Actin acting at the Golgi

The organization, assembly and remodeling of the actin cytoskeleton provide force and tracks for a variety of (endo)membrane-associated events such as membrane trafficking. This review illustrates in different cellular models how actin and many of its numerous binding and regulatory proteins (actin and co-workers) participate in the structural organization of the Golgi apparatus and in traf- ficking-associated processes such as sorting, biogenesis and motion of Golgi-derived transport carriers

MSCs for Diabetes

Mesenchymal stromal cells (also often referred to as mesenchymal stem cells, MSCs) hold promise as a powerful tool in the treatment of human diseases. Because of their potent immunomodulatory properties, they are likely to impact in a positive fashion diseases in which inflammation and/or autoimmunity play a key role. Furthermore, they have been shown to possess plasticity as precursors of cells of various types. Their differentiation potential could span cell differentiation products that do not normally derive from the mesoderm, including cells of endodermal origin. These two remarkable features make them potentially ideal candidates for regenerative approaches. This chapter will briefly discuss the current state of the art in the emerging field of their use for autoimmune type 1 diabetes