Residential Segregation, Neighborhood Social and Physical Context in Obesity Disparities in Hispanic Preschoolers: A Conceptual Model

During the last decade, there has been a significant inclusion in obesity prevention studies from individual characteristics to household factors then neighborhood factors. The study of place in the context of early childhood obesity studies has been limited to the food and physical built environment. With the persistent disparities in the prevalence of childhood obesity, and Hispanic minorities being increasingly affected, there is a need to reexamine existing models and develop new model conceptual frameworks to examine the role of place and residential segregation in the context of race, ethnicity, social position, and socioeconomic disparities. In the context of place as a relational space linked to where young children live, play and learn, this paper conceptualizes the role of the neighborhood social and physical factors as well as organizational, household and/or individual factors as mediators of the correlation between residential segregation and obesity in Hispanic preschoolers. In the model, we also attempted to include the role of policies and programs in moderating the negative effects of racial residential segregation and resource inequalities and their interactions with the multiple factors that may contribute to childhood obesity. Recommendations for future research need are identified

A novel index-based decision support toolkit for safe reopening following a generalized lockdown in low and middle-income countries

While the effectiveness of lockdowns to reduce Coronavirus Disease-2019 (COVID-19) transmission is well established, uncertainties remain on the lifting principles of these restrictive interventions. World Health Organization recommends case positive rate of 5% or lower as a threshold for safe reopening. However, inadequate testing capacity limits the applicability of this recommendation, especially in the low-income and middle-income countries (LMICs). To develop a practical reopening strategy for LMICs, in this study, we first identify the optimal timing of safe reopening by exploring accessible epidemiological data of 24 countries during the initial COVID-19 surge. We find that a safe opening can occur two weeks after the crossover of daily infection and recovery rates while maintaining a negative trend in daily new cases. Epidemiologic SIRM model-based example simulation supports our findings. Finally, we develop an easily interpretable large-scale reopening (LSR) index, which is an evidence-based toolkit—to guide/inform reopening decision for LMICs

A novel index-based decision support toolkit for safe reopening following a generalized lockdown in low and middle-income countries

While the effectiveness of lockdowns to reduce Coronavirus Disease-2019 (COVID-19) transmission is well established, uncertainties remain on the lifting principles of these restrictive interventions. World Health Organization recommends case positive rate of 5% or lower as a threshold for safe reopening. However, inadequate testing capacity limits the applicability of this recommendation, especially in the low-income and middle-income countries (LMICs). To develop a practical reopening strategy for LMICs, in this study, we first identify the optimal timing of safe reopening by exploring accessible epidemiological data of 24 countries during the initial COVID-19 surge. We find that a safe opening can occur two weeks after the crossover of daily infection and recovery rates while maintaining a negative trend in daily new cases. Epidemiologic SIRM model-based example simulation supports our findings. Finally, we develop an easily interpretable large-scale reopening (LSR) index, which is an evidence-based toolkit-to guide/inform reopening decision for LMICs

HPV Vaccination and Knowledge of Cervical Cancer among Female University Students in a Multiethnic Institution, USA

Objective: College-aged women are at high-risk of Human Papillomavirus (HPV) infection. Although, HPV vaccination is most effective, its rates remain quite low among college students. It may be due to inadequate understanding of the relationship between HPV and cervical cancer. Therefore, the objective of this study was to examine the level of knowledge about HPV, cervical cancer and their associations with HPV vaccination among female college students. Methods: Cross-sectional questionnaire based survey was conducted among female students in a Multiethnic University in Florida. We assessed HPV vaccination status, annual health checkup status, knowledge about HPV and cervical cancer among the students. The response rate for the survey was 91.5%. Results: Out of 141 students, 39.7% received HPV vaccine, and 38.3% did annual medical checkup within a year. Out of 4, the mean and the median knowledge score of students about cervical cancer was 2.87 and 3.0, respectively. A greater percentage of students who did annual health checkup (44%) received HPV vaccine than those who did not (15%). The odds of receiv-ing HPV vaccine was nearly 5 times as much for the students who achieved knowledge scores about causes of cervical cancer greater than or equal to the median compared with the students with knowledge scores below the median (adjusted odds ratio [aOR]:4.85, 95% confidence interval [CI]:2.15, 10.92). The odds of receiving HPV vaccine was almost three times as much of students who knew that HPV causes cervical cancer than those who did not know it to be so (aOR:2.9, 95% CI:1.1, 8.2). Conclusion: Receipt of HPV vaccination was associated with knowing that HPV infection is a cause of cervical cancer and that it’s preventable. HPV vaccination was also associated with annual health checkup statu

A comparison of some confidence intervals for estimating the population coefficient of variation: a simulation study

This paper considers several confidence intervals for estimating the population coefficient of variation based on parametric, nonparametric and modified methods. A simulation study has been conducted to compare the performance of the existing and newly proposed interval estimators. Many intervals were modified in our study by estimating the variance with the median instead of the mean and these modifications were also successful. Data were generated from normal, chi-square, and gamma distributions for CV = 0.1, 0.3, and 0.5. We reported coverage probability and interval length for each estimator. The results were applied to two public health data: child birth weight and cigarette smoking prevalence. Overall, good intervals included an interval for chi-square distributions by McKay (1932), an interval estimator for normal distributions by Miller (1991), and our proposed interval

Reservoir Potential Evaluation of the Middle Paleocene Lockhart Limestone of the Kohat Basin, Pakistan: Petrophysical Analyses

The Lockhart Limestone is evaluated for its reservoir potential by utilizing wireline logs of Shakardara-01 well from Kohat Basin, Pakistan. The analyses showed 28.03% average volume of shale (Vsh), 25.57% average neutron porosity (NPHI), 3.31% average effective porosity (PHIE), 76% average water saturation (Sw), and 24.10% average hydrocarbon saturation (Sh) of the Lockhart Limestone in Shakardara-01 well. Based on variation in petrophysical character, the reservoir units of the Lockhart Limestone are divided into three zones i.e., zone-1, zone-2 and zone-3. Out of these zones, zone-1 and zone-2 possess a poor reservoir potential for hydrocarbons as reflected by very low effective porosity (1.40 and 2.02% respectively) and hydrocarbon saturation (15 and 5.20%), while zone-3 has a moderate reservoir potential due to its moderate effective porosity (6.50%) and hydrocarbon saturation (52%) respectively. Overall, the average effective porosity of 3.31% and hydrocarbon saturation of 24.10% as well as 28.03% volume of shale indicated poor reservoir potential of the Lockhart Limestone. Lithologically, this formation is dominated by limestone and shale interbeds in the Shakardara-01 well. Cross-plots of the petrophysical parameters versus depth showed that the Lockhart Limestone is a poor to tight reservoir in Shakardara-01 well and can hardly produce hydrocarbons under conventional drilling conditions

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Background Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects. Methods FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762. Findings Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months. Interpretation Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function. Funding UK Stroke Association and NIHR Health Technology Assessment Programme

Aging and the COVID-19 pandemic: The inter-related roles of biology, physical wellbeing, social norms and global health systems

10.1016/j.maturitas.2022.07.008MATURITAS16799-10