STRATEGI PENGEMBANGAN PURI MAEROKOCO TAMAN WISATA BUDAYA JAWA TENGAH

Puri Maerokoco is a potential and interesting tourism object site from Semarang. Puri Maerokoco is the only art and education tourism object and exhibits a miniature of East Java Province. The miniature includes its region and city. Although Puri Maerokoco is very potential, it doesn’t development well than the other site object in Semarang. Many ways have been done to promote and increase the visitors to visit, but it doesn’t help much. The purpose of this research is to analyze the match strategy for development Puri Maerokoco. This research using Analytical Network Process (ANP) methods. Develoment strategy analyze of object site Puri Maerokoco including economic aspect, infrastructure aspect, management aspect and promotion aspect. The result of ANP analyze showing that from the all of development aspect site objet Puri Maerokoco, have the economic aspect is the main priority and the match development strategy for using is had cooperation with the stakeholder. Strategy recommendation to had cooperation with the stakeholder is the strategy with the highest priority with score 0,444

PERILAKU PRONOMINA PERSONA /ITE/ UNTUK MENYATAKAN ASPEK DAN KEPEMILIKAN DALAM STRUKTUR KALIMAT BAHASA SASAK MASBAGIK

This study focuses on the behavior of pronouns persona /te/ to express aspects and possessions in the structure of the Masbagic sasak language sentence. This research is descriptive conducted solely based on the facts that exist or the phenomenon that empirically live on the speakers. Researchers describe the data contained in the systematic data related to the problems studied. Data collection referred to the technique of lively cognate and recording techniques. Data were analyzed using intralingual pad method, presenting the result on informal method. The results are pronomina persone has a clitic form of proclitik te- and enclitik -te. When the pronominal persona of the proclical form meets with the verb it will express an aspect and there will be phoneme changes in the verb. When the pronouns persona of the enclosed form meets the nouns it will declare an ownership that there will be an addition of phoneme /n/ if the word attached ends in the vowel and there is no phoneme change in the noun attached if the consonant ends

Semantik Verba dalam Membentuk Gaya Bahasa pada Judul Berita Tempodotco

The headline is the main highlight that readers see in a news story. Tempodotco digitized its printed news headlines. The digitization of this news title is done by visualizing it in the form of a poster. The purpose of this study is to describe the semantic behavior of groups of basic verbs, derivative verbs, and verbal phrases in forming metaphors and personifications in news titles on the Tempodotco digital media Instagram page. This research method uses descriptive method. The data collection method is the method of listening and documentation. The type of data in this research is qualitative data in the form of pictures and words in the news title. Data analysis used the Miles and Huberman model which includes data analysis, data reduction, data display, and data verification. In this study, it was found that 1) the basic verb group has three inherent meanings of action or action and one inherent meaning of state. The language style formed is three metaphors and one personification. 2) The semantic behavior of the derived verb group which is transitive has five inherent meanings, one action inherent meaning, and one process inherent meaning. The language style formed is three metaphors and two personifications. 3) The semantic behavior of the verbal phrase group has all the inherent meanings of the action and forms three metaphors and one personification. In this study, there is no reduplication of the verb.Keywords: Title, Verb, Semantics, Metaphor, Personification, Phras

Analisis Spasial Persebaran Toko Mebel Di Kabupaten Jepara Propinsi Jawa Tengah

Kabupaten Jepara merupakan kabupaten yang terkenal dengan sentra industri kerajinan ukir dan mebel kayu yang merupakan salah satu komoditi andalan Jawa Tengah. Adanya andalan industri mebel ini menyebabkan sebagian besar lahan di Kabupaten Jepara dimanfaatkan untuk pengembangan industri mebel kayu. Perkembangan industri mebel mempengaruhi pertumbuhan toko mebel kayu di setiap lokasi strategis di Kabupaten Jepara. Tujuan dari penelitian ini adalah untuk mengetahui pola persebaran toko mebel kayu di sepanjang jalan utama di Kabupaten Jepara menggunakan analisis spasial dengan buffering ArcGIS dan mengetahui besarnya pengaruh lokasi (place) terhadap status operasional (buka/tutup) toko mebel kayu menggunakan analisis regresi logistik biner dari SPSS dan OpenStat. Dalam penelitian ini, parameter lokasi yang ditetapkan adalah kedekatan dengan pusat kota dan persebaran pemukiman. Metode yang digunakan dalam penelitian ini adalah metode survei analitik dengan pendekatan cross sectional. Pengumpulan data dilakukan dengan cara pengukuran langsung menggunakan alat GPS Handheld di lapangan. Hasil analisis spasial menunjukkan bahwa jumlah toko mebel di sepanjang jalan utama Kabupaten Jepara pada tahun 2011 adalah sebanyak 377 buah toko dengan pola persebaran toko mebel yang mengumpul di kawasan dekat pusat kota. Nilai persentase toko mebel yang masih beroperasi (buka) adalah sebesar 88,59% dan toko mebel yang sudah tidak beroperasi (tutup) adalah sebesar 11,41 %. Sedangkan hasil analisis regresi logistik biner menunjukkan bahwa nilai persentase pengaruh bersama dari faktor kedekatan dengan pusat kota dan persebaran pemukiman terhadap status operasional toko mebel adalah sebesar 34,21 %. Dari uji statistik tersebut, didapatkan pula kesimpulan bahwa faktor kedekatan toko mebel dengan pusat kota memiliki pengaruh terhadap status operasional toko mebel. Sedangkan faktor kedekatan toko mebel dengan kawasan pemukiman tidak berpengaruh terhadap status operasional toko mebel

Efektivitas Terapi Aktivitas Kelompok Distraksi Halusinasi Pada Klien Dengan Halusinasi Auditori Di Rumah Pemulihan Efata Provinsi Jawa Tengah

Dampak halusinasi pendengaran dapat menyebabkan perubahan perilaku seperti perilaku agresif, bunuh diri, menarik diri dari lingkungan, atau menyakiti diri sendiri, maupun orang lain di lingkungan sekitar. Salah satu intervensi yang dapat diberikan kepada pasien halusinasi pendengaran ialah dengan terapi aktivitas kelompok (TAK) dengan memberikan edukasi kepada klien mengenai cara mengontrol halusinasi dengan Teknik distraksi. Metode penelitian pre-experiment dengan desain penelitian one group pre-test post-test with design. Subyek penelitian ini berjumlah tiga responden dengan kriteria inklusi halusinasi pendengaran di Rumah Pemulihan Efata Kabupaten Semarang. Untuk menguji efektifitas dilakukan menggunakan uji statistik paired sample t-test. Hasil penelitian menunjukkan adanya terapi aktivitas kelompok (TAK) efektif meningkatkan kemampuan kognitif (p-value: 0,001) dan kemampuan psikomotor (p-value: 0,000) antara sebelum dan setelah dilakukannya intervensi pada setiap kliennya, maka dapat disimpulkan bahwa terapi aktivitas kelompok distraksi halusinasi efektif diberikan kepada klien dengan halusinasi pendengaran guna mengontrol halusinasi pendengaran yang muncul

MENINGKATKAN PENDAPATAN UMKM MELALUI AKTIVITAS DIGITAL MARKETING DENGAN MEMANFAATKAN MEDIA SOSIAL INSTAGRAM DAN FACEBOOK

Program pengabdian masyarakat yang dilakukan tahun ini berfokus mengenai dampak ekonomi dari Pandemi Covid-19 terkait regulasi pemerintah berupa pembatasan aktivitas membuat banyak performa di berbagai sektor bisnis menurun, terutama bagi perusahaan besar atau korporasi. banyak pelaku UMKM yang kesulitan untuk memaksimalkan pemanfaatan digitalisasi ini baik bagi “pemain” lama maupun yang baru terjun ke dunia wirausaha sejak pandemi Covid-19 ini. Proses pengabdian masyarakat meliputi kegiatan tahap FGD, tahap survey, tahap sosialisasi, tahap pelatihan, tahap pendampingan, dan tahap evaluasi. Terlebih di masa pandemi Covid-19 sekarang ini dimana dengan diberlakukannya pembatasan aktivitas fisik diluar rumah dan mengakibatkan banyak dari pendapatan yang dilakukan oleh bisnis secara konvensional menurun dan mendorong mereka untuk beralih tempat berjualan ke ranah dunia maya dikarenakan meningkatnya aktivitas pengguna media sosial. UMKM yang berada di Jakarta yang dilaksanakan pada tanggal 8 Mei 2021 hingga sampai saat ini.   Kata Kunci

Penggunaan Media Kartu Putar dalam Penyuluhan untuk Meningkatkan Pengetahuan Mencuci Tangan Memakai Sabun pada Siswa SD Tegalrejo 2 Kota Yogyakarta

The practice of handwashing with soap need to be applied in early age as a disease prevention effort. One of the important main target groups is elementary school students. Counseling can be maximally accepted if the media used is appropriate with the target. The appropriate media of elementary school students is something that attract their attention so that can enable the delivery of the messages, such a pictured media, and one of which is named “rotating cards”. This study was aimed to determine the effect of those cards used in counselling for increasing the knowledge about handwashing with soap. The study was a quasi experiment with pre-tets post-test control group design, and was condected in Tegalrejo 2 Elementary School of Yogyakarta City. The study subject consisted of 30 students of class IV B and V B as the control group. The study result show that the use of “rotating cards” can increase the knowledge of treatment group (average=3,07) higher than that of the control group (average=1,57). The statistical analysis using independent t-test obtained p value = 0,013, which show that the difference is significant. Based on the result, it can be concluded that the use of the card media in counseling activities, influences the knowledge of handwashing with soap among students of Tegalrejo 2 Elementary School

Synergistic effect of the combination of Chrysanthemum cinerariifolium (Trev.) and doxorubicin in inhibiting PI3K and Cyclin D in oral squamous cell carcinoma: in vitro study

Background: The most common type of lips and oral cavity cancer is oral squamous cell carcinoma (OSCC). Doxorubicin (DX) is commonly used as a chemotherapy drug, but its use is limited due to risk factors and drug resistance. Chrysanthemum cinerariifolium (Trev.) (CC) has potential as an anticancer agent. Combining the plant extract and chemotherapy drug might prevent OSCC proliferation by inhibiting PI3K and cyclin D protein. Therefore, the present study aimed to determine the synergistic effect of the combination of C. cinerariifolium (Trev.) and doxorubicin in inhibiting PI3K and Cyclin D protein. Methods: Human oral squamous carcinoma cell lines SCC-9 were used in this study. A cytotoxicity assay was performed to obtain the IC50 value of CC ethanol extract and DX on the SCC-9 cell line. Synergism evaluation of the combination CC and DX was analyzed using CompuSyn software. ELISA and the immunofluorescent assay were performed to determine the level of PI3K and cyclin D in the SCC-9 cell line after being treated with IC50 value of CC, IC50 value of DX and three combinations of CC and DX [7/8 IC50 CC + 1/8 IC50 DX (dose 1), 6/8 IC50 CC + 2/8 IC50 DX (dose 2), and 4/8 IC50 CC + 4/8 IC50 DX (dose 3). Results: CC stem ethanol extract and DX inhibited the proliferation of SCC-9 cell lines with the IC50 value of 133.4 µg/mL and 288.3 nM, respectively. The combination of CC and DX at dose 2 (6/8 IC50 CC + 2/8 IC50 DX) exhibited a high decrease in PI3K and cyclin D expression. Conclusions: The combination of C. cinerariifolium and doxorubicin synergistically declined OSCC proliferation by inhibiting PI3K and cyclin D expression

Analysis of the metabolite compound of the ethanol extract of Chrysanthemum cinerariifolium stem and activity for inhibition of Oral Squamous Cell Carcinoma (OSCC) in silico study

Background: Oral cancer is a deadly disease that is expected to increase yearly. Current cancer treatment methods have side effects. C. cinerariifolium plants have potential as anticancer agents. Objective: To evaluate the anti-OSCC properties of the ethanol extract of C. cinerariifolium stems via an in-silico study. Materials and Methods: Analysis of active compounds in ethanol extracts of C. cinerariifolium stems using TLC and UPLC-QToF-MS/MS metabolic profiling. The data were analysed statistically using principal component analysis (PCA). In silico of C. cinerariifolium compounds on protein (PI3K and Cyclin D) from OSCC. Results: TLC procedures utilizing UV light with λ 366 nm after spraying with H2SO4 revealed multiple-colored spots, indicating that H2SO4 is a specific spray detector for terpenoid and carotene. Metabolic profiling in ethanol extract of C. cinerariifolium stem included Pronethalol (3.96%), 1-(4-Methoxyphenyl)-N-(1 naphthylmethyl) methanamine (7.34%), Orphenadrine (24.27%), Pentazocine (5.09%), 4-(Dodecyloxy) aniline (6.30%), Linoleamide (4.95%), and Pheophorbide A (8.05%). Orphenadrine had the highest percentage. Based on the Lipinski rule of five, pronethalol has the potential to be used as a drug-like therapy for OSCC. The anticancer activity profile is predicted by PASS online with a likely range of 0.065 to 0.385. An in-silico study showed that the strongest binding affinity is pronethalol to Cyclin D1 and pheophorbide A to the PI3K protein. Conclusion: The active metabolite of the ethanolic extract of C. cinerariifolium stem exhibits potency against oral squamous cell carcinoma via the downregulation of the cell cycle (cyclin D1) and P13K, especially pronethalo

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic