7,343 research outputs found
To Cover Our Daughters: A Modern Chastity Ritual in Evangelical America
Over the last ten years, a newly created ritual called a Purity Ball has become increasingly popular in American evangelical communities. In much of the present literature, Purity Balls are assumed solely to address a daughter’s emerging sexuality in a ritual designed to counteract evolving American norms on sexuality; however, the ritual may carry additional latent sociological functions. While experienced explicitly by the individual participants as a celebration of father/daughter relationships and a means to address evolutionary sexual mating strategies, Purity Balls may implicitly regenerate existing social hierarchy. This ritual facilitates a sociological purpose by means of re-establishing the role of the male through halting the psychological development of sexual identity in the daughter, and these rituals are enacted in the ownership of the daughter by the father, who is responsible for maintaining the daughter’s purity, for “covering her with his protection.
Effects of Collisions with Rocky Planets on the Properties of Hot Jupiters
Observed Hot Jupiters exhibit a wide range of physical properties. For a
given mass, many planets have inflated radii, while others are surprisingly
compact and may harbor large central cores. Motivated by the observational
sample, this paper considers possible effects from collisions of smaller rocky
planets with gas giant planets. In this scenario, the Jovian planets migrate
first and enter into (approximately) 4 day orbits, whereas rocky planets (mass
= 0.1-20 that of Earth) migrate later and then encounter the gaseous giants.
Previous work indicates that the collision rates are high for such systems.
This paper calculates the trajectories of incoming rocky planets as they orbit
within the gaseous planets and are subjected to gravitational, frictional, and
tidal forces. These collisions always increase the metallicity of the Jovian
planets. If the incoming rocky bodies survive tidal destruction and reach the
central regions, they provide a means of producing large planetary cores. Both
the added metallicity and larger cores act to decrease the radii of the gas
giants at fixed mass. The energy released during these collisions provides the
Jovian planet with an additional heat source; here we determine the radial
layers where kinetic energy of the colliding body is dissipated, including the
energy remaining upon impact with the existing core. This process could have
long-term effects if the colliding body deposits significant energy deep in the
interior, in regions of high opacity. Both Hot Jupiters and newly formed gas
giants have inflated radii, large enough to allow incoming rocky planets to
survive tidal disruption, enhance the central core mass, and deposit
significant energy (in contrast, denser giant planets with the mass and radius
of Jupiter are expected to tidally destroy incoming rocky bodies).Comment: 35 pages, 11 figures, accepted to PAS
The relationship between childcare and adiposity, body mass and obesity-related risk factors: protocol for a systematic review of longitudinal studies
BACKGROUND: The rising prevalence of obesity, particularly in childhood, is a global public health emergency. There is some evidence that exposure to non-parental childcare before age 6 years is associated with subsequent development of obesity and obesity-related behaviours such as physical activity, sedentary behaviour, sleep, diet and stress, although these findings are inconsistent. It is possible that the relationship between early childcare and later obesity and obesity-related behaviours depends on characteristics of childcare exposure such as type (i.e. informal versus formal care), duration (i.e. number of years spent in childcare), intensity (e.g. number of hours per week) and timing (i.e. age of onset of childcare) of care received. The relationship may also be moderated by socio-demographic characteristics of children and their families. We will conduct a systematic review exploring longitudinal associations between childcare (type, duration, intensity and timing) and measures of adiposity and body mass, physical activity, sedentary behaviour, sleep, diet and stress. We will also assess whether these relationships vary by socio-demographic factors. METHODS: We will include studies that explore longitudinal associations between childcare attendance in children aged <6 years not in primary school at first assessment and body weight, adiposity, physical activity, diet, sleep and stress. We will limit studies to those involving middle- and high-income countries. Two independent reviewers will screen search results in two stages: (1) title and abstract and (2) and full text. One reviewer will extract relevant data and a second will verify this information. We will assess risk of bias of included studies using an adaption of the United States Department of Agriculture National Evidence Library Bias Assessment Tool. We will tabulate and summarise results narratively. We may conduct meta-analysis if at least five studies report comparable data. DISCUSSION: To our knowledge, this will be the first systematic review to summarise the existing evidence on longitudinal associations between childcare and adiposity, body mass and obesity-related risk factors. The results will be of relevance to other researchers, childcare practitioners and policy makers. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015027233.British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, National Institute for Health Research, Wellcome Trus
Microscopic Aspects of Stretched Exponential Relaxation (SER) in Homogeneous Molecular and Network Glasses and Polymers
Because the theory of SER is still a work in progress, the phenomenon itself
can be said to be the oldest unsolved problem in science, as it started with
Kohlrausch in 1847. Many electrical and optical phenomena exhibit SER with
probe relaxation I(t) ~ exp[-(t/{\tau}){\beta}], with 0 < {\beta} < 1. Here
{\tau} is a material-sensitive parameter, useful for discussing chemical
trends. The "shape" parameter {\beta} is dimensionless and plays the role of a
non-equilibrium scaling exponent; its value, especially in glasses, is both
practically useful and theoretically significant. The mathematical complexity
of SER is such that rigorous derivations of this peculiar function were not
achieved until the 1970's. The focus of much of the 1970's pioneering work was
spatial relaxation of electronic charge, but SER is a universal phenomenon, and
today atomic and molecular relaxation of glasses and deeply supercooled liquids
provide the most reliable data. As the data base grew, the need for a
quantitative theory increased; this need was finally met by the
diffusion-to-traps topological model, which yields a remarkably simple
expression for the shape parameter {\beta}, given by d*/(d* + 2). At first
sight this expression appears to be identical to d/(d + 2), where d is the
actual spatial dimensionality, as originally derived. The original model,
however, failed to explain much of the data base. Here the theme of earlier
reviews, based on the observation that in the presence of short-range forces
only d* = d = 3 is the actual spatial dimensionality, while for mixed short-
and long-range forces, d* = fd = d/2, is applied to four new spectacular
examples, where it turns out that SER is useful not only for purposes of
quality control, but also for defining what is meant by a glass in novel
contexts. (Please see full abstract in main text
Topological and topological-electronic correlations in amorphous silicon
In this paper, we study several structural models of amorphous silicon, and
discuss structural and electronic features common to all. We note spatial
correlations between short bonds, and similar correlations between long bonds.
Such effects persist under a first principles relaxation of the system and at
finite temperature. Next we explore the nature of the band tail states and find
the states to possess a filamentary structure. We detail correlations between
local geometry and the band tails.Comment: 7 pages, 11 figures, submitted to Journal of Crystalline Solid
The Existence of Sterile Neutrino Halos in Galactic Centers as an Explanation of the Black Hole mass - Velocity Dispersion Relation
If sterile neutrinos exist and form halos in galactic centers, they can give
rise to observational consequences. In particular, the sterile neutrinos decay
radiatively and heat up the gas in the protogalaxy to achieve hydrostatic
equilibrium, and they provide the mass to form supermassive blackholes. A
natural correlation between the blackhole mass and velocity dispersion thus
arises with and .Comment: Accepted in Ap
Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay.
Current sequencing-based methods for profiling microbial communities rely on marker gene (e.g., 16S rRNA) or metagenome shotgun sequencing (mWGS) analysis. We present an approach based on a single-primer extension reaction using a highly multiplexed oligonucleotide probe pool. This approach, termed MA-GenTA (microbial abundances from genome tagged analysis), enables quantitative, straightforward, cost-effective microbiome profiling that combines desirable features of both 16S rRNA and mWGS strategies. The use of multiple probes per target genome and rigorous probe design criteria enabled robust determination of relative abundance. To test the utility of the MA-GenTA assay, probes were designed for 830 genome sequences representing bacteria present in mouse stool specimens. Comparison of the MA-GenTA data with mWGS data demonstrated excellent correlation down to 0.01% relative abundance and a similar number of organisms detected per sample. Despite the incompleteness of the reference database, nonmetric multidimensional scaling (NMDS) clustering based on the Bray-Curtis dissimilarity metric of sample groups was consistent between MA-GenTA, mWGS, and 16S rRNA data sets. MA-GenTA represents a potentially useful new method for microbiome community profiling based on reference genomes
Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay.
Current sequencing-based methods for profiling microbial communities rely on marker gene (e.g., 16S rRNA) or metagenome shotgun sequencing (mWGS) analysis. We present an approach based on a single-primer extension reaction using a highly multiplexed oligonucleotide probe pool. This approach, termed MA-GenTA (microbial abundances from genome tagged analysis), enables quantitative, straightforward, cost-effective microbiome profiling that combines desirable features of both 16S rRNA and mWGS strategies. The use of multiple probes per target genome and rigorous probe design criteria enabled robust determination of relative abundance. To test the utility of the MA-GenTA assay, probes were designed for 830 genome sequences representing bacteria present in mouse stool specimens. Comparison of the MA-GenTA data with mWGS data demonstrated excellent correlation down to 0.01% relative abundance and a similar number of organisms detected per sample. Despite the incompleteness of the reference database, nonmetric multidimensional scaling (NMDS) clustering based on the Bray-Curtis dissimilarity metric of sample groups was consistent between MA-GenTA, mWGS, and 16S rRNA data sets. MA-GenTA represents a potentially useful new method for microbiome community profiling based on reference genomes
EO9 (Apaziquone): from the clinic to the laboratory and back again
EO9 (Apaziquone) is a bioreductive drug that has a chequered history. It underwent clinical trial but failed to show activity in phase II clinical trials when administered i.v. Poor drug delivery to tumours caused by a combination of rapid pharmacokinetic elimination and poor penetration through avascular tissue were the major factors responsible for EO9’s poor efficacy. Based upon an understanding of why EO9 failed, a further clinical trial against patients with superficial transitional cell carcinoma
of the bladder was conducted. The rationale for this was that intravesical administration directly into the bladder would circumvent the drug delivery problem, and any drug reaching the blood supply would be rapidly cleared thereby reducing the risk of systemic exposure. EO9 was well tolerated, and clinical activity against marker lesions was recorded in both phase I and II clinical trials. This article charts the pharmacological history of EO9 and discusses the potential implications that ‘the EO9 story’ has for the development of other loco-regional therapies
Combined stable isotope and gut contents analysis of food webs in plant-dominated, shallow lakes
1. To determine feeding links between primary producers, invertebrates and fish, stable isotope analyses and gut content analyses of fish were conducted on the components of four shallow, eutrophic to hypertrophic, plant-dominated lakes.
2. Although separation of basal resources was possible, the diets of both fish and invertebrates were broad, comprising food from different compartments (planktonic, epiphytic/benthic), as well as from different trophic levels.
3. Mixing models were used to determine the extent to which periphyton production supported higher trophic levels. Only one species of invertebrate relied upon periphyton production exclusively.
4. Fish density affected the diets of invertebrates. The response was different for planktonic and epiphytic/benthic invertebrates. The proportion of periphyton production in the diets of zooplankton appeared to increase with fish density, whilst it decreased for other invertebrates.
5. As all zooplankton samples were collected in the open water at dusk, these results are further evidence for the diurnal horizontal migration of zooplankton. Although not conclusive, they are consistent with a behavioural response by invertebrates and zooplankton in the presence of fish
- …