Valoración de escenarios futuros a través de la conectividad del paisaje

En este trabajo se presenta una metodología SIG de valoración de la conectividad del paisaje aplicada a la valoración de escenarios futuros para el Área Metropolitana de Granada. Esta metodología será empleada para realizar un análisis comparado de las pérdidas de conectividad que los tres escenarios introducen unos con respecto a otros y se revela, junto con la generación de escenarios futuros como un instrumento útil para ayudar en la toma de decisiones en lo que respecta a las formas, lugares e intensidades del crecimiento urbano.This paper presents a GIS methodology to assess landscape connectivity through urban growth scenarios in the Metropolitan Area of Granada. This methodology will be useful to assess landscape connectivity loss in a compared evaluation of the scenarios. Thus, this evaluation will be show as a useful tool, combined with the scenario simulation, to help in the metropolitan decision making process

Design and simulation of metropolitan urban growth demands scenarios

La generación y simulación de escenarios exploratorios externos es un instrumento útil en los procesos de planificación y toma de decisiones, de especial relevancia en el ámbito territorial y metropolitano (Peterson et al, 2003; Pettit y Pullar, 2004; Luca, 2007; Carsjens, 2009), cuyo calado en el proceso de planificación en España es escaso hasta la fecha (Valenzuela, Aguilera, Soria y Molero, 2008). En este artículo se presenta un modelo basado en Dinámica de Sistemas para estimar las demandas de nuevo suelo urbano en ámbitos metropolitanos. El modelo se ha desarrollado concretamente para dos ámbitos metropolitanos españoles (Región Urbana de Madrid y Aglomeración Urbana de Granada) para los cuales se ha realizado un proceso de calibración individual, Una vez calibrado el modelo para dichos ámbitos, y a través del planteamiento de tres escenarios futuros, se han simulado las posibles tendencias de las demandas de ocupación urbana que podrían derivarse de las premisas establecidas en cada escenario, con unos resultados satisfactorios. Dichos resultados podrán ser empleados en otros trabajos que permitirán localizar espacialmente, mediante modelos de simulación espacial, las demandas estimadas, para mostrar y evaluar posibles consecuencias espaciales y territoriales de los procesos de crecimiento metropolitano.The design and development of future explorative external scenarios are useful tools for the spatial planning and even more for the metropolitan planning (Peterson et al, 2003; Pettit y Pullar, 2004; Luca, 2007; Carsjens, 2009). However, spatial planning policy and practices in Spain lack of this instruments (Valenzuela, Aguilera, Soria y Molero, 2008) This paper shows a System Dynamics-based model designed to estimate urban growth demands in metropolitan areas. This model has been specifically developed for Madrid and Granada metropolitan areas (Spain), where the model has been calibrated. After the calibration, three future urban growth demands scenarios has been designed and simulated using the model developed. The urban growth demands obtained may be used in later research to spatially locate that demands using spatial simulation models.Peer Reviewe

Neogene activity of the Barrancas Bancas Fault and its relationship with Hydrothermal and volcanic activity

The chronology and nature of the Neogene-Cuaternary deformation in the Central Volcanic Zone (CVZ) in the north of Chile is partially unclear. Some authors have identified compression in isolated areas of the western slopes of the Altiplano-Puna Plateau between the 23,5 and 25ºS, which deformed Miocene and Pliocene deposits (e.g. Gonzalez et al., 2009). In this context, Barrancas Blancas fault, located in the western limit of the Western Cordillera, outcrops in a scarp oriented NS and represents a record of the tectonic activity during the Miocene (Gardeweg et al., 1993). This fault affects to Pampa de Mulas gravels (23,6±1,6 Ma) and Rio Frio Ignimbrites (17,3± 1,7 Ma), and is covered by Miocene-to-Holocene alluvial deposits. In the eastern side of Punta Negra Salar was emplaced the Monognetic Punta Negra volcano, located over the Barrancas Blanca-Fault scarp (10±0,8 Ma) and immediately to the south of Punta Negra volcano, travertine deposits are present in the footwall of Barrancas Blancas fault (10-2 Ma; Quade et al., 2017). This work presents the preliminary results from geomorphologic and stratigraphic data, and structural analysis from Barrancas Blancas fault, and the sediment wedge related with the fault scarpament. These results were combined with geochronological data from magmatic and hydrothermal related rocks/minerals, with the objetive to rebuild the activity of Barrancas Blancas fault and its relation with the magmatic activity during Miocene-Pliocene. Our results show that Barrancas Blancas fault has reverse displacement during Lower Miocene, which caused folding of the Rio Frio ignimbrite and Pampa de Mulas Formation. This period has a maximum age of 11,7 Ma and can be related to the local uplift of the Altiplano-Puna plateau. Using a cinematic analysis, we have identified a period with transtensional activity for Barrancas Blancas fault, which had been coeval with magmatic/hydrothermal activity, the last represented by monogenetic (Punta Negra volcano, ca. 10 Ma) and geothermal activity. The hydrothermal activity in the Barrancas Blancas fault would have lasted until to ca. 2 Ma, coeval with the depositation of alluvial fans related with the scarp backward movement. Our hypothesis suggests that transtensional activity of the Barrancas Blancas fault is related with the uplift and local collapse of the Altiplano

Geochemistry of fluid discharges from Peteroa volcano (Argentina-Chile) in 2010-2015: Insights into compositional changes related to the fluid source region(s).

This study presents the first geochemical data of fluid discharges collected from February 2010 to March 2015 from the Planchon-Peteroa-Azufre Volcanic Complex (PPAVC), located in the Transitional Southern Volcanic Zone (TSVZ) at the border between Argentina and Chile. During the study period, from January 2010 to July 2011, Peteroa volcano experienced phreatic to phreatomagmatic eruption possibly related to the devastating Maule earthquake occurred on February 27, 2010. The compositional dataset includes low temperature (from 43.2 to 102 degrees C) gas discharges from (i) the summit of Peteroa volcano and (ii) the SE flank of Azufre volcano, both marked by a significant magmatic fluid contribution, as well as bubbling gases located at the foothill of the Peteroa volcanic edifice, which showed a chemical signature typical of hydrothermal fluids. In 2012, strong compositional changes affected the Peteroa gases from the summit area: the acidic gas species, especially SO2, increased, suggesting an input of fluids from magma degassing. Nevertheless, the R/Ra and delta C-13-CO2 values decreased, which would imply an enhanced contribution from a meteoric-hydrothermal source. In 2014-2015, the chemical and isotopic compositions of the 2010-2011 gases were partially restored. The anomalous decoupling between the chemical and the isotopic parameters was tentatively interpreted as produced by degassing activity from a small batch of dacitic magma that in 2012 masked the compositional signature of the magmatic fluids released from a basaltic magma that dominated the gas chemistry in 2010-2011. This explanation reliably justifies the observed geochemical data, although the mechanisms leading to the change in time of the dominating magmatic fluid source are not clear. At this regard, a geophysical survey able to provide information on the location of the two magma batches could be useful to clarify the possible relationships between the compositional changes that affected the Peteroa fluid discharges and the 2010-2011 eruptive activity.FONDECYT Iniciacion Project 11100372 FONDAP "Centro de Excelencia en Geotermia de los Andes" 15090013 Universidad de Buenos Aires UBACyT 20020120300077BA IDEAN institute (UBA-CONICET) Laboratory of Fluid and Rock Geochemistry of the Department of Earth Sciences (Florence, Italy

Long term variations measurement of electromagnetic field exposures in Alcalá de Henares (Spain)

Electromagnetic radiowave exposure is a major concern in most countries due to possible adverse health effects. Over the last 10 years, many technological changes (digital television, mobile technologies, wireless networks…) have led to variations in the electromagnetic field (EMF) levels. A large number of studies devoted to the analysis of EMF levels with personal dosimeters or computer models of the exposure of mobile stations have been conducted. However, the study of the exposure values, taking into account all the existing sources, and their evolution in a wide area, using measurements, has rarely been performed. In this paper, we provide a comparison of the EMF exposure levels for the city of Alcalá de Henares (Spain) over a ten-year period using a broadband isotropic probe in the range from 100 kHz to 3 GHz. A statistical and spatial analysis of the measurements and their variations are also presented for the study of the global and local variations. The measured values in the period from 2006 to 2015 were ranging from 0.02 to 2.05 V/m. Our global results show a moderate increase from 2006 to 2010 and they are almost invariant from 2010 to 2015. Although the whole dataset does not have relevant statistical difference, we have found marked local differences. In the city areas where the population density has remained unaltered, we have measured lower exposure levels. Conversely, new urban and industrial developments have demanded new resources, which have potentially contributed to the observed increase in the measured electric field levels within these areas

Gas emissions from five volcanoes in northern Chile, and implications for the volatiles budget of the Central Volcanic Zone

This study performed the first assessment of the volcanic gas output from the Central Volcanic Zone (CVZ) of northern Chile. We present the fluxes and compositions of volcanic gases (H2O, CO2, H2, HCl, HF, and HBr) from five of the most actively degassing volcanoes in this region—Láscar, Lastarria, Putana, Ollagüe, and San Pedro—obtained during field campaigns in 2012 and 2013. The inferred gas plume compositions for Láscar and Lastarria (CO2/Stot = 0.9–2.2; Stot/HCl = 1.4–3.4) are similar to those obtained in the Southern Volcanic Zone of Chile, suggesting uniform magmatic gas fingerprint throughout the Chilean arc. Combining these compositions with our own UV spectroscopy measurements of the SO2 output (summing to ~1800 t d−1 for the CVZ), we calculate a cumulative CO2 output of 1743–1988 t d−1 and a total volatiles output of >20,200 t d−1

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

A methodology to assess the future connectivity of protected areas by combining climatic representativeness and land cover change simulations: the case of the Guadarrama National Park (Madrid, Spain).

Protected areas are fundamental in conservation, but their intactness is increasingly threatened by the effects of climate and land-cover changes. Here, a methodological procedure is proposed able to determine the representative climatic conditions of a protected area in central Spain (Guadarrama National Park) pinpointing the natural areas that will host future analogous conditions, but also assessing the effects of land-cover changes on the connectivity of these areas. Future conditions provided by two 2050 IPCC climatic change scenarios and land-cover change simulations were jointly used for this purpose. According to the results obtained, climate change will produce notable effects, displacing its representative climatic conditions as well as modifying the land cover in the neighboring localities. Three areas appear as fundamental for the future maintenance of this reserve: two within the Iberian Central System (Gredos Mountains and Ayllón Mountains) and one in the Iberian System (Urbión Mountains). The proposed approach can be implemented in any protected area to examine its capacity to represent in the future the environmental conditions for which it was created

On the defensive A critical examination of concepts of `non-provocative defence', 1980-1992

SIGLEAvailable from British Library Document Supply Centre-DSC:D195372 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Design and simulation of metropolitan urban growth demands scenarios

La generación y simulación de escenarios exploratorios externos es un instrumento útil en los procesos de planificación y toma de decisiones, de especial relevancia en el ámbito territorial y metropolitano (Peterson et al, 2003; Pettit y Pullar, 2004; Luca, 2007; Carsjens, 2009), cuyo calado en el proceso de planificación en España es escaso hasta la fecha (Valenzuela, Aguilera, Soria y Molero, 2008). En este artículo se presenta un modelo basado en Dinámica de Sistemas para estimar las demandas de nuevo suelo urbano en ámbitos metropolitanos. El modelo se ha desarrollado concretamente para dos ámbitos metropolitanos españoles (Región Urbana de Madrid y Aglomeración Urbana de Granada) para los cuales se ha realizado un proceso de calibración individual, Una vez calibrado el modelo para dichos ámbitos, y a través del planteamiento de tres escenarios futuros, se han simulado las posibles tendencias de las demandas de ocupación urbana que podrían derivarse de las premisas establecidas en cada escenario, con unos resultados satisfactorios. Dichos resultados podrán ser empleados en otros trabajos que permitirán localizar espacialmente, mediante modelos de simulación espacial, las demandas estimadas, para mostrar y evaluar posibles consecuencias espaciales y territoriales de los procesos de crecimiento metropolitano.The design and development of future explorative external scenarios are useful tools for the spatial planning and even more for the metropolitan planning (Peterson et al, 2003; Pettit y Pullar, 2004; Luca, 2007; Carsjens, 2009). However, spatial planning policy and practices in Spain lack of this instruments (Valenzuela, Aguilera, Soria y Molero, 2008) This paper shows a System Dynamics-based model designed to estimate urban growth demands in metropolitan areas. This model has been specifically developed for Madrid and Granada metropolitan areas (Spain), where the model has been calibrated. After the calibration, three future urban growth demands scenarios has been designed and simulated using the model developed. The urban growth demands obtained may be used in later research to spatially locate that demands using spatial simulation models.Peer Reviewe