246 research outputs found

    Linking attentional processes and conceptual problem solving: visual cues facilitate the automaticity of extracting relevant information from diagrams

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    This study investigated links between visual attention processes and conceptual problem solving. This was done by overlaying visual cues on conceptual physics problem diagrams to direct participants’ attention to relevant areas to facilitate problem solving. Participants (N = 80) individually worked through four problem sets, each containing a diagram, while their eye movements were recorded. Each diagram contained regions that were relevant to solving the problem correctly and separate regions related to common incorrect responses. Problem sets contained an initial problem, six isomorphic training problems, and a transfer problem. The cued condition saw visual cues overlaid on the training problems. Participants’ verbal responses were used to determine their accuracy. This study produced two major findings. First, short duration visual cues which draw attention to solution-relevant information and aid in the organizing and integrating of it, facilitate both immediate problem solving and generalization of that ability to new problems. Thus, visual cues can facilitate re-representing a problem and overcoming impasse, enabling a correct solution. Importantly, these cueing effects on problem solving did not involve the solvers’ attention necessarily embodying the solution to the problem, but were instead caused by solvers attending to and integrating relevant information in the problems into a solution path. Second, this study demonstrates that when such cues are used across multiple problems, solvers can automatize the extraction of problem-relevant information extraction. These results suggest that low-level attentional selection processes provide a necessary gateway for relevant information to be used in problem solving, but are generally not sufficient for correct problem solving. Instead, factors that lead a solver to an impasse and to organize and integrate problem information also greatly facilitate arriving at correct solutions

    Amostragem de plantas para a caracterização botânica em cultivares de algodoeiro.

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    Uji Senyawa Taurin Sebagai Antikanker Terhadap Jumlah Sel-Sel Leukosit Dan Sel-Sel Eritrosit Mencit (Mus musculus L.) yang Diinduksi Benzo (Α) Pyren Secara In Vivo

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    The aim of this research was to determine the effect of taurine supplementation on the totalcount of leucocyte cells and erythrocyte cells of mice that have been induced to benzo (α)pyrene in vivo. The parameters of this experiment were the total count of leucocyte cells anderythrocyte cells of mice (Mus musculus L.). This experiment was conducted in a completerandomized design by using six treatments, each in five replications. The mice were dividedinto six groups. Group I used as control were not given any treatment. Group II were given0,2 mL of oleum olevarum (olive oil) orally to the end of the experiment. Group III wereinduced to benzo (α) pyrene without being given any taurine. Group IV were given 7,8mg/bw of taurine before being induced to benzo (α) pyrene. Group V were given 7,8 mg/bwof taurine after being induced to benzo (α) pyrene. Group VI were given 15,6 mg/bw oftaurine after being induced to benzo (α) pyrene. Mice of group III, V, and VI were injectedwith 0,5 mL of benzo (α) pyrene solution every day for 10 days on their subcutant tissue forthe purpose of a nodule being formed in this area. It was then continued by giving taurineorally for 15 days. In the final treatment, mice blood was taken to count the leucocyte cellsand erythrocyte cells. The data were analyzed using ANOVA (Analysis of Variance) thencontinued by calculating least significant difference at 5 per cent level of significance. Theresults indicated that taurine had the ability to reduce leucocyte cells into its normalquantity, and was able to increase the number of erythrocyte cells of mice suffered fromleukaemia back to normal.Key words: benzo (α) pyrene, leukaemia, leucocyte, mice , taurin

    The dynamics of inner dead-zone boundaries in protoplanetary disks

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    In protoplanetary disks, the inner radial boundary between the MRI turbulent (`active') and MRI quiescent (`dead') zones plays an important role in models of the disk evolution and in some planet formation scenarios. In reality, this boundary is not well-defined: thermal heating from the star in a passive disk yields a transition radius close to the star (<0.1 au), whereas if the disk is already MRI active, it can self-consistently maintain the requisite temperatures out to a transition radius of roughly 1 au. Moreover, the interface may not be static; it may be highly fluctuating or else unstable. In this paper, we study a reduced model of the dynamics of the active/dead zone interface that mimics several important aspects of a real disk system. We find that MRI-transition fronts propagate inward (a `dead front' suppressing the MRI) if they are initially at the larger transition radius, or propagate outward (an `active front' igniting the MRI) if starting from the smaller transition radius. In both cases, the front stalls at a well-defined intermediate radius, where it remains in a quasi-static equilibrium. We propose that it is this new, intermediate stalling radius that functions as the true boundary between the active and dead zones in protoplanetary disks. These dynamics are likely implicated in observations of variable accretion, such as FU Ori outbursts, as well as in those planet formation theories that require the accumulation of solid material at the dead/active interface.Comment: 16 pages, 10 figures; MNRAS accepted; v3 final correction

    Considerations in the determination of orientational order parameters from X-ray scattering experiments

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    An assessment of the data processing and analysis methods used to obtain the second- and fourth-rank orientational order parameters of liquid crystals from X-ray scattering experiments has been carried out, using experimental data from four extensively studied alkyl-cyanobiphenyls and calculated data generated from two general types of theoretical orientational distribution function. The application of a background subtraction and two different baseline correction methods to the scattering profiles is assessed, along with three different methods to analyse the processed data. The choice of baseline correction method is shown to have a significant effect: an offset to zero overestimates the order parameters from the experimental and calculated data sets, particularly for lower order parameters arising from broad distributions, whereas an offset to a value estimated from regions of low scattering intensity provides experimental values close to those reported from other experimental techniques. By contrast, the three different analysis methods are shown generally to result in relatively small absolute differences between the order parameters. We outline a straightforward general approach to experimental X-ray scattering data processing and analysis for uniaxial phases that results in order parameters that match well with those reported using other experimental techniques

    Measurement of the conductance of a hydrogen molecule

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    Recent years have shown steady progress in research towards molecular electronics [1,2], where molecules have been investigated as switches [3-5], diodes [6], and electronic mixers [7]. In much of the previous work a Scanning Tunnelling Microscope was employed to address an individual molecule. As this arrangement does not provide long-term stability, more recently metal-molecule-metal links have been made using break junction devices [8-10]. However, it has been difficult to establish unambiguously that a single molecule forms the contact [11]. Here, we show that a single H2 molecule can form a stable bridge between Pt electrodes. In contrast to results for other organic molecules, the bridge has a nearly perfect conductance of one quantum unit, carried by a single channel. The H2-bridge provides a simple test system and a fundamental step towards understanding transport properties of single-molecule devices.Comment: 6 pages, 4 figure

    Myocardial infarction with non-obstructive coronary arteries: A comprehensive review and future research directions

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    Acute coronary syndromes constitute a variety of myocardial injury presentations that include a subset of patients presenting with myocardial infarction with non-obstructive coronary arteries (MINOCA). This acute coronary syndrome differs from type 1 myocardial infarction (MI) regarding patient characteristics, presentation, physiopathology, management, treatment, and prognosis. Two-thirds of MINOCA subjects present ST-segment elevation; MINOCA patients are younger, are more often female and tend to have fewer cardiovascular risk factors. Moreover, MINOCA is a working diagnosis, and defining the aetiologic mechanism is relevant because it affects patient care and prognosis. In the absence of relevant coronary artery disease, myocardial ischaemia might be triggered by an acute event in epicardial coronary arteries, coronary microcirculation, or both. Epicardial causes of MINOCA include coronary plaque disruption, coronary dissection, and coronary spasm. Microvascular MINOCA mechanisms involve microvascular coronary spasm, takotsubo syndrome (TTS), myocarditis, and coronary thromboembolism. Coronary angiography with non-significant coronary stenosis and left ventriculography are first-line tests in the differential study of MINOCA patients. The diagnostic arsenal includes invasive and non-invasive techniques. Medical history and echocardiography can help indicate vasospasm or thrombosis, if one finite coronary territory is affected, or specify TTS if apical ballooning is present. Intravascular ultrasound, optical coherence tomography, and provocative testing are encouraged. Cardiac magnetic resonance is a cornerstone in myocarditis diagnosis. MINOCA is not a benign diagnosis, and its polymorphic forms differ in prognosis. MINOCA care varies across centres, and future multi-centre clinical trials with standardized criteria may have a positive impact on defining optimal cardiovascular care for MINOCA patients

    CD5L, Macrophage Apoptosis Inhibitor, Was Identified in Epicardial Fat-Secretome and Regulated by Isoproterenol From Patients With Heart Failure

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    Objectives: Neurohormonal dysfunction, which can regulate epicardial fat activity, is one of the main promoters of atrial fibrillation (AF) in patients with heart failure (HF). Our aim was to study the epicardial fat mediators for AF in patients with HF and its catecholaminergic regulation. Methods: We have included 29 patients with HF who underwent cardiac surgery and were followed up for 5 years. Released proteins by epicardial adipose tissue (EAT) after isoproterenol treatment were identified by nano-high-performance liquid chromatography (HPLC) and triple time-of-flight (TOF) analysis. Common and differential identified proteins in groups of patients with AF before and after surgery were determined by the FunRich tool. Plasma and epicardial fat biopsy proteins were quantified by western blot. Results: Our results identified 17 common released proteins by EAT, after isoproterenol treatment, from HF patients who suffered AF or developed new-onset AF during follow-up. Mostly, they were involved on inflammatory response and extracellular matrix. One of them was CD5L, a macrophage apoptosis inhibitor. Its secretion by isoproterenol treatment was validated on western blot. The CD5L levels on epicardial fat were also higher in the group of male patients who present or develop AF (0.44 +/- 0.05 vs. 0.18 +/- 0.15; p < 0.016). However, there were no differences regarding plasma levels. Conclusion: Our results suggest the role of epicardial fat CD5L as a mediator of AF and its possible paracrine effect by catecholaminergic activity
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