Millisecond pulsars and the gamma-ray excess in Andromeda

The Fermi Gamma-Ray Space Telescope has provided evidence for diffuse gamma-ray emission in the central parts of the Milky Way and the Andromeda galaxy. This excess has been interpreted either as dark matter annihilation emission or as emission from thousands of millisecond pulsars (MSPs). We have recently shown that old massive globular clusters may move towards the center of the Galaxy by dynamical friction and carry within them enough MSPs to account for the observed gamma-ray excess. In this paper we revisit the MSP scenario for the Andromeda galaxy, by modeling the formation and disruption of its globular cluster system. We find that our model predicts gamma-ray emission $\sim 2-3$ times larger than for the Milky Way, but still nearly an order of magnitude smaller than the observed Fermi excess in the Andromeda. Our MSP model can reproduce the observed excess only by assuming $\sim 8$ times larger number of old clusters than inferred from galaxy scaling relations. To explain the observations we require either that Andromeda deviates significantly from the scaling relations, or that a large part of its high-energy emission comes from additional sources.Comment: 5 pages, 2 figures, 1 Table, accepted by ApJ Let

General Framework of Competence and International Criminal Procedural Cooperation

El autor llama la atención sobre algunos elementos de derecho internacional acogidos en la codificación procesal penal mexicana. Presenta la temática relacionada con la competencia judicial internacional, el orden jurídico regulador de los problemas de tráfico jurídico internacional, la cooperación internacional en el nuevo Código Nacional de Procedimientos Penales, incluido el reconocimiento de decisiones extranjeras, la extradición, así como la asistencia consular.The author specifically highlights some elements of the international law adopted by the Mexican Criminal Procedural Code. The article shows the topic relating to international judicial competence, the legal system governing issues of international juridical trafficking, and international cooperation in the new National Criminal Procedural Code, including the recognition of foreign decisions, extradition, and consular assistance

Diesel exhaust particles suppress macrophage function and slow the pulmonary clearance of Listeria monocytogenes in rats.

In this study, we tested the hypothesis that exposure to diesel exhaust particles (DEP) may increase susceptibility of the host to pulmonary infection. Male Sprague-Dawley rats received a single dose of DEP (5 mg/kg), carbon black (CB, 5 mg/kg), or saline intratracheally. Three days later, the rats were inoculated intratracheally with approximately 5,000 Listeria monocytogenes and sacrificed at 3, 5, and 7 days postinfection, and we determined the number of viable Listeria in the left lobe of lungs. The remaining lungs underwent bronchoalveolar lavage (BAL) and the retrieved BAL cells were identified and counted. Luminol-dependent chemiluminescence, a measure of reactive oxygen species (ROS) formation, generated by BAL cells was monitored and the levels of nitric oxide and tumor necrosis factor (TNF)-[alpha] produced by macrophages in culture were determined. At 7 days postinfection, we excised the lung-draining lymph nodes and phenotyped the lymphocyte subpopulations. Exposure of rats to DEP, but not to CB, decreased the clearance of Listeria from the lungs. Listeria-induced generation of luminol-dependent chemiluminescence by pulmonary phagocytes decreased by exposure to DEP but not CB. Similarly, Listeria-induced production of NO by alveolar macrophages was negated at 3, 5, and 7 days after inoculation in DEP-exposed rats. In contrast, CB exposure had no effect on Listeria-induced NO production at 3 days after infection and had a substantially smaller effect than DEP at later days. Exposure to DEP or CB resulted in enlarged lung-draining lymph nodes and increased the number and percentage of CD4(+) and CD8(+) T cells. These results showed that exposure to DEP decreased the ability of macrophages to produce antimicrobial oxidants in response to Listeria, which may play a role in the increased susceptibility of rats to pulmonary infection. This DEP-induced suppression is caused partially by chemicals adsorbed onto the carbon core of DEP, because impaired macrophage function and decreased Listeria clearance were not observed following exposure to CB

Secular dynamics of multiplanet systems: implications for the formation of hot and warm Jupiters via high-eccentricity migration

Stars and planetary system

Is there a role of statins in the prevention of aortic biological prostheses degeneration

It has been recently observed that statins might slow the progression of aortic stenosis or sclerosis. Preliminary reports suggested a similar positive effect in reducing the degeneration of aortic valve bioprostheses even though this hypothesis should be further proven and supported by new data. In this review the present evidences of the possible effects of statins in this field are discussed

Experience-Driven Axon Retraction in the Pharmacologically Inactivated Visual Cortex Does Not Require Synaptic Transmission

BACKGROUND: Experience during early postnatal development plays an important role in the refinement of specific neural connections in the brain. In the mammalian visual system, altered visual experiences induce plastic adaptation of visual cortical responses and guide rearrangements of afferent axons from the lateral geniculate nucleus. Previous studies using visual deprivation demonstrated that the afferents serving an open eye significantly retract when cortical neurons are pharmacologically inhibited by applying a gamma-aminobutyric acid type A receptor agonist, muscimol, whereas those serving a deprived eye are rescued from retraction, suggesting that presynaptic activity can lead to the retraction of geniculocortical axons in the absence of postsynaptic activity. Because muscimol application suppresses the spike activity of cortical neurons leaving transmitter release intact at geniculocortical synapses, local synaptic interaction may underlie the retraction of active axons in the inhibited cortex. METHOD AND FINDINGS: New studies reported here determined whether experience-driven axon retraction can occur in the visual cortex inactivated by blocking synaptic inputs. We inactivated the primary visual cortex of kittens by suppressing synaptic transmission with cortical injections of botulinum neurotoxin type E, which cleaves a synaptic protein, SNAP-25, and blocks transmitter release, and examined the geniculocortical axon morphology in the animals with normal vision and those deprived of vision binocularly. We found that afferent axons in the animals with normal vision showed a significant retraction in the inactivated cortex, as similarly observed in the muscimol-treated cortex, whereas the axons in the binocularly deprived animals were preserved. CONCLUSIONS: Therefore, the experience-driven axon retraction in the inactivated cortex can proceed in the absence of synaptic transmission. These results suggest that presynaptic mechanisms play an important role in the experience-driven refinement of geniculocortical axons

Stem Cell–Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy

n/

Wavelet domain Bayesian denoising of string signal in the cosmic microwave background

An algorithm is proposed for denoising the signal induced by cosmic strings in the cosmic microwave background (CMB). A Bayesian approach is taken, based on modeling the string signal in the wavelet domain with generalized Gaussian distributions. Good performance of the algorithm is demonstrated by simulated experiments at arcminute resolution under noise conditions including primary and secondary CMB anisotropies, as well as instrumental noise.Comment: 16 pages, 11 figures. Version 2 matches version accepted for publication in MNRAS. Changes include substantial clarifications on our approach and a significant reduction of manuscript lengt

Wave power extraction from multiple oscillating water columns along a straight coast

The integration of oscillating water column (OWC) wave energy converters into a coastal structure (breakwater, jetty, pier, etc.) or, more generally, their installation along the coast is an effective way to increase the accessibility of wave power exploitation. In this paper, a theoretical model is developed based on the linear potential flow theory and eigenfunction matching method to evaluate the hydrodynamic performance of an array of OWCs installed along a vertical straight coast. The chamber of each OWC consists of a hollow vertical circular cylinder, which is half embedded in the wall. The OWC chambers in the theoretical model may have different sizes, i.e. different values of the radius, wall thickness and submergence. At the top of each chamber, a Wells turbine is installed to extract power. The effects of the Wells turbine together with the air compressibility are taken into account as a linear power take-off system. The hydrodynamic and wave power extraction performance of the multiple coast-integrated OWCs is compared with that of a single offshore/coast-integrated OWC and of multiple offshore OWCs. More specifically, we analyse the role of the incident wave direction, chamber size (i.e. radius, wall thickness and submergence), spacing between OWCs and number of OWCs by means of the present theoretical model. It is shown that wave power extraction from the coast-integrated OWCs for a certain range of wave conditions can be significantly enhanced due to both the constructive array effect and the constructive coast effect.Accepted Author ManuscriptCoastal Engineerin