Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Serotonin Metabolism and Serotonin Receptors Expression Are Altered in Colon Diverticulosis

Background and Objectives: Diverticulosis is frequently accompanied by altered bowel habits. The biogenic amines within colonic mucosa control bowel motility, and in particular, alterations in serotonin signaling may play a role in colon diverticulosis. The aim of the study was to assess the concentration of biogenic amines and serotonin receptor expression in the colonic mucosa in patients with diverticulosis and healthy controls. Materials and Methods: This prospective, comparative study included 59 individuals: 35 with sigmoid diverticulosis and 24 healthy controls. The study was held at the Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Poland. Mucosal samples were taken from the right and left colon during a colonoscopy in all patients. Concentrations of norepinephrine, 3-methoxy-4-hydroxyphenylglycol, dopamine, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid were measured with high-performance liquid chromatography. Expressions of human 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 4, 5-hydroxytryptamine receptor 7, solute carrier family 6 member 4 (SERT) for serotonin, as well as the neuroglia activation markers glial fibrillary acidic protein, S100 calcium-binding protein B, and proteolipid protein 1, were assessed with polymerase chain reaction. Results: The median age and sex distribution were comparable in both study groups (median 69 y vs. 52 y; p p p SERT expression was lower in the affected left segment compared to the right colon (median 0.88 vs. 1.36; p p -hydroxyindoleacetic acid/serotonin ratio (median 0.27 vs. 0.47; p Conclusions: The concentration of serotonin in the mucosa of the colon segment affected by diverticula is higher than in the healthy segment in the same individuals and higher than in healthy controls. These results underline serotonin signaling in colon diverticulosis pathophysiology

Developing an intelligent ICT system for environmentally optimized irrigation management in agriculture

Globally, agriculture makes use of 70% of all water withdrawn from aquifers, streams and lakes. Agriculture accounts for 22% of freshwater abstraction in Europe, outnumbered only by freshwater abstraction for cooling in energy production (45%). In the light of the real need to practically improve the environmental performance of irrigation systems and prevent the misuse of water, the ENORASIS project was established aimed to develop an intelligent, integrated Decision Support System (ENORASIS Service Platform and Components) for environmentally optimized and thus, sustainable irrigation management to be used by farmers and water management organizations. To achieve so, the ENORASIS project developed and integrated a bouquet of advanced technologies, methodologies and models in the fields of: (i) weather prediction systems that exploit satellite observations; (ii) irrigation optimization techniques and (iii) smart irrigation systems; and (iv) wireless sensor networks (functioning with solar energy) as key enabling technology for field measurements and monitoring conditions.The system was tested in 5 pilot locations in Poland, Serbia, Cyprus and Turkey, providing large savings in water use as comparted to other irrigation practices while not compromising crop yields. The highest savings were observed in raspberry and potato plantations in Poland, reaching 90%and 59% respectively