Integrated crop‐livestock technologies for improved production: Lessons from ZimCLIFS project

Australian Centre for International Agricultural Researc

Toward a Theology of Christian Worship and the Improvement of Worship Participation in Seventh-day Adventist Churches in Africa

In the typical mission station in West Africa in the nineteenth and even in the early twentieth century, life was routinely patterned after the Western mode, hardly reflecting at all the life and routine of the surrounding villages. This was particularly true of their worship. It is the thesis of this doctoral project that an effective approach to promoting and advancing African Christianity is to proclaim the basic principles of Christian worship and faith in such a way that these principles can be understood and lived in any society or culture. Christian worship must be seen as transcending ethnic and cultural barriers. It was the purpose, of this project to introduce these basic principles of worship to the student body and faculty of the Adventist Seminary of West Africa. This school was viewed as having the potential to play a key role through its graduates in influencing the worship patterns of the church in Africa. An extensive statement of a theological nature was prepared as a position paper on worship and constitutes the first part of this report. The practical application of the implications stemming from this statement is reported in the second part of this paper. Certain key concepts are extrapolated from the position paper as the basis for a program of education for worship. Recommendations for incorporating such a program at A.S.W. A. included preaching (as at a student Week of Spiritual Emphasis), the formation of a worship committee, a worship seminar/workshop, Bible-study groups, and a prayer-meeting study series. The first; steps in the implementation of such a program were taken in a Week of Spiritual Emphasis during which twelve sermons on the subject were presented. The activities of this special week are reported, evaluated, and analyzed in this report

PENGEMBANGAN MODUL PERMAINAN SEPAK BOLA BERBASIS LATIHAN SHOOTING DI KELAS VII SMP N 39 PALEMBANG

This research aimss to develop a soccer game module based on shooting practice and see the feasibility of the teaching material developed in the form of a shooting practice-based module on football game material in class VII of Junior High School. This type of research uses the R&D (Research and Development) method using the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model. This research was conducted at SMP Negeri 39 Palembang. The research subjects were class VII students using data collection techniques in the form of questionnaires, interviews and observations. This research obtained a score of 88.2% from 3 validators with the criteria "very valid". The practical results of 3 students got a score of 88%, and 33 large groups got a score of 83% with the criteria of "very practical". So the soccer game module based on shooting practice in class VII Junior High School is valid and practical. The module developed can be used in the learning process of class VII students at SMP N 39 Palembang. Keywords: development of a soccer game modul

Self-Stigma and Its Relationship with Victimization, Psychotic Symptoms and Self-Esteem among People with Schizophrenia Spectrum Disorders

Objective Self-stigma is highly prevalent in schizophrenia and can be seen as an important factor leading to low self-esteem. It is however unclear how psychological factors and actual adverse events contribute to self-stigma. This study empirically examines how symptom severity and the experience of being victimized affect both self-stigma and self-esteem. Methods Persons with a schizophrenia spectrum disorder (N = 102) were assessed with a battery of self-rating questionnaires and interviews. Structural equation modelling (SEM) was subsequently applied to test the fit of three models: a model with symptoms and victimization as direct predictors of self-stigma and negative self-esteem, a model with an indirect effect for symptoms mediated by victimization and a third model with a direct effect for negative symptoms and an indirect effect for positive symptoms mediated by victimization. Results Results showed good model fit for the direct effects of both symptoms and victimization: both lead to an increase of self-stigma and subsequent negative self-esteem. Negative symptoms had a direct association with self-stigma, while the relationship between positive symptoms and self-stigma was mediated by victimization. Conclusions Our findings suggest that symptoms and victimization may contribute to self-stigma, leading to negative self- esteem in individuals with a schizophrenia spectrum disorder. Especially for patients with positive symptoms victimization seems to be an important factor in developing self- stigma. Given the burden of self- stigma on patients and the constraining effects on societal participation and service use, interventions targeting victimization as well as self- stigma are needed

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review.

Colorectal cancer is a leading cause of cancer related mortality in the Western world. In recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment of this disease has led to improved disease free and overall survival. However drug resistance, both innate and acquired, remains an obstacle in the effective treatment of this disease. Apoptotic pathways are frequently altered in both tumor progression and drug resistance; therefore proteins associated with this pathway may have potential as prognostic biomarkers for this disease. Identification of clinical biomarkers that are able to identify patients who are more likely to respond to specific chemotherapy will lead to more personalized, effective, and less toxic therapy. This review focuses on the current status of apoptosis related proteins as biomarkers for colorectal cancer and discusses the possible application of systems approaches in this context

Low-field microwave absorption in pulse laser deposited FeSi thin film

Low field microwave absorption (LFMA) measurements at 9.4 GHz (X-band), were carried out on pulse laser deposited (PLD) polycrystalline B20 cubic structure FeSi thin film grown on Si (111) substrate. The LFMA properties of the films were investigated as a function of DC field, temperature, microwave power and the orientation of DC field with respect to the film surface. The LFMA signal is very strong when the DC field is parallel to the film surface and vanishes at higher angles. The LFMA signal strength increases as the microwave power is increased. The LFMA signal disappears around 340 K, which can be attributed to the disappearance of ferromagnetic state well above room temperature in these films. We believe that domain structure evolution in low fields, which in turn modifies the low field permeability as well as the anisotropy, could be the origin of the LFMA observed in these films. The observation of LFMA opens the possibility of the FeSi films to be used as low magnetic field sensors in the microwave and rf frequency regions.University of Pretoria research development program and NRF/Ithemba LABS.http://www.elsevier.com/locate/jmmmnf201

HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Background & aims: Ulcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, and is associated with specific risk single nucleotide polymorphisms in HLA class II. Given the recently discovered interactions between subsets of HLA-DP molecules and the activating natural killer (NK) cell receptor NKp44, genetic associations of UC and HLA-DP haplotypes and their functional implications were investigated.Methods: HLA-DP haplotype and UC risk association analyses were performed (UC: n = 13,927; control: n = 26,764). Expression levels of HLA-DP on intestinal epithelial cells (IECs) in individuals with and without UC were quantified. Human intestinal 3-dimensional (3D) organoid cocultures with human NK cells were used to determine functional consequences of interactions between HLA-DP and NKp44.Results: These studies identified HLA-DPA1∗01:03-DPB1∗04:01 (HLA-DP401) as a risk haplotype and HLA-DPA1∗01:03-DPB1∗03:01 (HLA-DP301) as a protective haplotype for UC in European populations. HLA-DP expression was significantly higher on IECs of individuals with UC compared with controls. IECs in human intestinal 3D organoids derived from HLA-DP401pos individuals showed significantly stronger binding of NKp44 compared with HLA-DP301pos IECs. HLA-DP401pos IECs in organoids triggered increased degranulation and tumor necrosis factor production by NKp44+ NK cells in cocultures, resulting in enhanced epithelial cell death compared with HLA-DP301pos organoids. Blocking of HLA-DP401-NKp44 interactions (anti-NKp44) abrogated NK cell activity in cocultures.Conclusions: We identified an UC risk HLA-DP haplotype that engages NKp44 and activates NKp44+ NK cells, mediating damage to intestinal epithelial cells in an HLA-DP haplotype-dependent manner. The molecular interaction between NKp44 and HLA-DP401 in UC can be targeted by therapeutic interventions to reduce NKp44+ NK cell-mediated destruction of the intestinal epithelium in UC