Dietary Behavior Related to Cancer Prevention in a Low Income Community

Background: The incidence of cancer is increasing in developing countries. Diet and cancer have a close relationship. Objectives: The objectives of this study were to measure the cancer prevention-related nutrition knowledge, attitudes, and practice and barriers related to healthy food in a low income community, and to assess their cancer worries. Subjects and Methods: This cross-section descriptive study was carried out in a slum area in Cairo on a convenience sample of 414 adults permanently residing in the area. A structured interview questionnaire was used for collecting participants' socio-demographic data, knowledge about cancer, attitude and practice towards cancer dietary prevention, cancer worry scale, and the barriers preventing eating healthy food. Results: The study revealed a wide range of participants' knowledge scores. Participants' attitude towards a healthy diet was also low. The most deficient practices were related to the intake of balanced diet and vitamins, practice of exercise, and cancer screening.  The most frequent barrier to a healthy diet was taste (42%), while the lack of information was the least (3.1%). Multivariate analysis showed that the knowledge score was positively predicted by cancer worry score. The attitude score was positively predicted by age and knowledge score, and the practice score by married status, crowding index, and attitude score. Conclusion: there is a poor level of knowledge and inadequate practices regarding cancer dietary prevention despite good attitudes, in addition to high worries about cancer. Implications for Practice: There is urgent need for awareness raising intervention programs for dietary prevention of cancer. Keywords: Cancer, Diet, Knowledge, Attitude, Practice, Barrie

Improve Knowledge, Beliefs and Behavior of Undergraduate Female Nursing Students in Al-Alzhar University toward Breast Self-Examination Practice

Breast cancer is a public health problem that is most common form of cancer among females in both developed and developing world, The Health Belief Model (HBM) has been used as a theoretical framework to study Breast Self-Examination and other breast cancer detection behaviors. The aim of this study: Was to improve knowledge, beliefs and behavior of undergraduate female nursing students in Al-Alzhar University toward breast self examination practice. Design: A quasi-experimental design was used in this study. Setting: The study was conducted in Health Technical Institute for female students at Al-Alzhar University for 113female student nurse. Tools: data was collected using self administered questionnaires prepared by researchers and Health Belief Model Scale Data. Results: The participants in the study showed more deficiency on screening knowledge, and poor practice of BSE at pre education. Also, the results of this study highlight the positive impact of the educational training on nursing students’ breast cancer and breast self exam  knowledge, practice and health beliefs which there was statistically significant differences were found between students' pretest and posttest BSE Knowledge, practice and  beliefs. Conclusion and recommendation: the results of this study concluded that this program could be instrumental in increasing nursing students’ perception of susceptibility may serve to improve not only their own health status but may empower them to teach women about the importance of early diagnosis and to seek early medical advice. This study emphasizes that the need to teach nursing students breast cancer awareness and early detection of breast cancer in their undergraduate courses. In addition, the provision of regular interventions is necessary to increase and build up the confidence and skills of nursing students in teaching preventive health behaviors including BSE to society and other students as colleagues. Keywords: Breast Self Exam (BSE), Breast Cancer, Nursing Students, Health Beliefs Mode

SVD Audio Watermarking: A Tool to Enhance the Security of Image Transmission over ZigBee Networks, Journal of Telecommunications and Information Technology, 2011, nr 4

The security is important issue in wireless networks. This paper discusses audio watermarking as a tool to improve the security of image communication over the IEEE 802.15.4 ZigBee network. The adopted watermarking method implements the Singular-Value Decomposition (SVD) mathematical technique. This method is based on embedding a chaotic encrypted image in the Singular Values (SVs) of the audio signal after transforming it into a 2-D format. The objective of chaotic encryption is to enhance the level of security and resist different attacks. Experimental results show that the SVD audio watermarking method maintains the high quality of the audio signals and that the watermark extraction and decryption are possible even in the presence of attacks over the ZigBee network

An Efficient Chaotic Interleaver for Image Transmission over IEEE 802.15.4 Zigbee Network, Journal of Telecommunications and Information Technology, 2011, nr 2

This paper studies a vital issue in wireless communications, which is the transmission of images over wireless networks. IEEE ZigBee 802.15.4 is a short-range communication standard that could be used for small distance multimedia transmissions. In fact, the ZigBee network is a wireless personal area network (WPAN), which needs a strong interleaving mechanism for protection against error bursts. This paper presents a novel chaotic interleaving scheme for this purpose. This scheme depends on the chaotic Baker map. A comparison study between the proposed chaotic interleaving scheme and the traditional block and convolutional interleaving schemes for image transmission over a correlated fading channel is presented. The simulation results show the superiority of the proposed chaotic interleaving scheme over the traditional schemes

Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents

Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesized using condensation reactions of celecoxib with 2-aminoanthraquinone derivatives or 2-aminoanthraquinon with celecoxib derivatives. Celecoxib was reacted with different acid chlorides, 2-chloroethylisocyanate and bis (2-chloroethyl) amine hydrochloride. These intermediates were then reacted with 2-aminoanthraquinone. Also the same different acid chlorides and 2-chloroethylisocyanate were reacted with 2-aminoanthraquinone and the resulting intermediates were reacted with celecoxib to give isomers for the previous compounds. The antitumor activities against hepatic carcinoma tumor cell line (HEPG2) have been investigated in vitro, and all these compounds showed promising activities, especially compound 3c, 7, and 12. Flexible docking studies involving AutoDock 4.2 was investigated to identify the potential binding affinities and the mode of interaction of the hybrid compounds into two protein tyrosine kinases namely, SRC (Pp60v-src) and platelet-derived growth factor receptor, PDGFR (c-Kit). The compounds in this study have a preferential affinity for the c-Kit PDGFR PTK over the non-receptor tyrosine kinase SRC (Pp60v-src)

Mortality and disability-adjusted life years in North Africa and Middle East attributed to kidney dysfunction : a systematic analysis for the Global Burden of Disease Study 2019

The authors would like to thank the hard work of the staff of the Institute for Health Metrics and Evaluation (IHME) for providing the best possible epidemiologic estimation of diseases in almost all regions and countries of the world, trying to reduce and eliminate poverty of knowledge and information about the diseases globally. Also, the core team authors sincerely thank all the collaborators of the GBD 2019 study who contributed to this study by providing data or a precise review of the manuscript. Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Peer reviewe

Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent

The occurrence of a functional relationship between the release of metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been inferred. While brain endothelial cells play an essential role as structural and functional components of the blood-brain barrier (BBB), increased BBB breakdown is thought to be linked to neuroinflammation. Chemopreventive mechanisms targeting both MMPs and COX-2 however remain poorly investigated. In this study, we evaluated the pharmacological targeting of Sirt1 by the diet-derived and antiinflammatory polyphenol resveratrol. Total RNA, cell lysates, and conditioned culture media from human brain microvascular endothelial cells (HBMEC) were analyzed using qRT-PCR, immunoblotting, and zymography respectively. Tissue scan microarray analysis of grade I–IV brain tumours cDNA revealed increased gene expression of Sirt-1 from grade I–III but surprisingly not in grade IV brain tumours. HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-κB. We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression. Gene silencing of Sirt1, a critical modulator of angiogenesis and putative target of resveratrol, did not lead to significant reversal of MMP-9 and COX-2 inhibition. Decreased resveratrol inhibitory potential of carcinogen-induced IκB phosphorylation in siSirt1-transfected HBMEC was however observed. Our results suggest that resveratrol may prevent BBB disruption during neuroinflammation by inhibiting MMP-9 and COX-2 and act as a pharmacological NF-κB signal transduction inhibitor independent of Sirt1

Burden of musculoskeletal disorders in the Eastern Mediterranean Region, 1990–2013: findings from the Global Burden of Disease Study 2013

Moradi-Lakeh M, Forouzanfar MH, Vollset SE, et al. Burden of musculoskeletal disorders in the Eastern Mediterranean Region, 1990–2013: findings from the Global Burden of Disease Study 2013. Annals of the Rheumatic Diseases. 2017;76(8):annrheumdis-2016-210146

Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.

Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w), results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively), to a similar extent to that following blueberry supplementation (p = 0.002). These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p<0.01), suggesting a common mechanism for the enhancement of memory. However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods

Transport injuries and deaths in the Eastern Mediterranean Region : findings from the Global Burden of Disease 2015 Study

Transport injuries (TI) are ranked as one of the leading causes of death, disability, and property loss worldwide. This paper provides an overview of the burden of TI in the Eastern Mediterranean Region (EMR) by age and sex from 1990 to 2015. Transport injuries mortality in the EMR was estimated using the Global Burden of Disease mortality database, with corrections for ill-defined causes of death, using the cause of death ensemble modeling tool. Morbidity estimation was based on inpatient and outpatient datasets, 26 cause-of-injury and 47 nature-of-injury categories. In 2015, 152,855 (95% uncertainty interval: 137,900-168,100) people died from TI in the EMR countries. Between 1990 and 2015, the years of life lost (YLL) rate per 100,000 due to TI decreased by 15.5%, while the years lived with disability (YLD) rate decreased by 10%, and the age-standardized disability-adjusted life years (DALYs) rate decreased by 16%. Although the burden of TI mortality and morbidity decreased over the last two decades, there is still a considerable burden that needs to be addressed by increasing awareness, enforcing laws, and improving road conditions.Peer reviewe