7,542 research outputs found

    Understanding edge-connectivity in the Internet through core-decomposition

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    Internet is a complex network composed by several networks: the Autonomous Systems, each one designed to transport information efficiently. Routing protocols aim to find paths between nodes whenever it is possible (i.e., the network is not partitioned), or to find paths verifying specific constraints (e.g., a certain QoS is required). As connectivity is a measure related to both of them (partitions and selected paths) this work provides a formal lower bound to it based on core-decomposition, under certain conditions, and low complexity algorithms to find it. We apply them to analyze maps obtained from the prominent Internet mapping projects, using the LaNet-vi open-source software for its visualization

    Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

    Germline MBD4 deficiency causes a multi-tumor predisposition syndrome

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    We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4. We identified five individuals with bi-allelic MBD4 variants within four families and these individuals had a personal and/or family history of adenomatous colorectal polyposis, acute myeloid leukemia, and uveal melanoma. MBD4 encodes a glycosylase involved in repair of G:T mismatches resulting from deamination of 5'-methylcytosine. The colorectal adenomas from MBD4-deficient individuals showed a mutator phenotype attributable to mutational signature SBS1, consistent with the function of MBD4. MBD4-deficient polyps harbored somatic mutations in similar driver genes to sporadic colorectal tumors, although AMER1 mutations were more common and KRAS mutations less frequent. Our findings expand the role of BER deficiencies in tumor predisposition. Inclusion of MBD4 in genetic testing for polyposis and multi-tumor phenotypes is warranted to improve disease management. Keywords: 5′-methylcytosine deamination; colorectal cancer; mutational signature; mutator phenotype; polyposi

    A COMPARISION BETWEEN STATIC AND DYNAMIC FOOT MOBILITY MAGNITUDE MEASURES

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    Traditional methods used to assess foot posture during dynamic activities rely on static measures of foot dimensions during partial weight bearing. In recent years, evidence was found which links musculoskeletal and overuse injury patterns in athletes to foot posture. To be able to accurately assess the relationship between injury patterns and foot posture, it might be necessary to study changes in the foot posture during the dynamic activities that the athlete normally undertakes. The purpose of this research is to introduce a method which can be used to measure changes in the foot posture during dynamic activities, hence providing a better prediction of the changes in the foot posture and its relationship to lower limb injuries. The results from static and dynamic Foot posture measures were compared for two subjects and the results showed significant differences

    A comparison between static and dynamic foot mobility magnitude measures

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    Traditional methods used to assess foot posture during dynamic activities rely on static measures of foot dimensions during partial weight bearing. In recent years, evidence was found which links musculoskeletal and overuse injury patterns in athletes to foot posture. To be able to accurately assess the relationship between injury patterns and foot posture, it might be necessary to study changes in the foot posture during the dynamic activities that the athlete normally undertakes. The purpose of this research is to introduce a method which can be used to measure changes in the foot posture during dynamic activities, hence providing a better prediction of the changes in the foot posture and its relationship to lower limb injuries. The results from static and dynamic foot posture measures were compared for two subjects and the results showed significant differences

    A business model perspective for ICTs in public engagement

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    This is the post-print version of the Article. The official published article can be accessed from the link below - Copyright @ 2012 ElsevierPublic institutions, in their efforts to promote meaningful citizen engagement, are increasingly looking at the democratic potential of Information and Communication Technologies (ICTs). Previous studies suggest that such initiatives seem to be impeded by socio-technical integration barriers such as low sustainability, poor citizen acceptance, coordination difficulties, lack of understanding and failure to assess their impact. Motivated by these shortcomings, the paper develops and applies a business model perspective as an interceding framework for analysis and evaluation. The underlying principle behind this approach is that it is not technology per se which determines success, but rather the way in which the businessmodel of the technological artifact is configured and employed to achieve the strategic goals. The business model perspective is empirically demonstrated with the case of an online petitioning system implemented by a UK local authority. The case illustrates the importance of considering ICTs in public engagement from a holistic view to make them more manageable and assessable
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