical shadows reaching the epidermal entrance echo (probably corresponding to the hair follicles) were seen and were wider and fewer in number in areas of AA than in normal control areas. No significant difference was found regarding number and width of hair follicles between UBM and histopathological examination. However, a significant increase in length of follicles in histopathology was detected, indicating that the UBM image was probably unable to reach the deepest part of the follicle. Main limitation of the study is small number of cases. No significant difference was found between UBM and histological measurements of hair follicle number and width in patients with AA, making UBM a useful tool for in vivo visualization of hair follicles. </p

Vinorelbine plus platinum compared to vinorelbine plus capecitabine in treatment of patients with metastatic triple negative breast cancer previously treated with anthracycline and taxane: a prospective randomized study

Introduction. This study aims to investigate the efficacy and tolerability of the vinorelbine-based combination chemotherapy with either cisplatin or capecitabine in metastatic triple-negative breast cancer (mTNBC) pretreated with anthracycline and taxane.  Material and methods. This is an open-labeled randomized prospective single-institute study, that included all patients who received chemotherapy for mTNBC in the period between 1st of July 2016 and 30th of June 2017 and were pretreated with anthracycline and taxane. Patients were randomized to either vinorelbine 25 mg/m2 I.V on days 1 and 8 plus oral capecitabine 1000 mg/m2 twice daily, on days 1–14 (NX); or vinorelbine 25 mg/m2 I.V on days 1 and 8 plus cisplatin 75 mg/m2 (NP), every 21 days. The primary endpoint was time to progression (TTP), whereas the secondary endpoints were objective response rate (ORR), safety, and overall survival (OS).  Results. Median TTP was 9.9 months with NP vs. 8 months with NX, (p = 0.22). ORR was 40% with NP vs. 36% with NX, (p = 0.77). Median OS was 13 months with NP vs. 13.2 months with NX (p = 0.599). Both regimens demonstrated similar rates of grade ≥ 3 vomiting and neutropenia. A higher incidence of thrombocytopenia, tinnitus, and kidney function alteration were reported with NP. A higher incidence of anorexia, diarrhea, mucositis, and hand-foot syndrome were reported with NX.  Conclusions. Vinorelbine-based combination chemotherapy regimens with either cisplatin or capecitabine are active in the treatment of mTNBC pretreated with anthracycline and taxane with manageable toxicity profiles. Both regimens have comparable TTP, ORR, OS, and safety profiles

New Landscapes and Horizons in Hepatocellular Carcinoma Therapy

Hepatocellular carcinoma (HCC), is the sixth most frequent form of cancer and leads to the fourth highest number of deaths each year. HCC results from a combination of environmental factors and aging as there are driver mutations at oncogenes which occur during aging. Most of HCCs are diagnosed at advanced stage preventing curative therapies. Treatment in advanced stage is a challenging and pressing problem, and novel and well-tolerated therapies are urgently needed. We will discuss further advances beyond sorafenib that target additional signaling pathways and immune checkpoint proteins. The scenario of possible systemic therapies for patients with advanced HCC has changed dramatically in recent years. Personalized genomics and various other omics approaches may identify actionable biochemical targets, which are activated in individual patients, which may enhance therapeutic outcomes. Further studies are needed to identify predictive biomarkers and aberrantly activated signaling pathways capable of guiding the clinician in choosing the most appropriate therapy for the individual patient

Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts

Abstract Background Prostate cancer is a significant health problem among American men. Treatment strategies for androgen-independent cancer are currently not available. Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a death receptor ligand that can induce apoptosis in a variety of cancer cell lines, including androgen-independent PC3 prostate carcinoma cells. In vitro, TRAIL-mediated apoptosis of prostate cancer cell lines can be enhanced by doxorubicin and correlates with the downregulation of the anti-apoptotic protein c-FLIP. This study evaluated the effects of doxorubicin on c-FLIP expression and tumor growth in combination with Apo2L/TRAIL in a xenograft model. Methods In vitro cytotoxic effects of TRAIL were measured using a MTS-based viability assay. For in vivo studies, PC3 prostate carcinoma cells were grown subcutaneously in athymic nude mice and tumor growth was measured following treatment with doxorubicin and/or Apo2L/TRAIL. c-FLIP expression was determined by western blot analysis. Apoptosis in xenografts was detected using TUNEL. Statistical analysis was performed using the student t-test. Results In vitro experiments show that PC3 cells are partially susceptible to Apo2L/TRAIL and that susceptibility is enhanced by doxorubicin. In mice, doxorubicin did not significantly affect the growth of PC3 xenografts but reduced c-FLIP expression in tumors. Expression of c-FLIP in mouse heart was decreased only at the high doxorubicin concentration (8 mg/kg). Combination of doxorubicin with Apo2L/TRAIL resulted in more apoptotic cell death and tumor growth inhibition than Apo2L/TRAIL alone. Conclusions Combination of doxorubicin and Apo2L/TRAIL is more effective in growth inhibition of PC3 xenografts in vivo than either agent alone and could present a novel treatment strategy against hormone-refractory prostate cancer. The intracellular mechanism by which doxorubicin enhances the effect of Apo2L/TRAIL on PC3 xenografts may be by reducing expression of c-FLIP.</p