Super-spreading Events and Contribution to Transmission of MERS, SARS, and COVID-19

There is no clear definition for the term ‘super-spreader’ or ‘super-spreading event’. The World Health Organization refers to a super-spreader as a patient (or an event) that may transmit infection to a larger number of individuals than is usual by one individual (or event). In the severe acute respiratory syndrome (SARS) situation, a super-spreading event was defined as the transmission of SARS to at ≥8 contacts, and other authors defined this as individuals infecting an unusually large number of secondary cases [ 1 , 2 ]. A super-spreading event could merely be defined as an event in which one patient infects far more people than an average patient does, which is estimated by the basic reproduction number (R0)

Convergent Validity and Internal Consistency of an Arabic Snaith Hamilton Pleasure Scale

Anhedonia, a reduced capacity for pleasure, is viewed as a trait-like vulnerability marker for schizophrenia and depressive disorders. To date there are scarce data from the Arab world on anhedonia as a symptom, and even less on the psychometric properties of instruments designed to assess it. This study examines the internal consistency of an Arabic version of the Snaith Hamilton Pleasure Scale (SHAPS), and its convergence with real-time hedonic responses to emotional stimuli. A correlational study design is used; undergraduate students ( N = 113) in the United Arab Emirates (UAE) completed the SHAPS, and also undertook an expanded version of the picture rating task (PRT). The PRT required participants to rate a series of pleasant and unpleasant images in terms of emotional valence. Levels of anhedonia as assessed by SHAPs were similar to those observed in nonclinical populations in other countries. Internal consistency for the Arabic version of SHAPs was very good; α = .86. Furthermore, SHAPS scores were correlated with lower valence ratings for pleasant images ( r = .36), and uncorrelated with unpleasant images. The SHAPS appears to be a useful instrument for assessing anhedonia in the present UAE student population

Optimization of Mixed Numerology Profiles for 5G Wireless Communication Scenarios

The management of 5G resources is a demanding task, requiring proper planning of operating numerology indexes and spectrum allocation according to current traffic needs. In addition, any reconfigurations to adapt to the current traffic pattern should be minimized to reduce signaling overhead. In this article, the pre-planning of numerology profiles is proposed to address this problem, and a mathematical optimization model for their planning is developed. The idea is to explore requirements and impairments usually present in a given wireless communication scenario to build numerology profiles and then adopt one of the profiles according to the current users/traffic pattern. The model allows the optimization of mixed numerologies in future 5G systems under any wireless communication scenario, with specific service requirements and impairments, and under any traffic scenario. Results show that, depending on the granularity of the profiles, the proposed optimization model is able to provide satisfaction levels of 60–100%, whereas a non-optimized approach provides 40–65%, while minimizing the total number of numerology indexes in operation.Competitiveness and Internationalization Operational Programme (COMPETE 2020), the Regional Operational Program of the Algarve (2020), and Fundação para a Ciência e Tecnologia; i-Five: Extensão do acesso de espectro dinâmico para rádio 5G, POCI-01-0145-FEDER-030500. This work is also supported by Fundação para a ciência e Tecnologia within CEOT (Center for Electronic, Optoelectronic and Telecommunications) and the UID/MULTI/00631/2020 projectinfo:eu-repo/semantics/publishedVersio

Ide-cel or standard regimens in relapsed and refractory multiple myeloma

BACKGROUND: Survival is poor among patients with triple-class-exposed relapsed and refractory multiple myeloma. Idecabtagene vicleucel (ide-cel), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T-cell therapy, previously led to deep, durable responses in patients with heavily pretreated relapsed and refractory multiple myeloma. METHODS: In this international, open-label, phase 3 trial involving adults with relapsed and refractory multiple myeloma who had received two to four regimens previously (including immunomodulatory agents, proteasome inhibitors, and daratumumab) and who had disease refractory to the last regimen, we randomly assigned patients in a 2:1 ratio to receive either ide-cel (dose range, 150×10 RESULTS: A total of 386 patients underwent randomization: 254 to ide-cel and 132 to a standard regimen. A total of 66% of the patients had triple-class-refractory disease, and 95% had daratumumab-refractory disease. At a median follow-up of 18.6 months, the median progression-free survival was 13.3 months in the ide-cel group, as compared with 4.4 months in the standard-regimen group (hazard ratio for disease progression or death, 0.49; 95% confidence interval, 0.38 to 0.65; P\u3c0.001). A response occurred in 71% of the patients in the ide-cel group and in 42% of those in the standard-regimen group (P\u3c0.001); a complete response occurred in 39% and 5%, respectively. Data on overall survival were immature. Adverse events of grade 3 or 4 occurred in 93% of the patients in the ide-cel group and in 75% of those in the standard-regimen group. Among the 225 patients who received ide-cel, cytokine release syndrome occurred in 88%, with 5% having an event of grade 3 or higher, and investigator-identified neurotoxic effects occurred in 15%, with 3% having an event of grade 3 or higher. CONCLUSIONS: Ide-cel therapy significantly prolonged progression-free survival and improved response as compared with standard regimens in patients with triple-class-exposed relapsed and refractory multiple myeloma who had received two to four regimens previously. The toxicity of ide-cel was consistent with previous reports. (Funded by 2seventy bio and Celgene, a Bristol-Myers Squibb company; KarMMa-3 ClinicalTrials.gov number, NCT03651128.)

Prepronociceptin-expressing neurons in the extended amygdala encode and promote rapid arousal responses to motivationally salient stimuli

Motivational states consist of cognitive, emotional, and physiological components controlled by multiple brain regions. An integral component of this neural circuitry is the bed nucleus of the stria terminalis (BNST). Here, we identify that neurons within BNST that express the gene prepronociceptin (Pno

Reusable Augmented Concrete System: Accessible Method for Formwork Manufacturing through Holographic Guidance

Reinforced concrete has been one of the essential materials for modern architecture for the last hundred years. Its use is entirely global, having been adopted by all cultures and styles since its invention in the late 19th century. Although its value is excellent due to its low cost, durability and adaptability, its environmental impact is significant, being, in fact, one of the most polluting industries in the world (Babor et al. 2009). This experimental project will research a more sustainable use of concrete, exploring a new form of reusable concrete formwork that will ideally reduce the CO2 footprint by removing wood waste in the casting process and replacing it with adaptable metal components. The modular part-based system for the concrete casting also attempts to simplify one of the current complexities for concrete construction, the Skilled-Labour shortage. (Yusoff et al. 2021). To mitigate this problem, the project also proposes using an Augmented Assembly logic for the casting parts to guide the ensemble and dismantle the formwork through an optimised algorithmic logic. The use of Augmented Reality as a replacement for traditional paper instructions will facilitate access to more workers to this construction art and potentially improve access to optimised use of concrete in developing communities with restricted building technological resources

OLA! A Scenario-Based Approach to Enhance Open Learning Through Accessibility

Open Educational Resources (OER) and Massive Open Online Courses (MOOC) have not developed with an inherent capacity to attend to the needs of disabled students. In our research, we aim to understand the social, contextual and organisational issues behind these inadequacies. Through this, interventions and best practices can be developed to improve the situation

Enabling digital grid for industrial revolution: self-healing cyber resilient platform

The key market objectives driving digital grid development are to provide sustainable, reliable and secure network systems that can support variety of applications against any potential cyber attacks. Therefore, there is an urgent demand to accelerate the development of intelligent Software-Defined Networking (SDN) platform that can address the tremendous challenges of data protection for digital resiliency. Modern grid technology tends to adopt distributed SDN controllers for further slicing power grid domain and protect the boundaries of electric data at network edges. To accommodate these issues, this article proposes an intelligent secure SDN controller for supporting digital grid resiliency, considering management coordination capability, to enable self-healing features and recovery of network traffic forwarding during service interruptions. A set of advanced features are employed in grid controllers to configure the network elements in response to possible disasters or link failures. In addition, various SDN topology scenarios are introduced for efficient coordination and configurations of network domains. Finally, to justify the potential advantages of intelligent secure SDN system, a case study is presented to evaluate the requirements of secure digital modern grid networks and pave the path towards the next phase of industry revolution

International Conference on NeuroRehabilitation 2012

This volume 3, number 2 gathers a set of articles based on the most outstanding research on accessibility and disability issues that was presented in the International Conference on NeuroRehabilitation 2012 (ICNR).The articles’ research present in this number is centred on the analysis and/or rehabilitation of body impairment most due to brain injury and neurological disorders.JACCES thanks the collaboration of the ICNR members and the research authors and reviewers that have collaborated for making possible that issue